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Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection 被引量:2
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作者 Ao-Han Li Su Bu +2 位作者 Ling Wang Ai-Min Liang Hui-Yu Luo 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第1期79-89,共11页
BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitiv... BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this procedure.AIM To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric cancer.METHODS A total of 80 patients were involved in this research.The subjects were divided into two groups:Propofol group and sevoflurane group.The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also measured.RESULTS The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group.Additionally,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group.The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group.Moreover,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.CONCLUSION Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer.Propofol anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative recovery.Sevoflurane anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental state.Therefore,the selection of anesthetic agents should be based on the individual patient's specific circumstances. 展开更多
关键词 PROPOFOL SEVOFLURANE Radical resection of gastric cancer Anesthetic effect cognitive function Negative emotion
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Characterization of Small-Scale Farmers and Assessment of Their Access to Crop Production Information in Selected Counties of Kenya
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作者 Anastasia Mumbi Wahome John B. K. Kiema +1 位作者 Galcano C. Mulaku Isaac Mukoko 《Agricultural Sciences》 2024年第5期565-589,共25页
Small-scale farming accounts for 78% of total agricultural production in Kenya and contributes to 23.5% of the country’s GDP. Their crop production activities are mostly rainfed subsistence with any surplus being sol... Small-scale farming accounts for 78% of total agricultural production in Kenya and contributes to 23.5% of the country’s GDP. Their crop production activities are mostly rainfed subsistence with any surplus being sold to bring in some income. Timely decisions on farm practices such as farm preparation and planting are critical determinants of the seasonal outcomes. In Kenya, most small-scale farmers have no reliable source of information that would help them make timely and accurate decisions. County governments have extension officers who are mandated with giving farmers advisory services to farmers but they are not able to reach most farmers due to facilitation constraints. The mode and format of sharing information is also critical since it’s important to ensure that it’s timely, well-understood and usable. This study sought to assess access to geospatial derived and other crop production information by farmers in four selected counties of Kenya. Specific objectives were to determine the profile of small-scale farmers in terms of age, education and farm size;to determine the type of information that is made available to them by County and Sub-County extension officers including the format and mode of provision;and to determine if the information provided was useful in terms of accuracy, timeliness and adequacy. The results indicated that over 80% of the farmers were over 35 years of age and over 56% were male. Majority had attained primary education (34%) or secondary education (29%) and most farmers in all the counties grew maize (71%). Notably, fellow farmers were a source of information (71%) with the frequency of sharing information being mostly seasonal (37%) and when information was available (43%). Over 66% of interviewed farmers indicating that they faced challenges while using provided information. The results from the study are insightful and helpful in determining effective ways of providing farmers with useful information to ensure maximum benefits. 展开更多
关键词 Small Scale farmers farmers Crop Production Information Services Geospatial Information Information Access
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Dual carbon goal and agriculture in China:Exploring key factors influencing farmers’behavior in adopting low carbon technologies
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作者 Jinpeng Zou Lulin Shen +2 位作者 Fang Wang Hong Tang Ziyang Zhou 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第9期3215-3233,共19页
Identifying the factors influencing farmers’adoption of low-carbon technologies(FA)and understanding their impacts are essential for shaping effective agricultural policies amied at emission reduction and carbon sequ... Identifying the factors influencing farmers’adoption of low-carbon technologies(FA)and understanding their impacts are essential for shaping effective agricultural policies amied at emission reduction and carbon sequestration in China.This study employs a meta-analysis of 122 empirical studies,delves into 23 driving factors affecting FA and addresses the inconsistencies present in the existing literature.We systematically examine the effect size,source of heterogeneity,and time-accumulation effect of the driving factors on FA.We find that significant heterogeneity in the factors influencing FA,except for farming experience,sources