Based on network pharmacology and molecular docking technology to explore the mechanism of Panax notoginseng in the treatment of membranous nephropathy

Objective:Based on network pharmacology and molecular docking technology to explore the mechanism of Professor Cao Enze's application of Panax notoginseng in the treatment of membranous nephropathy.Methods:TCMSP database was used to obtain the effective components and corresponding target information of Panax notoginseng,and Gene Cards database was used to obtain the disease target genes of membranous nephropathy.The intersection targets of the two were taken and the Venn diagram was drawn.The STRING database was used to obtain the protein interaction relationship,and the PPI network diagram was constructed by Cytoscape 3.9.1 software to screen out the core targets of Panax notoginseng in the treatment of membranous nephropathy.GO function and KEGG pathway enrichment analysis were performed using the David database to obtain the potential pathway of Panax notoginseng in the treatment of membranous nephropathy.Finally,Autodock software was used to verify the molecular docking of the main active components of the drug with the core targets.Results:A total of 7 effective components such as quercetin,ginsenoside rh2,Mandenol and Stigmasterol were retrieved,and 127 potential targets of Panax notoginseng in the treatment of membranous nephropathy were screened out.By PPI network topology analysis,23 core targets such as JUN,TP53,RELA,AKT1 and MAPK1 were screened out.GO functional enrichment analysis contained 703 biological processes,55 cell components and 121 molecular functions,and KEGG signal pathway enrichment analysis enriched 171 signal pathways.The results of molecular docking showed that there was a strong binding ability between the main core targets and the main components of Panax notoginseng.Conclusion:Through network pharmacology,it is concluded that Panax notoginseng treats membranous nephropathy through multiple targets and multiple pathways,which provides a theoretical basis for subsequent basic research.

Doctor Song Fuyin's Experience in Treating Hashimoto's Thyroiditis Based on Qi,Blood Essence and Spirit Syndrome Differentiation Stage Classification

The paper systematically summarizes the experience of Director Song Fuyin in treating Hashimoto's thyroiditis which is a typical emotional disease that causes obvious changes in organ morphology and endocrine and body fluid metabolism.It belongs to the category of psychosomatic diseases,and is the embodiment of a series of pathogenesis processes of qi disease,blood disease,essence disease and deformation in TCM theory.The whole course of the disease is dominated by the dialectical relationship of mutual influence,mutual control,mutual root and mutual use among the deity disease,qi disease,blood disease,essence and spiritual disease.Therefore,the treatment emphasizes the dialectical relationship based on qi,blood,essence and spirit.At the beginning,the treatment focuses on regulating qi and clearing heat and eliminating phlegm;at the middle stage,the treatment focuses on replenishing essence and promoting yang and eliminating wind and calming the deity;at the late stage,the treatment focuses on replenishing qi and eliminating phlegm and promoting collages.Flexible use of calming the spirits,regulating qi,dispersing essence,eliminating phlegm,promoting blood and other methods of stage classification treatment,can be targeted,improve the cure rate of the disease.This article aims to clarify the experience of Director Song Fuyin in treating Hashimoto's thyroiditis based on syndrome differentiation of qi,blood essence and spirit.

Professor Zhang Jun's four methods for treating Children with purpuric nephritis

Based on the theory of children's TCM constitution"children are Zhi yang wei chong,and Zhi yin wei zhang",combined with the etiology and pathogenesis of TCM in children with purpuric nephritis,Professor Zhang Jun uses The four methods of"Clearing heat,dampness,tonicity,and stasis"are used to treat children with purpuric nephritis,and it is advocated that the method of"resolving blood stasis"runs through the entire treatment process,and the clinical results are quite good.

