Background: Emergence agitation (EA) is a common phenomenon observed in pediatric patients following general anesthesia. This study aimed to assess the efficacy of propofol and fentanyl in preventing EA and to compare...Background: Emergence agitation (EA) is a common phenomenon observed in pediatric patients following general anesthesia. This study aimed to assess the efficacy of propofol and fentanyl in preventing EA and to compare their associated complications or side effects. Methods: This prospective randomized observational comparative study was conducted at Dhaka Medical College Hospital from July 2013 to June 2014. The study aimed to evaluate the effects of propofol and fentanyl on EA in children aged 18 to 72 months undergoing circumcision, herniotomy, and polypectomy operations. Ninety children were included in the study, with 45 in each group. Patients with psychological or neurological disorders were excluded. Various parameters including age, sex, weight, American Society of Anesthesiologists (ASA) class, duration of anesthesia, Saturation of Peripheral Oxygen (SPO2), heart rate (HR), respiratory rate (RR), Pediatric Anesthesia Emergence Delirium (PAED) score, duration of post-anesthesia care unit (PACU) stay, incidence of laryngospasm, nausea, vomiting, and rescue drug requirement were compared between the two groups. Results: Age, sex, weight, ASA class, and duration of anesthesia were comparable between the two groups. Perioperative SpO2 and HR were similar in both groups. However, the PAED score was significantly higher in the fentanyl group during all follow-ups except at 30 minutes postoperatively. The mean duration of PACU stay was significantly longer in the fentanyl group. Although the incidence of laryngospasm was higher in the fentanyl group, it was not statistically significant. Conversely, nausea or vomiting was significantly higher in the fentanyl group. The requirement for rescue drugs was significantly higher in the fentanyl group compared to the propofol group. Conclusion: Both propofol and fentanyl were effective in preventing emergence agitation in pediatric patients undergoing various surgical procedures under sevoflurane anesthesia. However, propofol demonstrated a better safety profile with fewer incidences of nausea, vomiting, and rescue drug requirements compared to fentanyl.展开更多
The United States is in the throes of a severe opioid overdose epidemic,primarily fueled by the pervasive use of fentanyl and the emerging threat of xylazine,a veterinary sedative often mixed with fentanyl.The high po...The United States is in the throes of a severe opioid overdose epidemic,primarily fueled by the pervasive use of fentanyl and the emerging threat of xylazine,a veterinary sedative often mixed with fentanyl.The high potency and long duration of fentanyl is compounded by the added risks from xylazine,heightening the lethal danger faced by opioid users.Measures such as enhanced surveillance,public awareness campaigns,and the distribution of fentanylxylazine test kits,and naloxone have been undertaken to mitigate this crisis.Fentanyl-related overdose deaths persist despite these efforts,partly due to inconsistent policies across states and resistance towards adopting harm reduction strategies.A multifaceted approach is imperative in effectively combating the opioid overdose epidemic.This approach should include expansion of treatment access,broadening the availability of medications for opioid use disorder,implementation of harm reduction strategies,and enaction of legislative reforms and diminishing stigma associated with opioid use disorder.展开更多
Quantum random number generators adopting single negligible dead time of avalanche photodiodes (APDs) photon detection have been restricted due to the non- We propose a new approach based on an APD array to improve...Quantum random number generators adopting single negligible dead time of avalanche photodiodes (APDs) photon detection have been restricted due to the non- We propose a new approach based on an APD array to improve the generation rate of random numbers significantly. This method compares the detectors' responses to consecutive optical pulses and generates the random sequence. We implement a demonstration experiment to show its simplicity, compactness and scalability. The generated numbers are proved to be unbiased, post-processing free, ready to use, and their randomness is verified by using the national institute of standard technology statistical test suite. The random bit generation efficiency is as high as 32.8% and the potential generation rate adopting the 32× 32 APD array is up to tens of Gbits/s.展开更多
