Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

Statistical analysis of generalized exponential distribution under progressive censoring with binomial removals

The estimation of generalized exponential distribution based on progressive censoring with binomial removals is presented, where the number of units removed at each failure time follows a binomial distribution. Maximum likelihood estimators of the parameters and their confidence intervals are derived. The expected time required to complete the life test under this censoring scheme is investigated. Finally, the numerical examples are given to illustrate some theoretical results by means of Monte-Carlo simulation.

CONSISTENCY OF MLE OF THE PARAMETER OF EXPONENTIAL LIFETIME DISTRIBUTION FOR RANDOM CENSORING MODEL WITH INCOMPLETE INFORMATION

In this paper, we have discussed a random censoring test with incomplete information, and proved that the maximum likelihood estimator(MLE) of the parameter based on the randomly censored data with incomplete information in the case of the exponential distribution has the strong consistency.

NEW TECHNOLOGY FOR FAULT DIAGNOSIS BASED ON WAVELET DENOISING AND MODIFIED EXPONENTIAL TIME-FREQUENCY DISTRIBUTION

Fast wavelet multi-resolution analysis (wavelet MRA) provides a effective tool for analyzing and canceling disturbing components in original signal. Because of its exponential frequency axis, this method isn't suitable for extracting harmonic components. The modified exponential time-frequency distribution ( MED) overcomes the problems of Wigner distribution( WD) ,can suppress cross-terms and cancel noise further more. MED provides high resolution in both time and frequency domains, so it can make out weak period impulse components fmm signal with mighty harmonic components. According to the 'time' behavior, together with 'frequency' behavior in one figure,the essential structure of a signal is revealed clearly. According to the analysis of algorithm and fault diagnosis example, the joint of wavelet MRA and MED is a powerful tool for fault diagnosis.

Exponential distribution-based genetic algorithm for solving mixed-integer bilevel programming problems

Two classes of mixed-integer nonlinear bilevel programming problems are discussed. One is that the follower＇s functions are separable with respect to the follower＇s variables, and the other is that the follower＇s functions are convex if the follower＇s variables are not restricted to integers. A genetic algorithm based on an exponential distribution is proposed for the aforementioned problems. First, for each fixed leader＇s variable x, it is proved that the optimal solution y of the follower＇s mixed-integer programming can be obtained by solving associated relaxed problems, and according to the convexity of the functions involved, a simplified branch and bound approach is given to solve the follower＇s programming for the second class of problems. Furthermore, based on an exponential distribution with a parameter λ, a new crossover operator is designed in which the best individuals are used to generate better offspring of crossover. The simulation results illustrate that the proposed algorithm is efficient and robust.

STRUCTURES OF SYSTEMS WITH EXPONENTIAL LIFE DISTRIBUTIONS

Structures of monotone systems and cold standby systems with exponen-tial life distributions and dependent components are studied. It is shown that a mono-tone system composed of components with multivariate HNBUE life distributions isessentially a series system composed of components with multivariate exponential lifedistributions. Also, it is proved that for cold standby systems composed of componentswith multivariate NBU life distributions, all but oue of the components are degenerateat zero while the remaining one is exponential. In addition, several equivalent char-acterizations of multivariate exponential distribution are provided in the multivariateHNBUE life distribution class which include many existing results as special cases.

Entropy Bayesian Analysis for the Generalized Inverse Exponential Distribution Based on URRSS

This paper deals with the Bayesian estimation of Shannon entropy for the generalized inverse exponential distribution.Assuming that the observed samples are taken from the upper record ranked set sampling(URRSS)and upper record values(URV)schemes.Formulas of Bayesian estimators are derived depending on a gamma prior distribution considering the squared error,linear exponential and precautionary loss functions,in addition,we obtain Bayesian credible intervals.The random-walk Metropolis-Hastings algorithm is handled to generate Markov chain Monte Carlo samples from the posterior distribution.Then,the behavior of the estimates is examined at various record values.The output of the study shows that the entropy Bayesian estimates under URRSS are more convenient than the other estimates under URV in the majority of the situations.Also,the entropy Bayesian estimates perform well as the number of records increases.The obtained results validate the usefulness and efficiency of the URV method.Real data is analyzed for more clarifying purposes which validate the theoretical results.

