According to the capillary theory,an equivalent capillary model of micro-resistivity imaging logging was built.On this basis,the theoretical models of porosity spectrum(Ф_(i)),permeability spectrum(K_(i))and equivale...According to the capillary theory,an equivalent capillary model of micro-resistivity imaging logging was built.On this basis,the theoretical models of porosity spectrum(Ф_(i)),permeability spectrum(K_(i))and equivalent capillary pressure curve(pe)were established to reflect the reservoir heterogeneity.To promote the application of the theoretical models,the Archie's equation was introduced to establish a general model for quantitatively characterizing bi,K,and pei.Compared with the existing models,it is shown that:(1)the existing porosity spectrum model is the same as the general equation of gi;(2)the Ki model can display the permeability spectrum as compared with Purcell's permeability model;(3)the per model is constructed on a theoretical basis and avoids the limitations of existing models that are built only based on the component of porosity spectrum,as compared with the empirical model of capillary pressure curve.The application in the Permian Maokou Formation of Well TsX in the Central Sichuan paleo-uplift shows that the Ф_(i),K_(i),and p_(ci) models can be effectively applied to the identification of reservoir types,calculation of reservoir properties and pore structure parameters,and evaluation of reservoir heterogeneity.展开更多
We present a path morphology method to separate total rock pore space into matrix, fractures and vugs and derive their pore structure spectrum. Thus, we can achieve fine pore evaluation in fracture–vug reservoirs bas...We present a path morphology method to separate total rock pore space into matrix, fractures and vugs and derive their pore structure spectrum. Thus, we can achieve fine pore evaluation in fracture–vug reservoirs based on electric imaging logging data. We automatically identify and extract fracture–vug information from the electric imaging images by adopting a path morphological operator that remains flexible enough to fit rectilinear and slightly curved structures because they are independent of the structuring element shape. The Otsu method was used to extract fracture–vug information from the background noise caused by the matrix. To accommodate the differences in scale and form of the different target regions,including fracture and vug path, operators with different lengths were selected for their recognition and extraction at the corresponding scale. Polynomial and elliptic functions are used to fit the extracted fractures and vugs, respectively, and the fracture–vug parameters are deduced from the fitted edge. Finally, test examples of numerical simulation data and several measured well data have been provided for the verification of the effectiveness and adaptability of the path morphology method in the application of electric imaging logging data processing. This also provides algorithm support for the fine evaluation of fracture–vug reservoirs.展开更多
Considering the fluid flow non-darcy characteristics in fracture-vug carbonate reservoirs, a new multi-scale conduit flow model production prediction method for fracture-vug carbonate reservoirs was presented using im...Considering the fluid flow non-darcy characteristics in fracture-vug carbonate reservoirs, a new multi-scale conduit flow model production prediction method for fracture-vug carbonate reservoirs was presented using image segmentation technique of electric imaging logging data. Firstly, based on Hagen-Poiseuille's law of incompressible fluid flow and the different cross-sectional areas in single fractures and vugs in carbonate reservoirs, a multi-scale conduit flow model for fracture-vug carbonate reservoir was established, and a multi-scale conduit radial fluid flow equation was deduced. Then, conduit flow production index was introduced. The conduit flow production index was calculated using fracture-vug area extracted from the result of electrical image segmentation. Finally, production prediction of fracture-vug carbonate reservoir was realized by using electric imaging logging data. The method has been applied to Ordovician fracture-vug carbonate reservoirs in the Tabei area, and the predicted results are in good agreement with the oil testing data.展开更多
Petroleum production logging needs to determine the interpretation models first and flow pattern identification is the foundation, but traditional flow pattern identification methods have some limitations. In this pap...Petroleum production logging needs to determine the interpretation models first and flow pattern identification is the foundation, but traditional flow pattern identification methods have some limitations. In this paper, a new method of flow pattern identification in oil wells by electromagnetic image logging is proposed. First, the characteristics of gas-water and oil-water flow patterns in horizontal and vertical wellbores are picked up. Then, the continuous variation of the two phase flow pattern in the vertical and horizontal pipe space is discretized into continuous fluid distribution models in the pipeline section. Second, the electromagnetic flow image measurement responses of all the eight fluid distribution models are simulated and the characteristic vector of each response is analyzed in order to distinguish the fluid distribution models. Third, the time domain changes of the fluid distribution models in the pipeline section are used to identify the flow pattern. Finally, flow simulation experiments using electromagnetic flow image logging are operated and the experimental and simulated data are compared. The results show that the method can be used for flow pattern identification of actual electromagnetic image logging data.展开更多
Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after ant...Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal Iobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.展开更多
Forest logging in the Congo Basin has led to forest fragmentation due to logging infrastructures and felling gaps. In the same vein, forest concessions in the Congo Basin have increasing interest in the REDD+ mechani...Forest logging in the Congo Basin has led to forest fragmentation due to logging infrastructures and felling gaps. In the same vein, forest concessions in the Congo Basin have increasing interest in the REDD+ mechanism. However, there is little information or field data on carbon emissions from forest degradation caused by logging. To help fill this gap, Landsat 7 and 8 and SPOT 4 images of the East Region of Cameroon were processed and combined with field measurements (measurement of forest roads widths, felling gaps and log yards) to assess all disturbed areas. Also, measurements of different types of forest infrastructures helped to highlight emission factors. Forest contributes to 5.18 % of the degradation of the annual allowable cut (AAC) (84.53 ha) corresponding to 4.09 % of forest carbon stock (6.92 t ha^-1). Felling gaps constitute the primary source of degradation, represented an estimated area of 32.41 ha (2 % of the cutting area) far ahead of primary roads (18.44ha) and skid trails (16.36 ha). Assessment of the impact of degradation under the canopy requires the use of high resolution satellite images and field surveys.展开更多
Photoacoustic molecular imaging,combined with the reporter-gene technique,can provide a valuable tool for cancer research.The expression of the lacZ reporter gene can be imaged using photoacoustic imaging following th...Photoacoustic molecular imaging,combined with the reporter-gene technique,can provide a valuable tool for cancer research.The expression of the lacZ reporter gene can be imaged using photoacoustic imaging following the injection of X-gal,a colorimetric assay for the lacZ-encoded enzymeβ-galactosidase.Dual-wavelength photoacoustic microscopy was used to non-invasively image the detailed morphology of a lacZ-marked 9L gliosarcoma and its surrounding microvasculature simultaneously in vivo,with a superior resolution on the order of 10μm.Tumor-feeding vessels were found,and the expression level of lacZ in tumor was estimated.With future development of new absorption-enhancing reporter-gene systems,we anticipate this strategy can lead to a better understanding of the role of tumor metabolism in cancer initiation,progression,and metastasis,and in its response to therapy.展开更多
AIM: To investigate the dynamic characteristics and the correlation between PCNA, Bax, nm23, E-cadherin expression and apparent diffusion coefficient (ADC) on MR diffusion-weighted imaging (DWI) after chemoembolizatio...AIM: To investigate the dynamic characteristics and the correlation between PCNA, Bax, nm23, E-cadherin expression and apparent diffusion coefficient (ADC) on MR diffusion-weighted imaging (DWI) after chemoembolization in rabbit liver VX-2 tumor model. METHODS: Forty New Zealand rabbit liver VX-2 tumor models were included in the study. DWI was carried out periodically after chemoembolization. All VX-2 tumor samples in each group were examined by histopathology and Strept Avidin-Biotin Complex (SABC) immunohistochemical staining. RESULTS: The PCNA expression index in VX-2 tumors was higher than in the normal parenchyma around the tumor (P < 0.001). Nm23, Bax or E-caderin expression index in VX-2 tumors were lower than in the normal parenchyma around the tumor (all P < 0.001). PCNAand nm23 expression in the VX-2 tumor periphery first increased and then decreased (P < 0.001 and P = 0.03, respectively), while the expression of Bax and E-cadherin before and after chemoembolization was insignificant. When b-value was 100 s/mm2, there was a linear correlation between PCNA expression and ADC in the area of VX-2 tumor periphery (P < 0.001), and PCNA expression in VX-2 tumor periphery influenced the ADC. CONCLUSION: The potential of VX-2 tumor infiltrating and metastasizing decreases, while its ability to proliferate increases for a short time after chemoembolization. To some degree, the ADC value indirectly reflects the proliferation of VX-2 tumor cells.展开更多
