High performance can be obtained for the integrated power electronics module(IPEM) by using a three-dimensional packaging structure instead of a planar structure. A three- dimensional packaged half bridge-IPEM (HB-...High performance can be obtained for the integrated power electronics module(IPEM) by using a three-dimensional packaging structure instead of a planar structure. A three- dimensional packaged half bridge-IPEM (HB-IPEM), consisting of two chip scale packaged MOSFETs and the corresponding gate driver and protection circuits, is fabricated at the laboratory. The reliability of the IPEM is controlled from the shape design of solder joints and the control of assembly process parameters. The parasitic parameters are extracted using Agilent 4395A impedance analyzer for building the parasitic parameter model of the HB- IPEM. A 12 V/3 A output synchronous rectifier Buck converter using the HB-IPEM is built to test the electrical performance of the HB-IPEM. Low voltage spikes on two MOSFETs illustrate that the three-dimensional package of the HB-IPEM can decrease parasitic inductance. Temperature distribution simulation results of the HB-IPEM using FLOTHERM are given. Heat dissipation of the solder joints makes the peak junction temperature of the chip drop obviously. The package realizes three-dimensional heat dissipation and has better thermal management.展开更多
Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face ...Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform.In this paper,we propose methodology and process on constructing large scale cohorts which forms the basis of causality and comparative effectiveness relationship in epidemiology.We firstly constructed a Chinese terminology knowledge graph to deal with the diversity of vocabularies on regional platform.Secondly,we built special disease case repositories (i.e.,heart failure repository) that utilize the graph to search the related patients and to normalize the data.Based on the requirements of the clinical research which aimed to explore the effectiveness of taking statin on 180-days readmission in patients with heart failure,we built a large-scale retrospective cohort with 29647 cases of heart failure patients from the heart failure repository.After the propensity score matching,the study group (n=6346) and the control group (n=6346) with parallel clinical characteristics were acquired.Logistic regression analysis showed that taking statins had a negative correlation with 180-days readmission in heart failure patients.This paper presents the workflow and application example of big data mining based on regional EHR data.展开更多
Objective:To develop the Electronic Cigarette Use Scale(ECUS)based on social cognitive theory and test its reliability and validity,so as to provide a scientific tool for evaluating the use of e-cigarette smokers in C...Objective:To develop the Electronic Cigarette Use Scale(ECUS)based on social cognitive theory and test its reliability and validity,so as to provide a scientific tool for evaluating the use of e-cigarette smokers in China.Methods:Based on the review of social cognitive theory and literature analysis,the item pool of ECUS was constructed to form the initial version.From January to March in 2022,using the convenient sampling method,electronic questionnaires were distributed to college students in Guangdong Province through the questionnaire star platform,and a total of 1047 valid questionnaires were collected for item screening.The total sample was randomly divided into sample 1(n=517)and sample 2(n=530)for Exploratory Factor Analysis(EFA)and Confirmatory Factor Analysis(CFA)respectively to further test the reliability and validity of the scale and finally form a 24-item scale.Results:The formal ECUS included 24 items,6 factors were extracted by EFA,and the cumulative explanatory variance was 72.774%.CFA showed that the goodness-of-fit indices were acceptable:χ^(2)/df=2.61,CFI=0.938,TLI=0.928,RMSEA=0.055,90%CI(0.050,0.061),SRMR=0.046,AIC=34694.405,BIC=35036.235.The Cronbach’saof the 24-item scale was 0.898,and the Cronbach’saof each dimension was between 0.839 and 0.954.Both convergent validity and discriminant validity reached the standard.Conclusion:The 24-item ECUS developed in this study has been tested with good reliability and validity and is suitable for evaluating the use of e-cigarette smokers in China.展开更多