Professor Zhang Yu-zhen's medication rule in treating metrorrhagia and bleeding based on data mining

Objective:To explore the medication rules of Professor Zhang Yuzhen in treating the bleeding period of metrorrhagia and metrostaxisthe,and to explore the treatment of the disease.Methods:Collected 520 prescriptions of Professor Zhang Yuzhen in the treatment of patients with the bleeding period of metrorrhagia and metrostaxis,and analyzed the regularity of medication by using"TCM inheritance assist platform(V2.5)".Results:According to the analysis,the top 30 most frequently used herbs for treating the bleeding period of metrorrhagia and metrostaxisthe were Codonopsis pilosula,Trogopterus dung,Cattail pollen,Motherwort,Cornus,Ophiopogon japonicas,Schisandra,Tortoiseshell,Panax notoginseng,Radix Paeoniae Alba,etc.Core combination 35 In the group,the core prescription has 1 hemostasis,followed by 2 hemostasis,and evolves to get 3 new prescriptions.Conclusion:Professor Zhang Yuzhen's medication for the treatment of metrorrhagia and metrostaxisthe is mostly Gan Wen's product.The treatment is based on the three organs of the liver,spleen,and kidney,and the disease is treated with"tonifying the kidney and benefiting qi,reducing blood stasis and stopping bleeding".

Professor LUO Zhijuan's experience in the treatment of infertility in elderly women

With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of disease dialectical trichotomy therapy to summarize professor LUO Zhi-juan clinical experience infertility think the disease occurs mainly in kidney empty as this, liver and spleen viscera dysfunction to heart, wet phlegm and blood stasis as the main pathological product of common cause kidney - menstruation - ran ren - cell palace reproductive axis dysfunction and infertility.

Professor Yanping Bai’s experience in treating alopecia areata

To summarize and analyze Professor Bai Yanping’s clinical experience in treating alopecia areata.Prof.Bai thinks the etiology of alopecia areata is a combination of liver-kidney depletion,qi and blood deficiency,qi stagnation and blood stasis,always along with wind-heat,damp-heat,blood heat and insomnia.It is indispensable to enrich and nourish the liver and kidney,supplement and nourish the qi and blood,invigorate blood and dissolve stasis,and at the same time,the usage of messenger drug and plum-blossom needle is important and formula has to vary from person to person on the basis of commonality.

Research Progress on Refractory Hypertension in Traditional Chinese Medicine

At present,the mortality rate and disability rate caused by cardiovascular and cerebrovascular diseases are very high in China.Individuals with refractory hypertension are at a greater risk of developing chronic kidney disease,heart failure,stroke and myocardial infarction.Therefore,how to effectively control blood pressure and identify the cause of refractory hypertension is a problem that medical workers need to solve,and it is also the key to prevent cardiovascular disease.In recent years,the government actively supports the development of traditional Chinese medicine.Since the curative effect of traditional Chinese medicine is recognized by the public,the prospect of traditional Chinese medicine in the prevention and treatment of refractory hypertension is considerable,and it is expected to become the main key research direction in the future.

Experience of the national-level old Chinese medicine expert Wu Zhengshi on syndrome differentiation and treatment of anaphylactoid purpura

This paper introduced and summarized the experience of the national-level old Chinese medicine expert Wu Zhengshi on syndrome differentiation and treatment of anaphylactoid purpura.Wu Zhengshi believes that blood-heat is the main cause of anaphylactoid purpura.When Qi is weak,the human body is attacked by external heat,resulting in the damage of the blood system,which lead to the anaphylactoid purpura.The blood is thermalized poison,which enters the vessel quickly and forces the blood to overflow the vessel,which develops for the purpura.According to the ancient book of Chinese medicine Jie Wei Yuan Sou(1550 C.E.),Wu Zhengshi put forward the treatment of relieving blood detoxification,heat and cooling blood,which achieved significant curative effects.

Summary on SHANG Hong-tao's Experience in Treating Alopecia of Spleen Deficiency with Shengyang Sanhuo Decoction (升阳散火汤)

Alopecia is a common but difficult miscellaneous disease in dermatology.Director SHANG Hong-tao believes that alopecia is often caused by exogenous cold or heat in daily life,internal damage of emotions and improper diet,leading to injury of spleen and stomach.So it can be treated with LI Dongyuan's Shengyang Sanhuo Decoction(升阳散火汤),which protects spleen and stomach.Here are 3 proved cases as evidence.

Professor Pei Ruixia's ExperienAce in Treating Diabetes with the"Harmony Method"

This paper introduces professor Pei Ruixia's experience in the treatment of diabetes with the"harmony method." Professor Pei believes that the pathogenic factors of diabetes are mainly divided into emotional and dietary factors,and the essence of diabetes are not in harmony of the human body.Thus,its treatment is to"make it harmonious."It is good to use the method of"clearing and harmonizing,"appropriately using Xiaochaihu decoction,paying attention to the compatibility of drugs,and taking care of spleen and stomach,as well as Qi.