In order to carry out numerical simulation using geologic structural data obtained from Landmark(seismic interpretation system), underground geological structures are abstracted into mechanical models which can reflec...In order to carry out numerical simulation using geologic structural data obtained from Landmark(seismic interpretation system), underground geological structures are abstracted into mechanical models which can reflect actual situations and facilitate their computation and analyses.Given the importance of model building, further processing methods about traditional seismic interpretation results from Landmark should be studied and the processed result can then be directly used in numerical simulation computations.Through this data conversion procedure, Landmark and FLAC(the international general stress software) are seamlessly connected.Thus, the format conversion between the two systems and the pre-and post-processing in simulation computation is realized.A practical application indicates that this method has many advantages such as simple operation, high accuracy of the element subdivision and high speed, which may definitely satisfy the actual needs of floor grid cutting.展开更多
The travel time data collection method is used to assist the congestion management. The use of traditional sensors (e.g. inductive loops, AVI sensors) or more recent Bluetooth sensors installed on major roads for coll...The travel time data collection method is used to assist the congestion management. The use of traditional sensors (e.g. inductive loops, AVI sensors) or more recent Bluetooth sensors installed on major roads for collecting data is not sufficient because of their limited coverage and expensive costs for installation and maintenance. Application of the Global Positioning Systems (GPS) in travel time and delay data collections is proven to be efficient in terms of accuracy, level of details for the data and required data collection of man-power. While data collection automation is improved by the GPS technique, human errors can easily find their way through the post-processing phase, and therefore data post-processing remains a challenge especially in case of big projects with high amount of data. This paper introduces a stand-alone post-processing tool called GPS Calculator, which provides an easy-to-use environment to carry out data post-processing. This is a Visual Basic application that processes the data files obtained in the field and integrates them into Geographic Information Systems (GIS) for analysis and representation. The results show that this tool obtains similar results to the currently used data post-processing method, reduces the post-processing effort, and also eliminates the need for the second person during the data collection.展开更多
When castings become complicated and the demands for precision of numerical simulation become higher,the numerical data of casting numerical simulation become more massive.On a general personal computer,these massive ...When castings become complicated and the demands for precision of numerical simulation become higher,the numerical data of casting numerical simulation become more massive.On a general personal computer,these massive numerical data may probably exceed the capacity of available memory,resulting in failure of rendering.Based on the out-of-core technique,this paper proposes a method to effectively utilize external storage and reduce memory usage dramatically,so as to solve the problem of insufficient memory for massive data rendering on general personal computers.Based on this method,a new postprocessor is developed.It is capable to illustrate filling and solidification processes of casting,as well as thermal stess.The new post-processor also provides fast interaction to simulation results.Theoretical analysis as well as several practical examples prove that the memory usage and loading time of the post-processor are independent of the size of the relevant files,but the proportion of the number of cells on surface.Meanwhile,the speed of rendering and fetching of value from the mouse is appreciable,and the demands of real-time and interaction are satisfied.展开更多
To improve the ability of detecting underwater targets under strong wideband interference environment,an efficient method of line spectrum extraction is proposed,which fully utilizes the feature of the target spectrum...To improve the ability of detecting underwater targets under strong wideband interference environment,an efficient method of line spectrum extraction is proposed,which fully utilizes the feature of the target spectrum that the high intense and stable line spectrum is superimposed on the wide continuous spectrum.This method modifies the traditional beam forming algorithm by calculating and fusing the beam forming results at multi-frequency band and multi-azimuth interval,showing an excellent way to extract the line spectrum when the interference and the target are not in the same azimuth interval simultaneously.Statistical efficiency of the estimated azimuth variance and corresponding power of the line spectrum band depends on the line spectra ratio(LSR)of the line spectrum.The change laws of the output signal to noise ratio(SNR)with the LSR,the input SNR,the