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Experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering boundary effect
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作者 Xuwei Wang Yeshuang Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期1072-1084,共13页
The boundary condition is a crucial factor affecting the permeability variation due to suffusion.An experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering the boundar... The boundary condition is a crucial factor affecting the permeability variation due to suffusion.An experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering the boundary effect is conducted,where the hydraulic head difference(DH)varies,and the boundary includes non-loss and soil-loss conditions.Soil samples are filled into seven soil storerooms connected in turn.After evaluation,the variation in content of fine sand(ΔR_(f))and the hydraulic conductivity of soils in each storeroom(C_(i))are analyzed.In the non-loss test,the soil sample filling area is divided into runoff,transited,and accumulated areas according to the negative or positive ΔR_(f) values.ΔR_(f) increases from negative to positive along the seepage path,and Ci decreases from runoff area to transited area and then rebounds in accumulated area.In the soil-loss test,all soil sample filling areas belong to the runoff area,where the gentle-loss,strengthened-loss,and alleviated-loss parts are further divided.ΔR_(f) decreases from the gentle-loss part to the strengthened-loss part and then rebounds in the alleviated-loss part,and C_(i) increases and then decreases along the seepage path.The relationship between ΔR_(f) and Ci is different with the boundary condition.Ci exponentially decreases with ΔR_(f) in the non-loss test and increases with ΔR_(f) generally in the soil-loss test. 展开更多
关键词 Suffusion PERMEABILITY experimental investigation Boundary effect Horizontal seepage
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Experimental investigation on coal pore-fracture variation and fractal characteristics synergistically affected by solvents for improving clean gas extraction
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作者 Feilin Han Sheng Xue +3 位作者 Chunshan Zheng Zhongwei Chen Guofu Li Bingyou Jiang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第3期413-425,共13页
Chemical solvents instead of pure water being as hydraulic fracturing fluid could effectively increase permeability and improve clean methane extraction efficiency.However,pore-fracture variation features of lean coal... Chemical solvents instead of pure water being as hydraulic fracturing fluid could effectively increase permeability and improve clean methane extraction efficiency.However,pore-fracture variation features of lean coal synergistically affected by solvents have not been fully understood.Ultrasonic testing,nuclear magnetic resonance analysis,liquid phase mass spectrometry was adopted to comprehensively analyze pore-fracture change characteristics of lean coal treated by combined solvent(NMP and CS_(2)).Meanwhile,quantitative characterization of above changing properties was conducted using geometric fractal theory.Relationship model between permeability,fractal dimension and porosity were established.Results indicate that the end face fractures of coal are well developed after CS2and combined solvent treatments,of which,end face box-counting fractal dimensions range from 1.1227 to 1.4767.Maximum decreases in ultrasonic longitudinal wave velocity of coal affected by NMP,CS_(2)and combined solvent are 2.700%,20.521%,22.454%,respectively.Solvent treatments could lead to increasing amount of both mesopores and macropores.Decrease ratio of fractal dimension Dsis 0.259%–2.159%,while permeability increases ratio of NMR ranges from 0.1904 to 6.4486.Meanwhile,combined solvent could dissolve coal polar and non-polar small molecules and expand flow space.Results could provide reference for solvent selection and parameter optimization of permeability-enhancement technology. 展开更多
关键词 Clean gas extraction Chemical solvent experimental investigation Fractal characteristics Pore fracture
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Auto-parametric resonance of a continuous-beam-bridge model under two-point periodic excitation:an experimental investigation and stability analysis
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作者 Li Yuchun Shen Chao +1 位作者 Liu Wei Li Dong 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第2期445-454,共10页
The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study.An auto-parametric resonance experiment of the ... The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study.An auto-parametric resonance experiment of the test model is conducted to observe and measure the auto-parametric resonance of a continuous beam under a two-point excitation on columns.The parametric vibration equation is established for the test model using the finite-element method.The auto-parametric resonance stability of the structure is analyzed by using Newmark's method and the energy-growth exponent method.The effects of the phase difference of the two-point excitation on the stability boundaries of auto-parametric resonance are studied for the test model.Compared with the experiment,the numerical instability predictions of auto-parametric resonance are consistent with the test phenomena,and the numerical stability boundaries of auto-parametric resonance agree with the experimental ones.For a continuous beam bridge,when the ratio of multipoint excitation frequency(applied to the columns)to natural frequency of the continuous girder is approximately equal to 2,the continuous beam may undergo a strong auto-parametric resonance.Combined with the present experiment and analysis,a hypothesis of Volgograd Bridge's serpentine vibration is discussed. 展开更多
