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Recent progresses in the development of tubular segmented-in-series solid oxide fuel cells:Experimental and numerical study 被引量:2
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作者 Shuo Han Tao Wei +6 位作者 Sijia Wang Yanlong Zhu Xingtong Guo Liang He Xiongzhuang Li Qing Huang Daifen Chen 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第3期427-442,共16页
Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs s... Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs suffer from having a higher volume,current leakage,complex connections,and difficulty in gas sealing.To solve these problems,Rolls-Royce has fabricated a simple design by stacking cells in series on an insulating porous support,resulting in the tubular segmented-in-series solid oxide fuel cells(SIS-SOFCs),which achieved higher output voltage.This work systematically reviews recent advances in the structures,preparation methods,perform-ances,and stability of tubular SIS-SOFCs in experimental and numerical studies.Finally,the challenges and future development of tubular SIS-SOFCs are also discussed.The findings of this work can help guide the direction and inspire innovation of future development in this field. 展开更多
关键词 solid oxide fuel cell SEGMENTED-IN-SERIES TUBULAR experimental study numerical study
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Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis 被引量:1
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作者 Chunyun Liu Shangde Guo +5 位作者 Rong Liu Minfang Guo Qing Wang Zhi Chai Baoguo Xiao Cungen Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期671-679,共9页
Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system.Macrophage polarization plays an important role in the pat... Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system.Macrophage polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple sclerosis.This study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune encephalomyelitis.We found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and interleukin-6.Crucially,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified macrophages.In addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced inflammation.These findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for multiple sclerosis. 展开更多
关键词 ANTI-INFLAMMATORY experimental autoimmune encephalomyelitis FASUDIL macrophage multiple sclerosis PRO-INFLAMMATORY Rho kinase
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Experimental investigation on coal pore-fracture variation and fractal characteristics synergistically affected by solvents for improving clean gas extraction 被引量:1
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作者 Feilin Han Sheng Xue +3 位作者 Chunshan Zheng Zhongwei Chen Guofu Li Bingyou Jiang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第3期413-425,共13页
Chemical solvents instead of pure water being as hydraulic fracturing fluid could effectively increase permeability and improve clean methane extraction efficiency.However,pore-fracture variation features of lean coal... Chemical solvents instead of pure water being as hydraulic fracturing fluid could effectively increase permeability and improve clean methane extraction efficiency.However,pore-fracture variation features of lean coal synergistically affected by solvents have not been fully understood.Ultrasonic testing,nuclear magnetic resonance analysis,liquid phase mass spectrometry was adopted to comprehensively analyze pore-fracture change characteristics of lean coal treated by combined solvent(NMP and CS_(2)).Meanwhile,quantitative characterization of above changing properties was conducted using geometric fractal theory.Relationship model between permeability,fractal dimension and porosity were established.Results indicate that the end face fractures of coal are well developed after CS2and combined solvent treatments,of which,end face box-counting fractal dimensions range from 1.1227 to 1.4767.Maximum decreases in ultrasonic longitudinal wave velocity of coal affected by NMP,CS_(2)and combined solvent are 2.700%,20.521%,22.454%,respectively.Solvent treatments could lead to increasing amount of both mesopores and macropores.Decrease ratio of fractal dimension Dsis 0.259%–2.159%,while permeability increases ratio of NMR ranges from 0.1904 to 6.4486.Meanwhile,combined solvent could dissolve coal polar and non-polar small molecules and expand flow space.Results could provide reference for solvent selection and parameter optimization of permeability-enhancement technology. 展开更多
关键词 Clean gas extraction Chemical solvent experimental investigation Fractal characteristics Pore fracture
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Experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering boundary effect
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作者 Xuwei Wang Yeshuang Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期1072-1084,共13页
