Objective:To analyze the clinical efficacy and safety of external counterpulsation combined with lipoic acid in the treatment of patients with type 2 diabetic foot of grade 0-2.Methods:62 patients with diabetic foot f...Objective:To analyze the clinical efficacy and safety of external counterpulsation combined with lipoic acid in the treatment of patients with type 2 diabetic foot of grade 0-2.Methods:62 patients with diabetic foot from January 2019 to October 2020 were selected and divided into control group and external counterpulsation group according to different treatment schemes,31 cases in each group.The control group was given intravenous lipoic acid,and the external counterpulsation group was given external counterpulsation combined with intravenous lipoic acid.The clinical efficacy and adverse reactions of the two groups were compared,and the blood flow parameters,ankle brachial index and common peroneal nerve conduction velocity of the two groups before and after treatment were compared.Results:The total effective rate of the treatment group(93.54%)was significantly higher than that of the control group(48.38%)(P<0.05).After treatment,the vessel diameter of dorsalis pedis artery(2.552±0.024mm)and ankle brachial index(0.923±0.036)in ECP group were significantly higher than those in control group(1.864±0.020)and ankle brachial index(0.843±0.030)(P<0.05).After the control group and the external counterpulsation group were treated,the levels of serum of VEGF,bFGF、IGF-1(85.479±4.239,148.27±14.25,62.33±3.75;94.163±8.917,200.88±14.58,81.35±1.08)was significantly higher than that before treatment(57.264±0.801,106.44±3.83,30.90±0.42;57.133±0.850,106.78±3.69,31.01±0.56),the levels of MMP-2(2.035±0.08,1.417±0.21)after treatment in the control group and the external counter stroke group after treatment(2.035±0.08,1.417±0.21)was significantly lower than that after treatment.The levels of VEGF,bFGF and IGF-1 in ECP group were significantly higher than those in control group,and MMP-2 was significantly lower than that in control group(P<0.05).Conclusion:The clinical effect of external counterpulsation combined with lipoic acid in the treatment of type 2 diabetic foot with grade 0-2 is significant,which can effectively improve the blood flow parameters of dorsal foot artery,ankle brachial index and common peroneal nerve conduction velocity,with less adverse reactions.展开更多
The external surface of HZSM-5 zeolite was passivated by liquid siliceous deposition and by acidic sites poisoning with lepidine, respectively. Then methanol-to-hydrocarbons （MTH） reaction was investigated over the ...The external surface of HZSM-5 zeolite was passivated by liquid siliceous deposition and by acidic sites poisoning with lepidine, respectively. Then methanol-to-hydrocarbons （MTH） reaction was investigated over the above as-prepared catalysts and the dissoluble coke on these used catalysts was analyzed by GC-MS, to study the role of the external surface of HZSM-5 in the catalytic reaction. Comparison with the experi- mental results based on parent ZSM-5 showed that the product distribution of MTH reaction was obviously influenced by the external surface. Evidences were listed as follows： （1） the final product on parent HZSM-5 showed higher aromatic selectivity, lower olefin selectivity, lower ra- tio of C2/C3＋ aliphatics and higher ratio of C3/C4＋ aliphatics than the reaction mixture produced by the sole catalysis of acidic sites in HZSM-5 channel; （2） a little of pentamethylbenzene and hexamethylbenzene in the product on parent HZSM-5, was produced via multi-methylation of methylbenzene on the external surface. The above conclusion may also be suitable for MTH reaction over other zeolites with 10-ring channel.展开更多
采用水热合成法制备了无模板剂ZSM-5分子筛并用正硅酸甲酯(TMOS)对其进行外表面修饰改性,利用XRD、SEM、^(29)Si MAS NMR、^(27)Al MAS NMR、NH_3-TPD、BET和UV-vis DRS对合成分子筛的物相、形貌和酸性等进行了表征,并将其应用于催化丁...采用水热合成法制备了无模板剂ZSM-5分子筛并用正硅酸甲酯(TMOS)对其进行外表面修饰改性,利用XRD、SEM、^(29)Si MAS NMR、^(27)Al MAS NMR、NH_3-TPD、BET和UV-vis DRS对合成分子筛的物相、形貌和酸性等进行了表征,并将其应用于催化丁烯裂解反应。研究表明,经水热合成的无模板剂ZSM-5结晶度较好,与添加模板剂合成的ZSM-5拥有相似的孔道结构和晶体结构以及相近的酸量,但在酸中心分布上有明显差异:孔道内酸中心数量增加且分布更加均匀,孔道交叉处酸中心数量减少;经过外表面修饰改性后,ZSM-5分子筛外表面部分不具备择形性的酸中心被钝化,使其择形选择能力增强。在催化丁烯裂解反应中,用TMOS进行外表面修饰改性的无模板剂ZSM-5分子筛作为催化剂能够有效抑制副反应的发生,丙烯和乙烯的总收率高达58%。展开更多