The compact physical parameters(μ_(α),U_(iα))in multichannel quantum defect theory(MQDT)can be directly calculated with relativistic multichannel theory(RMCT).Here we report a systematic study of the MQDT parameter...The compact physical parameters(μ_(α),U_(iα))in multichannel quantum defect theory(MQDT)can be directly calculated with relativistic multichannel theory(RMCT).Here we report a systematic study of the MQDT parameters(fiay Uia)with RMCT along the Ne-like iso-electronic sequence(including Ca^(10+),Fe^(16+),Ge^(22+),Ag^(37+) ions).We find that the physical parameters(μ_(α),U_(iα))show a very interesting scaling behavior along the iso-electronic sequence.展开更多
Objective: To determine the ultrastructural findings on Rectal Mucosa (RM) of patients with HIV/AIDS and anorectal pathologies (ARP), at micrometric and nanometric scales. Materials and methods: 5 patients were evalua...Objective: To determine the ultrastructural findings on Rectal Mucosa (RM) of patients with HIV/AIDS and anorectal pathologies (ARP), at micrometric and nanometric scales. Materials and methods: 5 patients were evaluated, 18 - 55 years old, with ARP (HIV co-infection with HPV, n = 4, and HIV-negative patient with HPV infection) (control n = 1), who were referred to the Coloproctology Unit of the HUC, and subjected to rectoscopy and biopsy. RM samples were identified, placed in a sterile plastic bottle with 1 mL of 2% glutaraldehyde and immediately transported for routine processing of fine cut (60 - 90 nm) to be evaluated via Transmission Electron Microscopy (TEM). They were fixed with Karnovsky solution with Millonig phosphate buffer (pH 7.4 and 320 mOsm) and post-fixed with OsO4 under the same conditions of pH and osmolarity. Results: Ultrastructural findings, at 10−6 scale: 1) Intestinal mucosa: vacuoles of mucus of different sizes that seem to be fused. 2) Smooth muscle cells: loss of definition of contractile myofilaments mass. 3) Unmyelinated axons and terminals of Schwann cells (SC): Edema and loss of their plasma membranes in some areas of association with axon terminals as well as abundant collagen fibers associated with SC. Ultrastructural findings, at 10−9 scale: 1) Smooth muscle cells: folded wrapper cores and edema of mitochondria and rough endoplasmic reticulum cisterns (RER). 2) Myelinated axon terminals: Loss of synaptic vesicles. 3) Fibroblasts: One observes mitochondria and cisterns of RER with alterations. All these alterations can generate intestinal and anorectal dysfunction in these patients. Conclusions: The HIV causes changes in rectal and muscular mucosa despite HAART treatment with undetectable viral load.展开更多
Stretchable electronics, which offers the performance of conventional wafer-based devices and mechan- ical properties of a rubber band, enables many novel applications that are not possible through conven- tional elec...Stretchable electronics, which offers the performance of conventional wafer-based devices and mechan- ical properties of a rubber band, enables many novel applications that are not possible through conven- tional electronics due to its brittle nature. One effective strategy to realize stretchable electronics is to design the inorganic semiconductor material in a stretchable format on a compliant elastomeric substrate. Engineering thermal management is essential for the development of stretchable electronics to avoid adverse thermal effects on its performance as well as in applications involving human body and biological tissues where even 1-2℃ temperature increase is not allowed. This article reviews the recent advances in thermal management of stretchable inorganic electronics with focuses on the thermal models and their comparisons to experiments and finite element simulations.展开更多
Reaction dynamics in gases at operating temperatures at the atomic level are the basis of heterogeneous gas-solid catalyst reactions and are crucial to the catalyst function.Supported noble metal nanocatalysts such as...Reaction dynamics in gases at operating temperatures at the atomic level are the basis of heterogeneous gas-solid catalyst reactions and are crucial to the catalyst function.Supported noble metal nanocatalysts such as platinum are of interest in fuel cells and as diesel oxidation catalysts for pollution control,and practical ruthenium nanocatalysts are explored for ammonia synthesis.Graphite and graphitic carbons are of interest as supports for the nanocatalysts.Despite considerable literature on the catalytic processes on graphite and graphitic supports,reaction dynamics of the nanocatalysts on the supports in different reactive gas environments and operating temperatures at the single atom level are not