The boundary condition is a crucial factor affecting the permeability variation due to suffusion.An experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering the boundar... The boundary condition is a crucial factor affecting the permeability variation due to suffusion.An experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering the boundary effect is conducted,where the hydraulic head difference(DH)varies,and the boundary includes non-loss and soil-loss conditions.Soil samples are filled into seven soil storerooms connected in turn.After evaluation,the variation in content of fine sand(ΔR_(f))and the hydraulic conductivity of soils in each storeroom(C_(i))are analyzed.In the non-loss test,the soil sample filling area is divided into runoff,transited,and accumulated areas according to the negative or positive ΔR_(f) values.ΔR_(f) increases from negative to positive along the seepage path,and Ci decreases from runoff area to transited area and then rebounds in accumulated area.In the soil-loss test,all soil sample filling areas belong to the runoff area,where the gentle-loss,strengthened-loss,and alleviated-loss parts are further divided.ΔR_(f) decreases from the gentle-loss part to the strengthened-loss part and then rebounds in the alleviated-loss part,and C_(i) increases and then decreases along the seepage path.The relationship between ΔR_(f) and Ci is different with the boundary condition.Ci exponentially decreases with ΔR_(f) in the non-loss test and increases with ΔR_(f) generally in the soil-loss test. 展开更多
关键词 Suffusion PERMEABILITY experimental investigation Boundary effect Horizontal seepage
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Experimental investigation of dynamic characteristics of leaching tubing for solution mining of salt cavern carbon and energy storage
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作者 Yin-Ping Li Xin-Bo Ge +1 位作者 Xi-Lin Shi Hong-Ling Ma 《Petroleum Science》 SCIE EI CAS CSCD 2024年第4期2703-2722,共20页
Salt caverns are extensively utilized for storing various substances such as fossil energy,hydrogen,compressed air,nuclear waste,and industrial solid waste.In China,when the salt cavern is leached through single-well ... Salt caverns are extensively utilized for storing various substances such as fossil energy,hydrogen,compressed air,nuclear waste,and industrial solid waste.In China,when the salt cavern is leached through single-well water solution mining with oil as a cushion,engineering challenges arise with the leaching tubing,leading to issues like damage and instability.These problems significantly hinder the progress of cavern construction and the control of cavern shape.The primary cause of this is the flowinduced vibration instability of leaching tubing within a confined space,which results in severe bending or damage to the tubing.This study presents a model experimental investigation on the dynamic characteristics of leaching tubing using a self-developed liquid-solid coupling physical model experiment apparatus.The experiment utilizes a silicone-rubber pipe(SRP)and a polycarbonate pipe(PCP)to examine the effects of various factors on the dynamic stability of cantilevered pipes conveying fluid.These factors include external space constraint,flexural rigidity,medium outside the pipe,overhanging length,and end conditions.The experiments reveal four dynamic response phenomena:water hammer,static buckling,chaotic motion,and flutter instability.The study further demonstrates that the length of the external space constraint has a direct impact on the flutter critical flow velocity of the cantilevered pipe conveying fluid.Additionally,the flutter critical flow velocity is influenced by the end conditions and different external media. 展开更多
关键词 Salt cavern storage Solution mining Leaching tubing experimental investigation Flutter instability
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Analytical and Experimental Research on Wave Scattering by an Open-Type Rectangular Breakwater with Horizontal Perforated Plates
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作者 HE Shuyue LIU Yong LI Huajun 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第5期1185-1201,共17页
This study proposes a novel open-type rectangular breakwater combined with horizontal perforated plates on both sides to enhance the sheltering effect of the rectangular box-type breakwaters against longer waves.The h... This study proposes a novel open-type rectangular breakwater combined with horizontal perforated plates on both sides to enhance the sheltering effect of the rectangular box-type breakwaters against longer waves.The hydrodynamic characteristics of this breakwater are analyzed through analytical potential solutions and experimental tests.The quadratic pressure drop conditions are exerted on the horizontal perforated plates to facilitate assessing the effect of wave height on the dissipated wave energy of breakwater through the analytical solution.The hydrodynamic quantities of the breakwater,including the reflection,transmission,and energyloss coefficients,together with vertical and horizontal wave forces,are calculated using the velocity potential decomposition method as well as an iterative algorithm.Furthermore,the reflection and transmission coefficients of the breakwater are measured by conducting experimental tests at various wave periods,wave heights,and both porosities and widths of the horizontal perforated plates.The analytical predicted results demonstrate good agreement with the iterative boundary element method solution and measured data.The influences of variable incident waves and structure parameters on the hydrodynamic characteristics of the breakwater are investigated through further calculations based on analytical solutions.Results indicate that horizontal perforated plates placed on the water surface for both sides of the rectangular breakwater can enhance the wave dissipation ability of the breakwater while effectively decreasing the transmission and reflection coefficients. 展开更多
关键词 rectangular breakwater horizontal perforated plates analytical solution experimental test hydrodynamic characteristics
