以EVENS综合征为主要表现的高龄B细胞淋巴瘤1例

患者,男,89岁,因“发现血小板减少2天”于2022年12月5日来院就诊。血常规:WBC:5.10×10^(9)/L,Hb:84g/L,PLT:33×10^(9)/L,总胆红素36.3μmol/L,间接胆红素25.1μmol/L,LDH:1123 U/L,血清铁蛋白>1675.56 ng/m L,网织红细胞计数:0.155,网织红细胞比值:5.32%。

Spatio-temporal evolution analysis of landscape pattern and habitat quality in the Qinghai Province section of the Yellow River Basin from 2000 to 2022 based on InVEST model

Habitat quality is an important indicator for evaluating the quality of ecosystem.The Qinghai Province section of the Yellow River Basin plays an important role in the ecological protection of the upper reaches of the Yellow River Basin.To comprehensively analysis the alterations of habitat quality in the Qinghai Province section of the Yellow River Basin,this study utilized the Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST)model to calculate the habitat quality index and analyze the spatio-temporal variation characteristics of habitat quality in the study area from 2000 to 2022,and calculated seven landscape pattern indices(number of patches,patch density,largest patch index(LPI),landscape shape index(LSI),contagion index(CONTAG),Shannon diversity index,and Shannon evenness index)to research the variation of landscape pattern in the study area.The results showed that the number of patches,patch density,LPI,LSI,Shannon diversity index,and Shannon evenness index increased from 2000 to 2022,while the CONTAG decreased,indicating that the landscape pattern in the Qinghai Province section of the Yellow River Basin changed in the direction of distribution fragmentation,shape complexity,and heterogeneity.The average value of the habitat quality index in the Qinghai Province section of the Yellow River Basin from 2000 to 2022 was 0.90.Based on the value of habitat quality index,we divided the level of habitat quality into five categories:lower(0.00-0.20),low(0.20-0.40),moderate(0.40-0.60),high(0.60-0.80),and higher(0.80-1.00).Most areas were at the higher habitat quality level.The lower habitat quality patches were mainly distributed in Longyang Gorge and Yellow River-Huangshui River Valley.From 2000 to 2022,the habitat quality in most areas was stable;the increase areas were mainly distributed in Guinan County,while the decrease areas were mainly distributed in Xining City,Maqen County,Xinghai County,Qumarleb County,and Darlag County.To show the extent of habitat quality variation,we calculated Sen index.The results showed that the higher habitat quality area had a decrease trending,while other categories had an increasing tendency,and the decreasing was faster than increasing.The research results provide scientific guidance for promoting ecological protection and high-quality development in the Qinghai Province section of the Yellow River Basin.

Sequencing a Juglans regia×J.microcarpa hybrid yields high-quality genome assemblies of parental species

Members of the genus Juglans are monecious wind-pollinated trees in the family Juglandaceae with highly heterozygous genomes,which greatly complicates genome sequence assembly.The genomes of interspecific hybrids are usually comprised of haploid genomes of parental species.We exploited this attribute of interspecific hybrids to avoid heterozygosity and sequenced an interspecific hybrid Juglans microcarpa×J.regia using a novel combination of single-molecule sequencing and optical genome mapping technologies.The resulting assemblies of both genomes were remarkably complete including chromosome termini and centromere regions.Chromosome termini consisted of arrays of telomeric repeats about 8 kb long and heterochromatic subtelomeric regions about 10 kb long.The centromeres consisted of arrays of a centromere-specific Gypsy retrotransposon and most contained genes,many of them transcribed.Juglans genomes evolved by a whole-genome-duplication dating back to the Cretaceous-Paleogene boundary and consist of two subgenomes,which were fractionated by numerous short gene deletions evenly distributed along the length of the chromosomes.Fractionation was shown to be asymmetric with one subgenome exhibiting greater gene loss than the other.The asymmetry of the process is ongoing and mirrors an asymmetry in gene expression between the subgenomes.Given the importance of J.microcarpa×J.regia hybrids as potential walnut rootstocks,we catalogued disease resistance genes in the parental genomes and studied their chromosomal distribution.We also estimated the molecular clock rates for woody perennials and deployed them in estimating divergence times of Juglans genomes and those of other woody perennials.