of heterogeneity from the survey zone,methodology model,technological attributes,report source,financial support,and the sampling year.Additionally,age,farming experience,and adoption cost negatively correlate with FA.In contrast,educational level,health status,technical training,economic and welfare cognition,land contract,soil quality,terrain,information accessibility,demonstration,government promotion,government regulation,government support,agricultural cooperatives member,peer effect,and agricultural income ratio demonstrate a positive correlation.Especially,demonstration and age show a particularly strong correlation.Finally,the effect of demonstration,age,economic and welfare cognition,farming experience,land contract,soil quality,information accessibility,government promotion,and support,as well as agricultural cooperative membership and peer effects on FA,are generally stable but exhibit varying degrees of attenuation over time.The effect of village cadre,family income,farm scale,gender,health status,technical training,and off-farm work on FA show notable temporal shifts and maintain a weak correlation with FA.This study contributes to shaping China’s current low-carbon agriculture policies across various regions.It encourages policymakers to comprehensively consider the stability of key factors,other potential factors,technological attributes,rural socio-economic context,and their interrelations. 展开更多
关键词 farmers influencing factors low-carbon technology adoption META-ANALYSIS
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Cholinesterase Activity as an Indicator of Health Risks among Kou Valley Farmers
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作者 Thiombiano Cherileila Hien S. Aristide +5 位作者 Koevi Nadège Bayili Bazoma Ouattara Abdoulaye Traore Patrice Traore T. Isidore Hien Herve 《Journal of Biosciences and Medicines》 2024年第7期71-86,共16页
Introduction: Pesticides are currently an essential component of agricultural production techniques for controlling pests and weeds. In Burkina Faso, non-compliance with good practice in the use of pesticides poses a ... Introduction: Pesticides are currently an essential component of agricultural production techniques for controlling pests and weeds. In Burkina Faso, non-compliance with good practice in the use of pesticides poses a real health problem for the population. This study examines the health risks associated with pesticide management in rice-growing areas. Material and Methods: A field survey was conducted in Bama, involving farmers, focusing on their socio-demographic characteristics, pesticide usage, and health effects. Cholinesterase levels were measured in subsample of farmers using a portable device. Data were analysed using Microsoft Excel, calculating means and percentages for various practices. Health consultations, protection methods, and pesticide management were studied. Erythrocyte acetylcholinesterase activity was compared before and after treatment. Data were categorised into classes based on inhibition levels, and correlation analyses determined relationships between variables such as age, years of experience, and cholinesterase activity. Results: The results indicate that rice cultivation is mainly carried out by a fairly young population, with nearly 63% being under the age of 50. Common poor practices in pesticide use include improper storage and reuse of leftover pesticides. Seven types of pesticides were identified, including organophosphates such as glyphosate, which was used in 26.7% of cases. This organophosphate has resulted in class B poisoning, causing a 30% - 50% reduction in erythrocyte cholinesterase activity. The health effects of pesticide use are felt by agricultural farmers through various symptoms of poisoning. Conclusion: To reduce the occurrence of pesticide poisoning, it is essential to launch information and awareness campaigns among the population and farmers to promote safe practices in pesticide use in Bama, Burkina Faso. 展开更多
关键词 PESTICIDES ENVIRONMENTAL Sanitary Risk ACETYLCHOLINESTERASE farmers Bama Burkina Faso
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Local Criteria Used by Farmers to Evaluate the Agronomic Performance and the Fertilizing Capacity of Cowpea Varieties: Diversity, Variability and Proximal Relation with Agronomic Measurements in Contrasted Sahelian Locations
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作者 Nouhou Salifou Jangorzo Abdoul-Aziz Saïdou +2 位作者 Abou-Soufianou Sadda Abdoulaye Moussa Mamoudou Hassane Bil-Assanou Issoufou 《Agricultural Sciences》 2024年第1期114-131,共18页