well understood.Here we present real time in-situ observations and analyses of reaction dynamics of Pt in oxidation,and practical Ru nanocatalysts in ammonia synthesis,on graphite and related supports under controlled reaction environments using a novel in-situ environmental(scanning) transmission electron microscope with single atom resolution.By recording snapshots of the reaction dynamics,the behaviour of the catalysts is imaged.The images reveal single metal atoms,clusters of a few atoms on the graphitic supports and the support function.These all play key roles in the mobility,sintering and growth of the catalysts.The experimental findings provide new structural insights into atomic scale reaction dynamics,morphology and stability of the nanocatalysts.展开更多
电子显微成像技术的快速发展使得对完整细胞、组织乃至整个机体进行高分辨三维结构解析研究成为可能,这些可进行大尺度生物样品三维结构研究的电子显微成像技术统称为体电子显微学技术(volume electron microscopy,vEM)。近年来,v EM在...电子显微成像技术的快速发展使得对完整细胞、组织乃至整个机体进行高分辨三维结构解析研究成为可能,这些可进行大尺度生物样品三维结构研究的电子显微成像技术统称为体电子显微学技术(volume electron microscopy,vEM)。近年来,v EM在研究尺度、分辨率、吞吐量和易用性等方面发展迅速,在整个生命科学领域的应用呈爆炸式增长,该技术因此被《自然》(Nature)评为2023年最值得关注的七项前沿技术之一。然而,vEM相关技术的发展和应用在国内起步较晚,亟待进一步推广。本综述涵盖了vEM的发展历程、技术分类、样品制备、数据收集、图像处理等全方位的内容,便于生命科学、医学等领域研究人员去了解、学习、应用和进一步发展该技术。展开更多
顶部电离层是指F2层电子密度最大值所在高度以上的电离层区域。掩星观测能够提供地面到低轨卫星轨道高度处的整个电离层电子密度剖面,对于顶部电离层的研究具有重要作用。标高是构建顶部以上电离层电子密度剖面模型的重要参数。本文使用...顶部电离层是指F2层电子密度最大值所在高度以上的电离层区域。掩星观测能够提供地面到低轨卫星轨道高度处的整个电离层电子密度剖面,对于顶部电离层的研究具有重要作用。标高是构建顶部以上电离层电子密度剖面模型的重要参数。本文使用2007—2020年的气象、电离层和气候星座观测系统(Constellation Observing System for Meteorology,Ionosphere and Climate,COSMIC)掩星观测数据,提取有效电子密度剖面数据的顶部标高,分析了其随地方时、季节、经纬度和太阳活动水平的变化特性。结果表明:顶部标高具有明显的日变化和季节变化规律,并且表现出强烈的太阳活动依赖性;顶部标高在纬度上的变化强烈依赖于地方时,同时在东西经向上表现出明显的波状结构,且这种经度波状结构在南北半球具有不同的形态;顶部标高在夏季半球具有显著的东西经向差异,南半球夏季更为明显。展开更多
基金Fok Ying Tung Education Foundation(No.91058)the Natural Science Foundation of High Education Institutions of Jiangsu Province(No.08KJD470004)Qing Lan Project of Jiangsu Province of 2008
文摘High performance can be obtained for the integrated power electronics module(IPEM) by using a three-dimensional packaging structure instead of a planar structure. A three- dimensional packaged half bridge-IPEM (HB-IPEM), consisting of two chip scale packaged MOSFETs and the corresponding gate driver and protection circuits, is fabricated at the laboratory. The reliability of the IPEM is controlled from the shape design of solder joints and the control of assembly process parameters. The parasitic parameters are extracted using Agilent 4395A impedance analyzer for building the parasitic parameter model of the HB- IPEM. A 12 V/3 A output synchronous rectifier Buck converter using the HB-IPEM is built to test the electrical performance of the HB-IPEM. Low voltage spikes on two MOSFETs illustrate that the three-dimensional package of the HB-IPEM can decrease parasitic inductance. Temperature distribution simulation results of the HB-IPEM using FLOTHERM are given. Heat dissipation of the solder joints makes the peak junction temperature of the chip drop obviously. The package realizes three-dimensional heat dissipation and has better thermal management.
基金Supported by the National Major Scientific and Technological Special Project for"Significant New Drugs Development’’(No.2018ZX09201008)Special Fund Project for Information Development from Shanghai Municipal Commission of Economy and Information(No.201701013)
文摘Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform.In this paper,we propose methodology and process on constructing large scale cohorts which forms the basis of causality and comparative effectiveness relationship in epidemiology.We firstly constructed a Chinese terminology knowledge graph to deal with the diversity of vocabularies on regional platform.Secondly,we built special disease case repositories (i.e.,heart failure repository) that utilize the graph to search the related patients and to normalize the data.Based on the requirements of the clinical research which aimed to explore the effectiveness of taking statin on 180-days readmission in patients with heart failure,we built a large-scale retrospective cohort with 29647 cases of heart failure patients from the heart failure repository.After the propensity score matching,the study group (n=6346) and the control group (n=6346) with parallel clinical characteristics were acquired.Logistic regression analysis showed that taking statins had a negative correlation with 180-days readmission in heart failure patients.This paper presents the workflow and application example of big data mining based on regional EHR data.
