Tennessee Williams is the most famous Southern playwright in the history of 20th century American literature,and southern identity is a thread that runs throughout Williams’work.The Glass Menagerie is one of his high...Tennessee Williams is the most famous Southern playwright in the history of 20th century American literature,and southern identity is a thread that runs throughout Williams’work.The Glass Menagerie is one of his highly representative dramatic works.The play tells the story of how an ordinary family in deep identity crisis escapes the harsh reality and cultural trauma during the Great Depression in the United States.Using trauma theory as a tool,this paper explores the complex relationship between the deep-seated causes of the tragedy of the two female characters in the play and the historical context through the traumatic events experienced by the characters in the play and the different attitudes they show in the face of trauma.Through this,the vulnerability and identity crisis of individuals during the period of social change and cultural breaks are analyzed.The purpose of the paper is to arouse human beings’thoughts on how to cope with cultural integration and foreign cultural invasion,and how to obtain salvation when they are amid an identity crisis.展开更多
[Objective] The experiment aimed to study the difference of water physiology of male and female Ginkgo biloba L. for discussing the strategy of water utilization as well as the important role of this difference during...[Objective] The experiment aimed to study the difference of water physiology of male and female Ginkgo biloba L. for discussing the strategy of water utilization as well as the important role of this difference during evolution process. [Method] The stem sap flow, stomatal conductance(Gs), transpiration rate(Tr) and water use efficiency (WUE) of male and female Ginkgo biloba L. were comparatively studied. [Result] The day-night processes of flow on male and female Ginkgo biloba L. were similar. The flow on male and female Ginkgo biloba L. in day were almost same while the flow at night on male Ginkgo biloba L. was bigger than that on female Ginkgo biloba L. The Tr and Gs of male and female Ginkgo biloba L. were high in morning and at night but low at noon ,while Tr and Gs of female Ginkgo biloba L. in morning and at night were higher than these of male Ginkgo biloba L. at the same time point. However, these indexes of female plant were lower than these of male plant from 11:00 to 14:00. WUE changing trends of male and female Ginkgo biloba L. were similar, while average water utilization rate of female Ginkgo biloba L. was slightly lower than that of male Ginkgo biloba L. [Conclusion] Compared with other companion plants, water physiology of male and female Ginkgo biloba L. had strong homoplasy. The phenomenon might be a survival strategy of dioecious plants under long term evolutionary pressure.展开更多
In American cultural and literary traditions, the black females are often marginalized and stereotyped as a voiceless dim backdrop. This paper argues that The Bluest Eye notes the process of voice deprivation, and rec...In American cultural and literary traditions, the black females are often marginalized and stereotyped as a voiceless dim backdrop. This paper argues that The Bluest Eye notes the process of voice deprivation, and records the black females' own stories to give them back a unique voice of their own in order to construct new black female characters. This paper analyzes the tragic life of Pecola Breedlove and explores possible ways of speaking out.展开更多
Female character in video games is the one of the most controversial topic in game studies and nowadays women's anthropology. From the beginning of role in games' plot to sexualized graphical representation, woman i...Female character in video games is the one of the most controversial topic in game studies and nowadays women's anthropology. From the beginning of role in games' plot to sexualized graphical representation, woman in virtual world were (and sometimes still are) a point of discussion about characters sexualisation and role of female sex in virtual industry. The main aim of this paper is to present analysis of female representation in video games and how in last 30 years it has changed. In other words, how female characters were ennobled from sex object to main protagonist status. In presented research, there were used mostly the examples of popular video games with extended plot and world which can be explored by protagonists. Video game historiography, textual analysis (which helped to treat video game character as a protagonist), and thematic analysis of video games were used as a main research method. The main conclusion of this paper is that female characters can overcome all gender or sexual stereotypes and even eventually became an icon of popular culture展开更多