When contributing to participatory research, farmers usually appreciate the performance of cowpea varieties using qualitative scores. The score they attribute to each variety are based on local knowledge. The specific... When contributing to participatory research, farmers usually appreciate the performance of cowpea varieties using qualitative scores. The score they attribute to each variety are based on local knowledge. The specific criteria they individually use to attribute a score are not well described. The objectives of this work were to: 1) identify and describe exhaustively the local criteria used by farmers to measure the agronomic performance of cowpea;2) assess the variability and statistical structure of these farmer criteria across local contexts;3) and analyze the association between these farmer criteria and the classical agronomic measurement. To achieve these objectives, an augmented block design was implemented across fifteen locations in the regions of Maradi, Dosso and Tillabéri, representing a diversity of local contexts. From a set of 36 cowpea varieties, fifteen varieties were sown per location, including five varieties (controls) common to all locations. In each location, two replicates were sown in randomized Fisher’s blocks. After agronomic measurement and participatory evaluation (scoring of varieties by farmers), a group survey (focus group) was conducted in each location to identify the criteria considered by farmers to found their discretional scoring of varieties during the participatory evaluation. The analysis of the data identified, across locations, thirteen criteria defined by farmers to characterize the agronomic performance of cowpea. Some of these criteria were different according to location. Farmers ranked the three varieties with the best performance for each agronomical trait (Top 3 varieties). A comparison of the farmer ranking with the ranking based on agronomic measurements revealed similarity and complementary between both methods. This study highlighted the importance of considering both local and scientific knowledge in local varietal evaluations. 展开更多
关键词 Agronomic Performance Participatory Research COWPEA farmers Criteria
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Navigating Market Choices: Understanding Carrot Market Outlet Selection among Smallholder Farmers in Kenya
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作者 Hillary Kiprotich Ngeno Ngenoh Evans +1 位作者 Oscar Ayuya Ingasia Hillary K. Bett 《Agricultural Sciences》 2024年第6期676-703,共28页
This research delves into the hurdles and strategies aimed at augmenting the market involvement of smallholder carrot farmers in Nakuru County, Kenya. Employing a Multinomial Logit (MNL) model, it scrutinizes the fact... This research delves into the hurdles and strategies aimed at augmenting the market involvement of smallholder carrot farmers in Nakuru County, Kenya. Employing a Multinomial Logit (MNL) model, it scrutinizes the factors influencing the selection of marketing outlets among carrot farmers. The findings unveil that a significant majority (81%) of surveyed farmers actively participate in diverse market outlets, encompassing the farm gate, cleaning point, local market, external market, and export market. Notably, pivotal buyers include aggregators, brokers, wholesalers, retailers, and consumers, with transactions predominantly occurring at the farm level. Additionally, the analysis discerns substantial influences of socio-economic characteristics, experiential factors, and geographical proximity on farmers’ choices of market outlets. Specifically, gender, age, land size, farming experience, and distance to markets emerge as critical determinants. Moreover, the study delves into the examination of market margins along the carrot value chain, shedding light on the potential profitability of carrot farming in the region. Remarkably, higher average gross margins are identified in export and external markets, signaling lucrative prospects for farmers targeting these segments. However, disparities in profit distribution between farmers and traders underscore the necessity for interventions to ensure equitable value distribution throughout the value chain. These findings underscore the imperative for tailored interventions to tackle challenges and foster inclusive agricultural development. Strategies such as farmer organizations, contracting, and vertical integration are advocated to enhance market access and profitability for smallholder carrot farmers. Thus, this study enriches our comprehension of the dynamics within carrot value chains and provides valuable insights for policymakers and development practitioners aiming to uplift rural livelihoods and bolster food security. 展开更多
关键词 Market Outlet Selection Smallholder farmers Multinomial Logit Model Determinants Carrot Value Chain
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Climatic and non-climatic factors driving the livelihood vulnerability of smallholder farmers in Ahafo Ano North District,Ghana
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作者 Frank BAFFOUR-ATA Louisa BOAKYE +7 位作者 Moses Tilatob GADO Ellen BOAKYE-YIADOM Sylvia Cecilia MENSAH Senyo Michael KWAKU KUMFO Kofi Prempeh OSEI OWUSU Emmanuel CARR Emmanuel DZIKUNU Patrick DAVIES 《Regional Sustainability》 2024年第3期24-39,共16页
