Autism and Schizophrenia Are Disorders of Evolvability

Autism and schizophrenia are of particular interest because new developments in genomic medicine address three aspects of the conditions that have been difficult, thus far, to resolve: their heterogeneity, from subclinical manifestations to disorders that are gravely disabling;the genetic basis for their high heritability;and the persistence of disorders in light of their high heritability but low reproductive success they convey. The origins of autism and schizophrenia, their persistence and heterogeneity can be understood by integrating information from genomic science, the social brain and the evolution of socialization, intelligence and language. Both conditions are associated with structural changes in the genome, specifically copy number variants. Such systemic mutations contribute to an unstable and mutable genome and have been especially notable during primate > hominid evolution. Along with mechanisms that affect gene expression, they contribute to a genome characterized by variability and evolvability. A dynamic and variable genome is reflected by a high degree of phenotypic variation. This, in turn, is reflected in the diversity of neurodevelopmental disorders, in particular autism and schizophrenia. Evolvability is more than a dispositional concept, it is a trait in its own right. In the special case of hominid evolution, evolvability has been both an independent and a dependent variable. Evolution of the modern human brain seems to have arisen during the cultivation of unstable regions in the genome that were conducive to a high degree of inter-individual and inter-generational variation. The consequence of even small aberrations in evolutionary processes and phenotypic variations is most likely to be manifest in the functions of the social brain: self-referential processing, perspective taking and the dual components of empathy;also language as well as intelligence itself. The trade-off is a dynamic genome that can rearrange itself in untoward ways and may be felt in one or more of the above functions. The occurrence of neurodevelopmental disorders ranging from the learning disabilities and ADD to autism and schizophrenia, are epiphenomenal to a genome that is unstable and mutable. The selective advantage of such a genome is the runaway evolution of positive prosocial and intellective traits. If there is a core to the pathology that emerges in autism and schizophrenia, it is at the genomic level, and is probably related to the unique evolvability of the human genome. Genetic transformation as an agent of evolvability is necessarily associated with untoward consequences. Just as point mutations may have deleterious effects, so do genomic transformations. The neurodevelopmental disorders, therefore, are the consequence of evolvability.

基于能量最小化的CCGA焊点形态仿真研究

为了确定某陶瓷柱栅阵列(CCGA)器件实现高焊接可靠性时的工艺参数组合范围,并研究焊点形态随不同参数变化的规律,以钎料润湿角、钎料体积以及焊柱偏移量作为关键变量因素,利用基于能量最小化原理的Surface Evolver软件,计算了不同因素水平组合下的实际焊点形态,并对参数化建模过程进行了详细介绍。通过对比形态结果与焊点可接收标准,寻找能够产生合格焊点的参量范围,为实际焊点微连接生产工艺提供合理的工艺指导。

PBGA焊点形态对疲劳寿命的影响

通过Surface Evolver软件预测了塑料球栅阵列(PBGA)焊点形态,将焊点形态结果导入Ansys软件中进行-55~125℃热循环仿真实验,通过Coffin-Masson模型预测焊点寿命。选取焊点钎料量、焊点高度、下焊盘直径作为影响焊点寿命的主要因素进行了3因素3水平正交实验,通过均值响应分析得到了影响凸点寿命的最敏感因素及最优形态尺寸组合。结果表明对焊点寿命影响最大的因素为下焊盘半径,其次是钎料量,最后是焊点高度,且上下等大的焊盘具有较好的可靠性。

Co-pyrolysis of Sewage Sludge with Distillation Residue: Kinetics Analysis via Iso-conversional Methods

This study explored the synergistic interaction of sewage sludge(SS)and distillation residue(DR)during co-pyrolysis for the optimized treatment of sewage sludge in cement kiln systems,utilizing thermogravimetric analysis(TGA)and thermogravimetric analysis with mass spectrometry(TGA-MS).The results reveal the coexisting synergistic and antagonistic effects in the co-pyrolysis of SS/DR.The synergistic effect arises from hydrogen free radicals in SS and catalytic components in ash fractions,while the antagonistic effect is mainly due to the melting of DR on the surface of SS particles during pyrolysis and the reaction of SS ash with alkali metals to form inert substances.SS/DR co-pyrolysis reduces the yielding of coke and gas while increasing tar production.This study will promote the reduction,recycling,and harmless treatment of hazardous solid waste.

Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease

Fullerenes:The extensive development of nanoscience that has marked this century continues to evolve,producing new materials,structures,and devices for the treatments of diverse pathologies.Fullerenes are a family of nanoparticles with great applicative promise due to their small size(approximately 1 nm in diameter),structure,and capacity to cross biological barriers.

Co-pyrolysis of Sewage Sludge with Paint Sludge: Kinetics and Thermodynamic Analysis via Iso-conversional Methods

This study explored the synergistic interaction of sewage sludge(SS)and automotive paint sludge(PS)during co-pyrolysis for the optimized treatment of sewage sludge in cement kiln systems,utilizing thermogravimetric analysis(TGA)and thermogravimetric-mass spectrometry(TGA-MS).The result reveals the coexisting synergistic and antagonistic effects in the co-pyrolysis of SS/PS.The synergistic effect arises from hydrogen free radicals in SS and catalytic components in PS,while the main source of the antagonistic effect is that,during the mechanical mixing process,the SS/PS is converted from the particulate form into a dough-like rubbery which contributes to the film-forming effect,hindering the volatilization of volatile components.SS/PS co-pyrolysis reduces the yielding of tar production while increasing coke and gas.This study will provide some in-depth insights into the co-pyrolysis of SS/PS,and offer theoretical support for the subsequent research on the collaborative disposal processes in cement kilns.

Ultrathin Limit on the Anisotropic Superconductivity of Single-Layered Cuprate Films

Exploring dimensionality effects on cuprates is important for understanding the nature of high-temperature superconductivity.By atomically layer-by-layer growth with oxide molecular beam epitaxy,we demonstrate that La_(2−x)Sr_(x)CuO_(4)(x=0.15)thin films remain superconducting down to 2 unit cells of thickness but quickly reach the maximum superconducting transition temperature at and above 4 unit cells.By fitting the critical magnetic field(μ0H_(c2)),we show that the anisotropy of the film’s superconductivity increases with decreasing film thickness,indicating that the superconductivity of the film gradually evolves from weak three-to two-dimensional character.These results are helpful to gain more insight into the nature of high-temperature superconductivity with dimensionality.

Genetic mechanism of body size variation in groupers:Insights from phylotranscriptomics

Animal body size variation is of particular interest in evolutionary biology,but the genetic basis remains largely unknown.Previous studies have shown the presence of two parallel evolutionary genetic clusters within the fish genus Epinephelus with evident divergence in body size,providing an excellent opportunity to investigate the genetic basis of body size variation in vertebrates.Herein,we performed phylotranscriptomic analysis and reconstructed the phylogeny of 13 epinephelids originating from the South China Sea.Two genetic clades with an estimated divergence time of approximately 15.4 million years ago were correlated with large and small body size,respectively.A total of 180 rapidly evolving genes and two positively selected genes were identified between the two groups.Functional enrichment analyses of these candidate genes revealed distinct enrichment categories between the two groups.These pathways and genes may play important roles in body size variation in groupers through complex regulatory networks.Based on our results,we speculate that the ancestors of the two divergent groups of groupers may have adapted to different environments through habitat selection,leading to genetic variations in metabolic patterns,organ development,and lifespan,resulting in body size divergence between the two locally adapted populations.These findings provide important insights into the genetic mechanisms underlying body size variation in groupers and species differentiation.

