BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patie...BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.展开更多
Group key security protocols play an important role in today’s communication systems. Their verification, however, remains a great challenge because of the dynamic characteristics of group key construction and distri...Group key security protocols play an important role in today’s communication systems. Their verification, however, remains a great challenge because of the dynamic characteristics of group key construction and distribution protocols. Security properties that are well defined in normal two-party protocols have different meanings and different interpretations in group key distribution protocols, specifically, secrecy properties, such as group secrecy, forward secrecy, backward secrecy, and key independence. In this paper, we present a method to verify forward secrecy properties for group-oriented protocols. The method is based on a correct semantical link between group key protocols and event-B models and also uses the refinement process in the B method to model and verify group and forward secrecy. We use an event-B first-order theorem proving system to provide invariant checking for these secrecy properties. We illustrate our approach on the Tree based Group Diffie-Hellman protocol as case study.展开更多
There is a long-standing controversy of what triggered the extinction at the Permian-Triassic boundary, the most severe mass extinction in the geologic record, including flood basaltic volcanism and/or bolide impact h...There is a long-standing controversy of what triggered the extinction at the Permian-Triassic boundary, the most severe mass extinction in the geologic record, including flood basaltic volcanism and/or bolide impact hypothesis. In order to clarify various pieces of evidence for the mass extinction event at the Permian-Triassic boundary, some researchers from some laboratories throughout the world have made a comprehensive study on a group of samples from the Meishan area of China. Some fresh core samples from the Permian-Triassic boundary in the Meishan area were analyzed in this study. The results showed that there is no Ir anomaly. Moreover, the PGEs patterns of those samples show obvious differentiation characteristics, that is different from the case encountered in meteorites. So no evidence supports the hypothesis of extraterrestrial impact. In contrast, the PGEs patterns are similar to those of Siberian and Emeishan basalts, which indicates that those PGEs are derived mainly from the basalts, lending a support to the correlation between mass extinction at the Permian-Triassic boundary and flood basaltic volcanism. This study has also confirmed the results for samples from section C prior to the analysis of the samples.展开更多
Due to the increasing demand for security, the development of intelligent surveillance systems has attracted considerable attention in recent years. This study aims to develop a system that is able to identify whether...Due to the increasing demand for security, the development of intelligent surveillance systems has attracted considerable attention in recent years. This study aims to develop a system that is able to identify whether or not the people need help in a public place. Different from previous work, our work considers not only the behaviors of the target person but also the interaction between him and nearby people. In the paper, we propose an event alarm system which can detect the human behaviors and recognize the happening event through integrating the results generated from the single and group behavior analysis. Several new effective features are proposed in the study. Besides, a mechanism capable of extracting one-to-one and multiple-to-one relations is also developed. Experimental results show that the proposed approach can correctly detect human behaviors and provide the alarm messages when emergency events occur.展开更多
-Using the COADS data set of sea surface temperature in the Equatorial Eastern Pacific, thirty one El Nino events and twenty four anti -El Nino events were identified for the period from 1854 to 1987. The results were...-Using the COADS data set of sea surface temperature in the Equatorial Eastern Pacific, thirty one El Nino events and twenty four anti -El Nino events were identified for the period from 1854 to 1987. The results were compared with those of the other authors. The El Nino events (or anti -El Nino events ) are classified into two groups according to the timing of occrrence of the events: one starts at the first half of a year, another begins at the second half of a year. Both 1982-1983 and 1986-1987 events fall into the second group, which are characterized by the eastward migration of the positive anomaly of the sea surface temperature and the significant increasing of the anomaly in September or October.展开更多
