According to the process of the second language acquisition,the study of English pronunciation for Chinese students must be influenced by the native language.This paper focuses on the analysis of the pronunciation pro...According to the process of the second language acquisition,the study of English pronunciation for Chinese students must be influenced by the native language.This paper focuses on the analysis of the pronunciation problems that Chinese students confront.The differences between English and Chinese pronunciation were analyzed in detail,and from this analysis some proper solutions for teaching such problems were proposed.展开更多
Although pre-Northridge earthquake steel moment resisting frame buildings have been shown to be susceptible to brittle connection failures,they still represent a large fraction of the existing steel buildings in the U...Although pre-Northridge earthquake steel moment resisting frame buildings have been shown to be susceptible to brittle connection failures,they still represent a large fraction of the existing steel buildings in the United States of America.In this study,the performance of the 3-and 9-story Los Angeles pre-Northridge SAC buildings are analyzed considering ductile and brittle beam-column connection failures,and their uncertainty.This paper contributes to understanding the influence of uncertainty associated with connections brittle fracture on building interstory deformation capacity and its impact on bias and variability of fragility functions and loss assessment.The results show that considering brittle connections leads to significantly l arger d rift demands a nd t o h igher r epair costs,particularly under intense ground shaking.New fragility curve parameters are derived that account for the effect of the uncertainty of the strength and deformation capacity of brittle connections.展开更多
A micromachined vertical cavity tunable filter with AlGaAs/GaAs distributed Bragg reflector is presented.This filter can be electrostatic tuning over a range of 28nm with an applied voltage of 7V.
As is known to all, nitrogen not only plays an important role in the industrial development of human society but also plays an important part in the proteins that constitute the essence of life[1]. In 1910, the Haber-...As is known to all, nitrogen not only plays an important role in the industrial development of human society but also plays an important part in the proteins that constitute the essence of life[1]. In 1910, the Haber-Bosch process was first used to synthesize ammonia.展开更多
Objective To analyze the differential gene expression profile of serum exosomes in patients with acute cerebral infarction(ACI)and clarify the changes in gene expression related to cerebral infarction injury and the p...Objective To analyze the differential gene expression profile of serum exosomes in patients with acute cerebral infarction(ACI)and clarify the changes in gene expression related to cerebral infarction injury and the potential serum markers.Methods Four patients with ACI and five healthy people were enrolled in the PhaseⅠstudy.After serum isolation from peripheral blood,exosomes were extracted with exosomes kits,highthroughput detection of m RNA was performed with gene chips,and differentially expressed m RNAs were screened.Gene Ontology(GO)functional analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed simultaneously.Furthermore,real-time polymerase chain reaction(q RT-PCR)was used to verify the expression levels of the screened differential m RNAs in the serum exosomes collected in PhaseⅡfrom 32 patients each in the ACI case and normal control groups.Results In the PhaseⅠstudy,there were 248 differentially expressed m RNAs(fold change≥2.0,P<0.05)among five patients in the normal control group and four patients in the case group,of which the expression of 242 was upregulated and that of six was downregulated.The results of GO functional enrichment analysis mainly included behavior regulation,cell connection,and antioxidant activity.The results of KEGG pathway enrichment analysis mainly included ribosomes,proteasomes,oxytocin signaling pathways,and oxidative phosphorylation.After researching and screening based on relevant literature,it was found that among the genes with significant differential expression,H3 F3 B m RNA may be associated with and might play an important role in ACI.The q RT-PCR method was used to detect the H3 F3 B mRNA expression in serum exosomes of 32 patients each in the normal control and case groups in PhaseⅡ;the expression was significantly higher in serum exosomes of the case group than in those of the normal control group(P<0.001).H3 F3 B mRNA expression in serum exosomes of the case group positively correlated with age,the National Institutes of Health Stroke Scale(NIHSS)score,and the maximum infarct size(P<0.05).Conclusion ACI can lead to changes in the serum exosomes mRNA expression profile,which may be closely related to the occurrence,development,and prognosis of this condition.These findings will provide direction for research on the molecular mechanism,diagnostic markers,and therapeutic targets of ACI.展开更多
文摘According to the process of the second language acquisition,the study of English pronunciation for Chinese students must be influenced by the native language.This paper focuses on the analysis of the pronunciation problems that Chinese students confront.The differences between English and Chinese pronunciation were analyzed in detail,and from this analysis some proper solutions for teaching such problems were proposed.
