The open-circuit fault is one of the most common faults of the automatic ramming drive system(ARDS),and it can be categorized into the open-phase faults of Permanent Magnet Synchronous Motor(PMSM)and the open-circuit ...The open-circuit fault is one of the most common faults of the automatic ramming drive system(ARDS),and it can be categorized into the open-phase faults of Permanent Magnet Synchronous Motor(PMSM)and the open-circuit faults of Voltage Source Inverter(VSI). The stator current serves as a common indicator for detecting open-circuit faults. Due to the identical changes of the stator current between the open-phase faults in the PMSM and failures of double switches within the same leg of the VSI, this paper utilizes the zero-sequence voltage component as an additional diagnostic criterion to differentiate them.Considering the variable conditions and substantial noise of the ARDS, a novel Multi-resolution Network(Mr Net) is proposed, which can extract multi-resolution perceptual information and enhance robustness to the noise. Meanwhile, a feature weighted layer is introduced to allocate higher weights to characteristics situated near the feature frequency. Both simulation and experiment results validate that the proposed fault diagnosis method can diagnose 25 types of open-circuit faults and achieve more than98.28% diagnostic accuracy. In addition, the experiment results also demonstrate that Mr Net has the capability of diagnosing the fault types accurately under the interference of noise signals(Laplace noise and Gaussian noise).展开更多
Intelligent fault diagnosis is an important method in rotating machinery fault diagnosis and equipment health management.To deal with co-frequency vibration faults,a type of typical fault in rotating machinery,this pa...Intelligent fault diagnosis is an important method in rotating machinery fault diagnosis and equipment health management.To deal with co-frequency vibration faults,a type of typical fault in rotating machinery,this paper proposes a fault diagnosis method based on the stacked autoencoder(SAE)and ensembled ResNet-SVM.Furthermore,the time-and frequency-domain features of several co-frequency vibration faults are summarized based on the mechanism analysis and calculated using actual vibration data.To realize and validate the high-precision diagnosis method of rotating equipment with co-frequency faults proposed in this study,the following three criteria are required:First,to improve the effectiveness and robustness of the ensembled model and the sliding window using data augmentation,adding noise,autoencoder(AE)and SAE methods are analyzed in terms of principle and practical effects.Second,ResNet is used as the feature extractor for the ensembled ResNet-SVM model.Feature extraction is carried out twice,and the extracted co-frequency fault features are more comprehensive.Finally,the data augmentation method and ensemble ResNet-SVM are combined for fault diagnosis and compared with other methods.The experimental results show that the accuracy of the proposed method can exceed 99.9%.展开更多
The co-frequency vibration fault is one of the common faults in the operation of rotating equipment,and realizing the real-time diagnosis of the co-frequency vibration fault is of great significance for monitoring the...The co-frequency vibration fault is one of the common faults in the operation of rotating equipment,and realizing the real-time diagnosis of the co-frequency vibration fault is of great significance for monitoring the health state and carrying out vibration suppression of the equipment.In engineering scenarios,co-frequency vibration faults are highlighted by rotational frequency and are difficult to identify,and existing intelligent methods require more hardware conditions and are exclusively time-consuming.Therefore,Lightweight-convolutional neural networks(LW-CNN)algorithm is proposed in this paper to achieve real-time fault diagnosis.The critical parameters are discussed and verified by simulated and experimental signals for the sliding window data augmentation method.Based on LW-CNN and data augmentation,the real-time intelligent diagnosis of co-frequency is realized.Moreover,a real-time detection method of fault diagnosis algorithm is proposed for data acquisition to fault diagnosis.It is verified by experiments that the LW-CNN and sliding window methods are used with high accuracy and real-time performance.展开更多
Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-mo...Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall phenotype.Clinically,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses inexorably.New biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).展开更多
Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the head.It is considered a silent public health epidemic causing significant death and disab...Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the head.It is considered a silent public health epidemic causing significant death and disability globally.There were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.展开更多
Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The ...Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota composition.Satisfactory results are lacking for conventional treatments for epilepsy.Surgical resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with epilepsy.Non-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research focus.This review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of epilepsy.It also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current stimulation.Numerous studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic seizures.Additionally,many new technologies for the diagnosis and treatment of epilepsy are being explored.However,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.展开更多
Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with...Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress disorder.In addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate treatment.Evidence suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress disorder.We performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December 2023.These included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum exosomes.One of these studies had also used whole plasma.Two studies were excluded as they did not involve microRNA biomarkers.Most of the studies had collected samples from adult male Veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult subjects.In measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString panels.Only six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to controls.The miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/exosomes;and miR-18a-3p and-7-1-5p in blood plasma.Several important limitations identified in the studies need to be taken into account in future studies.Further studies are warranted with war veterans and recently traumatized children,adolescents,and adults having PTSD and use of animal models subjected to various stressors and the effects of suppressing or overexpressing specific microRNAs.展开更多
We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies wer...We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear cells.Most of the studies involved children and the study cohorts were largely males.Many of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA expression.Only five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to controls.The microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of adults.Several important limitations were identified in the studies reviewed,and need to be taken into account in future studies.Further studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.展开更多
The condition characteristics of hydraulic systems reflect running condition for the hydraulic equipment directly. It is the key for condition monitoring and early fault diagnosis to select characteristics reasonably....The condition characteristics of hydraulic systems reflect running condition for the hydraulic equipment directly. It is the key for condition monitoring and early fault diagnosis to select characteristics reasonably. In this paper, the types, properties of characteristics in hydraulic equipment are analysed, and some considerations in their selection are presented.展开更多
Damping faults in a helicopter rotor hub are diagnosed by using vibration signals from the fuselage. Faults include the defective lag damper and raspings in its flap and feathering hinges. Experiments on the diagnosis...Damping faults in a helicopter rotor hub are diagnosed by using vibration signals from the fuselage. Faults include the defective lag damper and raspings in its flap and feathering hinges. Experiments on the diagnosis of three faults are carried out on a rotor test rig with the chosen fault each time. Fuselage vibration signals from specified locations are measured and analyzed by the fast Fourier transform in the frequency domain. It is demonstrated that fuselage vibration frequency spectra induced by three faults are different from each other. The probabilistic neural network (PNN) is adopted to detect three faults. Results show that it is feasible to diagnose three faults only using fuselage vibration data.展开更多
It is well known that the human auditory system possesses remarkable capabilities to analyze and identify signals. Therefore, it would be significant to build an auditory model based on the mechanism of human auditory...It is well known that the human auditory system possesses remarkable capabilities to analyze and identify signals. Therefore, it would be significant to build an auditory model based on the mechanism of human auditory systems, which may improve the effects of mechanical signal analysis and enrich the methods of mechanical faults features extraction. However the existing methods are all based on explicit senses of mathematics or physics, and have some shortages on distinguishing different faults, stability, and suppressing the disturbance noise, etc. For the purpose of improving the performances of the work of feature extraction, an auditory model, early auditory(EA) model, is introduced for the first time. This auditory model transforms time domain signal into auditory spectrum via bandpass filtering, nonlinear compressing, and lateral inhibiting by simulating the principle of the human auditory system. The EA model is developed with the Gammatone filterbank as the basilar membrane. According to the characteristics of vibration signals, a method is proposed for determining the parameter of inner hair cells model of EA model. The performance of EA model is evaluated through experiments on four rotor faults, including misalignment, rotor-to-stator rubbing, oil film whirl, and pedestal looseness. The results show that the auditory spectrum, output of EA model, can effectively distinguish different faults with satisfactory stability and has the ability to suppress the disturbance noise. Then, it is feasible to apply auditory model, as a new method, to the feature extraction for mechanical faults diagnosis with effect.展开更多
