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UHPLC Q-Exactive Plus Orbitrap HRMS法鉴定隔山消提取物在功能性消化不良大鼠体内代谢产物
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作者 吴宗芹 勾健 +3 位作者 李勇军 陆苑 冉巧巧 孙佳 《中成药》 CAS CSCD 北大核心 2024年第9期2876-2884,共9页
目的建立UHPLC Q-Exactive Plus Orbitrap HRMS法鉴定隔山消提取物在功能性消化不良大鼠体内代谢产物。方法建立功能性消化不良大鼠模型。分析采用Hypersi 1 GOLD C_(18)色谱柱(2.1 mm×100 mm,1.9μm);流动相水(含0.1%甲酸)-乙腈(... 目的建立UHPLC Q-Exactive Plus Orbitrap HRMS法鉴定隔山消提取物在功能性消化不良大鼠体内代谢产物。方法建立功能性消化不良大鼠模型。分析采用Hypersi 1 GOLD C_(18)色谱柱(2.1 mm×100 mm,1.9μm);流动相水(含0.1%甲酸)-乙腈(含0.1%甲酸),梯度洗脱;体积流量0.3 mL/min;柱温40℃;电喷雾离子源;正负离子扫描。结果共鉴定出4种原型成分(白首乌二苯酮、去酰基萝藦苷元、青阳参苷元、丁香酸)及其110种代谢产物,其中粪便、尿液共有代谢产物12种,尿液特有代谢产物56种,粪便特有代谢产物42种。原型成分代谢途径包括Ⅰ相代谢(氧化、还原等)、Ⅱ相代谢(硫酸化、葡萄糖醛酸化等)及Ⅰ相、Ⅱ相复合反应。结论该方法高效全面,可为进一步寻找隔山消潜在活性代谢产物奠定基础。 展开更多
关键词 隔山消提取物 代谢产物 功能性消化不良 UHPLC Q-exactive Plus Orbitrap HRMS
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Frequentist and Bayesian Sample Size Determination for Single-Arm Clinical Trials Based on a Binary Response Variable: A Shiny App to Implement Exact Methods
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作者 Susanna Gentile Valeria Sambucini 《Open Journal of Statistics》 2024年第1期90-105,共16页
Sample size determination typically relies on a power analysis based on a frequentist conditional approach. This latter can be seen as a particular case of the two-priors approach, which allows to build four distinct ... Sample size determination typically relies on a power analysis based on a frequentist conditional approach. This latter can be seen as a particular case of the two-priors approach, which allows to build four distinct power functions to select the optimal sample size. We revise this approach when the focus is on testing a single binomial proportion. We consider exact methods and introduce a conservative criterion to account for the typical non-monotonic behavior of the power functions, when dealing with discrete data. The main purpose of this paper is to present a Shiny App providing a user-friendly, interactive tool to apply these criteria. The app also provides specific tools to elicit the analysis and the design prior distributions, which are the core of the two-priors approach. 展开更多
关键词 Binomial Proportion Frequentist and Bayesian Power functions exact Sample Size Determination Shiny App Two-Priors Approach
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Exactness of penalization for exact minimax penalty function method in nonconvex programming 被引量:2
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作者 T.ANTCZAK 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2015年第4期541-556,共16页
The exact minimax penalty function method is used to solve a noncon- vex differentiable optimization problem with both inequality and equality constraints. The conditions for exactness of the penalization for the exac... The exact minimax penalty function method is used to solve a noncon- vex differentiable optimization problem with both inequality and equality constraints. The conditions for exactness of the penalization for the exact minimax penalty function method are established by assuming that the functions constituting the considered con- strained optimization problem are invex with respect to the same function η (with the exception of those equality constraints for which the associated Lagrange multipliers are negative these functions should be assumed to be incave with respect to η). Thus, a threshold of the penalty parameter is given such that, for all penalty parameters exceeding this threshold, equivalence holds between the set of optimal solutions in the considered constrained optimization problem and the set of minimizer in its associated penalized problem with an exact minimax penalty function. It is shown that coercivity is not suf- ficient to prove the results. 展开更多
关键词 exact minimax penalty function method minimax penalized optimizationproblem exactness of penalization of exact minimax penalty function invex function incave function
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The Exact Measure Functions of the Images for a Class of Self-Similar Processes 被引量:2
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作者 HUANG Li-hu LI Bing-zhang LIU Lu-qin (College of Mathematics and Computer Science, Wuhan University, Wuhan 430072, China) 《Wuhan University Journal of Natural Sciences》 CAS 2000年第1期1-6,共6页
Let X= (Ω, ■, ■_t, X_t,, θ_t, p~x) be a self-similar Markov process on (0,∞) with non-decreasing path. The exact Hausdorff and Packing measure functions of the image X([0,t] ) are obtained.