Robust and Efficient Reliability Estimation for Exponential Distribution

In modeling reliability data,the exponential distribution is commonly used due to its simplicity.For estimating the parameter of the exponential distribution,classical estimators including maximum likelihood estimator represent the most commonly used method and are well known to be efficient.However,the maximum likelihood estimator is highly sensitive in the presence of contamination or outliers.In this study,a robust and efficient estimator of the exponential distribution parameter was proposed based on the probability integral transform statistic.To examine the robustness of this new estimator,asymptotic variance,breakdown point,and gross error sensitivity were derived.This new estimator offers reasonable protection against outliers besides being simple to compute.Furthermore,a simulation study was conducted to compare the performance of this new estimator with the maximum likelihood estimator,weighted likelihood estimator,and M-scale estimator in the presence of outliers.Finally,a statistical analysis of three reliability data sets was conducted to demonstrate the performance of the proposed estimator.

Empirical Bayes Test for Two-parameter Exponential Distribution under Type-Ⅱ Censored Samples

The empirical Bayes test problem is considered for scale parameter of twoparameter exponential distribution under type-II censored data.By using wavelets estimation method,the EB test function is constructed,of which the asymptotic optimality and convergence rates are obtained.Finally,an example concerning the main result is given.

STATISTICAL INFERENCE FOR A BIVARIATE EXPONENTIAL DISTRIBUTION BASED ON GROUPED DATA

Consider the bivariate exponential distribution due to Marshall and Olkin[2], whose survival function is F(x, g) = exp[-λ1x-λ2y-λ12 max(x, y)] (x 0,y 0)with unknown Parameters λ1 > 0, λ2 > 0 and λ12 0.Based on grouped data, a newestimator for λ1, λ2 and λ12 is derived and its asymptotic properties are discussed.Besides, some test procedures of equal marginals and independence are given. Asimulation result is given, too.

BAYESIAN PREDICTION FOR THE TWO-PARAMETER EXPONENTIAL DISTRIBUTION BASED ON TYPE Ⅱ DOUBLY CENSORING

The two-parameter exponential distribution is proposed to be an underlying model,and prediction bounds for future observations are obtained by using Bayesian approach.Prediction intervals are derived for unobserved lifetimes in one-sample prediction and two-sample prediction based on type Ⅱ doubly censored samples.A numerical example is given to illustrate the procedures,prediction intervals are investigated via Monte Carlo method,and the accuracy of prediction intervals is presented.

Random Timestepping Algorithm with Exponential Distribution for Pricing Various Structures of One-Sided Barrier Options

The exponentially-distributed random timestepping algorithm with boundary test is implemented to evaluate the prices of some variety of single one-sided barrier option contracts within the framework of Black-Scholes model, giving efficient estimation of their hitting times. It is numerically shown that this algorithm, as for the Brownian bridge technique, can improve the rate of weak convergence from order one-half for the standard Monte Carlo to order 1. The exponential timestepping algorithm, however, displays better results, for a given amount of CPU time, than the Brownian bridge technique as the step size becomes larger or the volatility grows up. This is due to the features of the exponential distribution which is more strongly peaked near the origin and has a higher kurtosis compared to the normal distribution, giving more stability of the exponential timestepping algorithm at large time steps and high levels of volatility.

Analytical Evaluation of Non-Elementary Integrals Involving Some Exponential, Hyperbolic and Trigonometric Elementary Functions and Derivation of New Probability Measures Generalizing the Gamma-Type and Gaussian-Type Distributions

The non-elementary integrals involving elementary exponential, hyperbolic and trigonometric functions, and where α,η and β are real or complex constants are evaluated in terms of the confluent hypergeometric function 1F1 and the hypergeometric function 1F2. The hyperbolic and Euler identities are used to derive some identities involving exponential, hyperbolic, trigonometric functions and the hypergeometric functions 1F1 and 1F2. Having evaluated, these non-elementary integrals, some new probability measures generalizing the gamma-type and Gaussian distributions are also obtained. The obtained generalized probability distributions may, for example, allow to perform better statistical tests than those already known (e.g. chi-square (x2) statistical tests and other statistical tests constructed based on the central limit theorem (CLT)), while avoiding the use of computational approximations (or methods) which are in general expensive and associated with numerical errors.

The Beta Power Exponential Distribution

A new three-parameter beta power distribution is introduced and studied. We derive formal expressions for its moments, generating function and Cumulative density function. The maximum likelihood estimation of the model parameters was also conducted. In the end, the superiority of the new distribution over the exponentiated exponential was made by means of data set.