The Mesoproterozoic Dongchuan Group that is widely exposed in Yimen area,central Yunnan Province is a series of sedimentary sort of low-grade metamorphic rocks interbedded with volcanic rocks,which are closely related...The Mesoproterozoic Dongchuan Group that is widely exposed in Yimen area,central Yunnan Province is a series of sedimentary sort of low-grade metamorphic rocks interbedded with volcanic rocks,which are closely related to the early tectonic evolution of the Earth.However,its formation era,sedimentary filling sequence,and geotectonic characteristics have always been in dispute.In this study,several rhyolitic tuffaceous slate interlayers with a centimeter-level thickness were found in the previously determined Heishan Formation of the Dongchuan Group located to the western part of Yimen-Luoci fault zone.This paper focuses on the study of the rhyolitic tuffaceous slate in Qifulangqing Village,Tongchang Township,Yimen County.LA-ICP-MS zircon dating was conducted,achieving the crystallization age of magma of 2491±15 Ma and the metamorphic ages of about 2.3 Ga,2.0 Ga,and 1.8 Ga for the first time.Meanwhile,according to in-situ Hf isotope analysis,the zirconεHf(t)values were determined to range from−3.0 to 7.6,with an average of 2.7.Furthermore,the first-stage Hf model age(TDM1)was determined to be 2513−2916 Ma,indicating that the provenance of the rhyolitic tuffaceous slate is the depleted mantle or juvenile crust between the Middle Mesoarchean and the Late Neoarchean.Therefore,it is believed that the strata of the slate were deposited in the Late Neoarchean,instead of the Mesoproterozoic as determined by previous researchers.Accordingly,it is not appropriate to group the strata into the Mesoproterozoic Dongchuan Group.Instead,they should be classified as the Maolu Formation of the Neoarchean Puduhe Group given the lithologic association and regional information.Furthermore,the magma ages of 2491±15 Ma are highly consistent with the eras of the large-scale Late Neoarchean orogenic magmatic activities on the northern margin of the Yangtze Craton,and thus reflect the orogenic process consisting of subduction and collision from Late Neoarchean to Early Paleoproterozoic.The magmatic activities during this period were possibly caused by the convergence of the supercontinent Kenorland.Meanwhile,the metamorphic ages of 2.3 Ga,2.0 Ga,and 1.8 Ga are highly consistent with three metamorphic ages of 2.36 Ga,1.95 Ga,and 1.85 Ga of the northern margin of the Yangtze Craton,indicating that the strata experienced Paleoproterozoic tectonic-thermal events.The study area is located on the eastern margin of Qinghai-Tibet Plateau,and thus was possibly re-transformed by magmatism subjected to the subduction of the Meso-Tethys Ocean during the Early Cretaceous.The discoveries made in this study will provide strong petrological and chronological evidence for analyzing the early crustal evolution of the Yangtze block.展开更多
After the occurrence of unexpected group events of network, the relevant opinion information will spread rapidly through micro-blog, and the negative public opinion information will aggravate the unexpected the group ...After the occurrence of unexpected group events of network, the relevant opinion information will spread rapidly through micro-blog, and the negative public opinion information will aggravate the unexpected the group events to upgrade and expand the scope of harm. It is difficult to deal. So public opinion control is very important. In this paper, we establish an influence model for spreading of public opinion based on SIR model. Through the political analysis, this paper finds that the network group events will subside, but the influence scope, time and ability of event cannot be ignored. As a result of this study, the corresponding strategies are put forward in this paper.展开更多
Between 1876 and 1878 a large-scale drought occurred in China. This is a major meteorological disaster and an extreme climate event despite the cold climate at the end of the Little Ice Age. In this paper the dynamic ...Between 1876 and 1878 a large-scale drought occurred in China. This is a major meteorological disaster and an extreme climate event despite the cold climate at the end of the Little Ice Age. In this paper the dynamic evolution of the occurrence and development of the drought is reproduced on the basis of historical literature records. These were used to calculate the yearly numbers of drought-hit counties and to determine the spatial distribution in addition with concomitant famine, locust plague and pestilence epidemic for each of the three years. The persistent drought disaster spread over 13 provinces with its center in Shaanxi, Henan and Shanxi provinces, where the continuous non-soaking rain period exceeded 340 days. Conclusively, it is more severe than the worst drought （1928-1930） in the 20th century. This drought disaster of 1876-1878 took place in the descending phase of the 11th sunspot activity period and the start of the 12th period. It also happened during a spell of frequent E1 Nino events and corresponds with an extremely strong E1 Nino.展开更多