integration time and the filtering bandwidth of different algorithms bring the selection principle of the critical LSR.As the basis,the detection gain of wideband energy integration and the narrowband line spectrum algorithm are theoretically analyzed.The simulation detection gain demonstrates a good match with the theoretical model.The application conditions of all methods are verified by the receiver operating characteristic(ROC)curve and experimental data from Qiandao Lake.In fact,combining the two methods for target detection reduces the missed detection rate.The proposed post-processing method in2-dimension with the Kalman filter in the time dimension and the background equalization algorithm in the azimuth dimension makes use of the strong correlation between adjacent frames,could further remove background fluctuation and improve the display effect.展开更多
This paper proposed improvements to the low bit rate parametric audio coder with sinusoid model as its kernel. Firstly, we propose a new method to effectively order and select the perceptually most important sinusoids...This paper proposed improvements to the low bit rate parametric audio coder with sinusoid model as its kernel. Firstly, we propose a new method to effectively order and select the perceptually most important sinusoids. The sinusoid which contributes most to the reduction of overall NMR is chosen. Combined with our improved parametric psychoacoustic model and advanced peak riddling techniques, the number of sinusoids required can be greatly reduced and the coding efficiency can be greatly enhanced. A lightweight version is also given to reduce the amount of computation with only little sacrifice of performance. Secondly, we propose two enhancement techniques for sinusoid synthesis: bandwidth enhancement and line enhancement. With little overhead, the effective bandwidth can be extended one more octave; the timbre tends to sound much brighter, thicker and more beautiful.展开更多
Low contrast of Magnetic Resonance(MR)images limits the visibility of subtle structures and adversely affects the outcome of both subjective and automated diagnosis.State-of-the-art contrast boosting techniques intole...Low contrast of Magnetic Resonance(MR)images limits the visibility of subtle structures and adversely affects the outcome of both subjective and automated diagnosis.State-of-the-art contrast boosting techniques intolerably alter inherent features of MR images.Drastic changes in brightness features,induced by post-processing are not appreciated in medical imaging as the grey level values have certain diagnostic meanings.To overcome these issues this paper proposes an algorithm that enhance the contrast of MR images while preserving the underlying features as well.This method termed as Power-law and Logarithmic Modification-based Histogram Equalization(PLMHE)partitions the histogram of the image into two sub histograms after a power-law transformation and a log compression.After a modification intended for improving the dispersion of the sub-histograms and subsequent normalization,cumulative histograms are computed.Enhanced grey level values are computed from the resultant cumulative histograms.The performance of the PLMHE algorithm is comparedwith traditional histogram equalization based algorithms and it has been observed from the results that PLMHE can boost the image contrast without causing dynamic range compression,a significant change in mean brightness,and contrast-overshoot.展开更多
In the analysis of high-rise building, traditional displacement-based plane elements are often used to get the in-plane internal forces of the shear walls by stress integration. Limited by the singular problem produce...In the analysis of high-rise building, traditional displacement-based plane elements are often used to get the in-plane internal forces of the shear walls by stress integration. Limited by the singular problem produced by wall holes and the loss of precision induced by using differential method to derive strains, the displacement-based elements cannot always present accuracy enough for design. In this paper, the hybrid post-processing procedure based on the Hellinger-Reissner variational principle is used for improving the stress precision of two quadrilateral plane elements. In order to find the best stress field, three different forms are assumed for the displacement-based plane elements and with drilling DOF. Numerical results show that by using the proposed method, the accuracy of stress solutions of these two displacement-based plane elements can be improved.展开更多