文摘Although pre-Northridge earthquake steel moment resisting frame buildings have been shown to be susceptible to brittle connection failures,they still represent a large fraction of the existing steel buildings in the United States of America.In this study,the performance of the 3-and 9-story Los Angeles pre-Northridge SAC buildings are analyzed considering ductile and brittle beam-column connection failures,and their uncertainty.This paper contributes to understanding the influence of uncertainty associated with connections brittle fracture on building interstory deformation capacity and its impact on bias and variability of fragility functions and loss assessment.The results show that considering brittle connections leads to significantly l arger d rift demands a nd t o h igher r epair costs,particularly under intense ground shaking.New fragility curve parameters are derived that account for the effect of the uncertainty of the strength and deformation capacity of brittle connections.
文摘A micromachined vertical cavity tunable filter with AlGaAs/GaAs distributed Bragg reflector is presented.This filter can be electrostatic tuning over a range of 28nm with an applied voltage of 7V.
基金supported by the National Key R&D Program of China(2017YFA0208300 and 2017YFA0700104)the National Natural Science Foundation of China(21671180 and 21406184)+2 种基金the Chengdu International Science and Technology Cooperation Fund(2020GH0200069HZ)the funding support from CAS Fujian Institute of Innovationfinancially supported by the DNL Cooperation Fund(DNL201918)。
文摘As is known to all, nitrogen not only plays an important role in the industrial development of human society but also plays an important part in the proteins that constitute the essence of life[1]. In 1910, the Haber-Bosch process was first used to synthesize ammonia.
基金funding support from the National Natural Science Foundation of China(No.82074251)the Hunan Natural Science Foundation of China(No.2018JJ2413)the Hunan Provincial Health and Health Commission Project(No.c2018032)。
文摘Objective To analyze the differential gene expression profile of serum exosomes in patients with acute cerebral infarction(ACI)and clarify the changes in gene expression related to cerebral infarction injury and the potential serum markers.Methods Four patients with ACI and five healthy people were enrolled in the PhaseⅠstudy.After serum isolation from peripheral blood,exosomes were extracted with exosomes kits,highthroughput detection of m RNA was performed with gene chips,and differentially expressed m RNAs were screened.Gene Ontology(GO)functional analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed simultaneously.Furthermore,real-time polymerase chain reaction(q RT-PCR)was used to verify the expression levels of the screened differential m RNAs in the serum exosomes collected in PhaseⅡfrom 32 patients each in the ACI case and normal control groups.Results In the PhaseⅠstudy,there were 248 differentially expressed m RNAs(fold change≥2.0,P<0.05)among five patients in the normal control group and four patients in the case group,of which the expression of 242 was upregulated and that of six was downregulated.The results of GO functional enrichment analysis mainly included behavior regulation,cell connection,and antioxidant activity.The results of KEGG pathway enrichment analysis mainly included ribosomes,proteasomes,oxytocin signaling pathways,and oxidative phosphorylation.After researching and screening based on relevant literature,it was found that among the genes with significant differential expression,H3 F3 B m RNA may be associated with and might play an important role in ACI.The q RT-PCR method was used to detect the H3 F3 B mRNA expression in serum exosomes of 32 patients each in the normal control and case groups in PhaseⅡ;the expression was significantly higher in serum exosomes of the case group than in those of the normal control group(P<0.001).H3 F3 B mRNA expression in serum exosomes of the case group positively correlated with age,the National Institutes of Health Stroke Scale(NIHSS)score,and the maximum infarct size(P<0.05).Conclusion ACI can lead to changes in the serum exosomes mRNA expression profile,which may be closely related to the occurrence,development,and prognosis of this condition.These findings will provide direction for research on the molecular mechanism,diagnostic markers,and therapeutic targets of ACI.