Spatial-temporal distribution and geochemistry of highly evolved Mesozoic granites in Great Xing’an Range,NE China:Discriminant criteria and geological significance

Highly evolved granite is an important sign of the mature continent crust and closely associated with deposits of rare metals.In this work,the authors undertake systematically zircon U-Pb ages and whole rock elemental data for highly evolved granitic intrusions from the Great Xing’an Range(GXR),NE China,to elucidate their discriminant criteria,spatial-temporal distribution,differentiation and geodynamic mecha-nism.Geochemical data of these highly evolved granites suggest that high w(SiO_(2))(>70%)and differentiation index(DI>88)could be quantified indicators,while strong Eu depletion,high TE_(1,3),lowΣREE and low Zr/Hf,Nb/Ta,K/Rb could only be qualitative indicators.Zircon U-Pb ages suggest that the highly evolved gran-ites in the GXR were mainly formed in Late Mesozoic,which can be divided into two major stages:Late Ju-rassic-early Early Cretaceous(162-136 Ma,peak at 138 Ma),and late Early Cretaceous(136-106 Ma,peak at 126 Ma).The highly evolved granites are mainly distributed in the central-southern GXR,and display a weakly trend of getting younger from northwest to southeast,meanwhile indicating the metallogenic potential of rare metals within the central GXR.The spatial-temporal distribution,combined with regional geological data,indicates the highly evolved Mesozoic granites in the GXR were emplaced in an extensional environ-ment,of which the Late Jurassic-early Early Cretaceous extension was related to the closure of the Mongol-Okhotsk Ocean and roll-back of the Paleo-Pacific Plate,while the late Early Cretaceous extension was mainly related to the roll-back of the Paleo-Pacific Plate.

Closer Trade Ties:An Engine for Economic Growth

The origins of Malaysia-China ties can be traced back to ancient trade of goods.Throughout history,the bilateral relationship has endured ebbs and flows to evolve into full-fledged diplomatic and economic interactions.This evolution reflects changes in Southeast Asian and global landscapes,which have been heavily influenced by post-World War II realignment,Cold War politics,and the rise of China.

Design of an Interconnection Architecture and Sizing of Two (2) EPC Core Networks: The Case of Orange-Guinea

With the arrival of the 4G and 5G,the telecommunications networks have experienced a large expansion of these networks.That enabled the integration of many services and adequate flow,thus enabling the operators to respond to the growing demand of users.This rapid evolution has given the operators to adapt,their methods to the new technologies that increase.This complexity becomes more important,when these networks include several technologies to access different from the heterogeneous network like in the 4G network.The dimensional new challenges tell the application and the considerable increase in demand for services and the compatibility with existing networks,the management of mobility intercellular of users and it offers a better quality of services.Thus,the proposed solution to meet these new requirements is the sizing of the EPC(Evolved Packet Core)core network to support the 5G access network.For the case of Orange Guinea,this involves setting up an architecture for interconnecting the core networks of Sonfonia and Camayenne.The objectives of our work are of two orders:(1)to propose these solutions and recommendations for the heart network EPC sizing and the deployment to be adopted;(2)supply and architectural interconnection in the heart network EPC and an existing heart network.In our work,the model of traffic in communication that we use to calculate the traffic generated with each technology has link in the network of the heart.

英国高中地理教材栏目设置的特点及启示——以Geography B Evolving Planet为例

以英国中学地理教材Geography B Evolving Planet中的教材栏目为研究对象,结合其在教材中实际发挥的功能,将八种主要的教材栏目划分为问题思考类、技能训练类、信息提示类和考试导向类四大类。这四大类教材栏目体现出了不同的特点。问题思考类栏目指向不同教学目标,技能训练类栏目凸显实用性和应用性的学科特色,信息提示类栏目关注学生心理特点,考试导向类栏目提高应试答题技巧。受此启发,未来我国中学地理教材栏目设置应有所侧重,即教材栏目在内容设置上要注重针对性,在形式设置上要增加多样性,在外观设置上要注重醒目性。

Editorial:Driving into Future with Reliable,Secure,Efficient and Intelligent MetaVehicles

Welcome to the sixth issue of the IEEE/CAA Journal of Automatica Sinica(JAS)in 2023!In the first issue in 2023,I briefly discussed about MetaVehicles,a technological expression of intelligent vehicles,robotics,AI,blockchain,knowledge automation,networking and communication[1].As the concept of the Metaverse continues to evolve and expand,the range of vehicle entities is diversely enlarged,including passenger vehicles,heavy duty vehicles,rail vehicles,marine vehicles,aerial vehicles,and other types of transportation.The development and use of MetaVehicles are likely to become more sophisticated.Therefore,from a systems and control perspective,new methods of control,estimation and optimization should be developed to achieve the improved vehicular control system stability and reliability in the physical space.