Computer-empowered detection of possible faults for Heating,Ventilation and Air-Conditioning(HVAC)subsystems,e.g.,chillers,is one of the most important applications in Artificial Intelligence(AI)integrated Internet of...Computer-empowered detection of possible faults for Heating,Ventilation and Air-Conditioning(HVAC)subsystems,e.g.,chillers,is one of the most important applications in Artificial Intelligence(AI)integrated Internet of Things(IoT).The cyber-physical system greatly enhances the safety and security of the working facilities,reducing time,saving energy and protecting humans’health.Under the current trends of smart building design and energy management optimization,Automated Fault Detection and Diagnosis(AFDD)of chillers integrated with IoT is highly demanded.Recent studies show that standard machine learning techniques,such as Principal Component Analysis(PCA),Support Vector Machine(SVM)and tree-structure-based algorithms,are useful in capturing various chiller faults with high accuracy rates.With the fast development of deep learning technology,Convolutional Neural Networks(CNNs)have been widely and successfully applied to various fields.However,for chiller AFDD,few existing works are adopting CNN and its extensions in the feature extraction and classification processes.In this study,we propose to perform chiller FDD using a CNN-based approach.The proposed approach has two distinct advantages over existing machine learning-based chiller AFDD methods.First,the CNN-based approach does not require the feature selection/extraction process.Since CNN is reputable with its feature extraction capability,the feature extraction and classification processes are merged,leading to a more neat AFDD framework compared to traditional approaches.Second,the classification accuracy is significantly improved compared to traditional methods using the CNN-based approach.展开更多
In order to improve the evaluation process of inverter open-circuit faults diagnosis in permanent magnet synchronous motor(PMSM)drives,this paper presents a diagnosis method based on current residuals and machine lear...In order to improve the evaluation process of inverter open-circuit faults diagnosis in permanent magnet synchronous motor(PMSM)drives,this paper presents a diagnosis method based on current residuals and machine learning models.The machine learning models are introduced to make a comprehensive evaluation for the current residuals obtained from a state observer,instead of evaluating the residuals by comparing with thresholds.Meanwhile,fault diagnosis and location are conducted simultaneously by the machine learning models,which simplifies the diagnosis process.Besides,a sampling strategy is designed to implement the proposed scheme online.Experiments are carried out on a DSP based PMSM drive,and the effectiveness of the proposed method is verified.展开更多
Component failures can cause multi-agent system(MAS)performance degradation and even disasters,which provokes the demand of the fault diagnosis method.A distributed sliding mode observer-based fault diagnosis method f...Component failures can cause multi-agent system(MAS)performance degradation and even disasters,which provokes the demand of the fault diagnosis method.A distributed sliding mode observer-based fault diagnosis method for MAS is developed in presence of actuator and sensor faults.Firstly,the actuator and sensor faults are extended to the system state,and the system is transformed into a descriptor system form.Then,a sliding mode-based distributed unknown input observer is proposed to estimate the extended state.Furthermore,adaptive laws are introduced to adjust the observer parameters.Finally,the effectiveness of the proposed method is demonstrated with numerical simulations.展开更多
This paper presents a fault diagnosis method for process faults and sensor faults in a class of nonlinear uncertain systems.The fault detection and isolation architecture consists of a fault detection estimator and a ...This paper presents a fault diagnosis method for process faults and sensor faults in a class of nonlinear uncertain systems.The fault detection and isolation architecture consists of a fault detection estimator and a bank of adaptive isolation estimators,each corresponding to a particular fault type.Adaptive thresholds for fault detection and isolation are presented.Fault detectability conditions characterizing the class of process faults and sensor faults that are detectable by the presented method are derived.A simulation example of robotic arm is used to illustrate the effectiveness of the fault diagnosis method.展开更多