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An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation
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作者 Benfeng Gu Haiyuan Li Baoming Li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期254-261,共8页
To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore damage.In this paper,a three-dime... To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore damage.In this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried out.Various test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of rail.Combining the simulation results and experimental data,the damage condition of the contact surface is analyzed. 展开更多
关键词 Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling experimental validation PFN
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Theoretical and Experimental Study on the Performance of Hermetic Diaphragm Squeeze Film Dampers for Gas-Lubricated Bearings
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作者 Jianwei Wang Haoxi Zhang +3 位作者 Shaocun Han Hang Li Peng Wang Kai Feng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第3期151-169,共19页
Low damping characteristics have always been a key sticking points in the development of gas bearings.The application of squeeze film dampers can significantly improve the damping performance of gas lubricated bearing... Low damping characteristics have always been a key sticking points in the development of gas bearings.The application of squeeze film dampers can significantly improve the damping performance of gas lubricated bearings.This paper proposed a novel hermetic diaphragm squeeze film damper(HDSFD)for oil-free turbomachinery supported by gas lubricated bearings.Several types of HDSFDs with symmetrical structure were proposed for good damping performance.By considering the compressibility of the damper fluid,based on hydraulic fluid mechanics theory,a dynamic model of HDSFDs under medium is proposed,which successfully reflects the frequency dependence of force coefficients.Based on the dynamic model,the effects of damper fluid viscosity,bulk modulus of damper fluid,thickness of damper fluid film and plunger thickness on the dynamic stiffness and damping of HDSFDs were analyzed.An experimental test rig was assembled and series of experimental studies on HDSFDs were conducted.The damper fluid transverse flow is added to the existing HDSFD concept,which aims to make the dynamic force coefficients independent of frequency.Although the force coefficient is still frequency dependent,the damping coefficient at high frequency excitation with damper fluid supply twice as that without damper fluid supply.The results serve as a benchmark for the calibration of analytical tools under development. 展开更多
关键词 Hermetic diaphragm squeeze film damper COMPRESSIBILITY Dynamic model experimental studies
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Auto-parametric resonance of a continuous-beam-bridge model under two-point periodic excitation:an experimental investigation and stability analysis
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作者 Li Yuchun Shen Chao +1 位作者 Liu Wei Li Dong 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第2期445-454,共10页
The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study.An auto-parametric resonance experiment of the ... The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study.An auto-parametric resonance experiment of the test model is conducted to observe and measure the auto-parametric resonance of a continuous beam under a two-point excitation on columns.The parametric vibration equation is established for the test model using the finite-element method.The auto-parametric resonance stability of the structure is analyzed by using Newmark's method and the energy-growth exponent method.The effects of the phase difference of the two-point excitation on the stability boundaries of auto-parametric resonance are studied for the test model.Compared with the experiment,the numerical instability predictions of auto-parametric resonance are consistent with the test phenomena,and the numerical stability boundaries of auto-parametric resonance agree with the experimental ones.For a continuous beam bridge,when the ratio of multipoint excitation frequency(applied to the columns)to natural frequency of the continuous girder is approximately equal to 2,the continuous beam may undergo a strong auto-parametric resonance.Combined with the present experiment and analysis,a hypothesis of Volgograd Bridge's serpentine vibration is discussed. 展开更多
关键词 auto-parametric resonance continuous beam bridge model two-point excitation experimental investigation stability analysis vibration of Volgograd Bridge
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Potential-dependent insights into the origin of high ammonia yield rate on copper surface via nitrate reduction:A computational and experimental study
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作者 Yangge Guo Nannan Sun +5 位作者 Liuxuan Luo Xiaojing Cheng Xueying Chen Xiaohui Yan Shuiyun Shen Junliang Zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第9期272-281,共10页