文摘Objective:To develop the Electronic Cigarette Use Scale(ECUS)based on social cognitive theory and test its reliability and validity,so as to provide a scientific tool for evaluating the use of e-cigarette smokers in China.Methods:Based on the review of social cognitive theory and literature analysis,the item pool of ECUS was constructed to form the initial version.From January to March in 2022,using the convenient sampling method,electronic questionnaires were distributed to college students in Guangdong Province through the questionnaire star platform,and a total of 1047 valid questionnaires were collected for item screening.The total sample was randomly divided into sample 1(n=517)and sample 2(n=530)for Exploratory Factor Analysis(EFA)and Confirmatory Factor Analysis(CFA)respectively to further test the reliability and validity of the scale and finally form a 24-item scale.Results:The formal ECUS included 24 items,6 factors were extracted by EFA,and the cumulative explanatory variance was 72.774%.CFA showed that the goodness-of-fit indices were acceptable:χ^(2)/df=2.61,CFI=0.938,TLI=0.928,RMSEA=0.055,90%CI(0.050,0.061),SRMR=0.046,AIC=34694.405,BIC=35036.235.The Cronbach’saof the 24-item scale was 0.898,and the Cronbach’saof each dimension was between 0.839 and 0.954.Both convergent validity and discriminant validity reached the standard.Conclusion:The 24-item ECUS developed in this study has been tested with good reliability and validity and is suitable for evaluating the use of e-cigarette smokers in China.
基金Supported in part by the National Natural Science Foundation of China,Chinese ScienceTechnology Commission,Science+1 种基金Technology Funds of CAEP,National High-Tech.ICF Committee in ChinaChinese Association of Atomic and Molecular Data.
文摘The compact physical parameters(μ_(α),U_(iα))in multichannel quantum defect theory(MQDT)can be directly calculated with relativistic multichannel theory(RMCT).Here we report a systematic study of the MQDT parameters(fiay Uia)with RMCT along the Ne-like iso-electronic sequence(including Ca^(10+),Fe^(16+),Ge^(22+),Ag^(37+) ions).We find that the physical parameters(μ_(α),U_(iα))show a very interesting scaling behavior along the iso-electronic sequence.
文摘Objective: To determine the ultrastructural findings on Rectal Mucosa (RM) of patients with HIV/AIDS and anorectal pathologies (ARP), at micrometric and nanometric scales. Materials and methods: 5 patients were evaluated, 18 - 55 years old, with ARP (HIV co-infection with HPV, n = 4, and HIV-negative patient with HPV infection) (control n = 1), who were referred to the Coloproctology Unit of the HUC, and subjected to rectoscopy and biopsy. RM samples were identified, placed in a sterile plastic bottle with 1 mL of 2% glutaraldehyde and immediately transported for routine processing of fine cut (60 - 90 nm) to be evaluated via Transmission Electron Microscopy (TEM). They were fixed with Karnovsky solution with Millonig phosphate buffer (pH 7.4 and 320 mOsm) and post-fixed with OsO4 under the same conditions of pH and osmolarity. Results: Ultrastructural findings, at 10−6 scale: 1) Intestinal mucosa: vacuoles of mucus of different sizes that seem to be fused. 2) Smooth muscle cells: loss of definition of contractile myofilaments mass. 3) Unmyelinated axons and terminals of Schwann cells (SC): Edema and loss of their plasma membranes in some areas of association with axon terminals as well as abundant collagen fibers associated with SC. Ultrastructural findings, at 10−9 scale: 1) Smooth muscle cells: folded wrapper cores and edema of mitochondria and rough endoplasmic reticulum cisterns (RER). 2) Myelinated axon terminals: Loss of synaptic vesicles. 3) Fibroblasts: One observes mitochondria and cisterns of RER with alterations. All these alterations can generate intestinal and anorectal dysfunction in these patients. Conclusions: The HIV causes changes in rectal and muscular mucosa despite HAART treatment with undetectable viral load.