Smallholder farmers in Ahafo Ano North District,Ghana,face multiple climatic and non-climatic issues.This study assessed the factors contributing to the livelihood vulnerability of smallholder farmers in this district... Smallholder farmers in Ahafo Ano North District,Ghana,face multiple climatic and non-climatic issues.This study assessed the factors contributing to the livelihood vulnerability of smallholder farmers in this district by household surveys with 200 respondents and focus group discussions(FGDs)with 10 respondents.The Mann–Kendall trend test was used to assess mean annual rainfall and temperature trends from 2002 to 2022.The relative importance index(RII)value was used to rank the climatic and non-climatic factors perceived by respondents.The socioeconomic characteristics affecting smallholder farmers’perceptions of climatic and non-climatic factors were evaluated by the binary logistic regression model.Results showed that mean annual rainfall decreased(P>0.05)but mean annual temperature significantly increased(P<0.05)from 2002 to 2022 in the district.The key climatic factors perceived by smallholder farmers were extreme heat or increasing temperature(RII=0.498),erratic rainfall(RII=0.485),and increased windstorms(RII=0.475).The critical non-climatic factors were high cost of farm inputs(RII=0.485),high cost of healthcare(RII=0.435),and poor condition of roads to farms(RII=0.415).Smallholder farmers’perceptions of climatic and non-climatic factors were significantly affected by their socioeconomic characteristics(P<0.05).This study concluded that these factors negatively impact the livelihoods and well-being of smallholder farmers and socioeconomic characteristics influence their perceptions of these factors.Therefore,to enhance the resilience of smallholder farmers to climate change,it is necessary to adopt a comprehensive and context-specific approach that accounts for climatic and non-climatic factors. 展开更多
关键词 Smallholder farmers LIVELIHOOD VULNERABILITY Climate change SOCIOECONOMIC characteristics Food security Ghana
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Researching the Impact of the Quality of Village Governance on Farmers’Well-Being:From the Perspectives of Income and Occupational Differentiation
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作者 Chen Qiulin Peng Ziwei Fu Gang 《Contemporary Social Sciences》 2024年第4期17-40,共24页
The goal of village governance is to improve the well-being of farmers,so this study aims to measure the impact the quality of village governance on the well-being of farmers.It also examines the heterogeneity of this... The goal of village governance is to improve the well-being of farmers,so this study aims to measure the impact the quality of village governance on the well-being of farmers.It also examines the heterogeneity of this impact across different farmer groups from the perspectives of income levels and occupational differentiation.To this end,this study developed an indicator system based on survey data collected from 1,442 farmers in the Sichuan,Shaanxi,and Gansu provinces,as well as the Ningxia Hui autonomous region.Multiple linear regression models were then used to analyze this data,and the findings revealed that improvements in the quality of village governance significantly increased the well-being of farmers.Specifically,primary-level empowerment and capacity building were shown to contribute the most to the enhancement of the farmers’well-being,followed by social inclusion,and social cohesion was found to have only a minimal effect.In terms of income levels,improving the quality of village governance benefited middle-income farmers the most,followed by low-income farmers,and it had the least effect on high-income farmers.In terms of occupations,full-time farmers gained the most from improvements in the quality of village governance,followed by off-farm farmers,with part-time farmers benefiting the least.Based on these findings,this study suggests that policymakers should improve the quality of village governance to enhance the well-being of farmers,focusing on the impact that level of income and occupational differentiation have on village governance. 展开更多
关键词 quality of village governance farmers’well-being DIFFERENTIATION
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Pathway and Countermeasure of Farmers Livelihood Transformation in the Ecological Development Area of Northern Guangdong Province from the Perspective of Ecological Protection
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作者 Jinguo HUANG Xi HUANG +1 位作者 Faming ZENG Xizhi WANG 《Asian Agricultural Research》 2024年第9期7-10,共4页
[Objectives]To explore pathways and countermeasures for transforming farmers livelihoods in the way of reducing their dependence on land while promoting sustainable development and alleviating ecological degradation.[... [Objectives]To explore pathways and countermeasures for transforming farmers livelihoods in the way of reducing their dependence on land while promoting sustainable development and alleviating ecological degradation.[Methods]A combination of field research,literature review,and policy analysis was employed to identify key factors affecting farmers livelihoods and potential strategies for transformation.[Results]The study found that developing ecological agriculture and modern agriculture,promoting agricultural transformation and upgrading,cultivating alternative industries,strengthening ecological engineering construction,and establishing diversified ecological compensation methods and supporting policies are effective strategies for transforming farmers livelihoods.[Conclusions]Implementing these strategies can help alleviate the contradiction between ecological protection and farmers livelihood development,promoting coordinated development of both.This approach not only benefits farmers but also contributes to sustainable environmental management and biodiversity conservation. 展开更多
关键词 ECOLOGICAL protection farmers LIVELIHOOD TRANSFORMATION PATHWAYS and countermeasures ECOLOGICAL development area