关键词 auto-parametric resonance continuous beam bridge model two-point excitation experimental investigation stability analysis vibration of Volgograd Bridge
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Experimental Investigation on Vertical Hydraulic Transport of Ores in Deepsea Mining
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作者 LIU Lei LIU Jian-cheng +2 位作者 LI Xin XU Li-xin ZHANG Xiu-zhan 《China Ocean Engineering》 SCIE EI CSCD 2024年第1期42-53,共12页
Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on land.Vertical hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for... Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on land.Vertical hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for industrial applications.In the present study,an indoor model test of the vertical hydraulic transport of particles was conducted.A noncontact optical method has been proposed to measure the local characteristics of the particles inside a vertical pipe,including the local concentration and particle velocity.The hydraulic gradient of ore transport was evaluated with various particle size distributions,particle densities,feeding concentrations and mixture flow velocities.During transport,the local concentration is larger than the feeding concentration,whereas the particle velocity is less than the mixture velocity.The qualitative effects of the local concentration and local fluid velocity on the particle velocity and slip velocity were investigated.The local fluid velocity contributes significantly to particle velocity and slip velocity,whereas the effect of the local concentration is marginal.A higher feeding concentration and mixture flow velocity result in an increased hydraulic gradient.The effect of the particle size gradation is slight,whereas the particle density plays a crucial role in the transport. 展开更多
关键词 deepsea mining vertical hydraulic transport experiment flow characteristics
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Theoretical and experimental investigation of the resonance responses and chaotic dynamics of a bistable laminated composite shell in the dynamic snap-through mode
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作者 Meiqi WU Pengyu LV +3 位作者 Hongyuan LI Jiale YAN Huiling DUAN Wei ZHANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第4期581-602,共22页
The dynamic model of a bistable laminated composite shell simply supported by four corners is further developed to investigate the resonance responses and chaotic behaviors.The existence of the 1:1 resonance relations... The dynamic model of a bistable laminated composite shell simply supported by four corners is further developed to investigate the resonance responses and chaotic behaviors.The existence of the 1:1 resonance relationship between two order vibration modes of the system is verified.The resonance response of this class of bistable structures in the dynamic snap-through mode is investigated,and the four-dimensional(4D)nonlinear modulation equations are derived based on the 1:1 internal resonance relationship by means of the multiple scales method.The Hopf bifurcation and instability interval of the amplitude frequency and force amplitude curves are analyzed.The discussion focuses on investigating the effects of key parameters,e.g.,excitation amplitude,damping coefficient,and detuning parameters,on the resonance responses.The numerical simulations show that the foundation excitation and the degree of coupling between the vibration modes exert a substantial effect on the chaotic dynamics of the system.Furthermore,the significant motions under particular excitation conditions are visualized by bifurcation diagrams,time histories,phase portraits,three-dimensional(3D)phase portraits,and Poincare maps.Finally,the vibration experiment is carried out to study the amplitude frequency responses and bifurcation characteristics for the bistable laminated composite shell,yielding results that are qualitatively consistent with the theoretical results. 展开更多
关键词 bistable laminated composite shell dynamic snap-through mode Hopf bifurcation chaotic dynamics vibration experiment
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Experimental Investigation on the Strength and Ductility Performance of Steel-Timber-Steel Joints with Screw and Steel-Tube Fasteners
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作者 Huifeng Yang Mingwang Wu +3 位作者 Rixin Gu Hang Cao Kai Xiao Benkai Shi 《Journal of Renewable Materials》 EI 2023年第12期4175-4195,共21页