We describe the last glaciation climatic history Marine Isotope Stage(MIS, 2-4) from 66.7 ka to 14.5 ka in Hexigten, northeast Inner Mongolia, North China. The climate of the region experienced frequent and significan...We describe the last glaciation climatic history Marine Isotope Stage(MIS, 2-4) from 66.7 ka to 14.5 ka in Hexigten, northeast Inner Mongolia, North China. The climate of the region experienced frequent and significant fluctuations between dry-cold and less dry-cold during the late MIS4. The climate was generally warm and humid during early MIS3(MIS3 c) and late MIS3(MIS3 a), whereas it was cold and dry in middle MIS3(MIS3 b) and during MIS2. In this study, the cold and dry conditions were correlated with a stronger East Asian winter monsoon and strong dune activity; whereas, warm and humid conditions were related to a stronger East Asian summer monsoon(EASM) and weak dune activity. This study establishes six distinct dry and cold intervals during the last glacial period(66.7-14.5 ka) based on optically stimulated luminescence data, multi-proxies record(magnetic susceptibility, grain size analysis, Rb/Sr, SiO2/TiO2) and chemical index of alteration(CIA). The last glacial period may be correlated with Heinrich events 1 to 6 which were further confirmed by comparison with the Hulu cave stalagmites and Greenland ice core records. It is concluded that the study area was substantially affected by the EASM, as compared with the loess-desert transition zone of the Chinese Loess Plateau, especially in MIS3 c and suggested that the East Asian monsoon played a pivotal role in the last glacial period climate and dune activity.展开更多
In this paper, We show that the simple K\-3-groups can be characterized by the orders of their maximal abelian subgroups. That is, we have Theorem Let G be a finite group and M a simple K \-3-group. Then ...In this paper, We show that the simple K\-3-groups can be characterized by the orders of their maximal abelian subgroups. That is, we have Theorem Let G be a finite group and M a simple K \-3-group. Then G is isomorphic to M if and only if the set of the orders of the maximal abelian subgoups of G is the same as that of M .展开更多
The ability to recognise video events has become increasingly more popular owing to its extensive practical applications.Most events will occur in certain scene with certain people,and the scene context and group cont...The ability to recognise video events has become increasingly more popular owing to its extensive practical applications.Most events will occur in certain scene with certain people,and the scene context and group context provide important information for event recognition.In this paper,we present an algorithm to recognise video events in different scenes in which there are multiple agents.First,we recognise events for each agent based on Stochastic Context Sensitive Grammar(SCSG).Then we propose the model of a scene in order to infer the scene in which the events occur,and we use a co-occurrence matrix of events to represent the group context.Finally,the scene and group context are exploited to distinguish events having similar structures.Experimental results show that by adding the scene and group context,the performance of events recognition can be significantly improved.展开更多
Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target...Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related diseases.Furthermore,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling pathway.This study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling pathway.Methods Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different groups.The targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were investigated.In addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,respectively.Furthermore,changes of the NF-κB signaling pathway in ILC1s were examined in the different groups.For the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling pathway.Results The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all P<0.05).In addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(P<0.05).The number of ILC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion miR-142-3p can regulate ILC1s by targeting HMGB1 via the NF-κB signaling pathway,and attenuate the inflammation at the maternal-fetal interface in abortive mice.展开更多
In this paper, the winter atmospheric circulation, the convection along the equator and their variations of 1982 and 1983 are investigated. It is suggested that there was a well organized three dimensional structure o...In this paper, the winter atmospheric circulation, the convection along the equator and their variations of 1982 and 1983 are investigated. It is suggested that there was a well organized three dimensional structure of anomalies of the atmospheric circulations during 1982 winter which may be related to the variations of the convection in the equatorial region.展开更多
基金Supported by the National Natural Science Foundation of China,No.81900743Heilongjiang Province Outstanding Young Medical Talents Training Grant Project,China,No.HYD2020YQ0007.