In this paper, we describe some recent imaging technologies developed by Schlumberger for oilfield downhole mul- tiphase flow production logging (PL) and cross-well electromagnetic (EM) survey applications. FloScan Im...In this paper, we describe some recent imaging technologies developed by Schlumberger for oilfield downhole mul- tiphase flow production logging (PL) and cross-well electromagnetic (EM) survey applications. FloScan Imager (FSITM) has been introduced as a 3-phase oil/gas/water flow PL tool for deviated and horizontal wells. FSI sensors can map fluid velocity and holdup profiles along a vertical diameter of the wellbore at every survey depth, enabling a robust estimate of the individual phase flow rates in complex flow regimes. The cross-well EM survey is based on cross-borehole induction logging technique and provides resistivity distribution at a reservoir scale. It is a useful tool for reservoir management and is most effective in dynamic fields where fluid saturations are variable in time and space. The tool can be used to identify (water or steam) flooded and bypassed regions. By monitoring changes in the resistivity spatial distribution with time, cross-well EM survey is very effective at mapping inter-well temperature and structure. Some field examples are shown for both FloScan Imager PL tool and cross-well resistivity imaging survey.展开更多
Small tunnels such as engineering geological exploratory tunnels and mine roadways are generally narrow, which make the existing photographic geological logging technique inapplicable. Therefore, geological logging of...Small tunnels such as engineering geological exploratory tunnels and mine roadways are generally narrow, which make the existing photographic geological logging technique inapplicable. Therefore, geological logging of exploratory tunnels has always been taking the method of manual sketch work which has low efficiency and poor informatization degree of products, and it is a technical issue requiring urgent settlement for geological logging of small tunnels. This paper proposes and studies novel methods of photographic geological logging suitable for small tunnels, including image acquisition, image orientation control, image geometric correction, unfolded image map generation and geological attitude measurement, etc. Experiments show that the method can meet the precision requirement of geological logging. The novel method helps to realize the fast acquisition and processing of image-based geological logging data for small tunnels, and the forms of logging result are more abundant and more applicable to informatized management and application of geological logging data.展开更多
Assessment of reservoir and fracture parameters is necessary to optimize oil production,especially in heterogeneous reservoirs.Core and image logs are regarded as two of the best methods for this aim.However,due to co...Assessment of reservoir and fracture parameters is necessary to optimize oil production,especially in heterogeneous reservoirs.Core and image logs are regarded as two of the best methods for this aim.However,due to core limitations,using image log is considered as the best method.This study aims to use electrical image logs in the carbonate Asmari Formation reservoir in Zagros Basin,SW Iran,in order to evaluate natural fractures,porosity system,permeability profile and heterogeneity index and accordingly compare the results with core and well data.The results indicated that the electrical image logs are reliable for evaluating fracture and reservoir parameters,when there is no core available for a well.Based on the results from formation micro-imager(FMI)and electrical micro-imager(EMI),Asmari was recognized as a completely fractured reservoir in studied field and the reservoir parameters are mainly controlled by fractures.Furthermore,core and image logs indicated that the secondary porosity varies from 0%to 10%.The permeability indicator indicates that zones 3 and 5 have higher permeability index.Image log permeability index shows a very reasonable permeability profile after scaling against core and modular dynamics tester mobility,mud loss and production index which vary between 1 and 1000 md.In addition,no relationship was observed between core porosity and permeability,while the permeability relied heavily on fracture aperture.Therefore,fracture aperture was considered as the most important parameter for the determination of permeability.Sudden changes were also observed at zones 1-1 and 5 in the permeability trend,due to the high fracture aperture.It can be concluded that the electrical image logs(FMI and EMI)are usable for evaluating both reservoir and fracture parameters in wells with no core data in the Zagros Basin,SW Iran.展开更多