This article presents experimental results of steel-timber-steel(STS)joints loaded parallel to grain.Eight groups of specimens were designed,and tensile tests were performed.The fastener types and fastener numbers wer... This article presents experimental results of steel-timber-steel(STS)joints loaded parallel to grain.Eight groups of specimens were designed,and tensile tests were performed.The fastener types and fastener numbers were considered to evaluate the tensile strengths and ductility performances of the STS joints.The screws with 6 mm diameter and the innovative steel-tubes with 18 mm diameter were adopted as connecting fasteners.The experimental results were discussed in terms of yielding and ultimate strengths,slip stiffness,and ductility factors.The ductility classification and failure mechanisms of each group of specimens were analyzed.It was demonstrated that the STS joint with large diameter steel-tubes showed acceptable ductility,which was close to the ductility of the STS joint with small diameter screws,thanks to the hollow structure of the steel-tube.The theoretical strengths of various failure modes for the joints with small diameter screws or large diameter steel-tubes were calculated and compared with the experimental results.The ductile performance of the STS joint was discussed by comparing the theoretical strengths of various failure modes.The effective number of the STS joint with multifasteners was also analyzed by considering the failure mechanisms in aspects of tensile strength and slip stiffness. 展开更多
关键词 Steel-timber-steel joint SCREW steel-tube DUCTILITY experimental investigation timber structure
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Experimental investigation and flow analysis of clear-water scour around pier and abutment in proximity 被引量:1
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作者 Mohammad Saeed Fakhimjoo Abdollah Ardeshir +1 位作者 Kourosh Behzadian Hojat Karami 《Water Science and Engineering》 EI CAS CSCD 2023年第1期94-105,共12页
Local scour around bridge piers and abutments is one of the most significant causes of bridge failure.Despite a plethora of studies on scour around individual bridge piers or abutments,few studies have focused on the ... Local scour around bridge piers and abutments is one of the most significant causes of bridge failure.Despite a plethora of studies on scour around individual bridge piers or abutments,few studies have focused on the joint impact of a pier and an abutment in proximity to one another on scour.This study conducted laboratory experiments and flow analyses to examine the interaction of piers and abutments and their effect on clear-water scour.The experiments were conducted in a rectangular laboratory flume.They included 18 main tests(with a combination of different types of piers and abutments)and five control tests(with individual piers or abutments).Three pier types(a rectangular pier with a rounded edge,a group of three cylindrical piers,and a single cylindrical pier)and two abutment types(a wingewall abutment and a semicircular abutment)were used.An acoustic Doppler velocimeter was used to measure the three-dimensional flow velocity for analyses of streamline,velocity magnitude,vertical velocity,and bed shear stress.The results showed that the velocity near the pier and abutment increased by up to 80%.The maximum scour depth around the abutment increased by up to 19%.In contrast,the maximum scour depth around the pier increased significantly by up to l71%.The presence of the pier in the vicinity of the abutment led to an increase in the scour hole volume by up to 87%relative to the case with a solitary abutment.Empirical equations were also derived to accurately estimate the maximum scour depth at the pier adjacent to the abutment. 展开更多
关键词 ABUTMENT ADV Bridge scour Laboratory experiment Maximum scour depth PIER
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Gazing through the bubble:an experimental investigation into financial risk‑taking using eye‑tracking
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作者 Filip‑Mihai Toma Cosmin‑Octavian Cepoi +1 位作者 Matei Nicolae Kubinschi Makoto Miyakoshi 《Financial Innovation》 2023年第1期750-776,共27页
Eye tracking can facilitate understanding irrational decision-making in contexts such as financial risk-taking.For this purpose,we develop an experimental framework in which participants trade a risky asset in a simul... Eye tracking can facilitate understanding irrational decision-making in contexts such as financial risk-taking.For this purpose,we develop an experimental framework in which participants trade a risky asset in a simulated bubble market to maximize individual returns while their eye movements are recorded.Returns are sensitive to eye movement dynamics,depending on the presented visual stimuli.Using eye-tracking data,we investigated the effects of arousal,attention,and disengagement on individual payoffs using linear and nonlinear approaches.By estimating a nonlinear model using attention as a threshold variable,our results suggest that arousal positively influences trading returns,but its effect becomes smaller when attention exceeds a certain threshold,whereas disengagement has a higher negative impact on reduced attention levels and becomes almost irrelevant when attention increases.Hence,we provide a neurobehavioral metric as a function of attention that predicts financial gains in boomand-bust scenarios.This study serves as a proof-of-concept for developing future psychometric measures to enhance decision-making. 展开更多