基金supported by the Zhejiang Provincial Natural Science Foundation of China(Grant No.LR15A020001)the National Natural Science Foundation of China(Grant Nos.11502009,11372272 and 11321202)the National Basic Research Program of China(Grant No.2015CB351900)
文摘Stretchable electronics, which offers the performance of conventional wafer-based devices and mechan- ical properties of a rubber band, enables many novel applications that are not possible through conven- tional electronics due to its brittle nature. One effective strategy to realize stretchable electronics is to design the inorganic semiconductor material in a stretchable format on a compliant elastomeric substrate. Engineering thermal management is essential for the development of stretchable electronics to avoid adverse thermal effects on its performance as well as in applications involving human body and biological tissues where even 1-2℃ temperature increase is not allowed. This article reviews the recent advances in thermal management of stretchable inorganic electronics with focuses on the thermal models and their comparisons to experiments and finite element simulations.
基金the Engineering and Physical Science Research Council(EPSRC),U.K.for the award of a research grant EP/J0118058/1 and postdoctoral research assistantships(PDRAs) to M.R.W.and R.W.M.from the grant。
文摘Reaction dynamics in gases at operating temperatures at the atomic level are the basis of heterogeneous gas-solid catalyst reactions and are crucial to the catalyst function.Supported noble metal nanocatalysts such as platinum are of interest in fuel cells and as diesel oxidation catalysts for pollution control,and practical ruthenium nanocatalysts are explored for ammonia synthesis.Graphite and graphitic carbons are of interest as supports for the nanocatalysts.Despite considerable literature on the catalytic processes on graphite and graphitic supports,reaction dynamics of the nanocatalysts on the supports in different reactive gas environments and operating temperatures at the single atom level are not well understood.Here we present real time in-situ observations and analyses of reaction dynamics of Pt in oxidation,and practical Ru nanocatalysts in ammonia synthesis,on graphite and related supports under controlled reaction environments using a novel in-situ environmental(scanning) transmission electron microscope with single atom resolution.By recording snapshots of the reaction dynamics,the behaviour of the catalysts is imaged.The images reveal single metal atoms,clusters of a few atoms on the graphitic supports and the support function.These all play key roles in the mobility,sintering and growth of the catalysts.The experimental findings provide new structural insights into atomic scale reaction dynamics,morphology and stability of the nanocatalysts.
文摘电子显微成像技术的快速发展使得对完整细胞、组织乃至整个机体进行高分辨三维结构解析研究成为可能,这些可进行大尺度生物样品三维结构研究的电子显微成像技术统称为体电子显微学技术(volume electron microscopy,vEM)。近年来,v EM在研究尺度、分辨率、吞吐量和易用性等方面发展迅速,在整个生命科学领域的应用呈爆炸式增长,该技术因此被《自然》(Nature)评为2023年最值得关注的七项前沿技术之一。然而,vEM相关技术的发展和应用在国内起步较晚,亟待进一步推广。本综述涵盖了vEM的发展历程、技术分类、样品制备、数据收集、图像处理等全方位的内容,便于生命科学、医学等领域研究人员去了解、学习、应用和进一步发展该技术。
文摘顶部电离层是指F2层电子密度最大值所在高度以上的电离层区域。掩星观测能够提供地面到低轨卫星轨道高度处的整个电离层电子密度剖面,对于顶部电离层的研究具有重要作用。标高是构建顶部以上电离层电子密度剖面模型的重要参数。本文使用2007—2020年的气象、电离层和气候星座观测系统(Constellation Observing System for Meteorology,Ionosphere and Climate,COSMIC)掩星观测数据,提取有效电子密度剖面数据的顶部标高,分析了其随地方时、季节、经纬度和太阳活动水平的变化特性。结果表明:顶部标高具有明显的日变化和季节变化规律,并且表现出强烈的太阳活动依赖性;顶部标高在纬度上的变化强烈依赖于地方时,同时在东西经向上表现出明显的波状结构,且这种经度波状结构在南北半球具有不同的形态;顶部标高在夏季半球具有显著的东西经向差异,南半球夏季更为明显。