Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiqu...Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.展开更多
With an increasing proportion of sedentary lifestyle related chronic diseases,an efficient way to help fight the growing world epidemic of non-communicable diseases(NCDs)and promote public health in a fast-changing wo...With an increasing proportion of sedentary lifestyle related chronic diseases,an efficient way to help fight the growing world epidemic of non-communicable diseases(NCDs)and promote public health in a fast-changing world is urgently needed.Exercise and medicine science have played an important role in prevention and control of NCDs.However,the current status and future development directions regarding the integration of exercise science and medicine(IESM)in China have not been well discussed.During 2017 Belt and Road Initiative Global Health International Congress&2017 Chinese Preventive Medicine Association-Chinese Society on Global Health Annual Meeting,Xi’an Jiaotong University Global Health Institute,and the Integration of Sport and Medicine Innovation Research Center,China Institute of Sport Science organized the IESM Forum on September 27.Six leaders and experts from China and abroad presented excellent research reports in the IESM Forum from several aspects.Experts reached a consensus at the end of their discussions that,in the near future,the IESM will be a key part of a sustainable health care system and as such should contribute to prosperity in China and around the world.However,compared with European,American and Japanese universities,the development of the IESM in China is in its early stages with huge development potential.展开更多
目的探讨PDCA管理联合随机考核模式在冠状动脉粥样硬化性心脏病监护病房(Cardiac Care Unit,CCU)年轻护士护理能力中的应用效果。方法选择2022年1月—2023年12月徐州市中心医院工作的30名心内科CCU年轻护士作为研究对象,以2022年1—12...目的探讨PDCA管理联合随机考核模式在冠状动脉粥样硬化性心脏病监护病房(Cardiac Care Unit,CCU)年轻护士护理能力中的应用效果。方法选择2022年1月—2023年12月徐州市中心医院工作的30名心内科CCU年轻护士作为研究对象,以2022年1—12月实施常规管理模式为对照组,以2023年1—12月实施PDCA管理联合随机考核模式为研究组。比较两组年轻护士的评判性思维能力、临床演练评估能力、考核成绩、护理能力和护理质量。结果研究组评判性思维能力、临床演练评估能力、考核成绩、护理能力、护理质量显著优于对照组,差异有统计学意义(P均<0.05)。结论在CCU年轻护士的管理中,PDCA管理联合随机考核模式更为理想,可显著提升年轻护士的评判性思维能力和临床演练评估能力,提高其理论水平和实践技能,提升护理能力和护理质量。展开更多
基金supported by Project of the Health Shanghai Initiative Special Fund(Medical-Sports Integration,Creating a New Model of Exercise for Health),No.JKSHZX-2022-02(to SC).
文摘Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.
文摘With an increasing proportion of sedentary lifestyle related chronic diseases,an efficient way to help fight the growing world epidemic of non-communicable diseases(NCDs)and promote public health in a fast-changing world is urgently needed.Exercise and medicine science have played an important role in prevention and control of NCDs.However,the current status and future development directions regarding the integration of exercise science and medicine(IESM)in China have not been well discussed.During 2017 Belt and Road Initiative Global Health International Congress&2017 Chinese Preventive Medicine Association-Chinese Society on Global Health Annual Meeting,Xi’an Jiaotong University Global Health Institute,and the Integration of Sport and Medicine Innovation Research Center,China Institute of Sport Science organized the IESM Forum on September 27.Six leaders and experts from China and abroad presented excellent research reports in the IESM Forum from several aspects.Experts reached a consensus at the end of their discussions that,in the near future,the IESM will be a key part of a sustainable health care system and as such should contribute to prosperity in China and around the world.However,compared with European,American and Japanese universities,the development of the IESM in China is in its early stages with huge development potential.
文摘目的探讨PDCA管理联合随机考核模式在冠状动脉粥样硬化性心脏病监护病房(Cardiac Care Unit,CCU)年轻护士护理能力中的应用效果。方法选择2022年1月—2023年12月徐州市中心医院工作的30名心内科CCU年轻护士作为研究对象,以2022年1—12月实施常规管理模式为对照组,以2023年1—12月实施PDCA管理联合随机考核模式为研究组。比较两组年轻护士的评判性思维能力、临床演练评估能力、考核成绩、护理能力和护理质量。结果研究组评判性思维能力、临床演练评估能力、考核成绩、护理能力、护理质量显著优于对照组,差异有统计学意义(P均<0.05)。结论在CCU年轻护士的管理中,PDCA管理联合随机考核模式更为理想,可显著提升年轻护士的评判性思维能力和临床演练评估能力,提高其理论水平和实践技能,提升护理能力和护理质量。