Simultaneous faults often occur in running equipments, in order to solve the problems of the simultaneous faults, a new approach based on random sets and Dezert-Smarandache Theory (DSmT) is proposed in this paper. Fir...Simultaneous faults often occur in running equipments, in order to solve the problems of the simultaneous faults, a new approach based on random sets and Dezert-Smarandache Theory (DSmT) is proposed in this paper. Firstly, the simultaneous faults' model is built based on the generalized frame of discernment in DSmT. Secondly, according to the unified description of combination rules in evidence reasoning based on random sets, a new combination rule for simultaneous faults diagnosis is proposed. Thirdly, according to the working characteristics and environment of the sensors used to acquire fault characteristic information, a new method to construct basic probability assignment function is pro- posed based on membership. Finally, diagnosis result is obtained by use of the new combination rule combined with decision rules. A case pertaining to the fault diagnosis for a multi-function rotor test-bed is given, and the result shows that the proposed diagnosis approach is feasible and efficient.展开更多
Condition monitoring is increasingly used to anticipate and detect failures of industrial machines.Failures of machines can cause high maintenance or replacement costs.If neglected,it may result in catastrophic accide...Condition monitoring is increasingly used to anticipate and detect failures of industrial machines.Failures of machines can cause high maintenance or replacement costs.If neglected,it may result in catastrophic accidents leading to production shrinkage.The potential failure would negatively affect the profitability of the company,including production shut down,cost of spare parts,cost of labor,damage of reputation,risk of injury to people and the environment.In recent years,condition-based maintenance( CBM) and prognostic and health management( PHM) are developed and formed a strong connection among science,engineering,computer,reliability,communication,management,etc.Computerized maintenance management systems( CMMS) store a lot of data regarding the fault diagnosis and life prediction of the machinery equipment.It's too necessary to uncover useful knowledge from the huge amount of data.It's vital to find the ways to obtain useful and concise information from these data.This information can be of great influence in the decision making of managers.This article is a review of intelligent approaches in machinery faults diagnosis and prediction based on PHM and CBM.展开更多
The success of deep transfer learning in fault diagnosis is attributed to the collection of high-quality labeled data from the source domain.However,in engineering scenarios,achieving such high-quality label annotatio...The success of deep transfer learning in fault diagnosis is attributed to the collection of high-quality labeled data from the source domain.However,in engineering scenarios,achieving such high-quality label annotation is difficult and expensive.The incorrect label annotation produces two negative effects:1)the complex decision boundary of diagnosis models lowers the generalization performance on the target domain,and2)the distribution of target domain samples becomes misaligned with the false-labeled samples.To overcome these negative effects,this article proposes a solution called the label recovery and trajectory designable network(LRTDN).LRTDN consists of three parts.First,a residual network with dual classifiers is to learn features from cross-domain samples.Second,an annotation check module is constructed to generate a label anomaly indicator that could modify the abnormal labels of false-labeled samples in the source domain.With the training of relabeled samples,the complexity of diagnosis model is reduced via semi-supervised learning.Third,the adaptation trajectories are designed for sample distributions across domains.This ensures that the target domain samples are only adapted with the pure-labeled samples.The LRTDN is verified by two case studies,in which the diagnosis knowledge of bearings is transferred across different working conditions as well as different yet related machines.The results show that LRTDN offers a high diagnosis accuracy even in the presence of incorrect annotation.展开更多
The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault lo...The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault location and real-time monitoring.To solve the above problems,an expert experience and data-driven-based hybrid fault diagnosis method for high-speed wire rod finishing mills is proposed in this paper.First,based on its mechanical structure,time and frequency domain analysis are improved in fault feature extraction.The approach of combining virtual value,peak value with kurtosis value index,is adopted in time domain analysis.Speed adjustment and side frequency analysis are proposed in frequency domain analysis to obtain accurate component characteristic frequency and its corresponding sideband.Then,according to time and frequency domain characteristics,fault location based on expert experience is proposed to get an accurate fault result.Finally,the proposed method is implemented in the equipment intelligent diagnosis system.By taking an equipment fault on site,for example,the effectiveness of the proposed method is illustrated in the system.展开更多