关键词 Financial bubble Experiment Risk-taking EYE-TRACKING ATTENTION AROUSAL
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Investigation of Experimental Devices for Finger Active and Passive Tactile Friction Analysis
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作者 Xue Zhou Marc A.Masen +3 位作者 Jiliang Mo Xinyu Shi Yaosheng He Zhongmin Jin 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第2期129-139,共11页
Complicated tribological behavior occurs when human fingers touch and perceive the surfaces of objects.In this process,people use their exploration style with different conditions,such as contact load,sliding speed,sl... Complicated tribological behavior occurs when human fingers touch and perceive the surfaces of objects.In this process,people use their exploration style with different conditions,such as contact load,sliding speed,sliding direction,and angle of orientation between fingers and object surface consciously or unconsciously.This work addressed interlaboratory experimental devices for finger active and passive tactile friction analysis,showing two types of finger movement.In active sliding experiment,the participant slid their finger freely against the object surface,requiring the subject to control the motion conditions themselves.For passive sliding experiments,these motion conditions were adjusted by the device.Several analysis parameters,such as contact force,vibration acceleration signals,vibration magnitude,and fingerprint deformation were recorded simultaneously.Noticeable friction differences were observed when comparing active sliding and passive sliding.For passive sliding,stick-slip behavior occurred when sliding in the distal direction,evidenced by observing the friction force and the related deformation of the fingerprint ridges.The employed devices showed good repeatability and high reliability,which enriched the design of the experimental platform and provided guidance to the standardization research in the field of tactile friction. 展开更多
关键词 Finger friction experimental device Active sliding Passive sliding Rotating
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Experimental investigation and analytically modeling of hysteretic behavior of rigid bus-flexible connectors of 220 kV electrical substations
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作者 Tang Tingxuan He Jun 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2023年第3期841-852,共12页
This paper describes the quasi-static testing and analytical modelling of the hysteretic behavior of aluminum alloy rigid bus-flexible connectors of 220 kV electrical substations.The main objective of the study is to ... This paper describes the quasi-static testing and analytical modelling of the hysteretic behavior of aluminum alloy rigid bus-flexible connectors of 220 kV electrical substations.The main objective of the study is to experimentally investigate the hysteretic behavior of six different types of rigid bus-flexible connectors 220 kV electrical substations when subjected to cyclic loading.Another objective is to theoretically study the flexibility and effectiveness of a previously proposed analytical model in fitting the experimental hysteresis loops of the tested rigid bus-flexible connectors.The experimental investigation indicates that the tested rigid bus-flexible connectors exhibit highly asymmetric hysteresis behavior along with tension stiffening effect.The theoretical study demonstrates that the generalized Bouc-Wen model has high flexibility and is effective in fitting the experimental hysteresis resisting force-displacement curves of the six tested rigid bus-flexible connectors. 展开更多
关键词 rigid bus-flexible connectors 220 kV electrical substations hysteretic behavior experimental curves analytical model
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Experimental investigation of dynamic stall flow control using a microsecond-pulsed plasma actuator
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作者 徐泽阳 武斌 +2 位作者 高超 王娜 贾天昊 《Plasma Science and Technology》 SCIE EI CAS CSCD 2023年第3期193-203,共11页
To alleviate the performance deterioration caused by dynamic stall of a wind turbine airfoil,the flow control by a microsecond-pulsed dielectric barrier discharge(MP-DBD) actuator on the dynamic stall of a periodicall... To alleviate the performance deterioration caused by dynamic stall of a wind turbine airfoil,the flow control by a microsecond-pulsed dielectric barrier discharge(MP-DBD) actuator on the dynamic stall of a periodically pitching NACA0012 airfoil was investigated experimentally.Unsteady pressure measurements with high temporal accuracy were employed in this study,and the unsteady characteristics of the boundary layer were investigated by wavelet packet analysis and the moving root mean square method based on the acquired pressure.The experimental Mach number was 0.2,and the chord-based Reynolds number was 870 000.The dimensionless actuation frequencies F+ were chosen to be 0.5,1,2,and 3,respectively.For the light dynamic regime,the MP-DBD plasma actuator plays the role of suppressing flow separation from the trial edge and accelerating the flow reattachment due to the high-momentum freestream flow being