The purpose of this research was to investigate the manner of deaths in Marion County, throughout the years of 2018 to 2021 to see if there were any correlative increases in homicide, suicide, natural, accidental, or ...The purpose of this research was to investigate the manner of deaths in Marion County, throughout the years of 2018 to 2021 to see if there were any correlative increases in homicide, suicide, natural, accidental, or drug overdose related deaths. We surveyed the incidence of all deaths that occurred from 2018 through 2021 which came through the Marion County Coroner’s Office, Indiana. The data was then divided into two halves. According to the data, the leading manner of death in the first half and second half was accidental. This study revealed a total of 8732 cases: 3817 of them were observed to be accidental, 3092 natural, 956 homicide, 689 suicide, and 178 were undetermined. There were initially 318 drug overdose related deaths in 2018 and they increased to 2163 by 2021. In 2018, the number of deaths due to fentanyl related overdoses increased from 195 to 799 in 2021. This research will contribute to the forensic science field by providing information about the manner of death and fentanyl trends in Marion County over the last four years.展开更多
Objective: Objective: To assess the effect and adverse effects of transdermal fentanyl for elderly patients with cancer pain in China. Methods: A total of 1664 elderly patients (aged 65-90 with mean age of 72.6) with ...Objective: Objective: To assess the effect and adverse effects of transdermal fentanyl for elderly patients with cancer pain in China. Methods: A total of 1664 elderly patients (aged 65-90 with mean age of 72.6) with cancer pain enrolled in the multicenter study from 136 institutes in China. Of them, 408 (28.8%) patients were 75 years old or older. All patients received transdermal fentanyl for the management of cancer pain. The patients were asked to record the attacks of pain, quality of life, and any side effects of the treatment. Results: Baseline mean of pain intensity was 7.34. On day 1, 3, 6, 9 15, and 30, the pain mean scores were decreased to 3.82, 2.80, 2.43, 2.11, 1.83, 1.64 (P=0.000). The effective rate was 97.18%. The mean doses of fentanyl was 31.34 g/h (25-150 g/h) initially, and 40.59 g/h and 47.50 g/h (25-200 g/h) at day 15 and day 30. At treatment day 15, the dose of fentanyl was ranger from 25 to 50 g/h in 91.8% of patients, 75 to 100 g/h in 7.5% patients, and 125 to 200 g/h only in 0.8% patients. The fine quality of life was in 25.4% patients before treatment, and was 71.15% and 73.04% at day 15 and day 30 respectively (P=0.0000). The common side effects were constipation (10.70%), nausea (11.96%), dizzy (6.85%), vomiting (3.85%), sedation (2.40%), Respiratory depression (0.12%). 86.2% patients preferred continue treated by transdermal fentanyl. Conclusions: Transdermal fentanyl for the elderly with cancer pain is effective, safe, convenient, and can improve the quality of life. Transdermal fentanyl can be recommended as a first-line drug for the treatment of elderly patients with moderate to severe cancer pain, and the initial doses is recommended as 25 g/h.展开更多
Objective: To evaluate the effect of test dose fentanyl on predictingpostoperative analgesia and respiratory depression. Methods: Preoperatively the lowest pulseoximeter saturation (SpO_2) under room air breathing was...Objective: To evaluate the effect of test dose fentanyl on predictingpostoperative analgesia and respiratory depression. Methods: Preoperatively the lowest pulseoximeter saturation (SpO_2) under room air breathing was measured after 2 μg/kg of fentanyl givenintravenously in 35 patients who were scheduled with continuous intravenous morphine analgesia (12μg·kg^(-1)·h^(-1)) postoperatively. Results: The test dose fentanyl resulted in respiratorydepression in 19 of 35 cases, while 8 (42.1%) of the 19 cases developed respiratory depressionpostoperatively. However in the rest 16 patients, no patient (0) developed respiratory depression (P< 0.01). The fentanyl-induced lowest SpO_2 significantly correlated with the lowest SpO_2postoperatively (P < 0.01). The analgesia effect in terms of verbal analogue scale was correlatedneither with the fentanyl-induced lowest SpO_2 nor with the lowest SpO_2 postoperatively (P > 0.05).Conclusion: The patient who was sensitive to fentanyl-induced respiratory depression would take ahigh risk to develop postoperative respiratory depression with intravenous morphine analgesia andthe patient with respiratory depression does not always go with satisfactory analgesia.展开更多
目的:对比鞘内注射舒芬太尼与芬太尼对高龄股骨粗隆骨折近端股骨钉抗旋(PFNA)内固定术患者的镇痛效果及安全性对比。方法:选取2019年1月—2022年12月于常熟市第五人民医院接受股骨粗隆骨折PFNA内固定术的108例高龄患者作为研究对象,根...目的:对比鞘内注射舒芬太尼与芬太尼对高龄股骨粗隆骨折近端股骨钉抗旋(PFNA)内固定术患者的镇痛效果及安全性对比。方法:选取2019年1月—2022年12月于常熟市第五人民医院接受股骨粗隆骨折PFNA内固定术的108例高龄患者作为研究对象,根据随机数表法将患者分为研究组54例与常规组54例。研究组采用鞘内注射舒芬太尼,常规组采用鞘内注射芬太尼。比较两组手术时间、镇痛时间、术后6 h、12 h视觉模拟评分法(VAS)评分及不良反应发生情况。结果:两组手术时间比较,差异无统计学意义(P>0.05);研究组镇痛时间长于常规组,差异有统计学意义(P<0.05)。研究组术后6 h、12 h VAS评分低于常规组,且两组术后12 h VAS评分低于术后6 h,差异有统计学意义(P<0.05)。研究组不良反应发生率低于常规组,差异有统计学意义(P<0.05)。结论:相比芬太尼,舒芬太尼在高龄股骨粗隆骨折PFNA内固定术患者中的镇痛作用显著,能缓解术后疼痛,还可降低不良反应发生率。展开更多