Preparation and properties of PPSU/GO mixed matrix membrane

Polyphenylene sulfone/graphene oxide(PPSU/GO) mixed matrix membranes with different GO contents are prepared by phase inversion technique using, PEG-1000 as porogen, and N,N-dimethylacetamide(DMAC) as solvent.The hydrophilicity and pure water flux of the membrane are investigated. The morphology, hydrophilicity, thermodynamic stability and compatibility of the membranes are characterized by various techniques such as SEM,TGA, FTIR and so on. The permeation properties of the membrane are measured in terms of pure water flux and bovine serum albumin(BSA) retention. The results indicate that when the GO content is 1.5 wt%, an evenly distributed finger structure has been formed in the mixed matrix membranes. Owing to the presence of GO,the hydrophilicity and the thermal stability of the membranes are improved, and the fouling resistance is also enhanced.

Micro-Nanometer Parasitic Crystal Growth and Photoluminescence Property of Unique Screw-Cone Like Zn_(2)GeO_(4)-ZnO by Combustion Oxidization

screw-cone-like Zn_(2)GeO_(4)-ZnO particles with a base diameter of approximately 400 nm and a height of 400–800 nm or so were successfully synthesised by combustion oxidation of zinc and germanium powder at 960℃.No catalyst or carrier gases were used.XRD and SEM analyses reveal that Zn_(2)GeO_(4) and ZnO grew to parasitic crystals evenly in interaction with each other.EDS images exhibit the homogeneity of the distribution of Ge and Zn.The formation mechanism is discussed and attributed to the unique growth process of the screw-cone-like Zn_(2)GeO_(4)-ZnO particles and its vapour-solid(VS)growth mechanism.In addition,the Zn_(2)GeO_(4)-ZnO particles could tune the energy level structure of nano-tetrapod ZnO,which leads to the emission peak redshift from 376 nm to 435 nm and enhances the light emission intensity in the visible light region.

Landscape pattern and diversity of natural secondary forests in the eastern mountainous region, northeast China:A case study of Mao'ershan region in Heilongjiang Province

Mao抏rshan region is a representative natural secondary forested region in the eastern mountainous region, north-east of China. Under the support of ARC/INFO, the landscape pattern and landscape diversity of Maoerhshan region were studied by combining the forest type map (1:10000), which was drawn from the aerial photographs (1999), field investigation and land utilization map (1:10000). The selected indices included patch number, patch size, patch density index, richness index, dominance index, evenness index and diversity index. The results showed that the landscape dominant forest type in Mao抏rshan region was softwood broad-leaved forest. In all landscape types, the average patch area of natural secondary for-ests was bigger than that of artificial forest. The patch density index of each landscape formed in artificial forest was higher than that of natural secondary forest. The landscape diversity index and landscape evenness index of natural forest were highest, the landscape heterogeneity was also, but the landscape dominance was lower. In natural forest, the control effects of landscape elements on landscape-structure, function and its change were weakened. The artificial forest was on the contrary.

APPLICATION OF JIANG YA PASTE ONTO YONGQUAN ACUPOINT FOR TREATMENT OF PRIMARY HYPERTENSION

Since 1988, the authors have appliedthe Jiangya (BP lowering) Paste preparedaccording to his empirical recipe onto bilat-eral Yongquan acupoints (K 1) for treat-ment of primary hypertension. Clinical ob-servations have demonstrated that themethod has a very good effect on loweringhypertension. The method of treatment andthe therapeutic results are reported as fol-lows.

Fine mapping and characterization of the awn inhibitor B1 locus in common wheat(Triticum aestivum L.)

Awns play an important role in seed dispersal and photosynthesis of spikes.Three major awn inhibitors(Hd,B1,and B2)are reported in wheat.However,the molecular mechanism underlying awnlessness remained unknown until recently.In this study,we identified two F8 recombinant inbred lines(RILs)that were segregating for awn length.In order to identify the causal gene for awn length in the heterozygous inbred families(HIFs),SNPs were called from RNA sequencing(RNA-Seq)data for HIF-derived progenies with long and short awns.SNPs between long and short awn plants were evenly distributed on chromosomes(chr)other than chromosome 5 A.SNPs on chr 5 A were clustered in a region distal 688 Mb on the long arm,where inhibitor B1 was located.This suggested that B1 was the causal segregating locus.We precisely mapped B1 to^1 Mb region using two HIF-derived families.Considering that the lines segregated for long,intermediate and short awn phenotypes we speculated that B1 should have a dosage effect on awn length.Two differentially expressed genes(DEGs)located in the candidate region were regarded as candidate genes for B1,because the molecular expression pattern was consistent with the phenotype.HIFs with long and short awns showed no difference on grain yield and other agronomic traits.

