Working memory plays an important role in human cognition. This study investigated how working memory was encoded by the power of multichannel local field potentials (LFPs) based on sparse non negative matrix factor...Working memory plays an important role in human cognition. This study investigated how working memory was encoded by the power of multichannel local field potentials (LFPs) based on sparse non negative matrix factorization (SNMF). SNMF was used to extract features from LFPs recorded from the prefrontal cortex of four SpragueDawley rats during a memory task in a Y maze, with 10 trials for each rat. Then the powerincreased LFP components were selected as working memoryrelated features and the other components were removed. After that, the inverse operation of SNMF was used to study the encoding of working memory in the time frequency domain. We demonstrated that theta and gamma power increased significantly during the working memory task. The results suggested that postsynaptic activity was simulated well by the sparse activity model. The theta and gamma bands were meaningful for encoding working memory.展开更多
基金supported by the National Natural Science Foundation of China (61074131 and 91132722)the Doctoral Fund of the Ministry of Education of China (21101202110007)
文摘Working memory plays an important role in human cognition. This study investigated how working memory was encoded by the power of multichannel local field potentials (LFPs) based on sparse non negative matrix factorization (SNMF). SNMF was used to extract features from LFPs recorded from the prefrontal cortex of four SpragueDawley rats during a memory task in a Y maze, with 10 trials for each rat. Then the powerincreased LFP components were selected as working memoryrelated features and the other components were removed. After that, the inverse operation of SNMF was used to study the encoding of working memory in the time frequency domain. We demonstrated that theta and gamma power increased significantly during the working memory task. The results suggested that postsynaptic activity was simulated well by the sparse activity model. The theta and gamma bands were meaningful for encoding working memory.