Navigating the ethical terrain:Off-label and experimental treatments in medical case reports

This article explores the ethical considerations surrounding the reporting of offlabel and experimental treatments in medical case reports,with a focus on fields such as oncology,psychiatry,and pediatrics.It emphasizes the balance between innovation and evidence-based medicine,highlighting the critical role of case reports in disseminating clinical experiences and advancing medical knowledge.The discussion delves into the ethical framework guiding case reporting,including principles of patient autonomy,informed consent,non-maleficence,beneficence,justice,and transparency.Challenges such as negative outcome reporting,commercial interests,and the balance between innovation and caution are examined.Recommendations for ethical vigilance,the development of comprehensive guidelines,and the role of regulatory bodies are proposed to ensure patient safety and uphold scientific integrity.The article concludes by underscoring the importance of a collaborative effort among clinicians,researchers,ethicists,and regulatory bodies to foster the responsible advancement of medical science while adhering to the highest ethical standards.

Ethical-GPT:一种面向人工智能伦理教育的垂类GPT工具设计与实现

人工智能技术在推动教育变革的同时,也引发了诸如隐私泄露、技术滥用等伦理风险挑战,使得加强人工智能伦理教育势在必行。同时,当前教育人工智能伦理建设过程中存在的学习资源稀缺、教学方式单一、缺乏实质性的伦理实践等问题也亟待解决。对此,文章首先采用“大语言模型微调+本地知识库”的技术路线,设计了面向人工智能伦理教育的垂类GPT工具——Ethical-GPT,并介绍了Ethical-GPT的基础问答、案例学习、情境模拟、智能测验四大功能模块;之后,文章从大模型选取、本地知识库建设、高效模型微调等方面重点阐述了Ethical-GPT的技术实现,并通过对比不同模型的回答结果进行了模型效果分析,发现Ethical-GPT具有良好的专业问答能力,并且能够随机生成并呈现多样化的伦理案例;最后,文章深入探讨了Ethical-GPT的教育应用场景。文章设计的Ethical-GPT不仅为人工智能伦理的教育实践提供了工具支持,也为推动教育领域专用大语言模型的构建提供了参考思路。

Challenges and Suggestions of Ethical Review on Clinical Research Involving Brain-Computer Interfaces

Brain-computer interface(BCI)technology is rapidly advancing in medical research and application.As an emerging biomedical engineering technology,it has garnered significant attention in the clinical research of brain disease diagnosis and treatment,neurological rehabilitation,and mental health.However,BCI also raises several challenges and ethical concerns in clinical research.In this article,the authors investigate and discuss three aspects of BCI in medicine and healthcare:the state of international ethical governance,multidimensional ethical challenges pertaining to BCI in clinical research,and suggestive concerns for ethical review.Despite the great potential of frontier BCI research and development in the field of medical care,the ethical challenges induced by itself and the complexities of clinical research and brain function have put forward new special fields for ethics in BCI.To ensure"responsible innovation"in BCI research in healthcare and medicine,the creation of an ethical global governance framework and system,along with special guidelines for cutting-edge BCI research in medicine,is suggested.

Errata regarding missing Ethical Statements in previously published articles:Part 3

Ethical statements were not included in the published version of the following articles that appeared in previous issues of Journal of Integrative Agriculture.The appropriate statements provided by the Authors are included below.

Errata regarding missing Ethical Statements in previously published articles:Part 5

Ethical statements were not included in the published version of the following articles that appeared in previous issues of Journal of Integrative Agriculture.The appropriate statements provided by the Authors are included below.

Errata regarding missing Ethical Statements in previously published articles:Part 4

Ethical statements were not included in the published version of the following articles that appeared in previous issues of Journal of Integrative Agriculture.The appropriate statements provided by the Authors are included below.

Errata regarding missing Ethical Statements in previously published articles:Part 1

Ethical statements were not included in the published version of the following articles that appeared in previous issues of Journal of Integrative Agriculture.The appropriate statements provided by the Authors are included below.