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Cattle Production and Lumpy Skin Disease of Smallholder Farmers in Svay Rieng Province
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作者 Kimeang Chay Tola Ka +2 位作者 Sokun Khoeun Chann Bun Kouch Theng 《Journal of Environmental Science and Engineering(B)》 2024年第1期39-46,共8页
The cattle production in Romeas Haek district,Svay Rieng province,was developed remarkably,since there were some households raising cattle in large number,more than 20 heads.The grazing method of cattle was tethering ... The cattle production in Romeas Haek district,Svay Rieng province,was developed remarkably,since there were some households raising cattle in large number,more than 20 heads.The grazing method of cattle was tethering and free grassing in the commune grass,since the natural grass and rice straw were the main source of cattle feed,however some of them supplemented their cattle with crop-byproducts,planting grass or concentrated feed.For the majority,BCS(Body Condition Scoring)of the cattle in those areas was 3 accounting for 52%-73.33%,but it was found the thin cattle has low BCS of 2 accounting for 11.11%to 40.00%and also fat cattle has BCS of 4 up to 27.78%.However,the average BCS varied with village which ranged from 2.68 to 3.17,but is not different in term of commune and sex of cattle.Besides facing with shortage of feed,the experience with diseases was also another concern,since 85.71%to 95.83%of the households faced this problem last year.Among the clinical signs found,lumpy skin was 100%,i.e.no one escaped from this problem,thus making them aware of vaccinating their cattle against some diseases such as FMD(Foot and Mouth Disease),HS(Hemorrhagic Septicemia)and LSD(Lumpy Skin Disease),but mostly vaccination was used against FMD.Because the LSD has occurred in these areas since 2020,then the seroprevalence was found in high positive up to 72.62%by Enzyme-Linked Immunosorbent Assay(ELISA)test.This positive rate was also varying by villages,ranging from 53.3%to 94.44%.But there was no association between positive cattle with commune,BCS,sex and age of cattle.In conclusion,the cattle production in Romeas Haek district,Svay Rieng province had developed markedly,however the shortage of feed and disease occurrence are the main challenges for farmer cattle producers,especially LSD outbreak last year.However,most of the farmers have been aware of the benefit of vaccination and had vaccinated their cattle against those main disease,such as FMD,HS and LSD. 展开更多
关键词 Cattle production lumpy skin smallholder farmers seroprevalance
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Farmers’ Knowledge and Awareness towards the Use of Agrochemicals in Vegetable Cultivation, Fako Cameroon
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作者 Amungwa Ivan Tabikam Veronica Ebot Manga +3 位作者 Godswill Azinwie Asongwe Elmer Kanjo Ekinzog Mantah Marian Ngwatezeh Victorine Neh Akenji 《Journal of Geoscience and Environment Protection》 2024年第9期215-229,共15页
Agrochemicals are contemporary, omnipresent tool used in vegetable cultivation. Farmers’ knowledge and awareness of the proper usage of agrochemicals are critical for mitigating the negative effects on human health. ... Agrochemicals are contemporary, omnipresent tool used in vegetable cultivation. Farmers’ knowledge and awareness of the proper usage of agrochemicals are critical for mitigating the negative effects on human health. This cross-sectional study was aimed at assessing the usage knowledge, risk awareness of toxicological and chemical classes, proper handling and use practices for agrochemicals homologated for use in vegetable farming, and the occurrence of health-related symptoms as a result of exposure among these farmers. The study included 93 vegetable growers from agricultural hotspot towns in Fako, southwest Cameroon. The field study, ran from November 2021 to December 2023, using a questionnaire to collect information on farmers demographic, and their knowledge of pesticide classes, and the related risk of associated with the handling of agrochemicals. Results show that all vegetable farmers, particularly those engaged in agribusiness, employ pesticide inputs to maximize production. Six pesticides, two fertilizer types, and one unknown substance were identified. While 23 active compounds were found, the most utilized were abamectin, emamectin (10.46%), dimethoate (9.30%,) and ethoprophos (8.13%). Two active chemicals, dimethoate and methalaxyl, are illegal yet remain in circulation. Toxicological classes I and II, with the greatest harmful effect on human health, were the most commonly utilized (64.27%). Thirty-nine percent of farmers never use personal protection equipment when working with agrochemicals, demonstrating a significant gap in knowledge and awareness of agrochemicals and their various applications and handling procedures in the field. The government should implement an intensive specialized educational program for on-field farmers with incentives in order to promote sustainable agriculture methods that ensure environmental and human safety. 展开更多
关键词 farmers Knowledge Agrochemical Risk Awareness Vegetable Cultivation Agrochemical Use Practices Health Risk
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Impaired Cognition and Stroke Rehabilitation Outcomes: Are They Related?