关键词 self-similar Markov process exact Hausdorff measure functions exact Packing measure function
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General Exact Penalty Functions in Integer Programming 被引量:2
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作者 白富生 张连生 吴至友 《Journal of Shanghai University(English Edition)》 CAS 2004年第1期19-23,共5页
In this paper, the general exact penalty functions in integer programming were studied. The conditions which ensure the exact penalty property for the general penalty function with one penalty parameter were given and... In this paper, the general exact penalty functions in integer programming were studied. The conditions which ensure the exact penalty property for the general penalty function with one penalty parameter were given and a general penalty function with two parameters was proposed. 展开更多
关键词 integer programming exact penalty function penalty parameter.
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NONLINEAR PROGRAMMING VIA AN EXACT PENALTY FUNCTION:CONVERGENCE RATE ANALYSIS 被引量:2
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作者 Li Xuequan Li Songren Han Xuili(Department of Applied Mathematics and Applied Software, Central SouthUniversity of Technology, Changsha 410083, China) 《Journal of Central South University》 SCIE EI CAS 1996年第2期102-106,共5页
The algorithm proposed by T. F. Colemen and A. R. Conn is improved in this paper, and the improved algorithm can solve nonlinear programming problem with quality constraints. It is shown that the improved algorithm po... The algorithm proposed by T. F. Colemen and A. R. Conn is improved in this paper, and the improved algorithm can solve nonlinear programming problem with quality constraints. It is shown that the improved algorithm possesses global convergence, and under some conditions, it possesses locally supperlinear convergence. 展开更多
关键词 NONLINEAR PROGRAMMING exact PENALTY function algorithm
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Exact solution and transient behavior for torsional vibration of functionally graded finite hollow cylinders 被引量:2
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作者 H. M. Wang C. B. Liu H. J. Ding 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2009年第4期555-563,共9页
Exact solutions are obtained for transient torsio- nal responses of a finitely long, functionally graded hollow cylinder under three different end conditions, i.e. free-free, free-fixed and fixed-fixed. The cylinder w... Exact solutions are obtained for transient torsio- nal responses of a finitely long, functionally graded hollow cylinder under three different end conditions, i.e. free-free, free-fixed and fixed-fixed. The cylinder with its external surface fixed is subjected to a dynamic shearing stress at the internal surface. The material properties are assumed to vary in the radial direction in a power law form, while keep invariant in the axial direction. With expansion in the axial direction in terms of trigonometric series, the governing equations for the unknown functions about the radial coordinate r and time t are deduced. By applying the variable substitution technique, the superposition method and the separation of variables consecutively, series-form solutions of the equations are obtained. Natural frequencies and the transient torsional responses are finally discussed for a functionally graded finite hollow cylinder. 展开更多
关键词 exact solution functionally graded material Finite hollow cylinder Transient torsional vibration
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Trial function method and exact solutions to the generalized nonlinear Schrdinger equation with time-dependent coefficient 被引量:2
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作者 曹瑞 张健 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第10期182-185,共4页