Errata regarding missing Ethical Statements in previously published articles:Part 2

Ethical statements were not included in the published version of the following articles that appeared in previous issues of Journal of Integrative Agriculture.The appropriate statements provided by the Authors are included below.

Ethical Decision-Making Framework Based on Incremental ILP Considering Conflicts

Humans are experiencing the inclusion of artificial agents in their lives,such as unmanned vehicles,service robots,voice assistants,and intelligent medical care.If the artificial agents cannot align with social values or make ethical decisions,they may not meet the expectations of humans.Traditionally,an ethical decision-making framework is constructed by rule-based or statistical approaches.In this paper,we propose an ethical decision-making framework based on incremental ILP(Inductive Logic Programming),which can overcome the brittleness of rule-based approaches and little interpretability of statistical approaches.As the current incremental ILP makes it difficult to solve conflicts,we propose a novel ethical decision-making framework considering conflicts in this paper,which adopts our proposed incremental ILP system.The framework consists of two processes:the learning process and the deduction process.The first process records bottom clauses with their score functions and learns rules guided by the entailment and the score function.The second process obtains an ethical decision based on the rules.In an ethical scenario about chatbots for teenagers’mental health,we verify that our framework can learn ethical rules and make ethical decisions.Besides,we extract incremental ILP from the framework and compare it with the state-of-the-art ILP systems based on ASP(Answer Set Programming)focusing on conflict resolution.The results of comparisons show that our proposed system can generate better-quality rules than most other systems.

Ethical framework for artificial intelligence in healthcare research:A path to integrity

The integration of Artificial Intelligence(AI)into healthcare research promises unprecedented advancements in medical diagnostics,treatment personalization,and patient care management.However,these innovations also bring forth significant ethical challenges that must be addressed to maintain public trust,ensure patient safety,and uphold data integrity.This article sets out to introduce a detailed framework designed to steer governance and offer a systematic method for assuring that AI applications in healthcare research are developed and executed with integrity and adherence to medical research ethics.

Facing ethical concerns in the age of precise gene therapy:Outlook on inherited arrhythmias

This editorial,comments on the article by Spartalis et al published in the recent issue of the World Journal of Cardiology.We here provide an outlook on potential ethical concerns related to the future application of gene therapy in the field of inherited arrhythmias.As monogenic diseases with no or few therapeutic options available through standard care,inherited arrhythmias are ideal candidates to gene therapy in their treatment.Patients with inherited arrhythmias typically have a poor quality of life,especially young people engaged in agonistic sports.While genome editing for treatment of inherited arrhythmias still has theoretical application,advances in CRISPR/Cas9 technology now allows the generation of knock-in animal models of the disease.However,clinical translation is somehow expected soon and this make consistent discussing about ethical concerns related to gene editing in inherited arrhythmias.Genomic off-target activity is a known technical issue,but its relationship with ethnical and individual genetical diversity raises concerns about an equitable accessibility.Meanwhile,the costeffectiveness may further limit an equal distribution of gene therapies.The economic burden of gene therapies on healthcare systems is is increasingly recognized as a pressing concern.A growing body of studies are reporting uncertainty in payback periods with intuitive short-term effects for insurance-based healthcare systems,but potential concerns for universal healthcare systems in the long term as well.Altogether,those aspects strongly indicate a need of regulatory entities to manage those issues.

Integrating GPT into the Journalism and Communication Industries:The Technological Logic,Ecosystem Reconstruction,and Ethical Chal enges

Generative AI,represented by GPT(Generative Pre-trained Transformer),is now leading the technological revolution and is reconstructing the journalism and communication industries'ecosystems because of its powerful generative capacity and diverse range of outputs.While GPT is busy revolutionizing and innovating the production of news content,working patterns,and operation modes,it has also given rise to ethical concerns in regard to news authenticity,data security,humanistic values,and other related aspects.Therefore,it is imperative to initiate strategies and approaches,such as establishing a mechanism for verifying information authenticity,enhancing data security and privacy regulations,and instituting an ethical supervision and governance framework for AI,in order to facilitate the systematic advancement of AI-based news production while reinstating public trust.