The sedimentary facies/microfacies,which can be correlated with well logs,determine reservoir quality and hydrocarbon productivity in carbonate rocks.The identification and evaluation of sedimentary facies/microfacies...The sedimentary facies/microfacies,which can be correlated with well logs,determine reservoir quality and hydrocarbon productivity in carbonate rocks.The identification and evaluation of sedimentary facies/microfacies using well logs are very important in order to effectively guide the exploration and development of oil and gas.Previous carbonate facies/microfacies identification methods based on conventional well log data often exist multiple solutions.This paper presents a new method of facies/microfacies identification based on core-conventional logs-electrical image log-geological model,and the method is applied in the fourth member of the Dengying Formation(Deng 4)in the Gaoshiti-Moxi area of the Sichuan Basin.Firstly,core data are used to calibrate different types of facies/microfacies,with the aim to systematically clarify the conventional and electrical image log responses for each type of facies/microfacies.Secondly,through the pair wise correlation analysis of conventional logs,GR,RT and CNL,are selected as sensitive curves to establish the microfacies discrimination criteria separately.Thirdly,five well logging response models and identification charts of facies/microfacies are established based on electrical image log.The sedimentary microfacies of 60 exploratory wells was analyzed individually through this method,and the microfacies maps of 4 layers of the Deng 4 Member were compiled,and the plane distribution of microfacies in the Gaoshiti-Moxi area of the Sichuan Basin was depicted.The comparative analysis of oil testing or production results of wells reveals three most favorable types of microfacies and they include algal psammitic shoal,algal agglutinate mound,and algal stromatolite mound,which provide a reliable technical support to the exploration,development and well deployment in the study area.展开更多
There is a growing realization that cell-to-cell variations in gene expression have importantbiological consequences underlying phenotype diversity and cell fate. Although analytical toolsfor measuring gene expression...There is a growing realization that cell-to-cell variations in gene expression have importantbiological consequences underlying phenotype diversity and cell fate. Although analytical toolsfor measuring gene expression, such as DNA microarrays, reverse-transcriptase PCR and in situhybridization have been widely utilized to discover the role of genetic variations in governingcellular behavior, these methods are performed in cell lysates and/or on fixed cells, and thereforelack the ability to provide comprehensive spatial-dynamic information on gene expression. Thishas invoked the recent development of molecular imaging strategies capable of illuminatingthe distribution and dynamics of RNA molecules in living cells. In this review, we describe aclass of molecular imaging probes known as molecular beacons (MBs), which have increasinglybecome the probe of choice for imaging RNA in living cells. In addition, we present the majorchallenges that can limit the ability of MBs to provide accurate measurements of RNA, anddiscuss efforts that have been made to overcome these challenges. It is envisioned that withcontinued refinement of the MB design, MBs will eventually become an indispensable tool foranalyzing gene expression in biology and medicine.展开更多
In this paper, we propose a sparse overcomplete image approximation method based on the ideas of overcomplete log-Gabor wavelet, mean shift and energy concentration. The proposed approximation method selects the neces...In this paper, we propose a sparse overcomplete image approximation method based on the ideas of overcomplete log-Gabor wavelet, mean shift and energy concentration. The proposed approximation method selects the necessary wavelet coefficients with a mean shift based algorithm, and concentrates energy on the selected coefficients. It can sparsely approximate the original image, and converges faster than the existing local competition based method. Then, we propose a new compression scheme based on the above approximation method. The scheme has compression performance similar to JPEG 2000. The images decoded with the proposed compression scheme appear more pleasant to the human eyes than those with JPEG 2000.展开更多
Acoustic waves enter a rock formation from a borehole and are reflected or scattered upon encountering a geologic structure.Consequently,we obtain the structure location represented by the azimuth and distance from th...Acoustic waves enter a rock formation from a borehole and are reflected or scattered upon encountering a geologic structure.Consequently,we obtain the structure location represented by the azimuth and distance from the borehole using the acoustic reflection or scattering.Downhole acoustic measurements with the azimuthal resolution are realized using an azimuthal acoustic receiver sonde composed of several arcuate phased array receivers.Eight sensors distributed evenly across the arcuate phased array receiver can record acoustic waves independently;this allows us to adopt the beamforming method.We use a supporting logging tool to conduct the downhole test in two adjacent fluid-filled boreholes,for validating the evaluation of the geologic structure using scattered P-waves.The test results show the multi-azimuth images of the target borehole and the azimuthal variation in scattering amplitudes.Thus,we obtain the precise location of the target borehole.Furthermore,the measured values of the target borehole are consistent with the actual values,indicating that we can accurately evaluate a near-borehole geologic structure with scattered P-waves.展开更多
基金Supported by the National Natural Science Foundation of China(U2003102,41974117)China National Science and Technology Major Project(2016ZX05052001).