In this paper, the trial function method is extended to study the generalized nonlinear Schrodinger equation with time- dependent coefficients. On the basis of a generalized traveling wave transformation and a trial f... In this paper, the trial function method is extended to study the generalized nonlinear Schrodinger equation with time- dependent coefficients. On the basis of a generalized traveling wave transformation and a trial function, we investigate the exact envelope traveling wave solutions of the generalized nonlinear Schrodinger equation with time-dependent coefficients. Taking advantage of solutions to trial function, we successfully obtain exact solutions for the generalized nonlinear Schrodinger equation with time-dependent coefficients under constraint conditions. 展开更多
关键词 generalized nonlinear SchriSdinger equation exact solution trial function method
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The Jacobi elliptic function-like exact solutions to two kinds of KdV equations with variable coefficients and KdV equation with forcible term 被引量:10
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作者 套格图桑 斯仁到尔吉 《Chinese Physics B》 SCIE EI CAS CSCD 2006年第12期2809-2818,共10页
By use of an auxiliary equation and through a function transformation, the Jacobi elliptic function wave-like solutions, the degenerated soliton-like solutions and the triangle function wave solutions to two kinds of ... By use of an auxiliary equation and through a function transformation, the Jacobi elliptic function wave-like solutions, the degenerated soliton-like solutions and the triangle function wave solutions to two kinds of Korteweg de Vries (KdV) equations with variable coefficients and a KdV equation with a forcible term are constructed with the help of symbolic computation system Mathematica, where the new solutions are also constructed. 展开更多
关键词 auxiliary equation KdV equation with variable coefficients KdV equation with a forcible term Jacobi elliptic function-like exact solutions
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EXACT AUGMENTED LAGRANGIAN FUNCTION FOR NONLINEAR PROGRAMMING PROBLEMS WITH INEQUALITY CONSTRAINTS
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作者 杜学武 张连生 +1 位作者 尚有林 李铭明 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2005年第12期1649-1656,共8页
An exact augmented Lagrangian function for the nonlinear nonconvex programming problems with inequality constraints was discussed. Under suitable hypotheses, the relationship was established between the local unconstr... An exact augmented Lagrangian function for the nonlinear nonconvex programming problems with inequality constraints was discussed. Under suitable hypotheses, the relationship was established between the local unconstrained minimizers of the augmented Lagrangian function on the space of problem variables and the local minimizers of the original constrained problem. Furthermore, under some assumptions, the relationship was also established between the global solutions of the augmented Lagrangian function on some compact subset of the space of problem variables and the global solutions of the constrained problem. Therefore, f^om the theoretical point of view, a solution of the inequality constrained problem and the corresponding values of the Lagrange multipliers can be found by the well-known method of multipliers which resort to the unconstrained minimization of the augmented Lagrangian function presented. 展开更多
关键词 local minimizer global minimizer nonlinear programming exact penalty function augmented Lagrangian function
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Approximation-Exact Penalty Function Method for Solving a Class of Stochastic Programming
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作者 Wang Guang-min, Wan Zhong-ping School of Mathematics and Statistics, Wuhan University, Wuhan 430072, Hubei, China 《Wuhan University Journal of Natural Sciences》 CAS 2003年第04A期1051-1056,共6页
