The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal ...The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment signiifcantly increased the slope of input-output curves in rat neurons after lfuid per-cussion injury. Diazepam signiifcantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 μmol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the lfuid per-cussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.展开更多
The structure,function and plasticity of excitatory glutamatergic synapses in the brain are significantly altered by neurodevelopmental and neurodegenerative disorders（Grabrucker et al.,2011;Fourie et al.,2014;Musard...The structure,function and plasticity of excitatory glutamatergic synapses in the brain are significantly altered by neurodevelopmental and neurodegenerative disorders（Grabrucker et al.,2011;Fourie et al.,2014;Musardo et al.,2014;Lee et al.,2015）,resulting in impairments in cognition,learning,memory,motor and sensory function.展开更多
Inflammation is a complex and highly regulated response that occurs early after infection or injury.This process is initiated by cells of the immune system to re-establish tissue homeostasis.When the injury is persist...Inflammation is a complex and highly regulated response that occurs early after infection or injury.This process is initiated by cells of the immune system to re-establish tissue homeostasis.When the injury is persistent,however,chronic inflammation leads to overproduction of noxious mediators that contribute to cell dysfunction and death.展开更多
Drug addiction results in long-term synaptic potentiation at excitatory synapses in the brain reward circuitry,especially in the ventral tegmental area（VTA）and nucleus accumbens（NAc）,central parts of the mesolimbi...Drug addiction results in long-term synaptic potentiation at excitatory synapses in the brain reward circuitry,especially in the ventral tegmental area（VTA）and nucleus accumbens（NAc）,central parts of the mesolimbic dopamine system,and then progresses to other cortical regions[1,2].展开更多
Oscillatory neuronal activity is the fundamental signature of neural networks.In the EEG literature,the oscillations are described as belonging to different frequency bands that are commonly used in clinical monitoring.
基金supported by the National Natural Science Foundation of China,No.81201984the Scientific Research Project of Shaanxi Provincial Health Department in China,No.2010E03the Yulin Municipal Science and Technology Research and Development Project,No.Sf12-06
文摘The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment signiifcantly increased the slope of input-output curves in rat neurons after lfuid per-cussion injury. Diazepam signiifcantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 μmol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the lfuid per-cussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.
文摘The structure,function and plasticity of excitatory glutamatergic synapses in the brain are significantly altered by neurodevelopmental and neurodegenerative disorders（Grabrucker et al.,2011;Fourie et al.,2014;Musardo et al.,2014;Lee et al.,2015）,resulting in impairments in cognition,learning,memory,motor and sensory function.
基金supported by grants from the Canadian Institutes of Health Research and the Fonds de recherche du Québec-Santé (FRQS)National Chercheur Boursier award from FRQS
文摘Inflammation is a complex and highly regulated response that occurs early after infection or injury.This process is initiated by cells of the immune system to re-establish tissue homeostasis.When the injury is persistent,however,chronic inflammation leads to overproduction of noxious mediators that contribute to cell dysfunction and death.
基金supported by grants from the Postdoctoral Foundation of Jiangsu Province,China(1601180B)a Project of the Postdoctoral Science Foundation of China(2016M601841)
文摘Drug addiction results in long-term synaptic potentiation at excitatory synapses in the brain reward circuitry,especially in the ventral tegmental area（VTA）and nucleus accumbens（NAc）,central parts of the mesolimbic dopamine system,and then progresses to other cortical regions[1,2].
文摘Oscillatory neuronal activity is the fundamental signature of neural networks.In the EEG literature,the oscillations are described as belonging to different frequency bands that are commonly used in clinical monitoring.
