Systems biology requires the development of algorithms that use omics data to infer interaction networks among biomolecules working within an organism. One major type of evolutionary algorithm, genetic programming (GP...Systems biology requires the development of algorithms that use omics data to infer interaction networks among biomolecules working within an organism. One major type of evolutionary algorithm, genetic programming (GP), is useful for its high heuristic ability as a search method for obtaining suitable solutions expressed as tree structures. However, because GP determines the values of parameters such as coefficients by random values, it is difficult to apply in the inference of state equations that describe oscillatory biochemical reaction systems with high nonlinearity. Accordingly, in this study, we propose a new GP procedure called “k-step GP” intended for inferring the state equations of oscillatory biochemical reaction systems. The k-step GP procedure consists of two algorithms: 1) Parameter optimization using the modified Powell method—after genetic operations such as crossover and mutation, the values of parameters such as coefficients are optimized by applying the modified Powell method with secondary convergence. 2) GP using divided learning data—to improve the inference efficiency, imposes perturbations through the addition of learning data at various intervals and adaptations to these changes result in state equations with higher fitness. We are confident that k-step GP is an algorithm that is particularly well suited to inferring state equations for oscillatory biochemical reaction systems and contributes to solving inverse problems in systems biology.展开更多
In this paper we deal with the initial boundary value problem for two classes of reaction diffusion systems with two source terms in bounded domain. Under some assumptions on the exponents and the initial data, applyi...In this paper we deal with the initial boundary value problem for two classes of reaction diffusion systems with two source terms in bounded domain. Under some assumptions on the exponents and the initial data, applying the comparison principle, the maximum prin- ciple and the supersolution-subsolution method, we prove the global existence and blow up of solutions. We also establish some upper blow up rates.展开更多
The purpose of this work is to study the global existence and asymptotic behavior of solutions to a coupled reaction-diffusion system describing epidemiological or chemical situations. Our analytical proofs are based ...The purpose of this work is to study the global existence and asymptotic behavior of solutions to a coupled reaction-diffusion system describing epidemiological or chemical situations. Our analytical proofs are based on the Lyapunov functional methods.展开更多
A class of nonlinear singularly perturbed initial boundary value problems for reaction diffusion equations with two parameters and boundary perturbation were considered.Under suitable conditions,the existence,uniquene...A class of nonlinear singularly perturbed initial boundary value problems for reaction diffusion equations with two parameters and boundary perturbation were considered.Under suitable conditions,the existence,uniqueness and asymptotic behavior of solutions for the initial boundary value problems were studied.An example was also given to illustrate our main results.展开更多
This paper deals with an initial boundary value problem for the strongly coupledreaction-diffusion systems with a full matrix of diffusion coefficients. The global existence ofsolutions is proved by using the techniqu...This paper deals with an initial boundary value problem for the strongly coupledreaction-diffusion systems with a full matrix of diffusion coefficients. The global existence ofsolutions is proved by using the techniques based on invariant regions, Lyapunov functionalmethods, and local Lp prior estimates independent of time.展开更多
The initial boundary value problem of wave equations and reaction-diffusion equations with several nonlinear source terms in a bounded domain is studied by potential well method. The invarianee of some sets under the ...The initial boundary value problem of wave equations and reaction-diffusion equations with several nonlinear source terms in a bounded domain is studied by potential well method. The invarianee of some sets under the flow of these problems and the vacuum isolation of solutions are obtained by introducing a family of potential wells. Then the threshold result of global existence and nonexistence of solutions are given. Finally, the problem with critical initial conditions are discussed.展开更多
Reaction products of 2,4,6-tris(4-phenyl-phenoxy)-1,3,5-triazine derived from 4-phenylphenol cyanate ester and phenyl glycidyl ether were analyzed. In addition to an isocyanurate compound and an oxazolidone compound w...Reaction products of 2,4,6-tris(4-phenyl-phenoxy)-1,3,5-triazine derived from 4-phenylphenol cyanate ester and phenyl glycidyl ether were analyzed. In addition to an isocyanurate compound and an oxazolidone compound which were well known as reaction products of cyanate esters and epoxy resins, compounds with hybrid ring structure of cyanurate/isocyanurate were determined. Gibbs free energies of the compound having hybrid ring structure of cyanurate/isocyanurate with two isocyanurate moiety were found to be lower than that of the compound with cyanurate ring structure through calculations. Calculation data supported the existence of hybrid ring structure of cy-anurate/isocyanurate. It was revealed that isomerization from cyanurate to isocyanurate occurs via hybrid ring structure of cyanurate/isocyanurate in the reaction of aryl cyanurate and epoxy.展开更多
文摘Systems biology requires the development of algorithms that use omics data to infer interaction networks among biomolecules working within an organism. One major type of evolutionary algorithm, genetic programming (GP), is useful for its high heuristic ability as a search method for obtaining suitable solutions expressed as tree structures. However, because GP determines the values of parameters such as coefficients by random values, it is difficult to apply in the inference of state equations that describe oscillatory biochemical reaction systems with high nonlinearity. Accordingly, in this study, we propose a new GP procedure called “k-step GP” intended for inferring the state equations of oscillatory biochemical reaction systems. The k-step GP procedure consists of two algorithms: 1) Parameter optimization using the modified Powell method—after genetic operations such as crossover and mutation, the values of parameters such as coefficients are optimized by applying the modified Powell method with secondary convergence. 2) GP using divided learning data—to improve the inference efficiency, imposes perturbations through the addition of learning data at various intervals and adaptations to these changes result in state equations with higher fitness. We are confident that k-step GP is an algorithm that is particularly well suited to inferring state equations for oscillatory biochemical reaction systems and contributes to solving inverse problems in systems biology.
