The aim of the present study was to compare the coccidicidal efficacy of two commercial compounds for artificially infected dogs. Eighteen cocccidia-free dogs, male and female aged between 2 and 4 months old, were inf...The aim of the present study was to compare the coccidicidal efficacy of two commercial compounds for artificially infected dogs. Eighteen cocccidia-free dogs, male and female aged between 2 and 4 months old, were infected each with 20,000 Cystoisospora oocists cultured under laboratory conditions. When the poppies showed high counts of oocysts per gramm (OPG) (McMaster method), they were divided into 3 groups (G). G1 was treated with a compound named One® (Lab. Bio Zoo) containing 150 mg of toltrazuril/tablet, administered daily/5days dosing 1 tablet per 10 kg b.w. G2 received Giacoccide® (Pet’s Pharma) containing 250 mg of sulfadimetoxine and 165 mg of dimetridazole dosing 1 tablet per 10 kg b.w. twice a day for 10 days. G3 served as an untreated control. The puppies were coprologically monitored on Days 0, 3, 5, 10, 15, 20 and 25 to determine the percentage of OPG. Efficacy was measured based on the OPG reduction on treated animals relative to the untreated control. The results indicated an efficacy for compound One of 78.4%, 100%, 100%, 100%, 100% and 100%, for Days 3, 5, 10, 15, 20 and 25, respectively and for Giacoccide 40.6%, 45.5%, 47.4%, 65.9%, 90.4% and 92.7%, for Days 3, 5, 10, 15, 20 and 25, respectively. No statistical difference was observed on the weight of the treated puppies (p < 0.764), but the control group was statistically different to the treated ones (p < 0.014). It was concluded that compound One showed greater efficacy than Giacoccide for the treatment of canine coccidiosis in artificially infected dogs.展开更多
Drug absorptive function of the nasal mucosa has been a new and interesting subject of research in bridging rhinology and pharmacology. The authors applied a solution of gentamycin at a concentration of 40 mg/ml to 15...Drug absorptive function of the nasal mucosa has been a new and interesting subject of research in bridging rhinology and pharmacology. The authors applied a solution of gentamycin at a concentration of 40 mg/ml to 15 dogs at a dosage of 5 mg/kg for each through three routes of administration, ie, the intravenous, intramuscular and iutranasal. The serum levels of gentamyciu from 0 to 180 minutes after receiving the drug were determined with thin-layer scanning chromatographic method. It was found that if the bioavailability of the intravenous route was considered as 100%, the bioavailability of the intranasal route was 80.5%,and that of the intramuscular route was 42％. After giving drops of the drug into nasal cavity in above-mentioned dosage,the serum drug level reached a peak in 10 to 30 min ranging in 3.7 to 6.6 μg/ml. The half-life period of the drug given through this route was about three hours, indicating that the na sal mucosa is apt to be penetrated by gentamycin and allows the drug to be abso展开更多
文摘The aim of the present study was to compare the coccidicidal efficacy of two commercial compounds for artificially infected dogs. Eighteen cocccidia-free dogs, male and female aged between 2 and 4 months old, were infected each with 20,000 Cystoisospora oocists cultured under laboratory conditions. When the poppies showed high counts of oocysts per gramm (OPG) (McMaster method), they were divided into 3 groups (G). G1 was treated with a compound named One® (Lab. Bio Zoo) containing 150 mg of toltrazuril/tablet, administered daily/5days dosing 1 tablet per 10 kg b.w. G2 received Giacoccide® (Pet’s Pharma) containing 250 mg of sulfadimetoxine and 165 mg of dimetridazole dosing 1 tablet per 10 kg b.w. twice a day for 10 days. G3 served as an untreated control. The puppies were coprologically monitored on Days 0, 3, 5, 10, 15, 20 and 25 to determine the percentage of OPG. Efficacy was measured based on the OPG reduction on treated animals relative to the untreated control. The results indicated an efficacy for compound One of 78.4%, 100%, 100%, 100%, 100% and 100%, for Days 3, 5, 10, 15, 20 and 25, respectively and for Giacoccide 40.6%, 45.5%, 47.4%, 65.9%, 90.4% and 92.7%, for Days 3, 5, 10, 15, 20 and 25, respectively. No statistical difference was observed on the weight of the treated puppies (p < 0.764), but the control group was statistically different to the treated ones (p < 0.014). It was concluded that compound One showed greater efficacy than Giacoccide for the treatment of canine coccidiosis in artificially infected dogs.
文摘Drug absorptive function of the nasal mucosa has been a new and interesting subject of research in bridging rhinology and pharmacology. The authors applied a solution of gentamycin at a concentration of 40 mg/ml to 15 dogs at a dosage of 5 mg/kg for each through three routes of administration, ie, the intravenous, intramuscular and iutranasal. The serum levels of gentamyciu from 0 to 180 minutes after receiving the drug were determined with thin-layer scanning chromatographic method. It was found that if the bioavailability of the intravenous route was considered as 100%, the bioavailability of the intranasal route was 80.5%,and that of the intramuscular route was 42％. After giving drops of the drug into nasal cavity in above-mentioned dosage,the serum drug level reached a peak in 10 to 30 min ranging in 3.7 to 6.6 μg/ml. The half-life period of the drug given through this route was about three hours, indicating that the na sal mucosa is apt to be penetrated by gentamycin and allows the drug to be abso