To improve the accuracy of the stator winding fault diagnosis in induction motor,a new diagnostic method based on the Hilbert-Huang transform(HHT)was proposed.The ratio of fundamental zero sequence voltage to positive...To improve the accuracy of the stator winding fault diagnosis in induction motor,a new diagnostic method based on the Hilbert-Huang transform(HHT)was proposed.The ratio of fundamental zero sequence voltage to positive sequence voltage after switch-off was selected as the stator fault characteristic,which could effectively avoid the influence of the supply unbalance and the load fluctuation,and directly represent the asymmetry in the stator.Using the empirical mode decomposition(EMD)based on HHT,the zero sequence voltage after switch-off was decomposed and the fundamental component was extracted.Then,the fault characteristic can be acquired.Experimental results on a 4-kW induction motor demonstrate the feasibility and effectiveness of this method.展开更多
基金supported by the Natural Science Foundation of Jiangsu Province (Grant Nos. BK20210347)。
文摘The open-circuit fault is one of the most common faults of the automatic ramming drive system(ARDS),and it can be categorized into the open-phase faults of Permanent Magnet Synchronous Motor(PMSM)and the open-circuit faults of Voltage Source Inverter(VSI). The stator current serves as a common indicator for detecting open-circuit faults. Due to the identical changes of the stator current between the open-phase faults in the PMSM and failures of double switches within the same leg of the VSI, this paper utilizes the zero-sequence voltage component as an additional diagnostic criterion to differentiate them.Considering the variable conditions and substantial noise of the ARDS, a novel Multi-resolution Network(Mr Net) is proposed, which can extract multi-resolution perceptual information and enhance robustness to the noise. Meanwhile, a feature weighted layer is introduced to allocate higher weights to characteristics situated near the feature frequency. Both simulation and experiment results validate that the proposed fault diagnosis method can diagnose 25 types of open-circuit faults and achieve more than98.28% diagnostic accuracy. In addition, the experiment results also demonstrate that Mr Net has the capability of diagnosing the fault types accurately under the interference of noise signals(Laplace noise and Gaussian noise).
基金Supported by National Natural Science Foundation of China (Grant No.51875031)Beijing Municipal Natural Science Foundation (Grant No.3212010)。
文摘Intelligent fault diagnosis is an important method in rotating machinery fault diagnosis and equipment health management.To deal with co-frequency vibration faults,a type of typical fault in rotating machinery,this paper proposes a fault diagnosis method based on the stacked autoencoder(SAE)and ensembled ResNet-SVM.Furthermore,the time-and frequency-domain features of several co-frequency vibration faults are summarized based on the mechanism analysis and calculated using actual vibration data.To realize and validate the high-precision diagnosis method of rotating equipment with co-frequency faults proposed in this study,the following three criteria are required:First,to improve the effectiveness and robustness of the ensembled model and the sliding window using data augmentation,adding noise,autoencoder(AE)and SAE methods are analyzed in terms of principle and practical effects.Second,ResNet is used as the feature extractor for the ensembled ResNet-SVM model.Feature extraction is carried out twice,and the extracted co-frequency fault features are more comprehensive.Finally,the data augmentation method and ensemble ResNet-SVM are combined for fault diagnosis and compared with other methods.The experimental results show that the accuracy of the proposed method can exceed 99.9%.
基金Supported by National Natural Science Foundation of China(Grant Nos.51875031,52242507)Beijing Municipal Natural Science Foundation of China(Grant No.3212010)Beijing Municipal Youth Backbone Personal Project of China(Grant No.2017000020124 G018).
文摘The co-frequency vibration fault is one of the common faults in the operation of rotating equipment,and realizing the real-time diagnosis of the co-frequency vibration fault is of great significance for monitoring the health state and carrying out vibration suppression of the equipment.In engineering scenarios,co-frequency vibration faults are highlighted by rotational frequency and are difficult to identify,and existing intelligent methods require more hardware conditions and are exclusively time-consuming.Therefore,Lightweight-convolutional neural networks(LW-CNN)algorithm is proposed in this paper to achieve real-time fault diagnosis.The critical parameters are discussed and verified by simulated and experimental signals for the sliding window data augmentation method.Based on LW-CNN and data augmentation,the real-time intelligent diagnosis of co-frequency is realized.Moreover,a real-time detection method of fault diagnosis algorithm is proposed for data acquisition to fault diagnosis.It is verified by experiments that the LW-CNN and sliding window methods are used with high accuracy and real-time performance.
文摘Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall phenotype.Clinically,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses inexorably.New biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).
文摘Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the head.It is considered a silent public health epidemic causing significant death and disability globally.There were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.
基金supported by the National Natural Science Foundation of China,No.32130060(to XG).