This paper analyses the female characters in E.M.Forster’s novels from the perspective of feminism,through the deep exploration of E.M.Forster’s works,it is evident to draw a conclusion that there are four kinds of ...This paper analyses the female characters in E.M.Forster’s novels from the perspective of feminism,through the deep exploration of E.M.Forster’s works,it is evident to draw a conclusion that there are four kinds of female characters:first of all,stubborn and arrogant old ladies;the second type is insensitive but self-awakening middle-aged ladies;the third type is knowledgeable and smart young ladies;the last one is the warm-hearted and benevolent lady.These four kinds of different female characters can reveal that E.M.Forster has a contradictory attitude towards women.For one thing,he respected and sympathized with women,for another he discriminated against women.展开更多
By tagging different characters,Charles Dickens invented many distinct characters in his novels.Female charaters are a central of Charls Dickens literary works.They represent the unimportant and the weak in the Britis...By tagging different characters,Charles Dickens invented many distinct characters in his novels.Female charaters are a central of Charls Dickens literary works.They represent the unimportant and the weak in the British society in the 19th century.This essay briefly introduces the the connecting between Dickens female characters in novels and women in his life,and based on it,analyses the female characters in Victorian Ages.展开更多
On the Road is the masterpiece of Kerouac who is one of the most important writers of“Beat Generation”in America in the mid-20th century.It is acclaimed to be the Bible of“Beat Generation”.The novel narrates the s...On the Road is the masterpiece of Kerouac who is one of the most important writers of“Beat Generation”in America in the mid-20th century.It is acclaimed to be the Bible of“Beat Generation”.The novel narrates the stories of how Dean and his friends——some representative characters of the Beats travelled across continental U.S.several times and searched for new lifestyles and new faith on the road.In this novel,male characters are the main characters and the descriptions of all the female characters account for just one sixth of the whole book.Although the portrayal of the female characters is not profound like that of the male characters,the different personalities Kerouac endued the female characters are also the highlights of the novel.As a novel with strong nature of autobiography,Kerouac put his attitude and emotion into his portrayal.So it also can be a reflection of Kerouac’s female concepts.This paper aims at analyzing the female characters in On the Road by studying the types of the female characters in the novel and summarizing Kerouac’s female concepts reflected from the novel.展开更多
In the novel The Great Gatsby,three main female characters(Daisy Buchanan,Myrtle Wilson and Jordan Baker)each presents women with different social status in American’s Jazz Age.By analyzing these three characters,rea...In the novel The Great Gatsby,three main female characters(Daisy Buchanan,Myrtle Wilson and Jordan Baker)each presents women with different social status in American’s Jazz Age.By analyzing these three characters,readers could realize how the helplessness of the female characters contributes to their broken conscience and a further tragedy in that era.Moreover,the stereo situation of American society in theJazz Age is along vividly symbolized.展开更多
Mutations in mitochondrial DNA(mtDNA)are maternally inherited and have the potential to cause severe disorders.Mitochondrial replacement therapies,including spindle,polar body,and pronuclear transfers,are promising st...Mutations in mitochondrial DNA(mtDNA)are maternally inherited and have the potential to cause severe disorders.Mitochondrial replacement therapies,including spindle,polar body,and pronuclear transfers,are promising strategies for preventing the hereditary transmission of mtDNA diseases.While pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos,its application in non-human primates has not been previously reported.In this study,we successfully generated four healthy cynomolgus monkeys(Macaca fascicularis)via female pronuclear transfer.These individuals all survived for more than two years and exhibited minimal mtDNA carryover(3.8%–6.7%),as well as relatively stable mtDNA heteroplasmy dynamics during development.The successful establishment of this nonhuman primate model highlights the considerable potential of pronuclear transfer in reducing the risk of inherited mtDNA diseases and provides a valuable preclinical research model for advancing mitochondrial replacement therapies in humans.展开更多
