Objective The present retrospective study was to explore the clinical value of Six-Item Screener （SIS）, which is constituted by 6 items from mini-mental status examination （MMSE）, to identify cognitive impairment....Objective The present retrospective study was to explore the clinical value of Six-Item Screener （SIS）, which is constituted by 6 items from mini-mental status examination （MMSE）, to identify cognitive impairment. Methods A total number of 1976 patients aged over 50 years, from the Memory Clinic of Huashan Hospital were employed in a battery of neuropsychological tests including MMSE. Subjects with severe conditions, unable to cooperate, or having been previously enrolled, were excluded from this study. The employed subjects were divided into 3 groups： subjective memory complaints （SMCs） （475 cases）, patients with mild cognitive impairment （MCI） （440 cases）, and patients with Alzheimer＇s disease （AD） （1061 cases, including 555 mild, 339 moderate, and 167 severe）. A total score of MMSE and a score of SIS composed of date, month, year, three-word delayed recall from MMSE were calculated. Data were analyzed based on educational background. Results The cut-off of SIS score was 〈 2 for illiterate, 〈 3 for elementary, and 〈 4 for junior high school or above. The sensitivity and specificity of SIS for detecting mild AD were 88.5% and 78.3%, respectively, with an overall accuracy of 83.8%, while for detecting MCI, the sensitivity and specificity were 34.3% and 90.1%, respectively, with an overall accuracy of 63.2%. Conclusion SIS is an effective and reliable instrument for dementia detection in outpatient department. However, it has limited value for MCI identification.展开更多
文摘Objective The present retrospective study was to explore the clinical value of Six-Item Screener （SIS）, which is constituted by 6 items from mini-mental status examination （MMSE）, to identify cognitive impairment. Methods A total number of 1976 patients aged over 50 years, from the Memory Clinic of Huashan Hospital were employed in a battery of neuropsychological tests including MMSE. Subjects with severe conditions, unable to cooperate, or having been previously enrolled, were excluded from this study. The employed subjects were divided into 3 groups： subjective memory complaints （SMCs） （475 cases）, patients with mild cognitive impairment （MCI） （440 cases）, and patients with Alzheimer＇s disease （AD） （1061 cases, including 555 mild, 339 moderate, and 167 severe）. A total score of MMSE and a score of SIS composed of date, month, year, three-word delayed recall from MMSE were calculated. Data were analyzed based on educational background. Results The cut-off of SIS score was 〈 2 for illiterate, 〈 3 for elementary, and 〈 4 for junior high school or above. The sensitivity and specificity of SIS for detecting mild AD were 88.5% and 78.3%, respectively, with an overall accuracy of 83.8%, while for detecting MCI, the sensitivity and specificity were 34.3% and 90.1%, respectively, with an overall accuracy of 63.2%. Conclusion SIS is an effective and reliable instrument for dementia detection in outpatient department. However, it has limited value for MCI identification.
