Two new eremophilane sesquiterpenes 3β-angeloyloxy-8α-hydroxy-6β-methoxy eremophil-7 (11), 9 (10)-dien-8, 12-olide (1) and 3β-angeloyloxy-6β, 8α-dihydroxy-eremophi-7 (11), 9 (10)-dien-8, 12-olide (2) were isolat...Two new eremophilane sesquiterpenes 3β-angeloyloxy-8α-hydroxy-6β-methoxy eremophil-7 (11), 9 (10)-dien-8, 12-olide (1) and 3β-angeloyloxy-6β, 8α-dihydroxy-eremophi-7 (11), 9 (10)-dien-8, 12-olide (2) were isolated from Cacalia ainsliaeflora. Their structures were established by spectroscopic methods and 2D NMR experiments.展开更多
Six eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidated as 3-acetyl-9, 7 （11）-dien-7a-hydroxy-8-oxoeremophilane （1）, 3-acetyl-13-deoxyphomenone ...Six eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidated as 3-acetyl-9, 7 （11）-dien-7a-hydroxy-8-oxoeremophilane （1）, 3-acetyl-13-deoxyphomenone （2）, Sporogen-AO 1 （3）, 7-hydro- xypetasol （4）, 8a-hydroxy-13-deo -xyphomenone （5） and 6-dehydropetasol （6） based on detailed NMR analysis. 1 was a new compound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388, A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide rings in eremophilane molecules were essential for their activity, and acetylation could enhance their activity.展开更多
Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6 (7)-en-12-oic acid 2, and a novel nor-eremophilane derivative, 3β-angeloyl...Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6 (7)-en-12-oic acid 2, and a novel nor-eremophilane derivative, 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en 3 were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2D NMR.展开更多
Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane （1） and 6α, 15β-epoxy eremophila-7（11）-en-8α, 12-olide （2） were isolation from the roots of Ligularia macrophylla. Their structu...Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane （1） and 6α, 15β-epoxy eremophila-7（11）-en-8α, 12-olide （2） were isolation from the roots of Ligularia macrophylla. Their structures were deduced from spectroscopic methods and 2D NMR experiments.展开更多
基金This work was supported by the National Natural Sciencc Foundation of China No.29972017the Foundation of the Ministry of Education of China for Doctoral Program No.98073003
文摘Two new eremophilane sesquiterpenes 3β-angeloyloxy-8α-hydroxy-6β-methoxy eremophil-7 (11), 9 (10)-dien-8, 12-olide (1) and 3β-angeloyloxy-6β, 8α-dihydroxy-eremophi-7 (11), 9 (10)-dien-8, 12-olide (2) were isolated from Cacalia ainsliaeflora. Their structures were established by spectroscopic methods and 2D NMR experiments.
文摘Six eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidated as 3-acetyl-9, 7 （11）-dien-7a-hydroxy-8-oxoeremophilane （1）, 3-acetyl-13-deoxyphomenone （2）, Sporogen-AO 1 （3）, 7-hydro- xypetasol （4）, 8a-hydroxy-13-deo -xyphomenone （5） and 6-dehydropetasol （6） based on detailed NMR analysis. 1 was a new compound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388, A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide rings in eremophilane molecules were essential for their activity, and acetylation could enhance their activity.
文摘Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6 (7)-en-12-oic acid 2, and a novel nor-eremophilane derivative, 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en 3 were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2D NMR.
基金This work was supported by the National Natural Science Foundation of China(No.29972017).
文摘Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane （1） and 6α, 15β-epoxy eremophila-7（11）-en-8α, 12-olide （2） were isolation from the roots of Ligularia macrophylla. Their structures were deduced from spectroscopic methods and 2D NMR experiments.