文摘According to the capillary theory,an equivalent capillary model of micro-resistivity imaging logging was built.On this basis,the theoretical models of porosity spectrum(Ф_(i)),permeability spectrum(K_(i))and equivalent capillary pressure curve(pe)were established to reflect the reservoir heterogeneity.To promote the application of the theoretical models,the Archie's equation was introduced to establish a general model for quantitatively characterizing bi,K,and pei.Compared with the existing models,it is shown that:(1)the existing porosity spectrum model is the same as the general equation of gi;(2)the Ki model can display the permeability spectrum as compared with Purcell's permeability model;(3)the per model is constructed on a theoretical basis and avoids the limitations of existing models that are built only based on the component of porosity spectrum,as compared with the empirical model of capillary pressure curve.The application in the Permian Maokou Formation of Well TsX in the Central Sichuan paleo-uplift shows that the Ф_(i),K_(i),and p_(ci) models can be effectively applied to the identification of reservoir types,calculation of reservoir properties and pore structure parameters,and evaluation of reservoir heterogeneity.
基金granted access to projects supported by the National Major Fundamental Research Program of China ‘‘On basic research problems in applied geophysics for deep oil and gas fields’’(Grant Number 2013CB228605)CNPC Science and Technology Project(Grant Number 2016A-3303)and CNPC Logging Project(Grant Number 2017E-15)
文摘We present a path morphology method to separate total rock pore space into matrix, fractures and vugs and derive their pore structure spectrum. Thus, we can achieve fine pore evaluation in fracture–vug reservoirs based on electric imaging logging data. We automatically identify and extract fracture–vug information from the electric imaging images by adopting a path morphological operator that remains flexible enough to fit rectilinear and slightly curved structures because they are independent of the structuring element shape. The Otsu method was used to extract fracture–vug information from the background noise caused by the matrix. To accommodate the differences in scale and form of the different target regions,including fracture and vug path, operators with different lengths were selected for their recognition and extraction at the corresponding scale. Polynomial and elliptic functions are used to fit the extracted fractures and vugs, respectively, and the fracture–vug parameters are deduced from the fitted edge. Finally, test examples of numerical simulation data and several measured well data have been provided for the verification of the effectiveness and adaptability of the path morphology method in the application of electric imaging logging data processing. This also provides algorithm support for the fine evaluation of fracture–vug reservoirs.
基金Supported by the China National Science and Technology Major Project(2011ZX05020-008)
文摘Considering the fluid flow non-darcy characteristics in fracture-vug carbonate reservoirs, a new multi-scale conduit flow model production prediction method for fracture-vug carbonate reservoirs was presented using image segmentation technique of electric imaging logging data. Firstly, based on Hagen-Poiseuille's law of incompressible fluid flow and the different cross-sectional areas in single fractures and vugs in carbonate reservoirs, a multi-scale conduit flow model for fracture-vug carbonate reservoir was established, and a multi-scale conduit radial fluid flow equation was deduced. Then, conduit flow production index was introduced. The conduit flow production index was calculated using fracture-vug area extracted from the result of electrical image segmentation. Finally, production prediction of fracture-vug carbonate reservoir was realized by using electric imaging logging data. The method has been applied to Ordovician fracture-vug carbonate reservoirs in the Tabei area, and the predicted results are in good agreement with the oil testing data.
文摘Petroleum production logging needs to determine the interpretation models first and flow pattern identification is the foundation, but traditional flow pattern identification methods have some limitations. In this paper, a new method of flow pattern identification in oil wells by electromagnetic image logging is proposed. First, the characteristics of gas-water and oil-water flow patterns in horizontal and vertical wellbores are picked up. Then, the continuous variation of the two phase flow pattern in the vertical and horizontal pipe space is discretized into continuous fluid distribution models in the pipeline section. Second, the electromagnetic flow image measurement responses of all the eight fluid distribution models are simulated and the characteristic vector of each response is analyzed in order to distinguish the fluid distribution models. Third, the time domain changes of the fluid distribution models in the pipeline section are used to identify the flow pattern. Finally, flow simulation experiments using electromagnetic flow image logging are operated and the experimental and simulated data are compared. The results show that the method can be used for flow pattern identification of actual electromagnetic image logging data.