基金National Key Research and Development Projects:Demonstration Study on Early Identification(No.2018YFC2002500)。
文摘Objective:To analyze the clinical efficacy and safety of external counterpulsation combined with lipoic acid in the treatment of patients with type 2 diabetic foot of grade 0-2.Methods:62 patients with diabetic foot from January 2019 to October 2020 were selected and divided into control group and external counterpulsation group according to different treatment schemes,31 cases in each group.The control group was given intravenous lipoic acid,and the external counterpulsation group was given external counterpulsation combined with intravenous lipoic acid.The clinical efficacy and adverse reactions of the two groups were compared,and the blood flow parameters,ankle brachial index and common peroneal nerve conduction velocity of the two groups before and after treatment were compared.Results:The total effective rate of the treatment group(93.54%)was significantly higher than that of the control group(48.38%)(P<0.05).After treatment,the vessel diameter of dorsalis pedis artery(2.552±0.024mm)and ankle brachial index(0.923±0.036)in ECP group were significantly higher than those in control group(1.864±0.020)and ankle brachial index(0.843±0.030)(P<0.05).After the control group and the external counterpulsation group were treated,the levels of serum of VEGF,bFGF、IGF-1(85.479±4.239,148.27±14.25,62.33±3.75;94.163±8.917,200.88±14.58,81.35±1.08)was significantly higher than that before treatment(57.264±0.801,106.44±3.83,30.90±0.42;57.133±0.850,106.78±3.69,31.01±0.56),the levels of MMP-2(2.035±0.08,1.417±0.21)after treatment in the control group and the external counter stroke group after treatment(2.035±0.08,1.417±0.21)was significantly lower than that after treatment.The levels of VEGF,bFGF and IGF-1 in ECP group were significantly higher than those in control group,and MMP-2 was significantly lower than that in control group(P<0.05).Conclusion:The clinical effect of external counterpulsation combined with lipoic acid in the treatment of type 2 diabetic foot with grade 0-2 is significant,which can effectively improve the blood flow parameters of dorsal foot artery,ankle brachial index and common peroneal nerve conduction velocity,with less adverse reactions.
基金supported by Shanghai Key Basic Research(Grant No.11JC1412500)the National Natural Science Foundation of China(Grant No.51174277)
文摘The external surface of HZSM-5 zeolite was passivated by liquid siliceous deposition and by acidic sites poisoning with lepidine, respectively. Then methanol-to-hydrocarbons （MTH） reaction was investigated over the above as-prepared catalysts and the dissoluble coke on these used catalysts was analyzed by GC-MS, to study the role of the external surface of HZSM-5 in the catalytic reaction. Comparison with the experi- mental results based on parent ZSM-5 showed that the product distribution of MTH reaction was obviously influenced by the external surface. Evidences were listed as follows： （1） the final product on parent HZSM-5 showed higher aromatic selectivity, lower olefin selectivity, lower ra- tio of C2/C3＋ aliphatics and higher ratio of C3/C4＋ aliphatics than the reaction mixture produced by the sole catalysis of acidic sites in HZSM-5 channel; （2） a little of pentamethylbenzene and hexamethylbenzene in the product on parent HZSM-5, was produced via multi-methylation of methylbenzene on the external surface. The above conclusion may also be suitable for MTH reaction over other zeolites with 10-ring channel.
文摘采用水热合成法制备了无模板剂ZSM-5分子筛并用正硅酸甲酯(TMOS)对其进行外表面修饰改性,利用XRD、SEM、^(29)Si MAS NMR、^(27)Al MAS NMR、NH_3-TPD、BET和UV-vis DRS对合成分子筛的物相、形貌和酸性等进行了表征,并将其应用于催化丁烯裂解反应。研究表明,经水热合成的无模板剂ZSM-5结晶度较好,与添加模板剂合成的ZSM-5拥有相似的孔道结构和晶体结构以及相近的酸量,但在酸中心分布上有明显差异:孔道内酸中心数量增加且分布更加均匀,孔道交叉处酸中心数量减少;经过外表面修饰改性后,ZSM-5分子筛外表面部分不具备择形性的酸中心被钝化,使其择形选择能力增强。在催化丁烯裂解反应中,用TMOS进行外表面修饰改性的无模板剂ZSM-5分子筛作为催化剂能够有效抑制副反应的发生,丙烯和乙烯的总收率高达58%。
