In order to provide a guidance to specify the element size dynamically during adaptive finite element mesh generation, adaptive criteria are firstly defined according to the relationships between the geometrical featu...In order to provide a guidance to specify the element size dynamically during adaptive finite element mesh generation, adaptive criteria are firstly defined according to the relationships between the geometrical features and the elements of 3D solid. Various modes based on different datum geometrical elements, such as vertex, curve, surface, and so on, are then designed for generating local refined mesh. With the guidance of the defmed criteria, different modes are automatically selected to apply on the appropriate datum objects to program the element size in the local special areas. As a result, the control information of element size is successfully programmed covering the entire domain based on the geometrical features of 3D solid. A new algorithm based on Delatmay triangulation is then developed for generating 3D adaptive finite element mesh, in which the element size is dynamically specified to catch the geometrical features and suitable tetrahedron facets are selected to locate interior nodes continuously. As a result, adaptive mesh with good-quality elements is generated. Examples show that the proposed method can be successfully applied to adaptive finite element mesh automatic generation based on the geometrical features of 3D solid.展开更多
-STD Data obtained from the Third Chinese National Antarctic Research Expedition from January to February 1987 in the region near the South Shetland Islands are used to investigate an oceanic front, continental water ...-STD Data obtained from the Third Chinese National Antarctic Research Expedition from January to February 1987 in the region near the South Shetland Islands are used to investigate an oceanic front, continental water boundary (CWB), north of the South Shetland Islands. The characteristics of the CWB in surface and subsurface layers as well as deep layer are discussed respectively. The estimations of the geostrophic currents and the baroclinic deformed radius Rbc in this area show that the flow along the front is in the geostrophic equilibrium approximately, and the formation of the front is mainly due to the strong boundary current north of the South Shetland Islands. Its length along the front is estimated to be about 360 km and its width across the front is about 30 km.展开更多
Mitochondrial disease was a clinically and genetically heterogeneous group of diseases, thus the diagnosis was very difficult to clinicians. Our objective was to analyze clinical and genetic characteristics of childre...Mitochondrial disease was a clinically and genetically heterogeneous group of diseases, thus the diagnosis was very difficult to clinicians. Our objective was to analyze clinical and genetic characteristics of children with mitochondrial disease in China. We tested 141 candidate patients who have been suspected of mitochondrial disorders by using targeted next-generation sequencing(NGS), and summarized the clinical and genetic data of gene confirmed cases from Neurology Department, Beijing Children's Hospital, Capital Medical University from October 2012 to January 2015. In our study, 40 cases of gene confirmed mitochondrial disease including eight kinds of mitochondrial disease, among which Leigh syndrome was identified to be the most common type, followed by mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes(MELAS). The age-of-onset varies among mitochondrial disease, but early onset was common. All of 40 cases were gene confirmed, among which 25 cases(62.5%)with mitochondrial DNA(mtDNA) mutation, and 15 cases(37.5%) with nuclear DNA(nDNA) mutation. M.3243A>G(n=7)accounts for a large proportion of mtDNA mutation. The nDNA mutations include SURF1(n=7),PDHA1(n=2),and NDUFV1,NDUFAF6, SUCLA2, SUCLG1, RRM2 B, and C12orf65, respectively.展开更多
基金This project is supported by Provincial Project Foundation of Science and Technology of Guangdong, China(No.2002104040101).
文摘In order to provide a guidance to specify the element size dynamically during adaptive finite element mesh generation, adaptive criteria are firstly defined according to the relationships between the geometrical features and the elements of 3D solid. Various modes based on different datum geometrical elements, such as vertex, curve, surface, and so on, are then designed for generating local refined mesh. With the guidance of the defmed criteria, different modes are automatically selected to apply on the appropriate datum objects to program the element size in the local special areas. As a result, the control information of element size is successfully programmed covering the entire domain based on the geometrical features of 3D solid. A new algorithm based on Delatmay triangulation is then developed for generating 3D adaptive finite element mesh, in which the element size is dynamically specified to catch the geometrical features and suitable tetrahedron facets are selected to locate interior nodes continuously. As a result, adaptive mesh with good-quality elements is generated. Examples show that the proposed method can be successfully applied to adaptive finite element mesh automatic generation based on the geometrical features of 3D solid.
文摘-STD Data obtained from the Third Chinese National Antarctic Research Expedition from January to February 1987 in the region near the South Shetland Islands are used to investigate an oceanic front, continental water boundary (CWB), north of the South Shetland Islands. The characteristics of the CWB in surface and subsurface layers as well as deep layer are discussed respectively. The estimations of the geostrophic currents and the baroclinic deformed radius Rbc in this area show that the flow along the front is in the geostrophic equilibrium approximately, and the formation of the front is mainly due to the strong boundary current north of the South Shetland Islands. Its length along the front is estimated to be about 360 km and its width across the front is about 30 km.
文摘Mitochondrial disease was a clinically and genetically heterogeneous group of diseases, thus the diagnosis was very difficult to clinicians. Our objective was to analyze clinical and genetic characteristics of children with mitochondrial disease in China. We tested 141 candidate patients who have been suspected of mitochondrial disorders by using targeted next-generation sequencing(NGS), and summarized the clinical and genetic data of gene confirmed cases from Neurology Department, Beijing Children's Hospital, Capital Medical University from October 2012 to January 2015. In our study, 40 cases of gene confirmed mitochondrial disease including eight kinds of mitochondrial disease, among which Leigh syndrome was identified to be the most common type, followed by mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes(MELAS). The age-of-onset varies among mitochondrial disease, but early onset was common. All of 40 cases were gene confirmed, among which 25 cases(62.5%)with mitochondrial DNA(mtDNA) mutation, and 15 cases(37.5%) with nuclear DNA(nDNA) mutation. M.3243A>G(n=7)accounts for a large proportion of mtDNA mutation. The nDNA mutations include SURF1(n=7),PDHA1(n=2),and NDUFV1,NDUFAF6, SUCLA2, SUCLG1, RRM2 B, and C12orf65, respectively.