entrained into the boundary layer.Meanwhile,actuation effects were promoted with the increasing dimensionless actuation frequency F+.The control effects of the deep dynamic stall were to delay the onset and reduce the strength of the dynamic stall vortex due to the accumulating vorticity near the leading edge being removed by the induced coherent vortex structures.The laminar fluctuation and Kelvin-Helmholtz(K-H) instabilities of transition and relaminarization were also mitigated by the MP-DBD actuation,and the alleviated K-H rolls led to the delay of the transition onset and earlier laminar reattachment,which improved the hysteresis effect of the dynamic stall.For the controlled cases of F+=2,and F+=3,the laminar fluctuation was replaced by relatively low frequency band disturbances corresponding to the harmonic responses of the MP-DBD actuation frequency. 展开更多
关键词 microsecond-pulsed plasma actuator dielectric barrier discharge flow control dynamic stall wind turbine wind tunnel experiment
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Experimental investigation on pressure-buildup characteristics of a water lump immerged in a molten lead pool
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作者 Zi-Jian Deng Song-Bai Cheng Hui Cheng 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2023年第3期25-39,共15页
Motivated to understand the pressure-buildup characteristics in a circumstance of a water droplet immerged inside a heavy liquid metal pool,which is a key phenomenon during a Steam Generator Tube Rupture accident of L... Motivated to understand the pressure-buildup characteristics in a circumstance of a water droplet immerged inside a heavy liquid metal pool,which is a key phenomenon during a Steam Generator Tube Rupture accident of Lead-cooled Fast Reactor,many experiments have been conducted by injecting water lumps into a molten lead pool at Sun Yat-sen University.In order to deepen the understanding of the influence of melt material,this lead experiment was compared with a Lead-Bismuth-Eutectic(LBE)experiment in the literature.For both experiments,a steam explosion occurred in a small part of the experi-mental runs,which generally leads to strengthened pressure buildup.Regarding the non-explosion experimental cases,the impact of all parameters employed in lead experiments(i.e.,water lump volume,water lump shape,molten pool depth,and temperature of water and melt)on the pressure buildup is non-negligible and similar to that in our previous experiments using LBE.Notably,limited pressure buildup with an increase in water lump volume was also observed.A slightly more violent pressure buildup tends to appear in the lead experiments than in the LBE experiments under the same experimental conditions,which may be due to the higher thermal conductivity of lead than of LBE.In a few experimental runs with a relatively low melt temperature close to the melting point of lead,local solidification of liquid lead was observed,restricting pressure buildup.For the lead and LBE experiments,the calculated melt kinetic energy conversion efficiencyηhas a relatively small value(not exceeding 1.6%),and theηvalues have an overall positive correlation with the impulse on the molten pool. 展开更多
关键词 Lead-cooled fast reactor Steam generator tube rupture accident Pressure-buildup characteristics experimental study Melt material
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Effect of trigger system on experimental dispersion characteristics of active surface wave testing
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作者 Lin Shibin Jeramy C.Ashlock +4 位作者 Zhu Liming Qin Zexiang Li Bo Zhu Xingji Zhai Changhai 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第2期311-318,共8页
A trigger system is typically employed in active seismic testing to trigger and synchronize multichannel surface wave data acquisition.The effect of the trigger system on the dispersion image of surface waves is empir... A trigger system is typically employed in active seismic testing to trigger and synchronize multichannel surface wave data acquisition.The effect of the trigger system on the dispersion image of surface waves is empirically known to be negligible,however,theoretical explanation regarding the effect of the trigger system is insufficient.This study systematically examines the theory for surface wave dispersion analysis and proves that the effect of the trigger system on a dispersion image is negligible via a solid theoretical explanation.Subsequently,based on the new theoretical explanation,an alternative method that uses only the relative phase difference between sensors to extract dispersion characteristics with better conceptual clarity is proposed.Two active surface wave testing cases are considered to validate the theory and method.The results indicate that(1)an accurate trigger system is not necessary for surface wave data acquisition,and(2)it is unnecessary to assume that the impact point is the generation point of the surface waves for the experimental dispersion analysis. 展开更多
关键词 site investigation surface waves data acquisition DISPERSION
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Investigation of anisotropic strength criteria for layered rock mass
