Causal relationship between feelings and cognitive decline:An univariable and multivariable Mendelian randomization study

BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited attention.AIM To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)analysis.METHODS Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and cognition.In this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger methods.Additionally,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on cognition.IVW served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger methods.RESULTS In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger analyses.MR-Egger regression revealed pleiotropy in the impact of worrier/anxious feelings on cognition,presenting a challenge in identifying the effect.Notably,this study did not demonstrate any significant impact of guilty feelings,nervous feelings,miserableness,or loneliness/isolation on cognition.Due to a limited number of instrumental variables for happiness,this study was unable to analyze the relationship between happiness and cognition.CONCLUSION This MR study finds that sensitivity/hurt feelings are associated with cognitive decline,while the link between worrier/anxious feelings and cognition remains inconclusive.Insufficient evidence supports direct associations between happiness,guilty feelings,nervous feelings,miserableness,loneliness/isolation,and cognition.

Common Emulsifier Combination Skin Feeling Research and Recommendation

Emulsifier is an important component of emulsified skin care BASE(matrix),and the common influencing factors affecting the skin feel of BASE are:emollient,thickeners,and emulsifier.The choice of emulsifier is crucial to the skin feel of cosmetics.In this paper,12 classical emulsifiers were selected and 13 combinations of them were made.Thirteen creams were designed using the same formulation structure,their physicochemical indexes were determined,and their skin feel was tested and evaluated using five expert panel scores,with the test site being the hand.Physicochemical parameters included pH and viscosity.Skin feel indicators include:stickiness,silkiness,whiteheads,greasiness at the end of application,absorption,softness after use,etc.The BASE formulations of the creams were tested and evaluated by five experts.Recommendations were also made for the selection of emulsifier combinations in the design of cream BASE formulations.

“FEELS”:一种建设性后现代的课程理念

"FEELS"是用五个英语词语的首字母编造的一个首字母缩写词,用来代表成功的教育五个方面的观念。这五个英语词语是:Flexible-goals(灵活的目标)、Engaged-learner(融入的学习者)、Embodied-knowledge(体现的知识)、Lively-interactive-learning(活泼互动的学习)和Supportive-teacher(支持性教师)。这一理念主要基于以下三种建设性后现代理论:以阿尔弗雷德.诺斯.怀特海哲学为基础的过程思想(也称"建设性后现代思想")、威廉.多尔后现代课程观中经验的认识论及其基于此的"四R"课程思想和王红宇的课程自传及其"第三空间"的舞蹈的课程理论。作为一个概念,"FEELS"同英语词"feels",指人的"感受",从怀特海的过程哲学角度关注教育事件中个人的经验和感受。基于怀特海的宇宙论思想,它甚至可以被理解为宇宙的本质:即宇宙中时时、事事、处处均存在感受。"FEELS"可以被作为一种分析工具,用来理解和欣赏成功的教育。其基本假设是,教育的根本目的是帮助一个人成为一个完整的人。

谈沙发高级样板师FEEL(感觉)的养成

样板师在企业中与各部门关系密切,起着桥梁的作用。FEEL(感觉)是沙发样板师综合技能中最核心的部分,样板师要提升对消费者生活行为方式的认知,把握产品的风格差异要素,并加强技艺的锤炼,从而实现以优质家具兴厂立业。

The Global Value ofMencius＇s Ideas on Moral Feeling and Reason： Reinterpreting the Feeling of Compassion From the Perspective of the Philosophy of Emotion