Subspace Clustering in High-Dimensional Data Streams:A Systematic Literature Review

Clustering high dimensional data is challenging as data dimensionality increases the distance between data points,resulting in sparse regions that degrade clustering performance.Subspace clustering is a common approach for processing high-dimensional data by finding relevant features for each cluster in the data space.Subspace clustering methods extend traditional clustering to account for the constraints imposed by data streams.Data streams are not only high-dimensional,but also unbounded and evolving.This necessitates the development of subspace clustering algorithms that can handle high dimensionality and adapt to the unique characteristics of data streams.Although many articles have contributed to the literature review on data stream clustering,there is currently no specific review on subspace clustering algorithms in high-dimensional data streams.Therefore,this article aims to systematically review the existing literature on subspace clustering of data streams in high-dimensional streaming environments.The review follows a systematic methodological approach and includes 18 articles for the final analysis.The analysis focused on two research questions related to the general clustering process and dealing with the unbounded and evolving characteristics of data streams.The main findings relate to six elements:clustering process,cluster search,subspace search,synopsis structure,cluster maintenance,and evaluation measures.Most algorithms use a two-phase clustering approach consisting of an initialization stage,a refinement stage,a cluster maintenance stage,and a final clustering stage.The density-based top-down subspace clustering approach is more widely used than the others because it is able to distinguish true clusters and outliers using projected microclusters.Most algorithms implicitly adapt to the evolving nature of the data stream by using a time fading function that is sensitive to outliers.Future work can focus on the clustering framework,parameter optimization,subspace search techniques,memory-efficient synopsis structures,explicit cluster change detection,and intrinsic performance metrics.This article can serve as a guide for researchers interested in high-dimensional subspace clustering methods for data streams.

An Overview of Government-Market Relationships:Evolving Perceptions,Role of the Market,and Government Functions

Building a high-level socialist market economy is conducive to giving full play to the market’s decisive role in resource allocations and bringing the government into better play.Correctly handling the market and the government relationships has been a central issue in China’s economic structural reform.Giving a comprehensive review and summary of the research findings achieved by the theoretical and academic circles in China,we generalize the evolution and working mechanisms of China’s socialist market economy system,following the developing trajectory and logic of relevant literature,focusing on the three aspects of evolving perceptions,the role of the market,and the functions of the government.Based on our literature overview,we also induced and extracted the basic conclusions and evolutionary features of relevant research and made suggestions for the future direction of theoretical research regarding China’s socialist market economy.

Courtside to Catwalk--Surging demand for sports fashion in China captures consumer interest

A mid the ever-changing tides of fashion,Arc’teryx,a high-performance outdoor equipment brand known for leading innovations in outdoor apparel tech and once beloved by middleaged outdoor enthusiasts,has now secured a place as social currency for Chinese trendsetters.Salomon,once associated with the“ugly shoe”aesthetic exclusive to mountaineers,has become a coveted fashion essential,commanding premium prices driven by fervent demand.In addition,as the Lululemon brand evolves from its body-conscious fit origins for yoga enthusiasts to a versatile wardrobe staple for commuters.

CHINA-ASEAN INTEGRATION THRIVES ON SHARED CULTURAL TIES AND MUTUAL BENEFITS

China’s Belt and Road Initiative is now in its tenth year.Practical experience has shown that the countries that comprise the Association of Southeast Asian Nations(ASEAN)make up a favorable region for Chinese entrepreneurs to expand their overseas endeavors,a region that has the potential to evolve into a model area for the BRI.