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作者 Shuling Huang Jinxin Zhang +4 位作者 Xiuli Ding Chuanqing Zhang Gang Han Guoqi Yu Lulu Qu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1289-1304,共16页
Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground works.To investigate the strength anisotropy of layered rock,the Moh... Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground works.To investigate the strength anisotropy of layered rock,the Mohr-Coulomb and Hoek-Brown criteria are introduced to establish the two transverse isotropic strength criteria based on Jaeger's single weak plane theory and maximum axial strain theory,and parameter determination methods.Furthermore,the sensitivity of strength parameters(K 1,K 2,and K 3)that are used to characterize the anisotropy strength of non-sliding failure involved in the strength criteria and confining pressure are investigated.The results demonstrate that strength parameters K 1 and K 2 affect the strength of layered rock samples at all bedding angles except for the bedding angle of 90°and the angle range that can cause the shear sliding failure along the bedding plane.The strength of samples at any bedding angle decreases with increasing K 1,whereas the opposite is for K 2.Except for bedding angles of 0°and 90°and the bedding angle range that can cause the shear sliding along the bedding plane,K 3 has an impact on the strength of rock samples with other bedding angles that the specimens'strength increases with increase of K 3.In addition,the strength of the rock sample increases as confining pressure rises.Furthermore,the uniaxial and triaxial tests of chlorite schist samples were carried out to verify and evaluate the strength criteria proposed in the paper.It shows that the predicted strength is in good agreement with the experimental results.To test the applicability of the strength criterion,the strength data of several types of rock in the literature are compared.Finally,a comparison is made between the fitting effects of the two strength criteria and other available criteria for layered rocks. 展开更多
关键词 Layered rock Strength anisotropy Strength criterion experimental verification
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Systematic investigation of Radix Salviae for treating diabetic peripheral neuropathy disease based on network Pharmacology
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作者 Tao Kang Xiao Qin +1 位作者 Yan Chen Qian Yang 《World Journal of Diabetes》 SCIE 2024年第5期945-957,共13页
BACKGROUND Diabetic peripheral neuropathy(DPN)is a debilitating complication of diabetes mellitus with limited available treatment options.Radix Salviae,a traditional Chinese herb,has shown promise in treating DPN,but... BACKGROUND Diabetic peripheral neuropathy(DPN)is a debilitating complication of diabetes mellitus with limited available treatment options.Radix Salviae,a traditional Chinese herb,has shown promise in treating DPN,but its therapeutic mech-anisms have not been systematically investigated.AIM Radix Salviae(Danshen in pinin),a traditional Chinese medicine(TCM),is widely used to treat DPN in China.However,the mechanism through which Radix Salviae treats DPN remains unclear.Therefore,we aimed to explore the mechanism of action of Radix Salviae against DPN using network pharmacology.METHODS The active ingredients and target genes of Radix Salviae were screened using the TCM pharmacology database and analysis platform.The genes associated with DPN were obtained from the Gene Cards and OMIM databases,a drug-com-position-target-disease network was constructed,and a protein–protein inter-action network was subsequently constructed to screen the main targets.Gene Ontology(GO)functional annotation and pathway enrichment analysis were performed via the Kyoto Encyclopedia of Genes and Genomes(KEGG)using Bioconductor.RESULTS A total of 56 effective components,108 targets and 4581 DPN-related target genes of Radix Salviae were screened.Intervention with Radix Salviae for DPN mainly involved 81 target genes.The top 30 major targets were selected for enrichment analysis of GO and KEGG pathways.CONCLUSION These results suggested that Radix Salviae could treat DPN by regulating the AGE-RAGE signaling pathway and the PI3K-Akt signaling pathway.Therefore,Danshen may affect DPN by regulating inflammation and apoptosis. 展开更多
关键词 Diabetic peripheral neuropathy Radix Salviae Network pharmacology Systematic investigation
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Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis
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作者 Chunyun Liu Shangde Guo +5 位作者 Rong Liu Minfang Guo Qing Wang Zhi Chai Baoguo Xiao Cungen Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期671-679,共9页
Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system.Macrophage polarization plays an important role in the pat... Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system.Macrophage polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple sclerosis.This study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune encephalomyelitis.We found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and interleukin-6.Crucially,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified macrophages.In addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced inflammation.These findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for multiple sclerosis. 展开更多