The female characters in Conrad's Heart of Darkness and Victory on one hand seem to be either too idealistic or rather uncivilized and insignificant.On the other hand,they have indispensable functions:they prepare...The female characters in Conrad's Heart of Darkness and Victory on one hand seem to be either too idealistic or rather uncivilized and insignificant.On the other hand,they have indispensable functions:they prepare the precondition for the plot,they can reverse the gender stereotype,and they help the inner growth of male protagonists.Even so,the focus of Joseph Conrad is still a patriarchal society where women are motivated by men.展开更多
The thesis analyzes two main female characters and their conflicts in Like Water for Chocolate.It discusses their different personalities as well as the historical setting,focusing on their struggles to survive and to...The thesis analyzes two main female characters and their conflicts in Like Water for Chocolate.It discusses their different personalities as well as the historical setting,focusing on their struggles to survive and to seek spiritual freedom in a traditional and patriarchal society.展开更多
The interpretation of black female characters in Richard Wright’s Native Son has long been degraded and ignored while the male protagonist consistently attracts the majority of academic attention.Through the scrutiny...The interpretation of black female characters in Richard Wright’s Native Son has long been degraded and ignored while the male protagonist consistently attracts the majority of academic attention.Through the scrutiny of the representative black women figures,we may discern the element of blindness to be the most prominent shared feature which turns out to be the inevitable product of double oppressions and discriminations from racism and sexism in the morbid society.For the disadvantaged black women,their path towards the awakening of self-identity and self-fulfillment is bound to be extremely arduous and tortuous.展开更多
Bone marrow edema(BME)is characterized by an accumulation of interstitial fluid within the bone marrow,the cancellous,hematopoietic compartment within bones.[1]BME is divided into two principal categories:idiopathic o...Bone marrow edema(BME)is characterized by an accumulation of interstitial fluid within the bone marrow,the cancellous,hematopoietic compartment within bones.[1]BME is divided into two principal categories:idiopathic or primary BME,with an unknown etiology,and secondary BME,which occurs as a result of an identifiable underlying pathology.[2]Although the prevalence of BME is not limited to specific demographic parameters,it shows a predilection for males or individuals assigned male at birth,predominantly aged between the ages of 30 and 60 years,especially in cases of bone marrow edema syndrome(BMES),a rare idiopathic variant.[3]The etiological spectrum of BME is diverse,including oncological entities(such as acute myeloid leukemia and osteosarcoma),degenerative diseases(such as osteoarthritis),infectious processes(osteomyelitis),ischemic conditions(avascular necrosis),metabolic dysfunctions(osteoporosis),inflammatory disorders(rheumatoid arthritis),and traumatic injuries(such as stress fractures).[1,2]Clinically,BME primarily manifests as localized pain,often accompanied by joint effusion and warmth near the affected joint.Diagnostic protocols typically include physical examination,serological assays,bone marrow biopsies,dual-energy X-ray absorptiometry(DEXA)scans,magnetic resonance imaging(MRI),and ultrasonography,with computed tomography(CT)scans and radiographs being less effective.展开更多
Dear Editor,We share our experience of two significant complications associated with female urethroplasty and their management in understanding the factors contributing to urinary continence.We have also tried to asse...Dear Editor,We share our experience of two significant complications associated with female urethroplasty and their management in understanding the factors contributing to urinary continence.We have also tried to assess the different components of female urinary continence mechanism and the ways to combat the postoperative urinary continence while performing female urethral surgeries(Fig.1).Informed consent was taken from each of the patients before their evaluation and management.They were explained properly and informed consents were taken from them before the publication of this article.展开更多
As the masterpiece of Wharton,The Age of Innocence mainly concentrates on women’s fates in the strict restraint of the New York society.In the novel,Wharton portrays two contrasting female characters—May Welland and...As the masterpiece of Wharton,The Age of Innocence mainly concentrates on women’s fates in the strict restraint of the New York society.In the novel,Wharton portrays two contrasting female characters—May Welland and Ellen Olenska,who are regarded as the most progressive ones among the female figures she has ever created.Scholars,both domestic and abroad,have studied this novel from a raft of perspectives.Most of them have explored the feminist ideas,the conventions of upper-class society,and the protagonist Newland’s perplexity which are embodied in the novel.However,this paper aims to examine the divergences between two female figures—May and Ellen.The exploration of their divergences makes it clear that May is an ideal woman of the 19th century New York while Ellen is an ideal woman of modern society.展开更多
