A set of evaluation indicators based on corrosion ratio in theory for assessing the extent of pitting corrosion and performance reduction are proposed. In order to quantify the morphology of pitting corrosion and extr...A set of evaluation indicators based on corrosion ratio in theory for assessing the extent of pitting corrosion and performance reduction are proposed. In order to quantify the morphology of pitting corrosion and extract the evaluation indicators,the 3D profile data obtained by pitting morphology measurement are imported into a special written program to automatically determine the location of each corrosion pit and distill any desired data pertinent to the pitting morphology. The results show that this method seems to be effective to analyze the corroded surface and characterize the pitting morphology.展开更多
Aim: polylactic acid(PLA) or polylactide-co-glycolide(PLGA) was used as biodegradable and biocompatible carriers to achieve sustained release of estradial-PLGA/PLA-Microspheres(E2-PLGA/PLA-MS).THF was added in the org...Aim: polylactic acid(PLA) or polylactide-co-glycolide(PLGA) was used as biodegradable and biocompatible carriers to achieve sustained release of estradial-PLGA/PLA-Microspheres(E2-PLGA/PLA-MS).THF was added in the organic phase to study its effects on the properties of MS.Methods:MS were formed by an emulsification-solvent extraction method with mixture of ethyl acetate(EtoAc) and tetraphydrofuran(THF) as the organic solvents,and then the properties and in vitro drug release behavior were examined.Results:The results indicated that the drug loading efficiency decreased when THF added.but when the ratio of EtoAc was more than 50%,there was no obvious effcet of THF ration,but the particle size increased accordingly.The carriers' properties and the drug contents were the main factors influencing the in vitro drug release.Conclusions:By controlling the technology and formulation,we can get sustained-release E2 biodegradable microsperes with proper particle size,drug content and low burst-release,although THF with readily solubility in water was used in the organic phase.展开更多
基金Sponsored by the National Natural Science Foundation of China(Grant No.51378417)Program for Changjiang Scholars and Innovative Research Team in University(IRT13089)PhD Innovation Fund of Xi'an University of Architecture and Technology
文摘A set of evaluation indicators based on corrosion ratio in theory for assessing the extent of pitting corrosion and performance reduction are proposed. In order to quantify the morphology of pitting corrosion and extract the evaluation indicators,the 3D profile data obtained by pitting morphology measurement are imported into a special written program to automatically determine the location of each corrosion pit and distill any desired data pertinent to the pitting morphology. The results show that this method seems to be effective to analyze the corroded surface and characterize the pitting morphology.
文摘Aim: polylactic acid(PLA) or polylactide-co-glycolide(PLGA) was used as biodegradable and biocompatible carriers to achieve sustained release of estradial-PLGA/PLA-Microspheres(E2-PLGA/PLA-MS).THF was added in the organic phase to study its effects on the properties of MS.Methods:MS were formed by an emulsification-solvent extraction method with mixture of ethyl acetate(EtoAc) and tetraphydrofuran(THF) as the organic solvents,and then the properties and in vitro drug release behavior were examined.Results:The results indicated that the drug loading efficiency decreased when THF added.but when the ratio of EtoAc was more than 50%,there was no obvious effcet of THF ration,but the particle size increased accordingly.The carriers' properties and the drug contents were the main factors influencing the in vitro drug release.Conclusions:By controlling the technology and formulation,we can get sustained-release E2 biodegradable microsperes with proper particle size,drug content and low burst-release,although THF with readily solubility in water was used in the organic phase.