Amid the recent global upsurge of studies on the philosophy of emotion, a reinterpretation of traditional Confucian philosophy, especially Mencius＇s ideas on the siduan （Four Original Sources） of morality, may shed new light on the subject in comparative philosophy. This paper probes the structure of moral feeling and reason described by Mencius＇s from five perspectives： （1） In view of the relationship between feeling and reason, is it better to use the expression ＂siduan＂ or the expression ＂sixin （Four Heart-minds）＂？ （2） In view of dispositional feeling, what are the four original sources？ （3） In view of moral feeling, what are the structural order of the four sources and the corresponding procedure of reasoning of four heart-minds of Humanity？ （4） In view of positive feeling, how does moral feeling grow out of the goodness of human nature？ （5） What is the global value of Mencius＇s ideas on human moral feeling？ The author concludes that Mencius＇s thought on moral feeing has a global value and cross-cultural significance, and that Chinese wisdom is more than regional but universally applicable. The structure of moral feeling and reason that Mencius identified is in accordance with the principles ofzhiliang （grasping the two poles of the beginning and the end） and yongzhong （emloying the middle）. The principles ofzhiliang and yongzhong are true universal wisdoms of Confucianism, which should be rekindled today. From a practical point of view, ＂the Way begins from moral feelings,＂ and Confucius and Yah Hui＇s seeking the simple, virtuous life is an ideal model of emotional well-being.

A Study on Feelings of Worriment Due to Middle-Sized Robot in Living Space

Recently, the demand of services for architectural space is more increasing due to the diversification and complication of people＇s needs. In this research, it is assumed that the robot will support people＇s various needs and people＇s lives in the near future. In this study, the authors investigated the relationship between a robot and a person in quasi space close to actual life space. The authors carried out an experiment to clarify the feelings of worriment due to a robot in the living room in the case of Japanese males. This research aims to establish architecture techniques for robots and humans living together. In this experiment, the robot approached a male sitting on a sofa in quasi space. At different distances between the robot and the male, the subject evaluated his feelings of worriment from ＂no worriment＂ to ＂worriment＂ in five steps from one to five. The robot used in this experiment is middle-sized （380 mm （L） × 380 mm （W） × 350 mm （H））. In this experiment, it is considered that the robot asks for help outside when an emergency occurs. In this experiment, the authors had three situations for the subject： watching television, reading a magazine and just sitting.

The Application of Fuzzy Mathematic in Fabrics Feel Valuation

This paper not only introduce fuzzy mathematic method into the evaluation of fabrics’ style and put forward a new comprehensive fuzzy method on the fabric’s evaluate, but also develop a set of software to set automatic valuation of fabric’s style, “the intelligent system evaluation of fabric”. The system quoted the expert system principle.

THE FEELING THOUGHT PROCESS DURING QIGONG

Setting one’s mind at complete rest dur-ing Qigong requires a process which includesadjustment of the body,breathing andmind,with adjustment of mind as most im-portant.As adjustment of the mind may beregarded as the thought process,we may saythat the thought process is the key to put-ring one’s mind at complete rest.

Empirical Study on the Empowerment of Families Raising Children with Severe Motor and Intellectual Disabilities in Japan: The Association with Positive Feelings towards Child Rearing

Background: “Children with severe motor and intellectual disabilities” refers to children with markedly limited activity due to severe overlapping of physical and intellectual disabilities. The physical and mental burden placed on families raising severely disabled children, particularly the primary caregivers, is great in home settings. For families to effectively utilize services and over-come child rearing problems, the families themselves need the “strength” to cooperate with others for the purpose of raising a severely disabled child. The ultimate goal of family support is to enable such families to achieve satisfaction and self-growth in child rearing. Methods: We used a questionnaire to survey 75 primary caregivers to empirically elucidate the empowerment and positive feelings towards child rearing of families raising children with severe motor and intellectual disabilities and the related factors. The t-test and Spearman’s rank correlation coefficient were used to examine the association with bivariates. A multiple regression analysis was conducted for empowerment and positive feelings. Results: Results revealed that life events, livelihood, awareness of social support and the child’s sleep problems were factors related to empowerment. Of these, awareness of social support from outside of the family was found to contribute the most to empowerment. Furthermore, improvement and maintenance of positive feelings towards child rearing reaffirmed the existence of empowerment in addition to reducing negative feelings towards child rearing and ensuring social support. Conclusions: Raising children with severe motor and intellectual disabilities requires specialist knowledge and skills. Support from professionals to empower the entire family is therefore important in order to strengthen positive feelings towards child rearing.