文摘BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.
文摘Group key security protocols play an important role in today’s communication systems. Their verification, however, remains a great challenge because of the dynamic characteristics of group key construction and distribution protocols. Security properties that are well defined in normal two-party protocols have different meanings and different interpretations in group key distribution protocols, specifically, secrecy properties, such as group secrecy, forward secrecy, backward secrecy, and key independence. In this paper, we present a method to verify forward secrecy properties for group-oriented protocols. The method is based on a correct semantical link between group key protocols and event-B models and also uses the refinement process in the B method to model and verify group and forward secrecy. We use an event-B first-order theorem proving system to provide invariant checking for these secrecy properties. We illustrate our approach on the Tree based Group Diffie-Hellman protocol as case study.
基金financially supported by the National Natural Science Foundation of China (No. 41073053)
文摘There is a long-standing controversy of what triggered the extinction at the Permian-Triassic boundary, the most severe mass extinction in the geologic record, including flood basaltic volcanism and/or bolide impact hypothesis. In order to clarify various pieces of evidence for the mass extinction event at the Permian-Triassic boundary, some researchers from some laboratories throughout the world have made a comprehensive study on a group of samples from the Meishan area of China. Some fresh core samples from the Permian-Triassic boundary in the Meishan area were analyzed in this study. The results showed that there is no Ir anomaly. Moreover, the PGEs patterns of those samples show obvious differentiation characteristics, that is different from the case encountered in meteorites. So no evidence supports the hypothesis of extraterrestrial impact. In contrast, the PGEs patterns are similar to those of Siberian and Emeishan basalts, which indicates that those PGEs are derived mainly from the basalts, lending a support to the correlation between mass extinction at the Permian-Triassic boundary and flood basaltic volcanism. This study has also confirmed the results for samples from section C prior to the analysis of the samples.
基金supported by the“MOST”under Grant No.104-2221-E-259-024-MY2
文摘Due to the increasing demand for security, the development of intelligent surveillance systems has attracted considerable attention in recent years. This study aims to develop a system that is able to identify whether or not the people need help in a public place. Different from previous work, our work considers not only the behaviors of the target person but also the interaction between him and nearby people. In the paper, we propose an event alarm system which can detect the human behaviors and recognize the happening event through integrating the results generated from the single and group behavior analysis. Several new effective features are proposed in the study. Besides, a mechanism capable of extracting one-to-one and multiple-to-one relations is also developed. Experimental results show that the proposed approach can correctly detect human behaviors and provide the alarm messages when emergency events occur.
文摘-Using the COADS data set of sea surface temperature in the Equatorial Eastern Pacific, thirty one El Nino events and twenty four anti -El Nino events were identified for the period from 1854 to 1987. The results were compared with those of the other authors. The El Nino events (or anti -El Nino events ) are classified into two groups according to the timing of occrrence of the events: one starts at the first half of a year, another begins at the second half of a year. Both 1982-1983 and 1986-1987 events fall into the second group, which are characterized by the eastward migration of the positive anomaly of the sea surface temperature and the significant increasing of the anomaly in September or October.
基金The work was financially supported by Project of 1∶50000 Regional Geological Survey of Samaki,Yinmin,Guicheng and Shugu Sheets in Yunnan Province by Land and Resources Department of Yunnan Province(D201905)Project of 1∶50000 Regional Geological Survey of Erjie,Yimen,Mingyihe and Shangpubei Sheets in Yunnan Province(DD20160017)Regional Geological Survey Area Summary and Service Product Development in Yunnan Province by China Geological Survey(121201102000150012-02).