The experiences of Zheng-ping Bai in treating gastric cancer based on qi,phlegm,and stasis

This paper will introduce the clinical experiences of Professor Zheng-pingBai in treating gastric cancer.In his diagnosis and treatment of this disease,Professor Bai advocates the integration of disease,symptom,and syndrome differentiation,pointing out that gastric cancer is caused by the accumulation of phlegm-dampness and blood stasis in the stomach due to qi stagnation.Therefore,the basic pathogenic mechanism involves the loss of harmonious descent in the stomach.This implies that treatment should prioritize qi activity by calming the stomach and suppressing the abnormal ascent of qi,as well as emphasizing the elimination of phlegm and stasis,and this has achieved significant therapeutic efficacy.

Multi-target therapy for autoimmune hemolytic anemia under the guidance of traditional Chinese medicine pharmacology

Autoimmune hemolytic anemia(AIHA)is a rare and refractory acquired autoimmune disease.At present,western medicine treatment has obvious side effects,low drug sensitivity,easy to relapse and other problems.Multi-target treatment of autoimmune hemolytic anemia through the study of pharmacology of traditional Chinese medicine can effectively improve the clinical efficacy of autoimmune hemolytic anemia,and the price is low,worthy of promotion.This paper discusses the effects of traditional Chinese medicine on maintaining acid-base balance,alleviating liver and kidney function damage and immune collapse.

庄礼兴“调神针法”治疗双心疾病经验撷要

This study summarizes Prof. Li-xing ZHUANG's experience in treating psycho-cardiological disease, which is characterized by cardiovascular somatic symptoms and emotional abnormalities. Psycho-cardiological disease is mainly caused by disorders of the brain and heart shen-mind, and related to the dysfunction of zangfu functions. In acupuncture treatment, attention should be paid to “regulation of the heart and brain, and taking zangfu organs in to account at the same time.” Sìshénzhēn (四神针) of JIN’s three-needle, Shéntíng (神庭GV 24) and Yìntáng (印堂GV29) are adopted to regulate the brain, Shénmén (神门HT7) or Nèiguān (内关PC6) are used to regulate the heart shen-mind, Hégǔ (合谷LI4), Tàichōng (太冲LR3), and Sānyīnjiāo (三阴交SP6) are used to regulate zangfu, and the Daoqi Tongjing method is applied to regulate the qi and blood, achieving good effects in the clinical setting.

Experience of professor JIA Chun-sheng in rapid analgesia by subcutaneous penetration needling of auricular acupuncture

To introduce the experience of professor JIA Chun-sheng in rapid analgesia and motor function rehabilitation by subcutaneous penetration needling of auricular acupuncture.Subcutaneous penetration needling of auricular acupuncture plays a role in rapid analgesia and motor function rehabilitation in treatment of pain in limbs and trunk and/or limb dysfunction caused by migraine,cervical spondylosis,acute lumbar sprain,soft tissue injury,scapulohumeral periarthritis,lumbar disc herniation,sciatica,stroke or cerebral trauma,and it is worthy of being widely promoted and applied clinically.

Prof.Ren ZHANG’s experience in acupuncture for neuromyelitis optica spectrum disorders

Prof.Ren ZHANG’s experience in clinical treatment of neuromyelitis optica spectrum disorders(NMOSD)is summarized in this paper.The pathogenesis of this kind of disease is complicated.Prof.Ren ZHANG treats it in both symptoms and root cause.In the acute stage and remission stage,based on the standard application of western medicines,acupuncture should be applied as early as possible and continued.In the acute stage,acupuncture can be an alternative and complementary treatment to reduce the adverse reaction of high dose hormone and shorten the acute course of this disease.In the remission stage,acupuncture can not only improve the visual function of patients,but also helps to retard the deterioration of this disease,reduce the recurrence and disability degree,having a long-term effect.The specific treatment method of Prof.Ren ZHANG emphasizes a combination of acupuncture and acupoint injection,with the extraordinary points as the main acupoints and coordinate with meridian acupoints in application.In the manipulation,it is emphasized deep insertion,penetrating method,and needling sensation to the diseased location.For the treatment course,it is emphasized that early intervention and long-term regular treatment.Here is the summarization of Prof.Ren ZHANG’s experience in treating this disease,which can be the reference for clinicians.