基金supported by the National Natural Science Foundation of China(11471087)the China Postdoctoral Science Foundation(2013M540270)+1 种基金the Heilongjiang Postdoctoral Foundation(LBH-Z13056,LBHZ15036)the Fundamental Research Funds for the Central Universities
文摘In this paper we deal with the initial boundary value problem for two classes of reaction diffusion systems with two source terms in bounded domain. Under some assumptions on the exponents and the initial data, applying the comparison principle, the maximum prin- ciple and the supersolution-subsolution method, we prove the global existence and blow up of solutions. We also establish some upper blow up rates.
文摘The purpose of this work is to study the global existence and asymptotic behavior of solutions to a coupled reaction-diffusion system describing epidemiological or chemical situations. Our analytical proofs are based on the Lyapunov functional methods.
基金National Natural Science Foundation of China(No.11271372)Hunan Provincial National Natural Science Foundation of China(No.12JJ2004)the Graduate Innovation Project of Central South University,China(No.2014zzts136)
文摘A class of nonlinear singularly perturbed initial boundary value problems for reaction diffusion equations with two parameters and boundary perturbation were considered.Under suitable conditions,the existence,uniqueness and asymptotic behavior of solutions for the initial boundary value problems were studied.An example was also given to illustrate our main results.
基金Supported by the Henan Innovation Project for University Prominent Research Talents (2003KJCX008)
文摘This paper deals with an initial boundary value problem for the strongly coupledreaction-diffusion systems with a full matrix of diffusion coefficients. The global existence ofsolutions is proved by using the techniques based on invariant regions, Lyapunov functionalmethods, and local Lp prior estimates independent of time.
基金the National Natural Science Foundation of China(No.10271034)the Basic Research Foundation of Harbin Engineering University(No.HEUF04012)
文摘The initial boundary value problem of wave equations and reaction-diffusion equations with several nonlinear source terms in a bounded domain is studied by potential well method. The invarianee of some sets under the flow of these problems and the vacuum isolation of solutions are obtained by introducing a family of potential wells. Then the threshold result of global existence and nonexistence of solutions are given. Finally, the problem with critical initial conditions are discussed.
文摘Reaction products of 2,4,6-tris(4-phenyl-phenoxy)-1,3,5-triazine derived from 4-phenylphenol cyanate ester and phenyl glycidyl ether were analyzed. In addition to an isocyanurate compound and an oxazolidone compound which were well known as reaction products of cyanate esters and epoxy resins, compounds with hybrid ring structure of cyanurate/isocyanurate were determined. Gibbs free energies of the compound having hybrid ring structure of cyanurate/isocyanurate with two isocyanurate moiety were found to be lower than that of the compound with cyanurate ring structure through calculations. Calculation data supported the existence of hybrid ring structure of cy-anurate/isocyanurate. It was revealed that isomerization from cyanurate to isocyanurate occurs via hybrid ring structure of cyanurate/isocyanurate in the reaction of aryl cyanurate and epoxy.
基金Characteristic Innovation Projects of Higher Learning in Guangdong Province(2016KTSCX028)the High-Level Talents Project of Guangdong Province(2014011)。