文摘Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota composition.Satisfactory results are lacking for conventional treatments for epilepsy.Surgical resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with epilepsy.Non-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research focus.This review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of epilepsy.It also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current stimulation.Numerous studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic seizures.Additionally,many new technologies for the diagnosis and treatment of epilepsy are being explored.However,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.
文摘Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress disorder.In addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate treatment.Evidence suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress disorder.We performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December 2023.These included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum exosomes.One of these studies had also used whole plasma.Two studies were excluded as they did not involve microRNA biomarkers.Most of the studies had collected samples from adult male Veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult subjects.In measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString panels.Only six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to controls.The miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/exosomes;and miR-18a-3p and-7-1-5p in blood plasma.Several important limitations identified in the studies need to be taken into account in future studies.Further studies are warranted with war veterans and recently traumatized children,adolescents,and adults having PTSD and use of animal models subjected to various stressors and the effects of suppressing or overexpressing specific microRNAs.
文摘We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear cells.Most of the studies involved children and the study cohorts were largely males.Many of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA expression.Only five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to controls.The microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of adults.Several important limitations were identified in the studies reviewed,and need to be taken into account in future studies.Further studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.
文摘The condition characteristics of hydraulic systems reflect running condition for the hydraulic equipment directly. It is the key for condition monitoring and early fault diagnosis to select characteristics reasonably. In this paper, the types, properties of characteristics in hydraulic equipment are analysed, and some considerations in their selection are presented.
文摘Damping faults in a helicopter rotor hub are diagnosed by using vibration signals from the fuselage. Faults include the defective lag damper and raspings in its flap and feathering hinges. Experiments on the diagnosis of three faults are carried out on a rotor test rig with the chosen fault each time. Fuselage vibration signals from specified locations are measured and analyzed by the fast Fourier transform in the frequency domain. It is demonstrated that fuselage vibration frequency spectra induced by three faults are different from each other. The probabilistic neural network (PNN) is adopted to detect three faults. Results show that it is feasible to diagnose three faults only using fuselage vibration data.
基金supported by National Natural Science Foundation of China (Grant No. 50805021)
文摘It is well known that the human auditory system possesses remarkable capabilities to analyze and identify signals. Therefore, it would be significant to build an auditory model based on the mechanism of human auditory systems, which may improve the effects of mechanical signal analysis and enrich the methods of mechanical faults features extraction. However the existing methods are all based on explicit senses of mathematics or physics, and have some shortages on distinguishing different faults, stability, and suppressing the disturbance noise, etc. For the purpose of improving the performances of the work of feature extraction, an auditory model, early auditory(EA) model, is introduced for the first time. This auditory model transforms time domain signal into auditory spectrum via bandpass filtering, nonlinear compressing, and lateral inhibiting by simulating the principle of the human auditory system. The EA model is developed with the Gammatone filterbank as the basilar membrane. According to the characteristics of vibration signals, a method is proposed for determining the parameter of inner hair cells model of EA model. The performance of EA model is evaluated through experiments on four rotor faults, including misalignment, rotor-to-stator rubbing, oil film whirl, and pedestal looseness. The results show that the auditory spectrum, output of EA model, can effectively distinguish different faults with satisfactory stability and has the ability to suppress the disturbance noise. Then, it is feasible to apply auditory model, as a new method, to the feature extraction for mechanical faults diagnosis with effect.
基金supported by two Ministry of Education(MoE)Singapore Tier 1 research grants under grant numbers R-296-000-208-133 and R-296-000-241-114.