Despite the maturity of ensemble numerical weather prediction(NWP),the resulting forecasts are still,more often than not,under-dispersed.As such,forecast calibration tools have become popular.Among those tools,quantil...Despite the maturity of ensemble numerical weather prediction(NWP),the resulting forecasts are still,more often than not,under-dispersed.As such,forecast calibration tools have become popular.Among those tools,quantile regression(QR)is highly competitive in terms of both flexibility and predictive performance.Nevertheless,a long-standing problem of QR is quantile crossing,which greatly limits the interpretability of QR-calibrated forecasts.On this point,this study proposes a non-crossing quantile regression neural network(NCQRNN),for calibrating ensemble NWP forecasts into a set of reliable quantile forecasts without crossing.The overarching design principle of NCQRNN is to add on top of the conventional QRNN structure another hidden layer,which imposes a non-decreasing mapping between the combined output from nodes of the last hidden layer to the nodes of the output layer,through a triangular weight matrix with positive entries.The empirical part of the work considers a solar irradiance case study,in which four years of ensemble irradiance forecasts at seven locations,issued by the European Centre for Medium-Range Weather Forecasts,are calibrated via NCQRNN,as well as via an eclectic mix of benchmarking models,ranging from the naïve climatology to the state-of-the-art deep-learning and other non-crossing models.Formal and stringent forecast verification suggests that the forecasts post-processed via NCQRNN attain the maximum sharpness subject to calibration,amongst all competitors.Furthermore,the proposed conception to resolve quantile crossing is remarkably simple yet general,and thus has broad applicability as it can be integrated with many shallow-and deep-learning-based neural networks.展开更多
文摘Background: Emergence agitation (EA) is a common phenomenon observed in pediatric patients following general anesthesia. This study aimed to assess the efficacy of propofol and fentanyl in preventing EA and to compare their associated complications or side effects. Methods: This prospective randomized observational comparative study was conducted at Dhaka Medical College Hospital from July 2013 to June 2014. The study aimed to evaluate the effects of propofol and fentanyl on EA in children aged 18 to 72 months undergoing circumcision, herniotomy, and polypectomy operations. Ninety children were included in the study, with 45 in each group. Patients with psychological or neurological disorders were excluded. Various parameters including age, sex, weight, American Society of Anesthesiologists (ASA) class, duration of anesthesia, Saturation of Peripheral Oxygen (SPO2), heart rate (HR), respiratory rate (RR), Pediatric Anesthesia Emergence Delirium (PAED) score, duration of post-anesthesia care unit (PACU) stay, incidence of laryngospasm, nausea, vomiting, and rescue drug requirement were compared between the two groups. Results: Age, sex, weight, ASA class, and duration of anesthesia were comparable between the two groups. Perioperative SpO2 and HR were similar in both groups. However, the PAED score was significantly higher in the fentanyl group during all follow-ups except at 30 minutes postoperatively. The mean duration of PACU stay was significantly longer in the fentanyl group. Although the incidence of laryngospasm was higher in the fentanyl group, it was not statistically significant. Conversely, nausea or vomiting was significantly higher in the fentanyl group. The requirement for rescue drugs was significantly higher in the fentanyl group compared to the propofol group. Conclusion: Both propofol and fentanyl were effective in preventing emergence agitation in pediatric patients undergoing various surgical procedures under sevoflurane anesthesia. However, propofol demonstrated a better safety profile with fewer incidences of nausea, vomiting, and rescue drug requirements compared to fentanyl.
文摘The United States is in the throes of a severe opioid overdose epidemic,primarily fueled by the pervasive use of fentanyl and the emerging threat of xylazine,a veterinary sedative often mixed with fentanyl.The high potency and long duration of fentanyl is compounded by the added risks from xylazine,heightening the lethal danger faced by opioid users.Measures such as enhanced surveillance,public awareness campaigns,and the distribution of fentanylxylazine test kits,and naloxone have been undertaken to mitigate this crisis.Fentanyl-related overdose deaths persist despite these efforts,partly due to inconsistent policies across states and resistance towards adopting harm reduction strategies.A multifaceted approach is imperative in effectively combating the opioid overdose epidemic.This approach should include expansion of treatment access,broadening the availability of medications for opioid use disorder,implementation of harm reduction strategies,and enaction of legislative reforms and diminishing stigma associated with opioid use disorder.