Microtubule-severing enzymes(MTSEs)play important roles in mitosis and meiosis of the primitive organisms.However,their roles in mammalian female meiosis,which accounts for over 80%of gamete-originated human reproduct...Microtubule-severing enzymes(MTSEs)play important roles in mitosis and meiosis of the primitive organisms.However,their roles in mammalian female meiosis,which accounts for over 80%of gamete-originated human reproductive diseases,remain unexplored.In the current study,we reported that katanin-like 2(KL2)was the only MTSE concentrating at chromosomes.Furthermore,the knockdown of KL2 significantly reduced the chromosome-based increase in the microtubule(MT)polymer,increased aberrant kinetochore-MT(K-MT)attachment,delayed meiosis,and severely affected normal fertility.We demonstrated that the inhibition of aurora B,a key kinase for correcting aberrant K-MT attachment,significantly eliminated KL2 expression from chromosomes.Additionally,KL2 interacted with phosphorylated eukaryotic elongation factor-2 kinase,and they competed for chromosome binding.Phosphorylated KL2 was also localized at spindle poles,with its phosphorylation regulated by extracellular signal-regulated kinase 1/2.In summary,the current study reveals a novel function of MTSEs in mammalian female meiosis and demonstrates that multiple kinases coordinate to regulate the levels of KL2 at chromosomes.展开更多
This cross-sectional study investigates a connection between female infertility and obesity across various regions of the United States, utilizing data from the NIH’s “All of Us” Researcher Workbench. Analysis sugg...This cross-sectional study investigates a connection between female infertility and obesity across various regions of the United States, utilizing data from the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese females at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in medically underserved areas where healthcare access is limited. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its impact on infertility. Further, these results advocate for enhanced public health education and policies aimed at improving healthcare accessibility, with the goal of mitigating the adverse effects of obesity on reproductive health.展开更多
The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in...The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer etc.Despite this,there has been limited discussion on the underlying mechanisms.This editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite pathway.We focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.展开更多
This study presents a single-class and multi-class instance segmentation approach applied to ancient Palmyrene inscriptions,employing two state-of-the-art deep learning algorithms,namely YOLOv8 and Roboflow 3.0.The go...This study presents a single-class and multi-class instance segmentation approach applied to ancient Palmyrene inscriptions,employing two state-of-the-art deep learning algorithms,namely YOLOv8 and Roboflow 3.0.The goal is to contribute to the preservation and understanding of historical texts,showcasing the potential of modern deep learning methods in archaeological research.Our research culminates in several key findings and scientific contributions.We comprehensively compare the performance of YOLOv8 and Roboflow 3.0 in the context of Palmyrene character segmentation—this comparative analysis mainly focuses on the strengths and weaknesses of each algorithm in this context.We also created and annotated an extensive dataset of Palmyrene inscriptions,a crucial resource for further research in the field.The dataset serves for training and evaluating the segmentation models.We employ comparative evaluation metrics to quantitatively assess the segmentation results,ensuring the reliability and reproducibility of our findings and we present custom visualization tools for predicted segmentation masks.Our study advances the state of the art in semi-automatic reading of Palmyrene inscriptions and establishes a benchmark for future research.The availability of the Palmyrene dataset and the insights into algorithm performance contribute to the broader understanding of historical text analysis.展开更多