文摘Computer-empowered detection of possible faults for Heating,Ventilation and Air-Conditioning(HVAC)subsystems,e.g.,chillers,is one of the most important applications in Artificial Intelligence(AI)integrated Internet of Things(IoT).The cyber-physical system greatly enhances the safety and security of the working facilities,reducing time,saving energy and protecting humans’health.Under the current trends of smart building design and energy management optimization,Automated Fault Detection and Diagnosis(AFDD)of chillers integrated with IoT is highly demanded.Recent studies show that standard machine learning techniques,such as Principal Component Analysis(PCA),Support Vector Machine(SVM)and tree-structure-based algorithms,are useful in capturing various chiller faults with high accuracy rates.With the fast development of deep learning technology,Convolutional Neural Networks(CNNs)have been widely and successfully applied to various fields.However,for chiller AFDD,few existing works are adopting CNN and its extensions in the feature extraction and classification processes.In this study,we propose to perform chiller FDD using a CNN-based approach.The proposed approach has two distinct advantages over existing machine learning-based chiller AFDD methods.First,the CNN-based approach does not require the feature selection/extraction process.Since CNN is reputable with its feature extraction capability,the feature extraction and classification processes are merged,leading to a more neat AFDD framework compared to traditional approaches.Second,the classification accuracy is significantly improved compared to traditional methods using the CNN-based approach.
文摘In order to improve the evaluation process of inverter open-circuit faults diagnosis in permanent magnet synchronous motor(PMSM)drives,this paper presents a diagnosis method based on current residuals and machine learning models.The machine learning models are introduced to make a comprehensive evaluation for the current residuals obtained from a state observer,instead of evaluating the residuals by comparing with thresholds.Meanwhile,fault diagnosis and location are conducted simultaneously by the machine learning models,which simplifies the diagnosis process.Besides,a sampling strategy is designed to implement the proposed scheme online.Experiments are carried out on a DSP based PMSM drive,and the effectiveness of the proposed method is verified.
基金supported by the National Natural Science Foundation of China(62020106003,62003162)111 project(B20007)+1 种基金the Natural Science Foundation of Jiangsu Province of China(BK20200416)the China Postdoctoral Science Foundation(2020TQ0151,2020M681590).
文摘Component failures can cause multi-agent system(MAS)performance degradation and even disasters,which provokes the demand of the fault diagnosis method.A distributed sliding mode observer-based fault diagnosis method for MAS is developed in presence of actuator and sensor faults.Firstly,the actuator and sensor faults are extended to the system state,and the system is transformed into a descriptor system form.Then,a sliding mode-based distributed unknown input observer is proposed to estimate the extended state.Furthermore,adaptive laws are introduced to adjust the observer parameters.Finally,the effectiveness of the proposed method is demonstrated with numerical simulations.
文摘This paper presents a fault diagnosis method for process faults and sensor faults in a class of nonlinear uncertain systems.The fault detection and isolation architecture consists of a fault detection estimator and a bank of adaptive isolation estimators,each corresponding to a particular fault type.Adaptive thresholds for fault detection and isolation are presented.Fault detectability conditions characterizing the class of process faults and sensor faults that are detectable by the presented method are derived.A simulation example of robotic arm is used to illustrate the effectiveness of the fault diagnosis method.
基金Supported by the National Natural Science Foundation of China (No.60434020, No.60772006)the Zhejiang Natural Science Foundation (R106745, Y1080422)
文摘Simultaneous faults often occur in running equipments, in order to solve the problems of the simultaneous faults, a new approach based on random sets and Dezert-Smarandache Theory (DSmT) is proposed in this paper. Firstly, the simultaneous faults' model is built based on the generalized frame of discernment in DSmT. Secondly, according to the unified description of combination rules in evidence reasoning based on random sets, a new combination rule for simultaneous faults diagnosis is proposed. Thirdly, according to the working characteristics and environment of the sensors used to acquire fault characteristic information, a new method to construct basic probability assignment function is pro- posed based on membership. Finally, diagnosis result is obtained by use of the new combination rule combined with decision rules. A case pertaining to the fault diagnosis for a multi-function rotor test-bed is given, and the result shows that the proposed diagnosis approach is feasible and efficient.