Monotone Empirical Bayes Test for the Exponential Distribution

We study the two-action problem in the exponential distribution via empirical Bayes （EB） approach. Based on type Ⅱ censored samples, we construct an EB test rule and obtain an optimal rate of convergence which much improves the existing results in the literature.

Reliability analysis of extended generalized inverted exponential distribution with applications

A general version of the inverted exponential distribution is introduced, studied and analyzed. This generalization depends on the method of Marshall-Olkin to extend a family of distributions. Some statistical and reliability properties of this family are studied. In addition, numerical estimation of the maximum likelihood estimate（MLE） parameters are discussed in details. As an application, some real data sets are analyzed and it is observed that the presented family provides a better fit than some other known distributions.

The Modi Exponentiated Exponential Distribution

In this study, a new four-parameter distribution called the Modi Exponentiated Exponential distribution was proposed and studied. The new distribution has three shape and one scale parameters. Its mathematical and statistical properties were investigated. The parameters of the new model were estimated using the method of Maximum Likelihood Estimation. Monte Carlo simulation was used to evaluate the performance of the MLEs through average bias and RMSE. The flexibility and goodness-of-fit of the proposed distribution were demonstrated by applying it to two real data sets and comparing it with some existing distributions.

On Size-Biased Double Weighted Exponential Distribution (SDWED)

This paper introduces a new distribution based on the exponential distribution, known as Size-biased Double Weighted Exponential Distribution (SDWED). Some characteristics of the new distribution are obtained. Plots for the cumulative distribution function, pdf and hazard function, tables with values of skewness and kurtosis are provided. As a motivation, the statistical application of the results to a problem of ball bearing data has been provided. It is observed that the new distribution is skewed to the right and bears most of the properties of skewed distribution. It is found that our newly proposed distribution fits better than size-biased Rayleigh and Maxwell distributions and many other distributions. Since many researchers have studied the procedure of the weighted distributions in the estates of forest, biomedicine and biostatistics etc., we hope in numerous fields of theoretical and applied sciences, the findings of this paper will be useful for the practitioners.

Heavy-Tailed Distributions Generated by Randomly Sampled Gaussian, Exponential and Power-Law Functions

A simple stochastic mechanism that produces exact and approximate power-law distributions is presented. The model considers radially symmetric Gaussian, exponential and power-law functions inn= 1, 2, 3 dimensions. Randomly sampling these functions with a radially uniform sampling scheme produces heavy-tailed distributions. For two-dimensional Gaussians and one-dimensional exponential functions, exact power-laws with exponent –1 are obtained. In other cases, densities with an approximate power-law behaviour close to the origin arise. These densities are analyzed using Padé approximants in order to show the approximate power-law behaviour. If the sampled function itself follows a power-law with exponent –α, random sampling leads to densities that also follow an exact power-law, with exponent -n/a – 1. The presented mechanism shows that power-laws can arise in generic situations different from previously considered specialized systems such as multi-particle systems close to phase transitions, dynamical systems at bifurcation points or systems displaying self-organized criticality. Thus, the presented mechanism may serve as an alternative hypothesis in system identification problems.

A Study on Mixture of Exponentiated Rayleigh and Exponentiated Exponential Distributions Based on Order Statistics

Mixtures of lifetime distributions occur when two different causes of failure arc present, each with the same parametric form of lifetime distributions. This paper is considered with the mixture model of exponentiated Rayleigh and exponentiated exponential distributions. The author＇s objectives are finding the statistical properties of the model and estimating the parameters of the model by using point estimation and interval estimation methods. First, some properties of the model with some graphs of the density function are discussed. Next, the maximum likelihood method of estimation is used for estimating scale and shape parameters of the model. Estimating the parameters is studied under complete and type II censored samples for different sample sizes. Asymptotic Fisher information matrix of the estimators for complete samples is founded with different sample sizes. The asymptotic variances of the maximum likelihood estimates are derived. Based on the asymptotic variances of the maximum likelihood estimates, interval estimates of the parameters are obtained. Some of the equations in this paper are solved by using numerical iteration such as Newton Raphson method by using Mathematica 7.0. The performance of findings in the paper is showed by demonstrating some numerical illustrations through Monte Carlo simulation study based on absolute relative bias and mean square error.