基金supported by research grants from the National Natural Science Foundation of China (No. 81071099)the Liaoning Science and Technology Foundation (No. 2008225010-14)Doctoral Foundation of the First Affiliated Hospital in China Medical University (No. 2010)
文摘Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal Iobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.
基金financially supported by FORAFAMA and COBAM project
文摘Forest logging in the Congo Basin has led to forest fragmentation due to logging infrastructures and felling gaps. In the same vein, forest concessions in the Congo Basin have increasing interest in the REDD+ mechanism. However, there is little information or field data on carbon emissions from forest degradation caused by logging. To help fill this gap, Landsat 7 and 8 and SPOT 4 images of the East Region of Cameroon were processed and combined with field measurements (measurement of forest roads widths, felling gaps and log yards) to assess all disturbed areas. Also, measurements of different types of forest infrastructures helped to highlight emission factors. Forest contributes to 5.18 % of the degradation of the annual allowable cut (AAC) (84.53 ha) corresponding to 4.09 % of forest carbon stock (6.92 t ha^-1). Felling gaps constitute the primary source of degradation, represented an estimated area of 32.41 ha (2 % of the cutting area) far ahead of primary roads (18.44ha) and skid trails (16.36 ha). Assessment of the impact of degradation under the canopy requires the use of high resolution satellite images and field surveys.
基金funded in part by the NIH grants R01 NS46214(BRP)and R01 EB000712.
文摘Photoacoustic molecular imaging,combined with the reporter-gene technique,can provide a valuable tool for cancer research.The expression of the lacZ reporter gene can be imaged using photoacoustic imaging following the injection of X-gal,a colorimetric assay for the lacZ-encoded enzymeβ-galactosidase.Dual-wavelength photoacoustic microscopy was used to non-invasively image the detailed morphology of a lacZ-marked 9L gliosarcoma and its surrounding microvasculature simultaneously in vivo,with a superior resolution on the order of 10μm.Tumor-feeding vessels were found,and the expression level of lacZ in tumor was estimated.With future development of new absorption-enhancing reporter-gene systems,we anticipate this strategy can lead to a better understanding of the role of tumor metabolism in cancer initiation,progression,and metastasis,and in its response to therapy.
基金The National Natural Science Foundation of China, No. 30070235 and 30470508The Natural Science Foundation of Hunan Province, No. 08JJ5043+1 种基金The Science and Technology Foundation of Hunan Province, No. 06FJ3120 and 2007SK3072The Medical Science and Technology Foundation of Hunan Province, No. B2006-159
文摘AIM: To investigate the dynamic characteristics and the correlation between PCNA, Bax, nm23, E-cadherin expression and apparent diffusion coefficient (ADC) on MR diffusion-weighted imaging (DWI) after chemoembolization in rabbit liver VX-2 tumor model. METHODS: Forty New Zealand rabbit liver VX-2 tumor models were included in the study. DWI was carried out periodically after chemoembolization. All VX-2 tumor samples in each group were examined by histopathology and Strept Avidin-Biotin Complex (SABC) immunohistochemical staining. RESULTS: The PCNA expression index in VX-2 tumors was higher than in the normal parenchyma around the tumor (P < 0.001). Nm23, Bax or E-caderin expression index in VX-2 tumors were lower than in the normal parenchyma around the tumor (all P < 0.001). PCNAand nm23 expression in the VX-2 tumor periphery first increased and then decreased (P < 0.001 and P = 0.03, respectively), while the expression of Bax and E-cadherin before and after chemoembolization was insignificant. When b-value was 100 s/mm2, there was a linear correlation between PCNA expression and ADC in the area of VX-2 tumor periphery (P < 0.001), and PCNA expression in VX-2 tumor periphery influenced the ADC. CONCLUSION: The potential of VX-2 tumor infiltrating and metastasizing decreases, while its ability to proliferate increases for a short time after chemoembolization. To some degree, the ADC value indirectly reflects the proliferation of VX-2 tumor cells.