Focusing on revealing the origin of high ammonia yield rate on Cu via nitrate reduction(NO3RR),we herein applied constant potential method via grand-canonical density functional theory(GC-DFT)with implicit continuum s... Focusing on revealing the origin of high ammonia yield rate on Cu via nitrate reduction(NO3RR),we herein applied constant potential method via grand-canonical density functional theory(GC-DFT)with implicit continuum solvation model to predict the reaction energetics of NO3RR on pure copper surface in alkaline media.The potential-dependent mechanism on the most prevailing Cu(111)and the minor(100)and(110)facets were established,in consideration of NO_(2)_(−),NO,NH_(3),NH_(2)OH,N_(2),and N_(2)O as the main products.The computational results show that the major Cu(111)is the ideal surface to produce ammonia with the highest onset potential at 0.06 V(until−0.37 V)and the highest optimal potential at−0.31 V for ammonia production without kinetic obstacles in activation energies at critical steps.For other minor facets,the secondary Cu(100)shows activity to ammonia from−0.03 to−0.54 V with the ideal potential at−0.50 V,which requires larger overpotential to overcome kinetic activation energy barriers.The least Cu(110)possesses the longest potential range for ammonia yield from−0.27 to−1.12 V due to the higher adsorption coverage of nitrate,but also with higher tendency to generate di-nitrogen species.Experimental evaluations on commercial Cu/C electrocatalyst validated the accuracy of our proposed mechanism.The most influential(111)surface with highest percentage in electrocatalyst determined the trend of ammonia production.In specific,the onset potential of ammonia production at 0.1 V and emergence of yield rate peak at−0.3 V in experiments precisely located in the predicted potentials on Cu(111).Four critical factors for the high ammonia yield and selectivity on Cu surface via NO3RR are summarized,including high NO3RR activity towards ammonia on the dominant Cu(111)facet,more possibilities to produce ammonia along different pathways on each facet,excellent ability for HER inhibition and suitable surface size to suppress di-nitrogen species formation at high nitrate coverage.Overall,our work provides comprehensive potential-dependent insights into the reaction details of NO3RR to ammonia,which can serve as references for the future development of NO3RR electrocatalysts,achieving higher activity and selectivity by maximizing these characteristics of copper-based materials. 展开更多
关键词 Nitrate reduction to ammonia Copper surface Density functional theory Constant electrode potential method experimental validation
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Adaptive Robust Servo Control for Vertical Electric Stabilization System of Tank and Experimental Validation
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作者 Darui Lin Xiuye Wang +1 位作者 Yimin Wang Guolai Yang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期326-342,共17页
A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is addressed.This paper mainly focuses on two types of possibly fast timevaryin... A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is addressed.This paper mainly focuses on two types of possibly fast timevarying but bounded uncertainty within the vertical electric stabilization system:model parameter uncertainty and uncertain nonlinearity.First,the vertical electric stabilization system is constructed as an uncertain nonlinear dynamic system that can reflect the practical mechanics transfer process of the system.Second,the dynamical equation in the form of state space is established by designing the angular tracking error.Third,the comprehensive parameter of system uncertainty is designed to estimate the most conservative effects of uncertainty.Finally,an adaptive robust servo control which can effectively handle the combined effects of complex nonlinearity and uncertainty is proposed.The feasibility of the proposed control strategy under the practical physical condition is validated through the tests on the experimental platform.This paper pioneers the introduction of the internal nonlinearity and uncertainty of the vertical electric stabilization system into the settlement of the tracking stability control problem,and validates the advanced servo control strategy through experiment for the first time. 展开更多
关键词 Adaptive robust servo control experimental validation Nonlinearity compensation System uncertainty Vertical electric stabilization system
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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis
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作者 Li Xu Huiming Xu Changyong Tang 《Neural Regeneration Research》 SCIE CAS 2025年第2期354-365,共12页
Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism rem... Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism remains unknown.Therefore,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic targets.Since most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets astrocytes.These experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum disorders.In this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model choices.In addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials. 展开更多
关键词 AQUAPORIN-4 experimental model neuromyelitis optica spectrum disorder PATHOGENESIS
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Optimization of Center of Gravity Position and Anti-Wave Plate Angle of Amphibious Unmanned Vehicle Based on Orthogonal Experimental Method
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作者 Deyong Shang Xi Zhang +3 位作者 Fengqi Liang Chunde Zhai Hang Yang Yanqi Niu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期2027-2041,共15页