The Ethical Choice of Business English Interpreters under Chesterman’s Model of Translation Ethics

This paper explores the ethical challenges encountered by business English interpreters using Chesterman’s Model of Translation Ethics,set against the context of economic globalization and the“Belt and Road”initiative.With the increasing demand for interpreters,the paper delves into the ongoing discussion about the role of AI in translation and its limitations,especially concerning cultural subtleties and ethical issues.It highlights the importance of human interpreters’cross-cultural understanding and the ethical principles that inform their work,such as the Ethics of Representation,Service,Communication,Norm-based Ethics,and Commitment.Moreover,the paper examines how these ethical models are applied in practical business situations,including business banquets,business negotiations,business talks and business visits,etc.,and investigates the cultural misunderstandings that may occur during these interactions.The study concludes that although AI provides efficiency and cost savings,human interpreters are essential for their capacity to handle the intricacies of cross-cultural communication with cultural awareness and ethical discernment.

Promoting Ethical Sensitivity in Nursing Education:A Systematic Review of Case Study-Based Health Education

Introduction: Nursing ethical sensitivity refers to a nurse’s capacity for thoughtful consideration of ethical issues when faced with dilemmas. In the nursing domain, ethical dilemmas arise when nurses face challenges in making sound ethical decisions during clinical practice. These challenges may stem from conflicts between personal values and professional responsibilities. Methodology: Articles downloaded from Pub Med, CNKI, and Google Scholar were reviewed. Results: After rigorous screening, a meticulous analysis was conducted, encompassing 10 articles and involving a substantial cohort of 2863 participants. Existing literature revealed variations in the ethical dilemmas faced by nurses across different departments. The ethical sensitivity of nurses also varies, with higher ethical sensitivity correlating with stronger empathetic abilities. Zhen et al. classified the causes of ethical dilemmas into four main categories: (1) Ethical dilemmas arising from personal reasons of nursing students;(2) Ethical dilemmas stemming from the actions of teachers;(3) Ethical dilemmas triggered by patients;(4) Ethical dilemmas resulting from miscellaneous reasons. Conclusion: According to literature findings, nursing ethical sensitivity was positively linked to the nurse’s ethical decision-making ability. A case study-oriented teaching program has proven effective in enhancing ethical sensitivity among nursing students.

Ethical frontiers in liver transplantation

Liver transplantation represents a pivotal intervention in the management of end-stage liver disease,offering a lifeline to countless patients.Despite significant strides in surgical techniques and organ procurement,ethical dilemmas and de-bates continue to underscore this life-saving procedure.Navigating the ethical terrain surrounding this complex procedure is hence paramount.Dissecting the nuances of ethical principles of justice,autonomy and beneficence that underpin transplant protocols worldwide,we explore the modern challenges that plaques the world of liver transplantation.We investigate the ethical dimensions of organ transplantation,focusing on allocation,emerging technologies,and decision-making processes.PubMed,Scopus,Web of Science,Embase and Central were searched from database inception to February 29,2024 using the following key-words:“liver transplant”,“transplantation”,“liver donation”,“liver recipient”,“organ donation”and“ethics”.Information from relevant articles surrounding ethical discussions in the realm of liver transplantation,especially with regards to organ recipients and allocation,organ donation,transplant tourism,new age technologies and developments,were extracted.From the definition of death to the long term follow up of organ recipients,liver transplantation has many ethical quandaries.With new transplant techniques,societal acceptance and perceptions also play a pivotal role.Cultural,religious and regional factors including but not limited to beliefs,wealth and accessibility are extremely influential in public at-titudes towards donation,xenotransplantation,stem cell research,and adopting artificial intelligence.Understanding and addressing these perspectives whilst upholding bioethical principles is essential to ensure just distribution and fair allocation of resources.Robust regulatory oversight for ethical sourcing of organs,ensuring good patient selection and transplant techniques,and high-quality long-term surveillance to mitigate risks is essential.Efforts to promote equitable access to transplantation as well as prioritizing patients with true needs are essential to address disparities.In conclusion,liver transplantation is often the beacon of hope for individuals suffering from end-stage liver disease and improves quality of life.The ethics related to transplantation are complex and multifaceted,considering not just the donor and the recipient,but also the society as a whole.