Background: In Africa, female genital mutilation (FGM) is a widespread and harmful practice, with Somalia having the highest incidence at 98%. This practice has severe and long-lasting physical and mental health conse...Background: In Africa, female genital mutilation (FGM) is a widespread and harmful practice, with Somalia having the highest incidence at 98%. This practice has severe and long-lasting physical and mental health consequences. The aim of the study was to evaluate the different types of FGM;immediate and long-term complications associated with the practice, and identify factors related to its prevalence. Method: In a one-year cross-sectional hospital-based study, data were collected from females aged 18 - 50 with a history of FGM. Face-to-face semi-structured questionnaires were used for data collection. Data analysis was performed using SPSS version 26, utilizing univariate and bivariate analyses to identify correlations between variables, which were presented in tables. Results: In a study involving 255 female participants, 65.5% were between 18 and 30 years old. The majority (82.7%) were married, while 47.1% were illiterate. FGM cases were more prevalent in rural areas (61.6%). Among the participants, 45.1% were employed. Type 3 FGM was the most common (44.3%), followed by Type 2 (32.2%) and Type 1 (23.9%). In terms of short-term complications experienced by circumcised women, the most common were bleeding, reported by 29.8% of participants, followed by infection (25.1%), and urinary retention (19.2%). Among the long-term complications observed, recurrent vaginal infections were the most prevalent, affecting 29.8% of the surveyed females. This was episiotomy during delivery (22.3%) and genital scarring (10.2%). Conclusion: The study reveals that Type 3 FGM is highly prevalent among the surveyed females, contributing to an increased risk of recurrent vaginal infections, prolonged second stage of labor, higher likelihood of episiotomy during delivery, and genital scarring. These findings emphasize the urgent need for effective preventive strategies and implementation from both international and local organizations to eliminate the harmful practice of FGM.展开更多
文摘Tennessee Williams is the most famous Southern playwright in the history of 20th century American literature,and southern identity is a thread that runs throughout Williams’work.The Glass Menagerie is one of his highly representative dramatic works.The play tells the story of how an ordinary family in deep identity crisis escapes the harsh reality and cultural trauma during the Great Depression in the United States.Using trauma theory as a tool,this paper explores the complex relationship between the deep-seated causes of the tragedy of the two female characters in the play and the historical context through the traumatic events experienced by the characters in the play and the different attitudes they show in the face of trauma.Through this,the vulnerability and identity crisis of individuals during the period of social change and cultural breaks are analyzed.The purpose of the paper is to arouse human beings’thoughts on how to cope with cultural integration and foreign cultural invasion,and how to obtain salvation when they are amid an identity crisis.
基金Supported by the State Key Fundamental Science Fund of China(2005CB422208)NSF-China Project(40671132)the State Data Synthesis and Analysis Funds of China(2006DKA32300-08)~~
文摘[Objective] The experiment aimed to study the difference of water physiology of male and female Ginkgo biloba L. for discussing the strategy of water utilization as well as the important role of this difference during evolution process. [Method] The stem sap flow, stomatal conductance(Gs), transpiration rate(Tr) and water use efficiency (WUE) of male and female Ginkgo biloba L. were comparatively studied. [Result] The day-night processes of flow on male and female Ginkgo biloba L. were similar. The flow on male and female Ginkgo biloba L. in day were almost same while the flow at night on male Ginkgo biloba L. was bigger than that on female Ginkgo biloba L. The Tr and Gs of male and female Ginkgo biloba L. were high in morning and at night but low at noon ,while Tr and Gs of female Ginkgo biloba L. in morning and at night were higher than these of male Ginkgo biloba L. at the same time point. However, these indexes of female plant were lower than these of male plant from 11:00 to 14:00. WUE changing trends of male and female Ginkgo biloba L. were similar, while average water utilization rate of female Ginkgo biloba L. was slightly lower than that of male Ginkgo biloba L. [Conclusion] Compared with other companion plants, water physiology of male and female Ginkgo biloba L. had strong homoplasy. The phenomenon might be a survival strategy of dioecious plants under long term evolutionary pressure.
文摘In American cultural and literary traditions, the black females are often marginalized and stereotyped as a voiceless dim backdrop. This paper argues that The Bluest Eye notes the process of voice deprivation, and records the black females' own stories to give them back a unique voice of their own in order to construct new black female characters. This paper analyzes the tragic life of Pecola Breedlove and explores possible ways of speaking out.