基金Fundamental Research Funds for the Central Universities,China(No.DUT17GF214)
文摘Condition monitoring is increasingly used to anticipate and detect failures of industrial machines.Failures of machines can cause high maintenance or replacement costs.If neglected,it may result in catastrophic accidents leading to production shrinkage.The potential failure would negatively affect the profitability of the company,including production shut down,cost of spare parts,cost of labor,damage of reputation,risk of injury to people and the environment.In recent years,condition-based maintenance( CBM) and prognostic and health management( PHM) are developed and formed a strong connection among science,engineering,computer,reliability,communication,management,etc.Computerized maintenance management systems( CMMS) store a lot of data regarding the fault diagnosis and life prediction of the machinery equipment.It's too necessary to uncover useful knowledge from the huge amount of data.It's vital to find the ways to obtain useful and concise information from these data.This information can be of great influence in the decision making of managers.This article is a review of intelligent approaches in machinery faults diagnosis and prediction based on PHM and CBM.
基金the National Key R&D Program of China(2022YFB3402100)the National Science Fund for Distinguished Young Scholars of China(52025056)+4 种基金the National Natural Science Foundation of China(52305129)the China Postdoctoral Science Foundation(2023M732789)the China Postdoctoral Innovative Talents Support Program(BX20230290)the Open Foundation of Hunan Provincial Key Laboratory of Health Maintenance for Mechanical Equipment(2022JXKF JJ01)the Fundamental Research Funds for Central Universities。
文摘The success of deep transfer learning in fault diagnosis is attributed to the collection of high-quality labeled data from the source domain.However,in engineering scenarios,achieving such high-quality label annotation is difficult and expensive.The incorrect label annotation produces two negative effects:1)the complex decision boundary of diagnosis models lowers the generalization performance on the target domain,and2)the distribution of target domain samples becomes misaligned with the false-labeled samples.To overcome these negative effects,this article proposes a solution called the label recovery and trajectory designable network(LRTDN).LRTDN consists of three parts.First,a residual network with dual classifiers is to learn features from cross-domain samples.Second,an annotation check module is constructed to generate a label anomaly indicator that could modify the abnormal labels of false-labeled samples in the source domain.With the training of relabeled samples,the complexity of diagnosis model is reduced via semi-supervised learning.Third,the adaptation trajectories are designed for sample distributions across domains.This ensures that the target domain samples are only adapted with the pure-labeled samples.The LRTDN is verified by two case studies,in which the diagnosis knowledge of bearings is transferred across different working conditions as well as different yet related machines.The results show that LRTDN offers a high diagnosis accuracy even in the presence of incorrect annotation.
基金the National Key Research and Development Program of China under Grant 2021YFB3301300the National Natural Science Foundation of China under Grant 62203213+1 种基金the Natural Science Foundation of Jiangsu Province under Grant BK20220332the Open Project Program of Fujian Provincial Key Laboratory of Intelligent Identification and Control of Complex Dynamic System under Grant 2022A0004.
文摘The reliable operation of high-speed wire rod finishing mills is crucial in the steel production enterprise.As complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault location and real-time monitoring.To solve the above problems,an expert experience and data-driven-based hybrid fault diagnosis method for high-speed wire rod finishing mills is proposed in this paper.First,based on its mechanical structure,time and frequency domain analysis are improved in fault feature extraction.The approach of combining virtual value,peak value with kurtosis value index,is adopted in time domain analysis.Speed adjustment and side frequency analysis are proposed in frequency domain analysis to obtain accurate component characteristic frequency and its corresponding sideband.Then,according to time and frequency domain characteristics,fault location based on expert experience is proposed to get an accurate fault result.Finally,the proposed method is implemented in the equipment intelligent diagnosis system.By taking an equipment fault on site,for example,the effectiveness of the proposed method is illustrated in the system.
基金Project (No. 50677060) supported by the National Natural ScienceFoundation of China
文摘To improve the accuracy of the stator winding fault diagnosis in induction motor,a new diagnostic method based on the Hilbert-Huang transform(HHT)was proposed.The ratio of fundamental zero sequence voltage to positive sequence voltage after switch-off was selected as the stator fault characteristic,which could effectively avoid the influence of the supply unbalance and the load fluctuation,and directly represent the asymmetry in the stator.Using the empirical mode decomposition(EMD)based on HHT,the zero sequence voltage after switch-off was decomposed and the fundamental component was extracted.Then,the fault characteristic can be acquired.Experimental results on a 4-kW induction motor demonstrate the feasibility and effectiveness of this method.