When the amphibious vehicle navigates in water,the angle of the anti-wave plate and the position of the center of gravity greatly influence the navigation characteristics.In the relevant research on reducing the navig... When the amphibious vehicle navigates in water,the angle of the anti-wave plate and the position of the center of gravity greatly influence the navigation characteristics.In the relevant research on reducing the navigation resistance of amphibious vehicles by adjusting the angle of the anti-wave plate,there is a lack of scientific selection of parameters and reasonable research of simulation results by using mathematical methods,and the influence of the center of gravity position on navigation characteristics is not considered at the same time.To study the influence of the combinations of the angle of the anti-wave plate and the position of the center of gravity on the resistance reduction characteristics,a numerical calculation model of the amphibious unmanned vehicle was established by using the theory of computational fluid dynamics,and the experimental data verified the correctness of the numerical model.Based on this numerical model,the navigation characteristics of the amphibious unmanned vehicle were studied when the center of gravity was located at different positions,and the orthogonal experimental design method was used to optimize the parameters of the angle of the anti-wave plate and the position of the center of gravity.The results show that through the parameter optimization analysis based on the orthogonal experimental method,the combination of the optimal angle of the anti-wave plate and the position of the center of gravity is obtained.And the numerical simulation result of resistance is consistent with the predicted optimal solution.Compared with the maximum navigational resistance,the parameter optimization reduces the navigational resistance of the amphibious unmanned vehicle by 24%. 展开更多
关键词 Amphibious unmanned vehicle orthogonal experimental design anti-wave plate center of gravity resistance characteristic
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Experimental Analysis of Radial Centrifugal Pump Shutdown
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作者 Xiao Sun Jiangbo Tong +4 位作者 Yuliang Zhang Haibing Cai Wen Zhou Xiaoqi Jia Litao Ou 《Fluid Dynamics & Materials Processing》 EI 2024年第4期725-737,共13页
Centrifugal pumps are widely used in the metallurgy,coal,and building sectors.In order to study the hydraulic characteristics of a closed impeller centrifugal pump during its shutdown in the so-called power frequency ... Centrifugal pumps are widely used in the metallurgy,coal,and building sectors.In order to study the hydraulic characteristics of a closed impeller centrifugal pump during its shutdown in the so-called power frequency and frequency conversion modes,experiments were carried to determine the characteristic evolution of parameters such as speed,inlet and outlet pressure,head,flow rate and shaft power.A quasi-steady-state method was also used to further investigate these transient behaviors.The results show that,compared to the power frequency input,the performance parameter curves for the frequency conversion input are less volatile and smoother.The characteristic time is longer and the response to shutdown is slower.The quasi-steady-state theoretical head-flow curves match the experimental head-flow curves more closely at low flow rates when the frequency conversion input is considered.Moreover,in this case,the similarity law predicts the hydraulic performance more accurately. 展开更多
关键词 Centrifugal pump power frequency frequency conversion SHUTDOWN external characteristic experimental study
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Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models
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作者 Pan Zheng Xue-Yang Li +8 位作者 Xiao-Yu Yang Huan Wang Ling Ding Cong He Jian-Hua Wan Hua-Jing Ke Nong-Hua Lu Nian-Shuang Li Yin Zhu 《World Journal of Gastroenterology》 SCIE CAS 2024年第14期2038-2058,共21页
BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ failure.Given the challenges associated ... BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ failure.Given the challenges associated with obtaining human pancreatic samples,research on AP predominantly relies on animal models.In this study,we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP models.AIM To investigate the shared molecular changes underlying the development of AP across varying severity levels.METHODS AP was induced in animal models through treatment with caerulein alone or in combination with lipopolysaccharide(LPS).Additionally,using Ptf1αto drive the specific expression of the hM3 promoter in pancreatic acinar cells transgenic C57BL/6J-hM3/Ptf1α(cre)mice were administered Clozapine N-oxide to induce AP.Subsequently,we conducted RNA sequencing of pancreatic tissues and validated the expression of significantly different genes using the Gene Expression Omnibus(GEO)database.RESULTS Caerulein-induced AP showed severe inflammation and edema,which were exacerbated when combined with LPS and accompanied by partial pancreatic tissue necrosis.Compared with the control group,RNA sequencing analysis revealed 880 significantly differentially expressed genes in the caerulein model and 885 in the caerulein combined with the LPS model.Kyoto Encyclopedia of Genes and Genomes enrichment analysis and Gene Set Enrichment Analysis indicated substantial enrichment of the TLR and NOD-like receptor signaling pathway,TLR signaling pathway,and NF-κB signaling pathway,alongside elevated levels of apoptosis-related pathways,such as apoptosis,P53 pathway,and phagosome pathway.The significantly elevated genes in the TLR and NOD-like receptor signaling pathways,as well as in the apoptosis pathway,were validated through quantitative