Negative feelings experienced by people with mental disorder in the workplace: A qualitative study

Mental disorders are a significant cause of disability and loss of workplace productivity. Many people with mental illness want to work. Occupational health in the world has to face up to psychosocial risks to protect the health of employees. My study aims are to improve negative feelings in work place and work functioning and to stimulate better coping mechanisms. Participants were collected from “Mental health daycare facility”, “Regional living assistance center” and “B-type employment assistance office” in Japan. I took interviews with 25 members. The content of the interviews was categorized about negative feelings in work place. A total of 33 small category negative feelings of mental disorder were extracted and were classified into 11 subcategories. These subcategories were then classified into two higher-level categories: inward-directed feelings and outward-directed feelings. Inward-directed feelings include “reserve or timidity,” “hesitation about being open about the illness,” “anxiety about being dismissed,” “regrets about resigning,” “sense of isolation,” “feelings of remorse,” and “suffering.” Outward-directed feelings include “failure in interpersonal relationships,” “distrust,” “frustrations,” “negative feelings toward those with mental disorder.” Employment has been linked to having better social networks, to enhanced quality of life and to overall wellbeing. We will have to defend them legally. The legal and moral obligations placed on the employer require that it provides a healthy, harassment-free work environment.

How Do We Have Feelings?

For centuries, the question of how a physical structure (the brain) generates the subjective feeling of consciousness has plagued neuroscientists, physiologists, psychologists, linguists, and philosophers. This has become known as the “hard problem of consciousness” and has been the subject of many publications. Although lots of answers have been proposed, none has been completely satisfactory. The focus of most of these studies has been on the neuronal structures and activities. Experiential consciousness emerges from neural processes, but it has not been explained with models that have been based solely on the electro-mechanical aspects of the processes. There must be some other dynamic features of neuronal activity to explain the emergence of experiential consciousness. I argue that a likely answer to the dilemma resides in the added dimension of the neurochemistry of the brain that has, so far, received little attention.

Serum 17β-estradiol and oral dryness feeling in menopause

The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the re-lationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 - 77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student’s t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = –0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.

Study on Prediction and Application of Human Body Feeling Temperature

[ Objective] The study aimed to forecast human body feeling temperature. [ Method] Using air temperature data outside shutter boxes of cement and asphalt underlying surface at 1.5 m and conventional observation data from 2008 to 2010 as well as T639 and Japan numerical forecast product, the characteristics of the minimum temperature in winter half year and the maximum temperature in summer half year in Changzhou were analyzed, and the prediction equation of the maximum temperature from May to September as well as year-round comfort prediction index were es- tablished. Moreover, the announcement platform of human body feeling temperature was developed to forecast it. [ Result] There remained a tiny discrepancy in the winter minimum temperature between inside and outside shutter box, and clays with the minimum temperature difference lower than 2 ℃ accounted for 94.3% of total days. However, the summer maximum temperature difference between inside and outside shutter box was larger, and days with the maximum temperature difference higher than 2 ℃ accounted for 82.0%, while the maximum difference was 5.5 ℃. The prediction accuracy of the inside maximum temperature was 78%. Wind was considered as the primary factor based on the effective temperature, and comfort index forecast and service were determined based on human feelings, dress, meteorological care and so forth. Both human body feel- ing temperature and comfort index forecast were released in the temperature forecast service. [ Condusion] The prediction of human body feeling temperature could provide scientific references for people＇s dress and traveling in daily life.