关键词 ANTI-INFLAMMATORY experimental autoimmune encephalomyelitis FASUDIL macrophage multiple sclerosis PRO-INFLAMMATORY Rho kinase
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Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice
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作者 Yan Zheng Ei Ei Khine +9 位作者 Khin Mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin Khin Than Oo Myat Myat Moe San San Aye Weiren Wu 《The Crop Journal》 SCIE CSCD 2024年第2期549-557,共9页
Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq ... Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability. 展开更多
关键词 BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation
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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis
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作者 Li Xu Huiming Xu Changyong Tang 《Neural Regeneration Research》 SCIE CAS 2025年第2期354-365,共12页
Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism rem... Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism remains unknown.Therefore,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic targets.Since most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets astrocytes.These experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum disorders.In this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model choices.In addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials. 展开更多
关键词 AQUAPORIN-4 experimental model neuromyelitis optica spectrum disorder PATHOGENESIS
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Unexpected Diversity in Ecosystem Nutrient Responses to Experimental Drought in Temperate Grasslands
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作者 Biying Qiu Niwu Te +8 位作者 Lin Song Yuan Shi Chuan Qiu Xiaoan Zuo Qiang Yu Jianqiang Qian Zhengwen Wang Honghui Wu Wentao Luo 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第4期831-841,共11页
The responses of ecosystem nitrogen (N) and phosphorus (P) to drought are an important component of globalchange studies. However, previous studies were more often based on site-specific experiments, introducing a sig... The responses of ecosystem nitrogen (N) and phosphorus (P) to drought are an important component of globalchange studies. However, previous studies were more often based on site-specific experiments, introducing a significantuncertainty to synthesis and site comparisons. We investigated the responses of vegetation and soil nutrientsto drought using a network experiment of temperate grasslands in Northern China. Drought treatment (66%reduction in growing season precipitation) was imposed by erecting rainout shelters, respectively, at the driest,intermediate, and wettest sites. We found that vegetation nutrient concentrations increased but soil nutrient concentrationsdecreased along the aridity gradient. Differential responses were observed under experimentaldrought among the three grassland sites. Specifically, the experimental drought did not change vegetation andsoil nutrient status at the driest site, while strongly reduced vegetation but increased soil nutrient concentrationsat the site with intermediate precipitation. On the contrary, experimental drought increased vegetation N concentrationsbut did not change vegetation P and soil nutrient concentrations at the wettest site. In general, the differentialeffects of drought on ecosystem nutrients were observed between manipulative and observationalexperiments as well as between sites. Our research findings suggest that conducting large-scale, consistent, andcontrolled network experiments is essential to accurately evaluate the effects of global climate change on terrestrialecosystem bio-geochemistry. 展开更多
关键词 Climate change drought experiment PRECIPITATION nutrient cycles
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Recent progresses in the development of tubular segmented-in-series solid oxide fuel cells:Experimental and numerical study
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作者 Shuo Han Tao Wei +6 位作者 Sijia Wang Yanlong Zhu Xingtong Guo Liang He Xiongzhuang Li Qing Huang Daifen Chen 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第3期427-442,共16页
Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs s... Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs suffer from having a higher volume,current leakage,complex connections,and difficulty in gas sealing.To solve these problems,Rolls-Royce has fabricated a simple design by stacking cells in series on an insulating porous support,resulting in the tubular segmented-in-series solid oxide fuel cells(SIS-SOFCs),which achieved higher output voltage.This work systematically reviews recent advances in the structures,preparation methods,perform-ances,and stability of tubular SIS-SOFCs in experimental and numerical studies.Finally,the challenges and future development of tubular SIS-SOFCs are also discussed.The findings of this work can help guide the direction and inspire innovation of future development in this field. 展开更多
关键词 solid oxide fuel cell SEGMENTED-IN-SERIES TUBULAR experimental study numerical study
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