文摘Female character in video games is the one of the most controversial topic in game studies and nowadays women's anthropology. From the beginning of role in games' plot to sexualized graphical representation, woman in virtual world were (and sometimes still are) a point of discussion about characters sexualisation and role of female sex in virtual industry. The main aim of this paper is to present analysis of female representation in video games and how in last 30 years it has changed. In other words, how female characters were ennobled from sex object to main protagonist status. In presented research, there were used mostly the examples of popular video games with extended plot and world which can be explored by protagonists. Video game historiography, textual analysis (which helped to treat video game character as a protagonist), and thematic analysis of video games were used as a main research method. The main conclusion of this paper is that female characters can overcome all gender or sexual stereotypes and even eventually became an icon of popular culture
文摘This paper analyses the female characters in E.M.Forster’s novels from the perspective of feminism,through the deep exploration of E.M.Forster’s works,it is evident to draw a conclusion that there are four kinds of female characters:first of all,stubborn and arrogant old ladies;the second type is insensitive but self-awakening middle-aged ladies;the third type is knowledgeable and smart young ladies;the last one is the warm-hearted and benevolent lady.These four kinds of different female characters can reveal that E.M.Forster has a contradictory attitude towards women.For one thing,he respected and sympathized with women,for another he discriminated against women.
文摘By tagging different characters,Charles Dickens invented many distinct characters in his novels.Female charaters are a central of Charls Dickens literary works.They represent the unimportant and the weak in the British society in the 19th century.This essay briefly introduces the the connecting between Dickens female characters in novels and women in his life,and based on it,analyses the female characters in Victorian Ages.
文摘On the Road is the masterpiece of Kerouac who is one of the most important writers of“Beat Generation”in America in the mid-20th century.It is acclaimed to be the Bible of“Beat Generation”.The novel narrates the stories of how Dean and his friends——some representative characters of the Beats travelled across continental U.S.several times and searched for new lifestyles and new faith on the road.In this novel,male characters are the main characters and the descriptions of all the female characters account for just one sixth of the whole book.Although the portrayal of the female characters is not profound like that of the male characters,the different personalities Kerouac endued the female characters are also the highlights of the novel.As a novel with strong nature of autobiography,Kerouac put his attitude and emotion into his portrayal.So it also can be a reflection of Kerouac’s female concepts.This paper aims at analyzing the female characters in On the Road by studying the types of the female characters in the novel and summarizing Kerouac’s female concepts reflected from the novel.
文摘In the novel The Great Gatsby,three main female characters(Daisy Buchanan,Myrtle Wilson and Jordan Baker)each presents women with different social status in American’s Jazz Age.By analyzing these three characters,readers could realize how the helplessness of the female characters contributes to their broken conscience and a further tragedy in that era.Moreover,the stereo situation of American society in theJazz Age is along vividly symbolized.
基金supported by the National Natural Science Foundation of China (82021001,31825018)National Key Research and Development Program of China (2022YFF0710901)+3 种基金Shanghai Municipal Science and Technology Major Project (2018SHZDZX05)Strategic Priority Research Program of the Chinese Academy of Sciences (XDB32060100)Biological Resources Program of Chinese Academy of Sciences (KFJ-BRP-005)National Science and Technology Innovation 2030 Major Program 2021ZD0200900。
文摘Mutations in mitochondrial DNA(mtDNA)are maternally inherited and have the potential to cause severe disorders.Mitochondrial replacement therapies,including spindle,polar body,and pronuclear transfers,are promising strategies for preventing the hereditary transmission of mtDNA diseases.While pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos,its application in non-human primates has not been previously reported.In this study,we successfully generated four healthy cynomolgus monkeys(Macaca fascicularis)via female pronuclear transfer.These individuals all survived for more than two years and exhibited minimal mtDNA carryover(3.8%–6.7%),as well as relatively stable mtDNA heteroplasmy dynamics during development.The successful establishment of this nonhuman primate model highlights the considerable potential of pronuclear transfer in reducing the risk of inherited mtDNA diseases and provides a valuable preclinical research model for advancing mitochondrial replacement therapies in humans.
文摘The female characters in Conrad's Heart of Darkness and Victory on one hand seem to be either too idealistic or rather uncivilized and insignificant.On the other hand,they have indispensable functions:they prepare the precondition for the plot,they can reverse the gender stereotype,and they help the inner growth of male protagonists.Even so,the focus of Joseph Conrad is still a patriarchal society where women are motivated by men.
文摘The thesis analyzes two main female characters and their conflicts in Like Water for Chocolate.It discusses their different personalities as well as the historical setting,focusing on their struggles to survive and to seek spiritual freedom in a traditional and patriarchal society.
