One of the most important issues in geotechnical engineering is excess pore pressure caused by clay soil loading and consolidation. Regarding uncertainties and complexities, this issue has long been the subject of att...One of the most important issues in geotechnical engineering is excess pore pressure caused by clay soil loading and consolidation. Regarding uncertainties and complexities, this issue has long been the subject of attention of many researchers. In this work, a one-dimensional consolidation apparatus was equipped in a way that pore water pressure and settlement could be continuously read and recorded during consolidation process under static loading. The end of primary consolidation was obtained using water pressure changes helping to present a new method for determining the end of primary consolidation and consolidation coefficient. This method was then compared with two classical theory methods of lg t and t. Using Terzaghi's theory, the way of pore pressure dissipation for lg t, t and the new method was found and compared with experimental results. It is concluded that the new method has better results.展开更多
Objective:This paper aims to study the clinical characteristics of patients with different types of primary hyperuricemia(HUA).Methods:Using a retrospective research method,200 patients with primary HUA in the hospita...Objective:This paper aims to study the clinical characteristics of patients with different types of primary hyperuricemia(HUA).Methods:Using a retrospective research method,200 patients with primary HUA in the hospital from June 2020 to January 2023 were selected as the research objects.Patients were grouped according to the detection results of 24-hour urinary uric acid excretion(UUE)and fractional excretion of uric acid(FEUA)(renal insufficiency type,renal overload type,mixed type,and other types).The general information of patients in the four groups(gender,age,body mass index,living habits,etc.),underlying diseases(hypertension,diabetes),blood test results[uric acid(UA),creatinine(Cre)],urine test results(24-hour urine UA,24-hour urine Cre)were summarized and the differences between the groups were analyzed.Results:The 200 cases of HUA patients were divided into 54.00%with renal insufficiency type,38.50%with mixed type,6.00%with renal overload type,and 1.50%with other types.The age of patients with mixed HUA was younger than that of patients with other types,renal overload type,and renal insufficiency type,and the difference was statistically significant(P<0.05).The UA level of patients with other types of HUA was lower than that of patients with mixed type HUA,and there was statistical significance(P<0.05).The Cre level of patients with mixed type HUA was lower than that of patients with renal insufficiency type and renal overload type,and the difference was statistically significant(P<0.05).The 24-hour urinary UA level in patients with renal insufficiency type HUA was lower than that in patients with renal overload type and mixed type HUA,and the difference was statistically significant(P<0.05).The 24-hour urinary Cre level of patients with other types of HUA was lower than that of patients with renal overload type and mixed HUA,the difference was statistically significant(P<0.05).The estimated glomerular filtration rate(eGFR)level of patients with other types of HUA was lower than that of patients with mixed type HUA,and the difference was statistically significant(P<0.05).There was no significant difference in the proportions of hypertension,diabetes,coronary heart disease,and urinary calculi among patients with renal insufficiency type,renal overload type,mixed type,and other types of HUA(P>0.05).Conclusion:The primary HUA patients are mainly of renal insufficiency type,followed by mixed type.There are significant differences in the clinical characteristics of patients with different types of HUA.Among them,patients with other types of HUA are the oldest and have the lowest uric acid levels.Patients with mixed HUA had the best renal function but the highest 24-hour urine creatinine level.This study can be used as a basis for rational selection of urate-lowering drugs for different HUA patients.展开更多
As an essential component of proteins and genetic material for all organisms, nitrogen(N) is one of the major limiting factors that control the dynamics, biodiversity and functioning of lacustrine wetlands, in which i...As an essential component of proteins and genetic material for all organisms, nitrogen(N) is one of the major limiting factors that control the dynamics, biodiversity and functioning of lacustrine wetlands, in which intensified N biogeochemical activities take place. Reactive N loaded into wetland ecosystems has been doubled due to various human activities, including industrial, agricultural activities and urbanization. The main driving mechanisms of N transport and transformation in lacustrine wetlands are categorized to pushing forces and pulling forces in this study. Geomorphology, wetland age, N concentrations, and temperature are the main pushing forces(passive forces); whereas water table variation, oxygen concentration, other elements availability, oxidation-reduction potential(Eh) and p H, and microorganisms are the predominant pulling forces(active forces). The direction and kinetic energy of reactions are determined by pulling forces and then are stimulated by pushing forces. These two types of forces are analyzed and discussed separately. Based on the analysis of driving mechanisms, possible solutions to wetland N pollutions are proposed at individual, regional and global scales, respectively. Additional research needs are addressed to obtain a thorough understanding of N transport and transformations in wetlands and to reduce detrimental impacts of excessive N on such fragile ecosystems.展开更多
文摘One of the most important issues in geotechnical engineering is excess pore pressure caused by clay soil loading and consolidation. Regarding uncertainties and complexities, this issue has long been the subject of attention of many researchers. In this work, a one-dimensional consolidation apparatus was equipped in a way that pore water pressure and settlement could be continuously read and recorded during consolidation process under static loading. The end of primary consolidation was obtained using water pressure changes helping to present a new method for determining the end of primary consolidation and consolidation coefficient. This method was then compared with two classical theory methods of lg t and t. Using Terzaghi's theory, the way of pore pressure dissipation for lg t, t and the new method was found and compared with experimental results. It is concluded that the new method has better results.