real-time PCR experiments in animal models.Validation from the GEO database revealed that only MYD88 concurred in both mouse pancreatic tissue and human AP peripheral blood,while TLR1,TLR7,RIPK3,and OAS2 genes exhibited marked elevation in human AP.The genes TUBA1A and GADD45A played significant roles in apoptosis within human AP.The transgenic mouse model hM3/Ptf1α(cre)successfully validated significant differential genes in the TLR and NOD-like receptor signaling pathways as well as the apoptosis pathway,indicating that these pathways represent shared pathological processes in AP across different models.CONCLUSION The TLR and NOD receptor signaling pathways play crucial roles in the inflammatory progression of AP,notably the MYD88 gene.Apoptosis holds a central position in the necrotic processes of AP,with TUBA1A and GADD45A genes exhibiting prominence in human AP. 展开更多
关键词 Acute pancreatitis RNA-sequencing experimental acute pancreatitis models INFLAMMATORY Apoptosis TLR and NOD-like signaling pathways
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Experimental research on affecting factors of the cutting quality of sugarcane harvesters under complicated excitations
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作者 Hanning Mo Shaochun Ma +2 位作者 Chen Qiu Zhimin Huang Shangping Li 《International Journal of Agricultural and Biological Engineering》 SCIE 2024年第5期176-192,共17页
The sugarcane field excitation,cutting forces and the engine excitation constitute complicated excitations acting on sugarcane harvesters.In this study,the sugarcane cutting mechanism under complicated excitations was... The sugarcane field excitation,cutting forces and the engine excitation constitute complicated excitations acting on sugarcane harvesters.In this study,the sugarcane cutting mechanism under complicated excitations was analyzed.The dynamics and the mathematical models of sugarcane harvesters were established and simulated.Based on theoretical analysis,sugarcane cutting experiments were done on a self-built sugarcane harvester test platform(SHTP),designed as single-factor and the orthogonal experiments.Effects of the sugarcane field excitation characterized by the sugarcane field excitation device(SFED)output frequency,the engine excitation characterized by the actuating engine output frequency,the cutter rotating speed,the sugarcane harvester travelling speed simulated through the sugarcane transporting speed of the SHTP and the cutter inclination angle on the cutting quality of sugarcane harvesters were studied.Effects of the axial cutter vibration on three-directional cutting forces and the sugarcane cutting quality(SCQ)as well as effects of three-directional cutting forces on the SCQ were further studied.It is shown that the sugarcane field excitation,the axial cutter vibration amplitude and frequency as well as the three-directional cutting forces have significantly negative monotonic correlated effects on the SCQ while the cutter rotating speed,the sugarcane harvester travelling speed and the cutter inclination angle have significantly positive monotonic correlated effects on the SCQ.Significance levels of effects on three-directional cutting forces and the SCQ form high to low are as follow,the axial cutter vibration,the sugarcane field excitation,the cutter rotating speed,the engine excitation,the cutter inclination angle,the sugarcane harvester travelling speed.The theoretical analysis results were verified through experiment and an optimal combination was obtained with the cutter rotating speed of 700 r/min,sugarcane harvester travelling speed of 0.6 m/s and cutter inclination angle of 8º.This study can provide a reference for setting cutting parameters of sugarcane harvesters with a good SCQ. 展开更多
关键词 sugarcane harvester cutting quality complicated excitations experimental research theoretical analysis
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Experimental and numerical study of buckling-restrained braces configured with out-of-plane eccentricity under cyclic loading
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作者 Cao Yongsheng Zhou Yun +3 位作者 Takagi Jiro Jiang Ke Deng Xuesong Fang Xiaojun 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第4期957-971,共15页
This study focuses on variations in the hysteretic behavior of buckling-restrained braces(BRBs)configured with or without out-of-plane eccentricity under cyclic loading.Quasi-static experiments and numerical simulatio... This study focuses on variations in the hysteretic behavior of buckling-restrained braces(BRBs)configured with or without out-of-plane eccentricity under cyclic loading.Quasi-static experiments and numerical simulations were carried out on concentrically and eccentrically loaded BRB specimens to investigate the mechanical properties,energy dissipation performance,stress distribution,and high-order deformation pattern.The experimental and numerical results showed that compared to the concentrically loaded BRBs,the stiffness,yield force,cumulated plastic ductility(CPD)coefficient,equivalent viscous damping coefficient and energy dissipation decreased,and the yield displacement and compression strength adjustment factor increased for the eccentrically loaded BRBs.With the existence of the out-of-plane eccentricity,the initial yield position changes from the yield segment to the junction between the yield segment and transition segment under a tensile load,while the initial high-order buckling pattern changes from a first-order C-shape to a secondorder S-shape under a compressive load. 展开更多
