The similarities and differences of essential oil components in the raw ingredients of Ephedra （RIE） and processed products of Ephedra obtained by stir-baking with honey or stir-baking without any supplements were a...The similarities and differences of essential oil components in the raw ingredients of Ephedra （RIE） and processed products of Ephedra obtained by stir-baking with honey or stir-baking without any supplements were analyzed by GC-MS.Wet distillation （WD） and supercritical fluid extraction （SFE） were used to extract essential oil components from the samples.Total 48,57 and 48 compounds were found in the extracted essential oils using WD from RIE,the products obtained by stir-baking with honey from Ephedra （SBHE） and the products obtained by stir-baking without any supplements from Ephedra （SBE）,respectively whereas total 22,36 and 28 compounds were identified in the extracted essential oils using SPE from these three samples,respectively.In addition,14 and 9 new compounds were found in the essential oils extracted using WD from SBHE and SBE,whereas 15 and 23 new compounds were found in the essential oils extracted by SFE from SBHE and SBE,respectively.The composition and concentration of the essential oil components in the processed products were significantly different from RIE.Such changes in essential oil components might affect drug actions,which is dependent on the manner in which the sample is processed.The findings in this study may shed some lights on the understanding and further exploration of Ephedra processing.展开更多
The 2016 Albert Lasker Basic Medical Research Award honors three physician-scientists： William G. Kaelin, Jr. from Harvard Medical School, Peter J. Ratcliffe from Uni- versity of Oxford and Gregg L. Semenza, from Joh...The 2016 Albert Lasker Basic Medical Research Award honors three physician-scientists： William G. Kaelin, Jr. from Harvard Medical School, Peter J. Ratcliffe from Uni- versity of Oxford and Gregg L. Semenza, from Johns Hopkins University School of Medicine, for their discovery of the pathway by which cells from human and most animals sense and adapt to changes in oxygen availability, a process essential for survival. The Lasker Award is widely considered as America＇s mosLt prestigious honor in the biomedical field. For 71 years,展开更多
Summary Nucleolar GTP-binding protein 1 （NOG1） is a highly conserved GTPase first reported in Trypanosoma as required for ribosome biogenesis. We characterized NbNOG1, a Nicotiana benthamiana NOG1 ortholog sharing m...Summary Nucleolar GTP-binding protein 1 （NOG1） is a highly conserved GTPase first reported in Trypanosoma as required for ribosome biogenesis. We characterized NbNOG1, a Nicotiana benthamiana NOG1 ortholog sharing more than 4570 amino acid identity with Trypanosoma, yeast, and human NOG1. N. benthamiana plants silenced for NbNO0 were stunted and produced sterile flowers.展开更多
基金State Projects of the Eleventh-Five-year Plan (Grant No.2006BAI09B06-08-05)
文摘The similarities and differences of essential oil components in the raw ingredients of Ephedra （RIE） and processed products of Ephedra obtained by stir-baking with honey or stir-baking without any supplements were analyzed by GC-MS.Wet distillation （WD） and supercritical fluid extraction （SFE） were used to extract essential oil components from the samples.Total 48,57 and 48 compounds were found in the extracted essential oils using WD from RIE,the products obtained by stir-baking with honey from Ephedra （SBHE） and the products obtained by stir-baking without any supplements from Ephedra （SBE）,respectively whereas total 22,36 and 28 compounds were identified in the extracted essential oils using SPE from these three samples,respectively.In addition,14 and 9 new compounds were found in the essential oils extracted using WD from SBHE and SBE,whereas 15 and 23 new compounds were found in the essential oils extracted by SFE from SBHE and SBE,respectively.The composition and concentration of the essential oil components in the processed products were significantly different from RIE.Such changes in essential oil components might affect drug actions,which is dependent on the manner in which the sample is processed.The findings in this study may shed some lights on the understanding and further exploration of Ephedra processing.
文摘The 2016 Albert Lasker Basic Medical Research Award honors three physician-scientists： William G. Kaelin, Jr. from Harvard Medical School, Peter J. Ratcliffe from Uni- versity of Oxford and Gregg L. Semenza, from Johns Hopkins University School of Medicine, for their discovery of the pathway by which cells from human and most animals sense and adapt to changes in oxygen availability, a process essential for survival. The Lasker Award is widely considered as America＇s mosLt prestigious honor in the biomedical field. For 71 years,
文摘Summary Nucleolar GTP-binding protein 1 （NOG1） is a highly conserved GTPase first reported in Trypanosoma as required for ribosome biogenesis. We characterized NbNOG1, a Nicotiana benthamiana NOG1 ortholog sharing more than 4570 amino acid identity with Trypanosoma, yeast, and human NOG1. N. benthamiana plants silenced for NbNO0 were stunted and produced sterile flowers.