Crucial, But not Systematically Investigated: Rock Glaciers, the Concealed Water Reservoirs of the Himalayas: An Opinion

The current article is an opinion on the sensitivity of high mountain regions which are the most fragile,sensitive and vulnerable to ongoing climate change.Its impacts are especially severe on the high mountain communities owing to their weak socio-economic profile,limited livelihood resources and agricultural land.The melting of glaciers and changes in the snow cover under the climate change scenario is leading to the scarcity of freshwater supplies,affecting both local and downstream communities.Changes in the precipitation patterns have been suggested to cause droughts,impact restricted agriculture,and limit the availability of water for domestic use.Additionally,the high mountain areas contain distinct flora and fauna,and climate change is not just altering them,but also has resulted in biodiversity loss as species are unable to adapt to the changing climate.Because of its higher altitudes and semi-arid to arid climate,the consequences of climate change are more evident in the higher Himalayas.Climate change is affecting the availability of key resources,such as freshwater and agriculture and pasture lands,resulting in food and water insecurity and their reliance on imports from other regions.As a result,high mountain communities in the Himalayas are progressively shifting to higher glacier valleys in search of suitable cultivable land with adequate irrigation.People are engaging in agro-pastoral activities around thermokarst lakes(Oasis)atop rock glaciers as part of this endeavour.Such actions underscore the crucial role of rock glaciers in dealing with and adjusting to the consequences of climate change.Despite its relevance,rock glacier research in the Himalayan region is still in its infancy.The purpose of this work is to emphasise the significance of these major climate-resilient water resources,as well as the methodology that must be adopted for their systematic and compressive investigations.

The Evolving Bipartite Network and Semi-Bipartite Network Models with Adjustable Scale and Hybrid Attachment Mechanisms

The bipartite graph structure exists in the connections of many objects in the real world, and the evolving modeling is a good method to describe and understand the generation and evolution within various real complex networks. Previous bipartite models were proposed to mostly explain the principle of attachments, and ignored the diverse growth speed of nodes of sets in different bipartite networks. In this paper, we propose an evolving bipartite network model with adjustable node scale and hybrid attachment mechanisms, which uses different probability parameters to control the scale of two disjoint sets of nodes and the preference strength of hybrid attachment respectively. The results show that the degree distribution of single set in the proposed model follows a shifted power-law distribution when parameter r and s are not equal to 0, or exponential distribution when r or s is equal to 0. Furthermore, we extend the previous model to a semi-bipartite network model, which embeds more user association information into the internal network, so that the model is capable of carrying and revealing more deep information of each user in the network. The simulation results of two models are in good agreement with the empirical data, which verifies that the models have a good performance on real networks from the perspective of degree distribution. We believe these two models are valuable for an explanation of the origin and growth of bipartite systems that truly exist.

Bacteriophages inhibit and evade cGAS-like immune function in bacteria

A fundamental strategy of eukaryotic antiviral immunity involves the cGAS enzyme, which synthesizes 2',3'-cGAMP andactivates the effector STING. Diverse bacteria contain cGAS-like enzymes that produce cyclic oligonucleotides and induce antiphageactivity, known as CBASS. However, this activity has only been demonstrated through heterologous expression. Whetherbacteria harboring CBASS antagonize and co-evolve with phages is unknown. Here, we identified an endogenous cGAS-likeenzyme in Pseudomonas aeruginosa that generates 3',3'-cGAMP during phage infection, signals to a phospholipase effector, andlimits phage replication. In response, phages express an anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity. Acb2 also binds to molecules produced by other bacterial cGAS-likeenzymes (3',3'-cUU/UA/UG/AA) and mammalian cGAS (2',3'-cGAMP), suggesting broad inhibition of cGAS-based immunity.Upon Acb2 deletion, CBASS blocks lytic phage replication and lysogenic induction, but rare phages evade CBASS through majorcapsid gene mutations. Altogether, we demonstrate endogenous CBASS anti-phage function and strategies of CBASS inhibitionand evasion.