文摘The Mesoproterozoic Dongchuan Group that is widely exposed in Yimen area,central Yunnan Province is a series of sedimentary sort of low-grade metamorphic rocks interbedded with volcanic rocks,which are closely related to the early tectonic evolution of the Earth.However,its formation era,sedimentary filling sequence,and geotectonic characteristics have always been in dispute.In this study,several rhyolitic tuffaceous slate interlayers with a centimeter-level thickness were found in the previously determined Heishan Formation of the Dongchuan Group located to the western part of Yimen-Luoci fault zone.This paper focuses on the study of the rhyolitic tuffaceous slate in Qifulangqing Village,Tongchang Township,Yimen County.LA-ICP-MS zircon dating was conducted,achieving the crystallization age of magma of 2491±15 Ma and the metamorphic ages of about 2.3 Ga,2.0 Ga,and 1.8 Ga for the first time.Meanwhile,according to in-situ Hf isotope analysis,the zirconεHf(t)values were determined to range from−3.0 to 7.6,with an average of 2.7.Furthermore,the first-stage Hf model age(TDM1)was determined to be 2513−2916 Ma,indicating that the provenance of the rhyolitic tuffaceous slate is the depleted mantle or juvenile crust between the Middle Mesoarchean and the Late Neoarchean.Therefore,it is believed that the strata of the slate were deposited in the Late Neoarchean,instead of the Mesoproterozoic as determined by previous researchers.Accordingly,it is not appropriate to group the strata into the Mesoproterozoic Dongchuan Group.Instead,they should be classified as the Maolu Formation of the Neoarchean Puduhe Group given the lithologic association and regional information.Furthermore,the magma ages of 2491±15 Ma are highly consistent with the eras of the large-scale Late Neoarchean orogenic magmatic activities on the northern margin of the Yangtze Craton,and thus reflect the orogenic process consisting of subduction and collision from Late Neoarchean to Early Paleoproterozoic.The magmatic activities during this period were possibly caused by the convergence of the supercontinent Kenorland.Meanwhile,the metamorphic ages of 2.3 Ga,2.0 Ga,and 1.8 Ga are highly consistent with three metamorphic ages of 2.36 Ga,1.95 Ga,and 1.85 Ga of the northern margin of the Yangtze Craton,indicating that the strata experienced Paleoproterozoic tectonic-thermal events.The study area is located on the eastern margin of Qinghai-Tibet Plateau,and thus was possibly re-transformed by magmatism subjected to the subduction of the Meso-Tethys Ocean during the Early Cretaceous.The discoveries made in this study will provide strong petrological and chronological evidence for analyzing the early crustal evolution of the Yangtze block.
文摘After the occurrence of unexpected group events of network, the relevant opinion information will spread rapidly through micro-blog, and the negative public opinion information will aggravate the unexpected the group events to upgrade and expand the scope of harm. It is difficult to deal. So public opinion control is very important. In this paper, we establish an influence model for spreading of public opinion based on SIR model. Through the political analysis, this paper finds that the network group events will subside, but the influence scope, time and ability of event cannot be ignored. As a result of this study, the corresponding strategies are put forward in this paper.
基金supported by the National Science and Technology Support Program of China under Grant No.2007BAC29B-01,and Grant No. 2010CB950103 under China Global Change Research Program
文摘Between 1876 and 1878 a large-scale drought occurred in China. This is a major meteorological disaster and an extreme climate event despite the cold climate at the end of the Little Ice Age. In this paper the dynamic evolution of the occurrence and development of the drought is reproduced on the basis of historical literature records. These were used to calculate the yearly numbers of drought-hit counties and to determine the spatial distribution in addition with concomitant famine, locust plague and pestilence epidemic for each of the three years. The persistent drought disaster spread over 13 provinces with its center in Shaanxi, Henan and Shanxi provinces, where the continuous non-soaking rain period exceeded 340 days. Conclusively, it is more severe than the worst drought （1928-1930） in the 20th century. This drought disaster of 1876-1878 took place in the descending phase of the 11th sunspot activity period and the start of the 12th period. It also happened during a spell of frequent E1 Nino events and corresponds with an extremely strong E1 Nino.