初绽·遇见新我——FEELING品牌发布会在京举办

6月7日,由青岛嘉乐兴贸易有限公司主办的2016FEELING品牌发布会在北京举行。中国家用纺织品行业协会秘书长李杰、青岛新亚太集团总裁常大勇、青岛嘉乐兴贸易有限公司(以下简称"嘉乐兴")销售总监孟祥杰等百余位嘉宾出席了活动。本次活动基于FEELING品牌发布,分别对FEELING和比华利·保罗两个不同定位的家纺品牌进行了重点介绍。

The Impact of Coronavirus on Staff Nurses’ Feeling While Giving Direct Care to COVID-19 Patients in Various COVID Facilities

Background: Nurses are very important frontline health care professionals as they spend more time with patients than other professionals. This is even more so at this critical time of the COVID-19 pandemic. The nursing profession is facing great challenges in coping with the pandemic as they are more vulnerable to exposure and infection with the disease. Kuwait is not spared from the global pandemic which has put the health sector under immense pressure. Because COVID-19 is highly transmissible and deadly, it poses a huge health risk to nurses and has a huge impact on their cognitive, emotional, behavioural and physical dimensions. Aim: The study aims to explore the positive and negative emotions and feelings of staff nurses while giving care to COVID-19 patients. Materials and Methods: A descriptive cross-sectional study was carried out. 300 nurses from different general hospitals, field hospitals, and quarantine facilities in Kuwait participated in the study. A questionnaire was used to collect the data. Results: The findings show that for the cognitive evaluation, 72% were moderately affected, for the emotional evaluation 51.3% and 44% were moderately and mildly affected respectively, for the behavioural evaluation, 66.7% were severely affected, and for the physical evaluation, 43.3% and 31.7% were moderately and severely affected respectively. Prolonged working hours has a highly significant negative correlation to emotional (r −0.165), behavioral (r −0.177) and physical (r −0.155) dimension of the nurses at 0.01 level using Spearman’s correlation. Conclusion: The study concluded that the COVID-19 pandemic has affected the psychophysical dimensions of staff nurses.

The Man of Feeling： Author, Sentimental Hero, and Reader

Henry Mackenzie＇ s The Man of Feeling （1771 ）, widely read m its time, has been generally regarded as an exemplar of sentimental fiction. As a typical man of the world, Mackenzie made arduous efforts to distance himself from Harley, the simple and naive sentimental hero he created in his novel. The novel described how the innocence and tenderness of Harley were thwarted by the evil world and how Harley responded with sighs and tears. The same response was asked of the reader. Hence, readings of sentimental novels became tear-demanding exhibitions of pathos, while the unkindness and perverseness of the world were minimized and even concealed.

情绪与情绪调节策略对知晓感(Feeling-of-Knowing)判断的影响

本研究通过两个实验来研究情绪和情绪调节策略对知晓感判断的影响。在实验一中,通过让被试观看影片片段,激发相应的情绪状态,然后对不同情绪的词对做知晓感判断;在实验二中,通过观看影片诱发被试的负性情绪,然后采用不同情绪调节策略对被试的情绪状态进行调节并对不同情绪词对做知晓感判断。结果表明:1) 情绪状态和词对的情绪性质对FOK的判断等级和准确性存在影响,表现为在中性状态下,中性词对的判断等级和准确性均高于情绪词对;2) 情绪调节策略对FOK的判断等级产生影响,评价忽视策略和表情宣泄策略条件下被试的FOK判断值显著高于评价重视和表达抑制;3) 情绪调节策略对FOK判断准确性也存在影响,评价重视和评价忽视两种调节策略下被试的FOK判断准确性显著高于表情宣泄和表情抑制策略。

Feeling the Pulse of the World

Dizziness from preoccupation with the 20th century robbed us of the time to contemplate the 21st century. This is a well-known dictum early back in the 1960s by the late French strategist Raymond Aron. Now the new century is upon us. What were believed to be irrelevant then have turned out into hot topics these days. An early warning for the unfolding century, the September 11 events represent but only a