文摘The interpretation of black female characters in Richard Wright’s Native Son has long been degraded and ignored while the male protagonist consistently attracts the majority of academic attention.Through the scrutiny of the representative black women figures,we may discern the element of blindness to be the most prominent shared feature which turns out to be the inevitable product of double oppressions and discriminations from racism and sexism in the morbid society.For the disadvantaged black women,their path towards the awakening of self-identity and self-fulfillment is bound to be extremely arduous and tortuous.
基金Sanming Project of Medicine in Shenzhen(No.SZSM202211019).
文摘Bone marrow edema(BME)is characterized by an accumulation of interstitial fluid within the bone marrow,the cancellous,hematopoietic compartment within bones.[1]BME is divided into two principal categories:idiopathic or primary BME,with an unknown etiology,and secondary BME,which occurs as a result of an identifiable underlying pathology.[2]Although the prevalence of BME is not limited to specific demographic parameters,it shows a predilection for males or individuals assigned male at birth,predominantly aged between the ages of 30 and 60 years,especially in cases of bone marrow edema syndrome(BMES),a rare idiopathic variant.[3]The etiological spectrum of BME is diverse,including oncological entities(such as acute myeloid leukemia and osteosarcoma),degenerative diseases(such as osteoarthritis),infectious processes(osteomyelitis),ischemic conditions(avascular necrosis),metabolic dysfunctions(osteoporosis),inflammatory disorders(rheumatoid arthritis),and traumatic injuries(such as stress fractures).[1,2]Clinically,BME primarily manifests as localized pain,often accompanied by joint effusion and warmth near the affected joint.Diagnostic protocols typically include physical examination,serological assays,bone marrow biopsies,dual-energy X-ray absorptiometry(DEXA)scans,magnetic resonance imaging(MRI),and ultrasonography,with computed tomography(CT)scans and radiographs being less effective.
文摘Dear Editor,We share our experience of two significant complications associated with female urethroplasty and their management in understanding the factors contributing to urinary continence.We have also tried to assess the different components of female urinary continence mechanism and the ways to combat the postoperative urinary continence while performing female urethral surgeries(Fig.1).Informed consent was taken from each of the patients before their evaluation and management.They were explained properly and informed consents were taken from them before the publication of this article.
文摘As the masterpiece of Wharton,The Age of Innocence mainly concentrates on women’s fates in the strict restraint of the New York society.In the novel,Wharton portrays two contrasting female characters—May Welland and Ellen Olenska,who are regarded as the most progressive ones among the female figures she has ever created.Scholars,both domestic and abroad,have studied this novel from a raft of perspectives.Most of them have explored the feminist ideas,the conventions of upper-class society,and the protagonist Newland’s perplexity which are embodied in the novel.However,this paper aims to examine the divergences between two female figures—May and Ellen.The exploration of their divergences makes it clear that May is an ideal woman of the 19th century New York while Ellen is an ideal woman of modern society.
基金supported by the Youth Program of National Natural Science Foundation of China(Grant No.82001539 to Leilei Gao)the Zhejiang Province Health Innovation Talent Project(Grant No.2021RC001 to Zhen Jin)+1 种基金the General Program of the National Natural Science Foundation of China(Grant No.31671561 to Dong Zhang)the Regional Program of National Natural Science Foundation of China(Grant No.82260126 to Xiaocong Liu).
文摘Microtubule-severing enzymes(MTSEs)play important roles in mitosis and meiosis of the primitive organisms.However,their roles in mammalian female meiosis,which accounts for over 80%of gamete-originated human reproductive diseases,remain unexplored.In the current study,we reported that katanin-like 2(KL2)was the only MTSE concentrating at chromosomes.Furthermore,the knockdown of KL2 significantly reduced the chromosome-based increase in the microtubule(MT)polymer,increased aberrant kinetochore-MT(K-MT)attachment,delayed meiosis,and severely affected normal fertility.We demonstrated that the inhibition of aurora B,a key kinase for correcting aberrant K-MT attachment,significantly eliminated KL2 expression from chromosomes.Additionally,KL2 interacted with phosphorylated eukaryotic elongation factor-2 kinase,and they competed for chromosome binding.Phosphorylated KL2 was also localized at spindle poles,with its phosphorylation regulated by extracellular signal-regulated kinase 1/2.In summary,the current study reveals a novel function of MTSEs in mammalian female meiosis and demonstrates that multiple kinases coordinate to regulate the levels of KL2 at chromosomes.