On Ethical Literary Criticism and Game Theory--An Interview with Professor Nie Zhenzhao

In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic visiting to Central China Normal University.As early as in 2005,Huang Kaihong conducted an interview with Professor Nie Zhenzhao on the topic of the general introduction of ethical literary criticism.So around 11 years later,the second interview mainly covers not only the ethical literary criticism theory,but the game theory and the relationship between them as well.Professor Nie thinks whether the game theory can be applied to literature research is still under discussion.The theory of ethical literary criticism is a kind of methodology based on science and it can get the attention of literary critics at home and abroad,which is because it fits the practical needs of literary criticism,draws the literary criticism away from only emphasizing criticism genres and the research of criticism terms,and pays attention to the true nature of the literary text in literature research.After consulting Professor Nie Zhenzhao about some related questions from the perspective of game theory.Huang Kaihong gets some significant information concerning literature research and understands the latest core terms and the concrete application method of ethical literary criticism,especially the relationship between the instructing and aesthetic functions of literature.

The Ethical Dilemmas of International Environmental Justice and its＇ Resolution

主权国家作为全球环境治理的最为重要的主体，在国际环境正义实践中发挥着决定性的作用，但另一方面由于主权国家“个体”利益的存在，主权国家在参与国际环境正义实践时面临着一些伦理困境。要化解这些伦理困境，构建和谐世界，主权国家除了要树立主体间性和生态文明的主体性之外，还要调适国家主权观，加强国际合作，建立新的全球伙伴关系。

An Ethical Interpretation of Virginia Woolf's Mrs.Dalloway

As a stream-of-consciousness novelist,Woolf is usually seen as being far away from social and political reality.This thesis attempts to apply Ethical Literary Criticism to analyze by rereading the text in detail in order to explore the ethical thinking embodied in Woolf's Mrs.Dalloway,exploring those ethical connotations usually ignored by former critics and scholars.

Artificial Intelligence in Healthcare and Medicine:Promises,Ethical Challenges and Governance

Artificial intelligence (AI) is rapidly being applied to a wide range of fields,including medicine,and has been considered as an approach that may augment or substitute human professionals in primary healthcare.However,AI also raises several challenges and ethical concerns.In this article,the author investigates and discusses three aspects of AI in medicine and healthcare:the application and promises of AI,special ethical concerns pertaining to AI in some frontier fields,and suggestive ethical governance systems.Despite great potentials of frontier AI research and development in the field of medical care,the ethical challenges induced by its applications has put forward new requirements for governance.To ensure “trustworthy” AI applications in healthcare and medicine,the creation of an ethical global governance framework and system as well as special guidelines for frontier AI applications in medicine are suggested.The most important aspects include the roles of governments in ethical auditing and the responsibilities of stakeholders in the ethical governance system.

The Ethical Explanation of The Spirit of Western Law

The order of western rule-of-law is always the sample of the construction of Chinese rule-of-law,but the spirit of western legal system,which is embodied as rule-of-law,right-equality,and rule-by-good-law,is correlated inherently with certain natural and social condition.Human nature theory of naturalism,the contract-ethics,and justice are the ethical foundations of Western law,and the idea of people-oriented,whose contents includes human's homony and happiness,always acompany with the western development history of rule-of-law.We should adhere the sense that people should abide by and respect law,and the law should constitute a kind of healthy and harmony interpersonal relationships and free and creative living-style.