基金supported by the Research Fund for Hexigten Global Geopark(Grant No.62932014004)Specialized Fund for Fundamental Research Program of China University of Geosciences,Beijing(Grant No.2011YYL016)+1 种基金the Specialized Fund for Public Welfare Industry,Ministry of Land and Resources of China(Grant No.201211077-3)the Specialized Research Fund for the Doctoral Program of Higher Education of China(for PhD supervisors,Grant No.20110022110005)
文摘We describe the last glaciation climatic history Marine Isotope Stage(MIS, 2-4) from 66.7 ka to 14.5 ka in Hexigten, northeast Inner Mongolia, North China. The climate of the region experienced frequent and significant fluctuations between dry-cold and less dry-cold during the late MIS4. The climate was generally warm and humid during early MIS3(MIS3 c) and late MIS3(MIS3 a), whereas it was cold and dry in middle MIS3(MIS3 b) and during MIS2. In this study, the cold and dry conditions were correlated with a stronger East Asian winter monsoon and strong dune activity; whereas, warm and humid conditions were related to a stronger East Asian summer monsoon(EASM) and weak dune activity. This study establishes six distinct dry and cold intervals during the last glacial period(66.7-14.5 ka) based on optically stimulated luminescence data, multi-proxies record(magnetic susceptibility, grain size analysis, Rb/Sr, SiO2/TiO2) and chemical index of alteration(CIA). The last glacial period may be correlated with Heinrich events 1 to 6 which were further confirmed by comparison with the Hulu cave stalagmites and Greenland ice core records. It is concluded that the study area was substantially affected by the EASM, as compared with the loess-desert transition zone of the Chinese Loess Plateau, especially in MIS3 c and suggested that the East Asian monsoon played a pivotal role in the last glacial period climate and dune activity.
文摘In this paper, We show that the simple K\-3-groups can be characterized by the orders of their maximal abelian subgroups. That is, we have Theorem Let G be a finite group and M a simple K \-3-group. Then G is isomorphic to M if and only if the set of the orders of the maximal abelian subgoups of G is the same as that of M .
基金partially supported by the National Natural Science Foundation of China under Grant No.61203291the Specialised Research Fund for the Doctoral Program under Grant No.20121101110035
文摘The ability to recognise video events has become increasingly more popular owing to its extensive practical applications.Most events will occur in certain scene with certain people,and the scene context and group context provide important information for event recognition.In this paper,we present an algorithm to recognise video events in different scenes in which there are multiple agents.First,we recognise events for each agent based on Stochastic Context Sensitive Grammar(SCSG).Then we propose the model of a scene in order to infer the scene in which the events occur,and we use a co-occurrence matrix of events to represent the group context.Finally,the scene and group context are exploited to distinguish events having similar structures.Experimental results show that by adding the scene and group context,the performance of events recognition can be significantly improved.
基金supported by the National Key Research and Development Program of China(Nos.2018YFC1002804 and 2016YFC1000600)the National Natural Science Foundation of China(Nos.81771618 and 81971356)the Fundamental Research Funds for the Central Universities(No.2042023kf0028).
文摘Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related diseases.Furthermore,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling pathway.This study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling pathway.Methods Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different groups.The targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were investigated.In addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,respectively.Furthermore,changes of the NF-κB signaling pathway in ILC1s were examined in the different groups.For the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling pathway.Results The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all P<0.05).In addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(P<0.05).The number of ILC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion miR-142-3p can regulate ILC1s by targeting HMGB1 via the NF-κB signaling pathway,and attenuate the inflammation at the maternal-fetal interface in abortive mice.
文摘In this paper, the winter atmospheric circulation, the convection along the equator and their variations of 1982 and 1983 are investigated. It is suggested that there was a well organized three dimensional structure of anomalies of the atmospheric circulations during 1982 winter which may be related to the variations of the convection in the equatorial region.