文摘This cross-sectional study investigates a connection between female infertility and obesity across various regions of the United States, utilizing data from the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese females at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in medically underserved areas where healthcare access is limited. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its impact on infertility. Further, these results advocate for enhanced public health education and policies aimed at improving healthcare accessibility, with the goal of mitigating the adverse effects of obesity on reproductive health.
基金Supported by Science and Technology Plan of Liaoning Province,No.2022JH2/101500063.
文摘The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer etc.Despite this,there has been limited discussion on the underlying mechanisms.This editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite pathway.We focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.
基金The results and knowledge included herein have been obtained owing to support from the following institutional grant.Internal grant agency of the Faculty of Economics and Management,Czech University of Life Sciences Prague,Grant No.2023A0004-“Text Segmentation Methods of Historical Alphabets in OCR Development”.https://iga.pef.czu.cz/.Funds were granted to T.Novák,A.Hamplová,O.Svojše,and A.Veselýfrom the author team.
文摘This study presents a single-class and multi-class instance segmentation approach applied to ancient Palmyrene inscriptions,employing two state-of-the-art deep learning algorithms,namely YOLOv8 and Roboflow 3.0.The goal is to contribute to the preservation and understanding of historical texts,showcasing the potential of modern deep learning methods in archaeological research.Our research culminates in several key findings and scientific contributions.We comprehensively compare the performance of YOLOv8 and Roboflow 3.0 in the context of Palmyrene character segmentation—this comparative analysis mainly focuses on the strengths and weaknesses of each algorithm in this context.We also created and annotated an extensive dataset of Palmyrene inscriptions,a crucial resource for further research in the field.The dataset serves for training and evaluating the segmentation models.We employ comparative evaluation metrics to quantitatively assess the segmentation results,ensuring the reliability and reproducibility of our findings and we present custom visualization tools for predicted segmentation masks.Our study advances the state of the art in semi-automatic reading of Palmyrene inscriptions and establishes a benchmark for future research.The availability of the Palmyrene dataset and the insights into algorithm performance contribute to the broader understanding of historical text analysis.
文摘Background: In Africa, female genital mutilation (FGM) is a widespread and harmful practice, with Somalia having the highest incidence at 98%. This practice has severe and long-lasting physical and mental health consequences. The aim of the study was to evaluate the different types of FGM;immediate and long-term complications associated with the practice, and identify factors related to its prevalence. Method: In a one-year cross-sectional hospital-based study, data were collected from females aged 18 - 50 with a history of FGM. Face-to-face semi-structured questionnaires were used for data collection. Data analysis was performed using SPSS version 26, utilizing univariate and bivariate analyses to identify correlations between variables, which were presented in tables. Results: In a study involving 255 female participants, 65.5% were between 18 and 30 years old. The majority (82.7%) were married, while 47.1% were illiterate. FGM cases were more prevalent in rural areas (61.6%). Among the participants, 45.1% were employed. Type 3 FGM was the most common (44.3%), followed by Type 2 (32.2%) and Type 1 (23.9%). In terms of short-term complications experienced by circumcised women, the most common were bleeding, reported by 29.8% of participants, followed by infection (25.1%), and urinary retention (19.2%). Among the long-term complications observed, recurrent vaginal infections were the most prevalent, affecting 29.8% of the surveyed females. This was episiotomy during delivery (22.3%) and genital scarring (10.2%). Conclusion: The study reveals that Type 3 FGM is highly prevalent among the surveyed females, contributing to an increased risk of recurrent vaginal infections, prolonged second stage of labor, higher likelihood of episiotomy during delivery, and genital scarring. These findings emphasize the urgent need for effective preventive strategies and implementation from both international and local organizations to eliminate the harmful practice of FGM.