Objective:To study the effects of NO precursor L-arginine on the recovery of traumatic facial paralysisin rats and the changes of constitutive NOS/inducible NOS in the facial nucleus. Methods: A small dose of L-argini...Objective:To study the effects of NO precursor L-arginine on the recovery of traumatic facial paralysisin rats and the changes of constitutive NOS/inducible NOS in the facial nucleus. Methods: A small dose of L-arginine was intraperitoneally injected into rats with facial paralysis, and the recovery of facial paralysis was observedat different time point. Immunohistochemical ABC method was used to study the changes of NOS positive neuronsin facial nucleus. Results: The recovery of facial paralysis in L-arginine chronic treatment group was faster thanthat in the experimental control group and the constitutive NOS immunoreactivity was intensive in facial nucleus,but the inducible NOS immunoreactivity had no apparent difference in comparison with that of the experimentalcontrol group. Conclusion: L-arginine chronic treatment can increase the constitutive NOS expression in facial nucleus and prornote the recovery of traumatic facial paralysis.展开更多
文摘Objective:To study the effects of NO precursor L-arginine on the recovery of traumatic facial paralysisin rats and the changes of constitutive NOS/inducible NOS in the facial nucleus. Methods: A small dose of L-arginine was intraperitoneally injected into rats with facial paralysis, and the recovery of facial paralysis was observedat different time point. Immunohistochemical ABC method was used to study the changes of NOS positive neuronsin facial nucleus. Results: The recovery of facial paralysis in L-arginine chronic treatment group was faster thanthat in the experimental control group and the constitutive NOS immunoreactivity was intensive in facial nucleus,but the inducible NOS immunoreactivity had no apparent difference in comparison with that of the experimentalcontrol group. Conclusion: L-arginine chronic treatment can increase the constitutive NOS expression in facial nucleus and prornote the recovery of traumatic facial paralysis.