文摘In this paper, we describe some recent imaging technologies developed by Schlumberger for oilfield downhole mul- tiphase flow production logging (PL) and cross-well electromagnetic (EM) survey applications. FloScan Imager (FSITM) has been introduced as a 3-phase oil/gas/water flow PL tool for deviated and horizontal wells. FSI sensors can map fluid velocity and holdup profiles along a vertical diameter of the wellbore at every survey depth, enabling a robust estimate of the individual phase flow rates in complex flow regimes. The cross-well EM survey is based on cross-borehole induction logging technique and provides resistivity distribution at a reservoir scale. It is a useful tool for reservoir management and is most effective in dynamic fields where fluid saturations are variable in time and space. The tool can be used to identify (water or steam) flooded and bypassed regions. By monitoring changes in the resistivity spatial distribution with time, cross-well EM survey is very effective at mapping inter-well temperature and structure. Some field examples are shown for both FloScan Imager PL tool and cross-well resistivity imaging survey.
基金Project(201508)supported by the Open Research Foundation of Engineering Research Center for Rock-Soil Drilling & Excavation and Protection(Ministry of Education),ChinaProject(BK2012812)supported by the Natural Science Foundation of Jiangsu Province,China+1 种基金Project(KYLX_0492)supported by the University Postgraduate Scientific Research and Innovation Project of Jiangsu Province,ChinaProject(2014B38714)supported by the Fundamental Research Funds for the Central Universities,China
文摘Small tunnels such as engineering geological exploratory tunnels and mine roadways are generally narrow, which make the existing photographic geological logging technique inapplicable. Therefore, geological logging of exploratory tunnels has always been taking the method of manual sketch work which has low efficiency and poor informatization degree of products, and it is a technical issue requiring urgent settlement for geological logging of small tunnels. This paper proposes and studies novel methods of photographic geological logging suitable for small tunnels, including image acquisition, image orientation control, image geometric correction, unfolded image map generation and geological attitude measurement, etc. Experiments show that the method can meet the precision requirement of geological logging. The novel method helps to realize the fast acquisition and processing of image-based geological logging data for small tunnels, and the forms of logging result are more abundant and more applicable to informatized management and application of geological logging data.
基金financial and data support from NISOC Oil Company.
文摘Assessment of reservoir and fracture parameters is necessary to optimize oil production,especially in heterogeneous reservoirs.Core and image logs are regarded as two of the best methods for this aim.However,due to core limitations,using image log is considered as the best method.This study aims to use electrical image logs in the carbonate Asmari Formation reservoir in Zagros Basin,SW Iran,in order to evaluate natural fractures,porosity system,permeability profile and heterogeneity index and accordingly compare the results with core and well data.The results indicated that the electrical image logs are reliable for evaluating fracture and reservoir parameters,when there is no core available for a well.Based on the results from formation micro-imager(FMI)and electrical micro-imager(EMI),Asmari was recognized as a completely fractured reservoir in studied field and the reservoir parameters are mainly controlled by fractures.Furthermore,core and image logs indicated that the secondary porosity varies from 0%to 10%.The permeability indicator indicates that zones 3 and 5 have higher permeability index.Image log permeability index shows a very reasonable permeability profile after scaling against core and modular dynamics tester mobility,mud loss and production index which vary between 1 and 1000 md.In addition,no relationship was observed between core porosity and permeability,while the permeability relied heavily on fracture aperture.Therefore,fracture aperture was considered as the most important parameter for the determination of permeability.Sudden changes were also observed at zones 1-1 and 5 in the permeability trend,due to the high fracture aperture.It can be concluded that the electrical image logs(FMI and EMI)are usable for evaluating both reservoir and fracture parameters in wells with no core data in the Zagros Basin,SW Iran.