Preparation of TiO_(x)/γ-Al_(2)O_(3) Catalyst on Powdery γ-Al_(2)O_(3) by Using Reactive Sputtering Deposition

A layer of TiO_(x) was deposited on powdery γ-Al_(2)O_(3) by using Sat-target magnetron sputtering in microwave electron cyclotron resonance plasma.A vibrator was developed to coat the γ-Al_(2)O_(3) particles evenly by TiO_(x).The conversion efficiency of methane and both the yield and the selectivity of C_(2) hydrocarbons and C_(2)H_(2) were revealed to be superior to that by conventional chemical method.The use of vibrator is effective.

这个从句中的that起什么作用?

[问][387]新修订的《大学英语》(上海外语教育出版社,1997年12月第2版)精读第三册第8单元中有一个句子(p.175):Attitudes to wards daydreamingare changing in much the same way thatattitudes towards night dreaming havechanged.请问that在这里起什么作用呢?

How to Identify Leap Years

A leap year has 366 days.Most years,ofcourse,have only 365 days.Leap year occurs everyfour years.Years that can be divided evenly byfour are almost always leap years.For example,

A New Process For RE-Treated Steel

A new process to manufacture RE-containing heavy cast steel ingots hasbeen:co-developed by Anshan Iron andSteel Corporation,Beijing University ofScience and Technology and MetalInstitute,Academia Sinica.In the process,a special movableequipment is employed to inject REalloy powder and argon,the RE carrier,into a tube.The RE alloy is swiftlymelted in the tube and evenly dis-tributed in molten steel which is thencast into ingots.Test production formore than ten thousand tons of suchsteel proved that by adopting thisprocess better RE distribution andhigher RE recovery(over 50%)in thesteel were achieved in comparison withthe oresent available data.The ratio

素数与合数

若a和b是自然数,且a=bq其中q也是个自然数,则q叫做是由数a除以数b所得到的商,并记作q=a/b.也可以说a能被b整除,或b除a而无余数。能除尽a的任何一个数b都叫做a的因数.数a本身相对于它的因数来说叫做倍数.因此,b的倍数是b,2b,3b,…数2的任何倍数（也就是能被2除尽的数）叫做偶数,不能被2整除的数叫做奇数.每一个自然数或是偶数,或是奇数.若两数a1,a2都是b的倍数,则它们的和a1+a2也是b的倍数.这显然可从下列得到:

Forest Community Structure and Species Diversity of Eight Forest Communities in Wenchang City

The research took different forest communities in Wenchang Satellite Launch Center as the research object and selected 8 forests to explore species diversity, evenness, and dominance of forests. The results showed that species diversity tended to be volatile upon forest communities; semi-mangrove species was the richest, as high as 2.38, followed by natural secondary forest and mixed forests. Plant evenness from high to low was as follows： herbaceous layer〉shrub layer〉tree layer. Natural secondary forest was higher in canopy density, and fewer in herbaceous plants; diversity and evenness were lower than shrub layer. Mangrove forests held lower dominance, and dominance showed insignificant differences among species.

Combination therapy using evening primrose oil and electrical stimulation to improve nerve function following a crush injury of sciatic nerve in male rats

Peripheral nerve injuries with a poor prognosis are common.Evening primrose oil（EPO） has beneficial biological effects and immunomodulatory properties.Since electrical activity plays a major role in neural regeneration,the present study investigated the effects of electrical stimulation（ES）,combined with evening primrose oil（EPO）,on sciatic nerve function after a crush injury in rats.In anesthetized rats,the sciatic nerve was crushed using small haemostatic forceps followed by ES and/or EPO treatment for 4 weeks.Functional recovery of the sciatic nerve was assessed using the sciatic functional index.Histopathological changes of gastrocnemius muscle atrophy were investigated by light microscopy.Electrophysiological changes were assessed by the nerve conduction velocity of sciatic nerves.Immunohistochemistry was used to determine the remyelination of the sciatic nerve following the interventions.EPO ＋ ES,EPO,and ES obviously improved sciatic nerve function assessed by the sciatic functional index and nerve conduction velocity of the sciatic nerve at 28 days after operation.Expression of the peripheral nerve remyelination marker,protein zero（P0）,was increased in the treatment groups at 28 days after operation.Muscle atrophy severity was decreased significantly while the nerve conduction velocity was increased significantly in rats with sciatic nerve injury in the injury ＋ EPO ＋ ES group than in the EPO or ES group.Totally speaking,the combined use of EPO and ES may produce an improving effect on the function of sciatic nerves injured by a crush.The increased expression of P0 may have contributed to improving the functional effects of combination therapy with EPO and ES as well as the electrophysiological and histopathological features of the injured peripheral nerve.

