Breast cancer is one of the most common cancers among women in the world, with more than two million new cases of breast cancer every year. This disease is associated with numerous clinical and genetic characteristics...Breast cancer is one of the most common cancers among women in the world, with more than two million new cases of breast cancer every year. This disease is associated with numerous clinical and genetic characteristics. In recent years, machine learning technology has been increasingly applied to the medical field, including predicting the risk of malignant tumors such as breast cancer. Based on clinical and targeted sequencing data of 1980 primary breast cancer samples, this article aimed to analyze these data and predict living conditions after breast cancer. After data engineering, feature selection, and comparison of machine learning methods, the light gradient boosting machine model was found the best with hyperparameter tuning (precision = 0.818, recall = 0.816, f1 score = 0.817, roc-auc = 0.867). And the top 5 determinants were clinical features age at diagnosis, Nottingham Prognostic Index, cohort and genetic features rheb, nr3c1. The study shed light on rational allocation of medical resources and provided insights to early prevention, diagnosis and treatment of breast cancer with the identified risk clinical and genetic factors.展开更多
Imitated handwriting and elderly handwriting are two manifestation patterns of altered handwriting.Several similarities in features can be found in both,such as gentle movement and curved jitter.In practice,it is very...Imitated handwriting and elderly handwriting are two manifestation patterns of altered handwriting.Several similarities in features can be found in both,such as gentle movement and curved jitter.In practice,it is very easy to confuse the two patterns,leading to wrong decisions and difficulties in document examination.The key to solving these problems is to recognize the similarities and differences between imitated handwriting and elderly handwriting.This paper comprises four parts.The first part introduces the general features of elderly handwriting;the second part takes up the general characteristics of imitated handwriting;the third part analyzes the common features of imitated handwriting and elderly handwriting;the fourth part draws a conclusion about their key points of identification.Since the number of cases requiring identification of elderly handwriting and imitated handwriting is increasing every year,this paper has practical significance for document examiners and provides theoretical support to questioned document examination.展开更多
Objective To compare the clinical features and high-resolution esophageal motility-impedance characteristics among esophagogastric junction outflow obstruction(Eoo)patients,typeⅡachalasia(Ach)patients and healthy con...Objective To compare the clinical features and high-resolution esophageal motility-impedance characteristics among esophagogastric junction outflow obstruction(Eoo)patients,typeⅡachalasia(Ach)patients and healthy controls(Con),in order to explore the values of esophageal high-resolution manometry(HRM)in diagnosis and treatment of Eoo patients.Methods Patients展开更多
文摘Breast cancer is one of the most common cancers among women in the world, with more than two million new cases of breast cancer every year. This disease is associated with numerous clinical and genetic characteristics. In recent years, machine learning technology has been increasingly applied to the medical field, including predicting the risk of malignant tumors such as breast cancer. Based on clinical and targeted sequencing data of 1980 primary breast cancer samples, this article aimed to analyze these data and predict living conditions after breast cancer. After data engineering, feature selection, and comparison of machine learning methods, the light gradient boosting machine model was found the best with hyperparameter tuning (precision = 0.818, recall = 0.816, f1 score = 0.817, roc-auc = 0.867). And the top 5 determinants were clinical features age at diagnosis, Nottingham Prognostic Index, cohort and genetic features rheb, nr3c1. The study shed light on rational allocation of medical resources and provided insights to early prevention, diagnosis and treatment of breast cancer with the identified risk clinical and genetic factors.
文摘Imitated handwriting and elderly handwriting are two manifestation patterns of altered handwriting.Several similarities in features can be found in both,such as gentle movement and curved jitter.In practice,it is very easy to confuse the two patterns,leading to wrong decisions and difficulties in document examination.The key to solving these problems is to recognize the similarities and differences between imitated handwriting and elderly handwriting.This paper comprises four parts.The first part introduces the general features of elderly handwriting;the second part takes up the general characteristics of imitated handwriting;the third part analyzes the common features of imitated handwriting and elderly handwriting;the fourth part draws a conclusion about their key points of identification.Since the number of cases requiring identification of elderly handwriting and imitated handwriting is increasing every year,this paper has practical significance for document examiners and provides theoretical support to questioned document examination.
文摘Objective To compare the clinical features and high-resolution esophageal motility-impedance characteristics among esophagogastric junction outflow obstruction(Eoo)patients,typeⅡachalasia(Ach)patients and healthy controls(Con),in order to explore the values of esophageal high-resolution manometry(HRM)in diagnosis and treatment of Eoo patients.Methods Patients