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作者 Eric F. Tanlaka Torri Trojand 《Open Journal of Therapy and Rehabilitation》 2024年第2期101-116,共16页
Background: Stroke survivors who exhibit impaired cognition at admission to inpatient rehabilitation may experience participation challenges and poorer functional outcomes than those without impaired cognition. Differ... Background: Stroke survivors who exhibit impaired cognition at admission to inpatient rehabilitation may experience participation challenges and poorer functional outcomes than those without impaired cognition. Differences in functional outcomes between stroke survivors with and without impaired cognition may be attributed to age, level of cognitive impairment, and severity of stroke. Materials and Methods: A retrospective secondary data analysis was conducted using health-related administrative data acquired from a Southwestern Ontario hospital’s stroke rehabilitation database. The aim was to explore potential linkages between post-stroke impaired cognition and functional gains, rehabilitation stays, and living settings after discharge from rehabilitation. Results: An aggregate sample of 393 males and 314 females subclassified as experiencing mild, moderate, and severe stroke was analyzed. At inpatient rehabilitation admission, 21.5% (n = 152) of these patients had no impaired cognition, 33.7% (n = 238) had mild impaired cognition, 22.2% (n = 157) had moderate impaired cognition, and 22.6% (n = 160) had severe impaired cognition. Cognitively impaired stroke patients were significantly (p 0.001) older, had (mostly) moderate to severe stroke with significantly (p = 0.012) more moderate cognitive impairment, had significantly (p 0.001) longer rehabilitation stays, and a high propensity for being discharged to longer-term care facilities compared to non-cognitively impaired patients. Conclusion: Presence of significant dissimilarity in rehabilitation stays and post-discharge destinations among stroke survivors with and without cognitive impairment is attributed to the age of the patient, level of cognitive impairment, and rigorous rehabilitation interventions. 展开更多
关键词 STROKE Impaired cognition Inpatient Rehabilitation Functional Outcomes
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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents
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作者 Irene Navarro-Lobato Mariam Masmudi-Martín +8 位作者 Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1835-1841,共7页
Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to ... Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to produce satisfa ctory effects.Therefore,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of ORM.In this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s disease.Furthermore,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM deficits.These findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s disease.Therefore,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits. 展开更多
关键词 behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling
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Exploration and Practice of Life Education Curriculum Based on Embodied Cognition Theory
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作者 Jing Zhang 《Journal of Contemporary Educational Research》 2024年第5期270-275,共6页
In recent years,the suicide rate of adolescents has been increasing year by year,and life and health problems have become the most important in education.It is urgent to promote the construction of the curriculum of l... In recent years,the suicide rate of adolescents has been increasing year by year,and life and health problems have become the most important in education.It is urgent to promote the construction of the curriculum of life education effectively.In view of the“vacuity”and“fragmented”state of traditional life education,this paper combs the teaching objectives,teaching contents,teaching methods,and teaching evaluation of life education from the perspective of embodied cognition theory,to explore the construction of positive experience of life education curriculum. 展开更多
关键词 Embodied cognition EXPERIENTIAL Life education
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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice
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作者 Yanli Zhang Tian Li +8 位作者 Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo 《Neural Regeneration Research》 SCIE CAS 2025年第2期533-547,共15页
In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of A... In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease. 展开更多
关键词 Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1
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Research on Children’s Game Activity Design Strategies Based on Embodied Cognition Theory
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作者 Xiangmiao He 《Journal of Contemporary Educational Research》 2024年第4期54-58,共5页
Edutainment,in the kindergarten education stage,emphasizes the game as the basic activity and combines the content of education with the form of the game,thus it also forms the educational method of gamification teach... Edutainment,in the kindergarten education stage,emphasizes the game as the basic activity and combines the content of education with the form of the game,thus it also forms the educational method of gamification teaching.Through investigation and analysis,it is found that the current kindergarten game activity design has the problem of improper combination of educational content and game form.The current kindergarten game activity design has problems such as stereotypes,children’s lack of active learning opportunities in activities,teachers’insufficient theoretical understanding,inappropriate teacher guidance methods,and so on.Embodied cognition theory attaches importance to the important role of the body in the development of cognition,provides new guidance for classroom teaching,and opens up a new path for classroom teaching reform.Based on the perspective of embodied cognition theory,the concept of body and mind integration should be adhered to in kindergarten teaching with games as the basic activity,experiential teaching situation should be created,children’s subjective experience should be respected,and games and interactions should be designed to promote children’s physical and mental participation,thus laying a foundation for the realization of children’s individual freedom,autonomy,and all-round development.Therefore,this paper aims at the existing problems in the current kindergarten gamification teaching and discusses the design strategy of children’s game activities based on embodied cognition theory. 展开更多