Diversity of woody plant species and their relationship to physiographic factors in central Zagros forests (Case study： Perc forest, Khorramabad, Iran)

Topography is the most factor that has the greatest impact of all factor that affect the distribution. To study the diversity of trees and shrub species in the Perc forest situated in Khorramabad, Lorestan, 140 circular plots of 1200 m2 in a grid of 300 m × 250 m were surveyed, using a systematic random sampling method. In each plot, the Margalef richness index, Shannon-Wiener diversity index, Hill＇s N1 and Simpson indices and the evenness index of Simpson and Smith-Wilson were calculated and ordered on the basis of different classes of elevation, exposition and slope. The results indicated that slope did not have any significant effect on the indices. Exposition and elevation classes significant impacted the richness and diversity indices, but did not influence evenness. In general, the highest plant diversity was observed for slopes less than 15 %, northern aspects, without geographical direction, and elevations of 2100-2200 m. This information can be very useful in achieving the goals for sustainable management of forests. In addition to greater protection for regions with high diversity and reforestation （compatible species） in degraded area, we can help increase diversity in forests.

Pedodiversity: a controversial concept

The concept of pedodiversity and its measurement methodology proposed and developed by Ibá?ez research term is introduced. An attempt to apply pedodiversity to analyze spatial soil variation and distribution patterns on the global scale is briefly demonstrated. Furthermore, constructive comments and criticisms on pedodiversity and its measurement from the noted pedologists and ecologists are outlined. Finally, potential applications of pedodiversity in soil science and other relevant disciplines are discussed.

Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function

Hepatocellular carcinoma(HCC) is one of the deadliest cancers in the world and is associated with a high risk of recurrence. The development of a wide range of new therapies is therefore essential. In this study, from the perspective of supportive therapy for the prevention of HCC recurrence and preservation of liver function in HCC patients, we surveyed a variety of different therapeutic agents. We show that branched chain amino acids(BCAA) supplementation and late evening snack with BCAA, strategies that address issues of protein-energy malnutrition, are important for liver cirrhotic patients with HCC. For chemoprevention of HCC recurrence, we show that viral control after radical treatment is important. We also reviewed the therapeutic potential of antiviral drugs, sorafenib, peretinoin, iron chelators. Sorafenib is a kinase inhibitor and a standard therapy in the treatment of advanced HCC. Peretinoin is a vitamin A-like molecule that targets the retinoid nuclear receptor to induce apoptosis and inhibit tumor growth in HCC cells. Iron chelators, such as deferoxamine and deferasirox, act to prevent cancer cell growth. These chelators may have potential as combination therapies in conjunction with peretinoin. Finally, we review the potential inhibitory effect of bone marrow cells on hepatocarcinogenesis.

The Typical Watershed of the Three Gorges Reservoir Area Soil Erosion Diversity Change on Different Slope Gradients Taking the Meixi River Watershed as an Example

[Objective] The diversity of soil erosion in the Meixi River watershed of the Three Gorges Reservoir Region was analyzed, in order to provide references for governance and protection of ecological environment of the study area. [Method] The soil erosion diversity index and evenness index of the Meixi River watershed in the Three Gorges Reservoir Region were studied based on the TM images in the year of 1988, 1999 and 2010, supported by GIS technology to extract various types of soil erosion in the area with different slope gradients and calculate soil erosion di- versity index and evenness index. [Result~ As slope gradients grew, the diversity in- dex and evenness index of soil erosion decrease after increasing with a turning point from 25~ to 35~. [Conchlsion] The proportion of light-erosion in the study area is 15.57%. Hence, the increase of diversity index and evenness index with gradients of 5^-35~ shows that the higher erosion intensity, the more uniform erosion types and the indexes decreased in gradients higher than 35°, suggesting that the lower erosion intensity, the better environment. Distribution and variation of different land types have close relation with soil erosion diversity and evenness indexes. Though soil erosion problems have been alleviated, by comparing soil erosion diversity index and evenness index, it can be concluded that changes of indexes are lower than 0.02, and soil erosion should be continued to be well controlled.