Massive‐scale genomic analysis reveals SARS‐CoV‐2 mutation characteristics and evolutionary trends

The severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)pandemic resulted in significant societal costs.Hence,an in‐depth understanding of SARS‐CoV‐2 virus mutation and its evolution will help determine the direction of the COVID‐19 pandemic.In this study,we identified 296,728 de novo mutations in more than 2,800,000 high‐quality SARS‐CoV‐2 genomes.All possible factors affecting the mutation frequency of SARS‐CoV‐2 in human hosts were analyzed,including zinc finger antiviral proteins,sequence context,amino acid change,and translation efficiency.As a result,we proposed that when adenine(A)and tyrosine(T)bases are in the context of AM(M stands for adenine or cytosine)or TA motif,A or T base has lower mutation frequency.Furthermore,we hypothesized that translation efficiency can affect the mutation frequency of the third position of the codon by the selection,which explains why SARS‐CoV‐2 prefers AT3 codons usage.In addition,we found a host‐specific asymmetric dinucleotide mutation frequency in the SARS‐CoV‐2 genome,which provides a new basis for determining the origin of the SARS‐CoV‐2.Finally,we summarize all possible factors affecting mutation frequency and provide insights into the mutation characteristics and evolutionary trends of SARS‐CoV‐2.

A Comparative Study of Supervised Classification Methods for Investigating Landslide Evolution in the Mianyuan River Basin,China

The Ms8.0 Wenchuan earthquake of 2008 dramatically changed the terrain surface and caused long-term increases in the scale and frequency of landslides and debris flows.The changing trend of landslides in the earthquake-affected area over the decade since the earthquake remains largely unknown.In this study,we were able to address this issue using supervised classification methods and multitemporal remote sensing images to study landslide evolution in the worst-affected area(Mianyuan River Basin)over a period of ten years.Satellite images were processed using the maximum likelihood method and random forest algorithm to automatically map landslide occurrence from 2007 to 2018.The principal findings are as follows:(1)when compared with visual image analysis,the random forest algorithm had a good average accuracy rate of 87%for landslide identification;(2)postevent landslide occurrence has generally decreased with time,but heavy monsoonal seasons have caused temporary spikes in activity;and(3)the postearthquake landslide activity in the Mianyuan River Basin can be divided into a strong activity period(2008 to 2011),medium activity period(2012 to 2016),and weak activity period(post 2017).Landslide activity remains above the prequake level,with damaging events being rare but continuing to occur.Long-term remote sensing and on-site monitoring are required to understand the evolution of landslide activity after strong earthquakes.

A review on palaeogeographic implications and temporal variation in glaucony composition

This study presents a review on palaeogeographic implications and temporal variations of giaucony coveringboth modern and ancient records. Phanerozoic giaucony preferably forms in a shelf depositional setting. Deep marine conditions and low seawater temperature discourage formation of glaucony. Around 75% of glaucony is recorded from the Cretaceous to the Holo- eene sediments, which are related to the abundance of the most common substrates, faecal pellets and bioclasts. TFe203 （total）, A1203, K20 and MgO contents of glaucony vary appreciably through geological time. IMhile TFe203 content of most Mesozoic and Cenozoic giaucony ex- ceeds 20%, it is always less than 20% in Precambrian varieties. High K20, A1203, MgO and low TFe203 distinguish the Precambrian glaucony from its Phanerozoic counterpart. Precambrian glaucony, preferably formed within a K-feldspar substrate, is always rich in potassium irre- spective of its degree of evolution, while high K-content in Phanerozoic evolved glaucony in- dicates significant stratigraphic condensation. K20 iJs. TFe203 relationship of glaucony exhibits three different evolutionary trends corresponding to three common modes of origin. Depositional conditions may influence the composition of glaucony as slightly reducing conditions favour Fe enrichment, whereas oxidising conditions cause Fe depletion in giaucony.

Progress of research on transportation geography in China

As an important branch of human geography, transportation geography has experienced three periods of evolution: foundation, systematization, and rapid development of the discipline. It has gradually become a relatively mature discipline. During the period 1930– 1980, the development of transportation geography consisted mainly of the publication of theoretical texts. During 1980–2000, it gradually became a systematic discipline. Since the start of the 21 st century, transportation geography has focused mainly on exploring the impacts of transportation on socio-economic development. Currently, studies on transportation geography have led to significant developments in a number of areas, including transportation theory, facility distribution and planning, transportation flows and network analysis, evaluation of transport modes, transportation planning, and simulation and assessment of urban transportation. Such studies have also enriched human geography research, provided a wider geographical overview and elucidated the development mechanism of transportation, as well as helped to understand the impacts of transport development on socio-economic systems. Some findings obtained by geographers have been widely used in transportation geography and related fields, including the four basic laws of transportation generation, the hub–spoke mode of transport organization, the subordinating and guiding functions of transportation on socio-economic development, regional transport dominance measures, accessibility measures, and spatial organization of port systems.

The Case of the Carnian(Triassic) Conodont Genus Metapolygnathus Hayashi

Successive evolutionary trends control the genera Paragondolella Mosher and Meta- polygnathus Hayashi over the about 20 Ma long Aegean-Tuvalian timespan. In consideration of their evolutionary criteria, these genera have been retained together with Carnepigondolella Kozur and the two new genera proposed herein, MazzaeUa （type species M. carnica） and Hayashiella （type species H. nodosa）. Mazzaella n. gen. represents a Late Julian side branch ofMetapolygnathus, harbouring a platform ornamentation similar to the several million years younger Tuvalian lineage of Carnepigondolella, issued from Hayashiella n. gen. that is intermediary between Metapolygnathus and CarnepigondoleUa, based on appearance and platform ornamentation.