关键词 buckling-restrained brace out-of-plane eccentricity EXPERIMENT numerical simulation mechanical properties
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Analysis and experimental study on resistance-increasing behavior of composite high efficiency autonomous inflow control device
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作者 Liang-Liang Dong Yu-Lin Zhang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1290-1304,共15页
Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks th... Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks through to the wellbore. Autonomous inflow control device(AICD) is an important instrument maintain normal production after bottom water coning, however, the resistance increasing ability of the swirl type AICD is insufficient at present, which seriously affects the water control effect. Aiming this problem, this paper designs a multi-stage resistance-increasing and composite type AICD. The separation mechanism of oil-water two phases in this structure, the resistance form of oil-water single phase and the resistance-increasing principle of water phase are analyzed. Establishing the dual-phase multi-stage separation and resistance-increasing model, and verified by measuring the throttling pressure drop and oil-water volume fraction of the AICD, it is found that the composite type AICD has the effect of ICD and AICD at the same time, which can balance the production rate of each well section at the initial stage of production, delay the occurrence of bottom water coning. In the middle and later stages of production, water-blocking can be effectively increased to achieve water control and stable production.After structural sensitivity analysis, the influence law of various structural parameters on the water control performance of composite AICD was obtained. The simulation calculation results show that,compared with the existing swirl type AICD, composite AICD has higher sensitivity to moisture content,the water phase throttling pressure drop is increased by 4.5 times on average. The composite AICD is suitable for the entire stage of horizontal well production. 展开更多
关键词 Water control Flow separation Flow resistance-increasing AICD device Simulation and experiment
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Experimental Investigation on Vertical Hydraulic Transport of Ores in Deepsea Mining
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作者 LIU Lei LIU Jian-cheng +2 位作者 LI Xin XU Li-xin ZHANG Xiu-zhan 《China Ocean Engineering》 SCIE EI CSCD 2024年第1期42-53,共12页
Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on land.Vertical hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for... Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on land.Vertical hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for industrial applications.In the present study,an indoor model test of the vertical hydraulic transport of particles was conducted.A noncontact optical method has been proposed to measure the local characteristics of the particles inside a vertical pipe,including the local concentration and particle velocity.The hydraulic gradient of ore transport was evaluated with various particle size distributions,particle densities,feeding concentrations and mixture flow velocities.During transport,the local concentration is larger than the feeding concentration,whereas the particle velocity is less than the mixture velocity.The qualitative effects of the local concentration and local fluid velocity on the particle velocity and slip velocity were investigated.The local fluid velocity contributes significantly to particle velocity and slip velocity,whereas the effect of the local concentration is marginal.A higher feeding concentration and mixture flow velocity result in an increased hydraulic gradient.The effect of the particle size gradation is slight,whereas the particle density plays a crucial role in the transport. 展开更多
关键词 deepsea mining vertical hydraulic transport experiment flow characteristics
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Experimental and Three-Dimensional Numerical Simulation of Phenomena Induced by Submerged Oblique Jet Scouring
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作者 Hao Chen Xianbin Teng +2 位作者 Faxin Zhu Zhibin Zhang Jie Wang 《Fluid Dynamics & Materials Processing》 EI 2024年第8期1799-1821,共23页
Scouring experiments were conducted using a three-dimensional laser scanning technology for angles of the jet spanning the interval from 0°to 30°,and the characteristics of the scour hole in equilibrium cond... Scouring experiments were conducted using a three-dimensional laser scanning technology for angles of the jet spanning the interval from 0°to 30°,and the characteristics of the scour hole in equilibrium conditions were investigated accordingly.The results indicate that the optimal scouring effects occur when the jet angle is in the ranges between 15°and 20°.Moreover,the dimensionless profiles of the scour hole exhibit a high degree of similarity at different jet angles.Numerical simulations conducted using the Flow-3D software to investigate the bed shear stress along the jet impingement surface have shown that this stress is influenced by both the resultant force and the jet impingement surface area.It reaches its maximum value when the jet is vertical,decreases rapidly as the jet starts to tilt,then increases slightly,and decreases again significantly when the angle exceeds 20°. 展开更多
关键词 Submerged jet jet angle experimental study numerical simulation bed shear stress
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