Summary for experience of FANG Jian-qiao in treating tennis elbow

Prof. FANG Jian-qiao is good at clinical and basic study on acupuncture analgesia. The therapeutic efficacy in treating tennis elbow of Prof. Fang is significant,＂needling painful point＂ on the basis of clarifying causes and pathogenesis of this disease in TCM and western medicine,treat this disease by using encircling needling in combina on with warm needling moxibus on,and it is convenient,safe and eff ec ve. The encircling needling in combina on with warm needling moxibus on has obvious advantages in trea ng external humeral epicondyli s.

田理教授运用保和丸加味治疗儿童变应性鼻炎经验举隅

介绍田理教授运用中医药治疗儿童变应性鼻炎的临床经验。变应性鼻炎属于中医'鼻鼽'范畴,常因脏腑虚损,正气不足引起。田理教授认为,小儿形体未充,脏腑'易虚易实',儿童变应性鼻炎的发病则主要在于肺脾两脏易虚易实的生理病理特点,与喂养不当、脾虚食积有密切关系,其常以保和丸消食和中治疗儿童变应性鼻炎,以健脾气、降胃气为主要治疗出发点,疗效确切、特色鲜明。

Essence of GAO Yu-chun's experience in treatment of stroke

Professor GAO Yu-chun＇s experience in treatment of stroke was systematically summarized in this study.Regulating governor vessel and unblocking brain was used to balance yin and yang and regulate vital activity,and nourishing water to moisten wood was used to restore essence,which were adopted as guiding principles.Qi and blood was observed carefully,acupoint property was known well,and time,acupoints and fomula were selected based on pattern differentiation.Opposing needling and contralateral collateral needling were combined,and needling was used to control the spirit and regulate qi,so as to flatly regulate qi-blood and yin-yang.At the same time,spleen and stomach functions were reinforced and protected.It was emphasized to regulate the mind and body simultaneously for stroke patients,which indicated professor GAO＇s academic ideas and clinical experience of careful observation of qi and blood,flat regulation of yin and yang,and treating disease according to its origin.

Case of geriatric enuresis

Professor JI O.ing-shan＇s experiences in treating geriatric enuresis were introduced, Professor JI Qing-shan emphasizes the pathogenesis, and acupoint selection was precise and appropriate, values needling sensation, and emphasize reinforcing and reducing method, combine acupuncture and moxibustion which can warm and unblock meridians. Acupuncture at Sanyinjiao （三阴交SP 6）, enuresis point, Guanyuan （关元 CV 4） and Qihai （气海 CV 6） was conducted. The needle was inserted into enuresis point for 2.5 mm, twirling for reducing was conducted to the extent that the needling sensation delivered to abdomen; twirling for reinforcing was conducted at CV 4 and CV 6 to the extent that the needling sensation radiated to pudendum. Reinforcing method was conducted at SP 6. The patient＇s family members were advised to conduct moxa stick moxibustion at CV 6, CV 4 and Shenshu （肾俞BL 23） for therapeutic effect consolidation, good efficacy was obtained.

Brief introduction to Professor Gao Wei-bin's needling technique of ‘Ten Acupuncture Skills'

‘Ten Acupuncture Skills＇ refers to ten types of needling techniques for difficult and intractable neurological diseases. It has been summarized by Prof. Gao Wei-bin, a famous traditional Chinese medicine expert in China, based upon his clinical experience for years, including neck acupuncture for bulbar palsy, neck acupuncture for laryngeal muscular paralysis, stuck needling technique for ocular muscular paralysis, electric field therapy at Jiaji（EX-B 2） points for incomplete spinal paraplegia, electroacupuncture（EA） for urination disorder, electric neck acupuncture for waking up and treating various cerebral and nuchal diseases, EA at Jiaji（EX-B 2） points for intractable hiccup, EA at Jiaji（EX-B 2） points for cervical and lumbar spondylopathy, antagonistic EA for post-apoplectic hemiplegia, and EA for facial paralysis. The ten acupuncture skills are summarized in order to guide the clinical application.