基金financially supported by oil and gas accumulation patterns,key technologies and targets evaluation of Lower Paleozoic-Precambrian carbonate rocks(No.2016ZX05004)。
文摘The sedimentary facies/microfacies,which can be correlated with well logs,determine reservoir quality and hydrocarbon productivity in carbonate rocks.The identification and evaluation of sedimentary facies/microfacies using well logs are very important in order to effectively guide the exploration and development of oil and gas.Previous carbonate facies/microfacies identification methods based on conventional well log data often exist multiple solutions.This paper presents a new method of facies/microfacies identification based on core-conventional logs-electrical image log-geological model,and the method is applied in the fourth member of the Dengying Formation(Deng 4)in the Gaoshiti-Moxi area of the Sichuan Basin.Firstly,core data are used to calibrate different types of facies/microfacies,with the aim to systematically clarify the conventional and electrical image log responses for each type of facies/microfacies.Secondly,through the pair wise correlation analysis of conventional logs,GR,RT and CNL,are selected as sensitive curves to establish the microfacies discrimination criteria separately.Thirdly,five well logging response models and identification charts of facies/microfacies are established based on electrical image log.The sedimentary microfacies of 60 exploratory wells was analyzed individually through this method,and the microfacies maps of 4 layers of the Deng 4 Member were compiled,and the plane distribution of microfacies in the Gaoshiti-Moxi area of the Sichuan Basin was depicted.The comparative analysis of oil testing or production results of wells reveals three most favorable types of microfacies and they include algal psammitic shoal,algal agglutinate mound,and algal stromatolite mound,which provide a reliable technical support to the exploration,development and well deployment in the study area.
基金the National Institutes of Health(NCI)R21 CA116102 and R21 CA125088the National Science Foundation BES-0616031,and the American Cancer Society RSG-07-005-01.
文摘There is a growing realization that cell-to-cell variations in gene expression have importantbiological consequences underlying phenotype diversity and cell fate. Although analytical toolsfor measuring gene expression, such as DNA microarrays, reverse-transcriptase PCR and in situhybridization have been widely utilized to discover the role of genetic variations in governingcellular behavior, these methods are performed in cell lysates and/or on fixed cells, and thereforelack the ability to provide comprehensive spatial-dynamic information on gene expression. Thishas invoked the recent development of molecular imaging strategies capable of illuminatingthe distribution and dynamics of RNA molecules in living cells. In this review, we describe aclass of molecular imaging probes known as molecular beacons (MBs), which have increasinglybecome the probe of choice for imaging RNA in living cells. In addition, we present the majorchallenges that can limit the ability of MBs to provide accurate measurements of RNA, anddiscuss efforts that have been made to overcome these challenges. It is envisioned that withcontinued refinement of the MB design, MBs will eventually become an indispensable tool foranalyzing gene expression in biology and medicine.
文摘In this paper, we propose a sparse overcomplete image approximation method based on the ideas of overcomplete log-Gabor wavelet, mean shift and energy concentration. The proposed approximation method selects the necessary wavelet coefficients with a mean shift based algorithm, and concentrates energy on the selected coefficients. It can sparsely approximate the original image, and converges faster than the existing local competition based method. Then, we propose a new compression scheme based on the above approximation method. The scheme has compression performance similar to JPEG 2000. The images decoded with the proposed compression scheme appear more pleasant to the human eyes than those with JPEG 2000.
基金supported by the National Natural Science Foundation of China(41874210 and 11734017)the National Science and Technology Major Project(2017ZX05019001 and 2017ZX05019006)+1 种基金the Petro China Innovation Foundation(2016D-5007-0303)the Science Foundation of China University of Petroleum,Beijing(2462016YJRC020)。
文摘Acoustic waves enter a rock formation from a borehole and are reflected or scattered upon encountering a geologic structure.Consequently,we obtain the structure location represented by the azimuth and distance from the borehole using the acoustic reflection or scattering.Downhole acoustic measurements with the azimuthal resolution are realized using an azimuthal acoustic receiver sonde composed of several arcuate phased array receivers.Eight sensors distributed evenly across the arcuate phased array receiver can record acoustic waves independently;this allows us to adopt the beamforming method.We use a supporting logging tool to conduct the downhole test in two adjacent fluid-filled boreholes,for validating the evaluation of the geologic structure using scattered P-waves.The test results show the multi-azimuth images of the target borehole and the azimuthal variation in scattering amplitudes.Thus,we obtain the precise location of the target borehole.Furthermore,the measured values of the target borehole are consistent with the actual values,indicating that we can accurately evaluate a near-borehole geologic structure with scattered P-waves.