We present an approximation-exact penalty function method for solving the single stage stochastic programming problem with continuous random variable. The original problem is transformed into a determinate nonlinear p... We present an approximation-exact penalty function method for solving the single stage stochastic programming problem with continuous random variable. The original problem is transformed into a determinate nonlinear programming problem with a discrete random variable sequence, which is obtained by some discrete method. We construct an exact penalty function and obtain an unconstrained optimization. It avoids the difficulty in solution by the rapid growing of the number of constraints for discrete precision. Under lenient conditions, we prove the equivalence of the minimum solution of penalty function and the solution of the determinate programming, and prove that the solution sequences of the discrete problem converge to a solution to the original problem. 展开更多
关键词 single stage stochastic programming discrete method exact penalty function CONVERGENCE
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A New Kind of Simple Smooth Exact Penalty Function of Constrained Nonlinear Programming
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作者 SUN Chu ren, ZHANG Lian sheng College of Sciences, Shanghai University, Shanghai 200072, China 《Journal of Shanghai University(English Edition)》 CAS 2001年第4期287-291,共5页
The penalty function method is one basic method for solving constrained nonlinear programming, in which simple smooth exact penalty functions draw much attention for their simpleness and smoothness. This article offer... The penalty function method is one basic method for solving constrained nonlinear programming, in which simple smooth exact penalty functions draw much attention for their simpleness and smoothness. This article offers a new kind of simple smooth approximative exact penalty function of general constrained nonlinear programmings and analyzes its properties. 展开更多
关键词 exact penalty function MFCQ constrain condition
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A hyperbolic function approach to constructing exact solitary wave solutions of the Hybrid lattice and discrete mKdV lattice 被引量:12
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作者 扎其劳 斯仁道尔吉 《Chinese Physics B》 SCIE EI CAS CSCD 2006年第3期475-477,共3页
Some new exact solitary wave solutions of the Hybrid lattice and discrete mKdV lattice are obtained by using a hyperbolic function approach. This approach can also be applied to other nonlinear differential-difference... Some new exact solitary wave solutions of the Hybrid lattice and discrete mKdV lattice are obtained by using a hyperbolic function approach. This approach can also be applied to other nonlinear differential-difference equations. 展开更多
关键词 hyperbolic function approach nonlinear differential-difference equation exact solitary wave solution
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Further Results on Meromorphic Functions and Their nth Order Exact Differences with Three Shared Values
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作者 CHEN SHENG-JIANG XU AI-ZHU LIN XIU-QIANG 《Communications in Mathematical Research》 CSCD 2019年第3期283-288,共6页
Let E(a;f) be the set of a-points of a meromorphic function f(z) counting multiplicities. We prove that if a transcendental meromorphic function f(z) of hyper order strictly less than 1 and its nth exact difference Δ... Let E(a;f) be the set of a-points of a meromorphic function f(z) counting multiplicities. We prove that if a transcendental meromorphic function f(z) of hyper order strictly less than 1 and its nth exact difference Δnc f(z) satisfy E(1;f)= E(1;Δnc f), E(0;f) E(0;Δnc f) and E(1;f) E(1;Δnc f), then Δnc f(z) f(z). This result improves a more recent theorem due to Gao et al.(Gao Z, Kornonen R, Zhang J, Zhang Y. Uniqueness of meromorphic functions sharing values with their nth order exact differences. Analysis Math., 2018, https://doi.org/10.1007/s10476- 018-0605-2) by using a simple method. 展开更多
