Non-alcoholic fatty liver disease(NAFLD)has become a significant public health burden affecting not only obese individuals but also people with normal weight.As opposed to previous beliefs,this particular subset of pa...Non-alcoholic fatty liver disease(NAFLD)has become a significant public health burden affecting not only obese individuals but also people with normal weight.As opposed to previous beliefs,this particular subset of patients has an increased risk of all-cause mortality and worse outcomes than their obese counterparts.The development of NAFLD in lean subjects seems to be interconnected with metabolic phenotype,precisely visceral fat tissue,sarcopenia,and insulin resistance.Here,we summarize available data focusing on the co-dependent relationship between metabolic phenotype,insulin resistance,and development of NAFLD in lean individuals,suggesting more appropriate tools for measuring body fat distribution for the screening of patients at risk.展开更多
Nowadays,most patients with severe burns will survive their injury.This evolution is accompanied by the challenge to cover a large percentage of total body surface area burned.Consequently,more and more patients have ...Nowadays,most patients with severe burns will survive their injury.This evolution is accompanied by the challenge to cover a large percentage of total body surface area burned.Consequently,more and more patients have to deal with the sequelae of burn scars and require(multiple)reconstructions.This review provides a gross overview of developments in the field of tissue engineering for permanent burn wound coverage and reconstructive burn surgery,focusing on usage and clinical effectiveness.Not only skin substitutes will be discussed but also the replacement of subcutaneous fat tissue and cartilage.展开更多
文摘Non-alcoholic fatty liver disease(NAFLD)has become a significant public health burden affecting not only obese individuals but also people with normal weight.As opposed to previous beliefs,this particular subset of patients has an increased risk of all-cause mortality and worse outcomes than their obese counterparts.The development of NAFLD in lean subjects seems to be interconnected with metabolic phenotype,precisely visceral fat tissue,sarcopenia,and insulin resistance.Here,we summarize available data focusing on the co-dependent relationship between metabolic phenotype,insulin resistance,and development of NAFLD in lean individuals,suggesting more appropriate tools for measuring body fat distribution for the screening of patients at risk.
文摘Nowadays,most patients with severe burns will survive their injury.This evolution is accompanied by the challenge to cover a large percentage of total body surface area burned.Consequently,more and more patients have to deal with the sequelae of burn scars and require(multiple)reconstructions.This review provides a gross overview of developments in the field of tissue engineering for permanent burn wound coverage and reconstructive burn surgery,focusing on usage and clinical effectiveness.Not only skin substitutes will be discussed but also the replacement of subcutaneous fat tissue and cartilage.