文摘Objective:This paper aims to study the clinical characteristics of patients with different types of primary hyperuricemia(HUA).Methods:Using a retrospective research method,200 patients with primary HUA in the hospital from June 2020 to January 2023 were selected as the research objects.Patients were grouped according to the detection results of 24-hour urinary uric acid excretion(UUE)and fractional excretion of uric acid(FEUA)(renal insufficiency type,renal overload type,mixed type,and other types).The general information of patients in the four groups(gender,age,body mass index,living habits,etc.),underlying diseases(hypertension,diabetes),blood test results[uric acid(UA),creatinine(Cre)],urine test results(24-hour urine UA,24-hour urine Cre)were summarized and the differences between the groups were analyzed.Results:The 200 cases of HUA patients were divided into 54.00%with renal insufficiency type,38.50%with mixed type,6.00%with renal overload type,and 1.50%with other types.The age of patients with mixed HUA was younger than that of patients with other types,renal overload type,and renal insufficiency type,and the difference was statistically significant(P<0.05).The UA level of patients with other types of HUA was lower than that of patients with mixed type HUA,and there was statistical significance(P<0.05).The Cre level of patients with mixed type HUA was lower than that of patients with renal insufficiency type and renal overload type,and the difference was statistically significant(P<0.05).The 24-hour urinary UA level in patients with renal insufficiency type HUA was lower than that in patients with renal overload type and mixed type HUA,and the difference was statistically significant(P<0.05).The 24-hour urinary Cre level of patients with other types of HUA was lower than that of patients with renal overload type and mixed HUA,the difference was statistically significant(P<0.05).The estimated glomerular filtration rate(eGFR)level of patients with other types of HUA was lower than that of patients with mixed type HUA,and the difference was statistically significant(P<0.05).There was no significant difference in the proportions of hypertension,diabetes,coronary heart disease,and urinary calculi among patients with renal insufficiency type,renal overload type,mixed type,and other types of HUA(P>0.05).Conclusion:The primary HUA patients are mainly of renal insufficiency type,followed by mixed type.There are significant differences in the clinical characteristics of patients with different types of HUA.Among them,patients with other types of HUA are the oldest and have the lowest uric acid levels.Patients with mixed HUA had the best renal function but the highest 24-hour urine creatinine level.This study can be used as a basis for rational selection of urate-lowering drugs for different HUA patients.
基金the National Natural Science Foundation of China (Grant No. 41272249)Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20110072110020)
文摘As an essential component of proteins and genetic material for all organisms, nitrogen(N) is one of the major limiting factors that control the dynamics, biodiversity and functioning of lacustrine wetlands, in which intensified N biogeochemical activities take place. Reactive N loaded into wetland ecosystems has been doubled due to various human activities, including industrial, agricultural activities and urbanization. The main driving mechanisms of N transport and transformation in lacustrine wetlands are categorized to pushing forces and pulling forces in this study. Geomorphology, wetland age, N concentrations, and temperature are the main pushing forces(passive forces); whereas water table variation, oxygen concentration, other elements availability, oxidation-reduction potential(Eh) and p H, and microorganisms are the predominant pulling forces(active forces). The direction and kinetic energy of reactions are determined by pulling forces and then are stimulated by pushing forces. These two types of forces are analyzed and discussed separately. Based on the analysis of driving mechanisms, possible solutions to wetland N pollutions are proposed at individual, regional and global scales, respectively. Additional research needs are addressed to obtain a thorough understanding of N transport and transformations in wetlands and to reduce detrimental impacts of excessive N on such fragile ecosystems.