关键词 Embodied cognition Children’s play Game activity design
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The Investigation Report of Farmers' Political Cognition and Ability
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作者 曾子成 《科技视界》 2015年第10期50-50,84,共2页
In order to investigate the situation of political cognition and ability,the research group had surveyed some rural areas by the methods of questionnaires,literature review and case interviews.The data results showed ... In order to investigate the situation of political cognition and ability,the research group had surveyed some rural areas by the methods of questionnaires,literature review and case interviews.The data results showed that farmers had an independent ability of political judgment,but on the other hand the actual voting rate was very low.In a word,there is a long way to improve farmers’political cognition and ability. 展开更多
关键词 政治认知能力 农民 中国 社会发展
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Farmers' Cognition of Circular Agriculture and its Influencing Factors: A Case Study of Wannian County in Jiangxi Province
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作者 Ying YANG Xiaohua PAN 《Asian Agricultural Research》 2014年第2期27-34,共8页
Based on the current situation of agricultural development and agricultural material utilization in Wannian County of Jiangxi Province,we mainly use the form of questionnaire survey and design the relevant questions,t... Based on the current situation of agricultural development and agricultural material utilization in Wannian County of Jiangxi Province,we mainly use the form of questionnaire survey and design the relevant questions,to study the farmers' awareness of circular agriculture and its influencing factors. The study results show that some factors have a significant impact on farmers' awareness of circular agriculture,such as householders' age,education level,the proportion of agricultural income to household income,having attended agriculture-related lectures,and whether to be concerned about the information related to agriculture. Through the study in this article,we aim to provide better theoretical reference for the development and study of circular agriculture in Wannian County of Jiangxi Province. 展开更多
关键词 CIRCULAR AGRICULTURE cognition Influencing FACTORS
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The Degree of Farmers' Cognition on Non-point Source Pollution:Based on the Statistical Analysis of 453 Farmers
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作者 Qian BI Huaiye WANG Jue PENG 《Asian Agricultural Research》 2014年第4期99-102,共4页
With the rapid development of modern agriculture,agricultural non-point source pollution becomes increasingly serious in China,improving farmers' environmental protection consciousness plays a very important role ... With the rapid development of modern agriculture,agricultural non-point source pollution becomes increasingly serious in China,improving farmers' environmental protection consciousness plays a very important role in the reduction of agricultural non-point source pollution.Therefore,this investigation and study chooses rural areas of five counties from Chongqing city and Zhejiang province as our samples,our investigation and statistical analysis includes the following four aspects:farmers' cognition on non-point source pollution concept,farmers' cognition to rural environment satisfaction,farmers' cognition on non-point source pollution in agricultural production and farmers' cognition on the consequences of agricultural non-point source pollution and the effects on ecological environment.The analysis and conclusions of farmers' consciousness cognition on agricultural non-point source pollution,provides the supports in theory and practice for optimizing the behavior of farmers,promoting the management of agricultural non-point source pollution and implementing new rural construction goal. 展开更多
关键词 AGRICULTURAL non-point SOURCE POLLUTION Environmen
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Study on Farmers' Cognition and Willingness to Plant Trees during Collective Forest Right Reform Based on Data from Plain Areas of Henan Province
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作者 Min LIU Shaozhou ZHOU 《Asian Agricultural Research》 2013年第6期14-18,23,共6页
On the basis of the survey data from plain areas of Henan Province,farmers' cognition and willingness to plant trees in collective forest right reform are studied. According to statistical analysis and regression ... On the basis of the survey data from plain areas of Henan Province,farmers' cognition and willingness to plant trees in collective forest right reform are studied. According to statistical analysis and regression equation of binary logistic regress analysis,it is generally believed that different participants have various attitudes to the reform,with regard to if planting trees or more,reform variables have a distinct effect,as well as income variable and loaning or lending variable. At last,some advices are put forward,that is,the government should strengthen collective forest right reform,accelerate matching reform and increase policy and financial support to forestry farmers. 展开更多
关键词 COLLECTIVE forest right system Plain areas PERFORM
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