关键词 MEROMORPHIC function exact difference UNIQUENESS SHARED value
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基于UPLC-Q-Exactive技术结合OTCML数据库快速分析沙棘的功效成分 被引量:40
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作者 孙燕 冯峰 +3 位作者 黄特辉 张旭帆 曹俊岭 张峰 《天然产物研究与开发》 CAS CSCD 北大核心 2019年第7期1192-1202,共11页
为探讨沙棘果茎叶功效成分的整体差异。实验应用超高效液相色谱-四极杆静电场轨道阱高分辨质谱联用技术(UPLC-Q-Exactive)结合中药成分高分辨质谱数据库(OTCML),对沙棘果茎叶的化学成分进行了快速鉴定与比较分析。色谱柱为HypersilGOLDa... 为探讨沙棘果茎叶功效成分的整体差异。实验应用超高效液相色谱-四极杆静电场轨道阱高分辨质谱联用技术(UPLC-Q-Exactive)结合中药成分高分辨质谱数据库(OTCML),对沙棘果茎叶的化学成分进行了快速鉴定与比较分析。色谱柱为HypersilGOLDaQ色谱柱(2.1mm×100mm,1.9μm),流动相为0.1%甲酸乙腈(A)-0.1%甲酸水(B)梯度洗脱,流速为0.3mL/min,高分辨质谱采用电喷雾离子源(ESI)正、负离子同时扫描模式。基于OTCML中所包含的1200余种中药化合物对照品的保留时间,分子离子、二级碎片离子谱图信息和文献数据进行结构鉴定。结果共鉴定出沙棘中102个功效成分,包括苷类18个,黄酮类21个,萜类18个,苯丙素类13个,生物碱类6个,挥发成分14个,多酚12个;其中有17个化合物是在沙棘中首次发现,对沙棘果茎叶比较表明这些功效成分在不同部位分布有明显差异。该方法为今后充分开发利用沙棘资源提供了基础数据,也为沙棘相关产品的质量控制和药效物质基础研究奠定了基础。 展开更多
关键词 超高效液相色谱-四极杆静电场轨道阱高分辨质谱联用技术 沙棘 功效成分 中药成分高分辨质谱数据库
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时间分数阶(2+1)-维扩展Fisher-Kolmogorov方程的精确解
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作者 王美乐 胡彦霞 《内蒙古大学学报(自然科学版)》 CAS 2024年第3期232-243,共12页
利用Lie方法对一类时间分数阶(2+1)-维扩展Fisher-Kolmogorov方程进行对称分析,并求得该方程的不变解,借助不变解对方程进行降维处理。对引入分数阶复变换得到的常微分方程运用辅助函数法,从而得到这类时间分数阶方程在参数满足各种不... 利用Lie方法对一类时间分数阶(2+1)-维扩展Fisher-Kolmogorov方程进行对称分析,并求得该方程的不变解,借助不变解对方程进行降维处理。对引入分数阶复变换得到的常微分方程运用辅助函数法,从而得到这类时间分数阶方程在参数满足各种不同情况下的精确解,包括三角函数解和孤波解等。最后绘出两类典型精确解的行波图。 展开更多
关键词 (2+1)-维扩展Fisher-Kolmogorov方程 Lie方法 辅助函数法 精确解
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(3+1)维广义非线性发展方程的双线性Backlund变换与精确解
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作者 薛宇英 套格图桑 《内蒙古师范大学学报(自然科学版)》 CAS 2024年第2期173-182,共10页
基于Hirota双线性方法和试探函数法,研究一个(3+1)维广义非线性发展方程的双线性Backlund变换和精确解问题。用Hirota双线性法,构造(3+1)维广义非线性发展方程的双线性形式和双线性Backlund变换。基于双线性形式和双线性Backlund变换,... 基于Hirota双线性方法和试探函数法,研究一个(3+1)维广义非线性发展方程的双线性Backlund变换和精确解问题。用Hirota双线性法,构造(3+1)维广义非线性发展方程的双线性形式和双线性Backlund变换。基于双线性形式和双线性Backlund变换,利用试探函数法与符号计算系统Mathematica,获得(3+1)维广义非线性发展方程的多种精确解,包括呼吸波解、复合型解、Lump周期解和孤子解,并分析解的相互作用情况。 展开更多
关键词 (3+1)维广义非线性发展方程 HIROTA双线性方法 BACKLUND变换 试探函数法 精确解
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Boussinesq方程的精确行波解
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作者 杨忠鑫 刘小华 《延边大学学报(自然科学版)》 CAS 2024年第1期76-80,共5页
利用广义kudryashov方法讨论了Boussinesq方程的行波解,给出了其5个精确指数函数解的显式表达式,并利用Maple软件给出了该方程3个精确解的性态。
关键词 BOUSSINESQ方程 广义kudryashov方法 行波解 精确指数函数解 解的性态
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一种构建非多项式QES势的方法
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作者 胡富望 肖倍 《大学物理》 2024年第4期10-14,共5页
构建准精确可解问题的方法有很多,例如超对称方法、Darboux方法、李代数方法等,但是这些方法构建的准精确可解问题往往得到的是多项式型的波函数.我们从一类含参变化的双势阱出发,研究了和参数相关的性质,并且发现了一种构建QES势的方法... 构建准精确可解问题的方法有很多,例如超对称方法、Darboux方法、李代数方法等,但是这些方法构建的准精确可解问题往往得到的是多项式型的波函数.我们从一类含参变化的双势阱出发,研究了和参数相关的性质,并且发现了一种构建QES势的方法,这种方法构建的QES势有李代数结构,但波函数的形式是非多项式. 展开更多
关键词 薛定谔方程 Huen函数 准精确可解
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A method for constructing exact solutions and application to Benjamin Ono equation 被引量:12
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作者 王振 李德生 +1 位作者 鲁慧芳 张鸿庆 《Chinese Physics B》 SCIE EI CAS CSCD 2005年第11期2158-2163,共6页
By using an improved projective Riccati equation method, this paper obtains several types of exact travelling wave solutions to the Benjamin Ono equation which include multiple soliton solutions, periodic soliton solu... By using an improved projective Riccati equation method, this paper obtains several types of exact travelling wave solutions to the Benjamin Ono equation which include multiple soliton solutions, periodic soliton solutions and Weierstrass function solutions. Some of them are found for the first time. The method can be applied to other nonlinear evolution equations in mathematical physics. 展开更多
关键词 Benjamin Ono equation nonlinear evolution equation Weierstrass function solutions exact solutions
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