基金Supported by the Chinese Academy of Sciences Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics,Shanghai Branch,University of Science and Technology of Chinathe National Natural Science Foundation of China under Grant No 11405172
文摘Quantum random number generators adopting single negligible dead time of avalanche photodiodes (APDs) photon detection have been restricted due to the non- We propose a new approach based on an APD array to improve the generation rate of random numbers significantly. This method compares the detectors' responses to consecutive optical pulses and generates the random sequence. We implement a demonstration experiment to show its simplicity, compactness and scalability. The generated numbers are proved to be unbiased, post-processing free, ready to use, and their randomness is verified by using the national institute of standard technology statistical test suite. The random bit generation efficiency is as high as 32.8% and the potential generation rate adopting the 32× 32 APD array is up to tens of Gbits/s.
基金Projects 50221402, 50490271 and 50025413 supported by the National Natural Science Foundation of Chinathe National Basic Research Program of China (2009CB219603, 2009 CB724601, 2006CB202209 and 2005CB221500)+1 种基金the Key Project of the Ministry of Education (306002)the Program for Changjiang Scholars and Innovative Research Teams in Universities of MOE (IRT0408)
文摘In order to carry out numerical simulation using geologic structural data obtained from Landmark(seismic interpretation system), underground geological structures are abstracted into mechanical models which can reflect actual situations and facilitate their computation and analyses.Given the importance of model building, further processing methods about traditional seismic interpretation results from Landmark should be studied and the processed result can then be directly used in numerical simulation computations.Through this data conversion procedure, Landmark and FLAC(the international general stress software) are seamlessly connected.Thus, the format conversion between the two systems and the pre-and post-processing in simulation computation is realized.A practical application indicates that this method has many advantages such as simple operation, high accuracy of the element subdivision and high speed, which may definitely satisfy the actual needs of floor grid cutting.
文摘The travel time data collection method is used to assist the congestion management. The use of traditional sensors (e.g. inductive loops, AVI sensors) or more recent Bluetooth sensors installed on major roads for collecting data is not sufficient because of their limited coverage and expensive costs for installation and maintenance. Application of the Global Positioning Systems (GPS) in travel time and delay data collections is proven to be efficient in terms of accuracy, level of details for the data and required data collection of man-power. While data collection automation is improved by the GPS technique, human errors can easily find their way through the post-processing phase, and therefore data post-processing remains a challenge especially in case of big projects with high amount of data. This paper introduces a stand-alone post-processing tool called GPS Calculator, which provides an easy-to-use environment to carry out data post-processing. This is a Visual Basic application that processes the data files obtained in the field and integrates them into Geographic Information Systems (GIS) for analysis and representation. The results show that this tool obtains similar results to the currently used data post-processing method, reduces the post-processing effort, and also eliminates the need for the second person during the data collection.
基金supported by the New Century Excellent Talents in University(NCET-09-0396)the National Science&Technology Key Projects of Numerical Control(2012ZX04014-031)+1 种基金the Natural Science Foundation of Hubei Province(2011CDB279)the Foundation for Innovative Research Groups of the Natural Science Foundation of Hubei Province,China(2010CDA067)
文摘When castings become complicated and the demands for precision of numerical simulation become higher,the numerical data of casting numerical simulation become more massive.On a general personal computer,these massive numerical data may probably exceed the capacity of available memory,resulting in failure of rendering.Based on the out-of-core technique,this paper proposes a method to effectively utilize external storage and reduce memory usage dramatically,so as to solve the problem of insufficient memory for massive data rendering on general personal computers.Based on this method,a new postprocessor is developed.It is capable to illustrate filling and solidification processes of casting,as well as thermal stess.The new post-processor also provides fast interaction to simulation results.Theoretical analysis as well as several practical examples prove that the memory usage and loading time of the post-processor are independent of the size of the relevant files,but the proportion of the number of cells on surface.Meanwhile,the speed of rendering and fetching of value from the mouse is appreciable,and the demands of real-time and interaction are satisfied.
基金supported by the National Natural Science Foundation of China(51875535)the Natural Science Foundation for Young Scientists of Shanxi Province(201701D221017,201901D211242)。
文摘To improve the ability of detecting underwater targets under strong wideband interference environment,an efficient method of line spectrum extraction is proposed,which fully utilizes the feature of the target spectrum that the high intense and stable line spectrum is superimposed on the wide continuous spectrum.This method modifies the traditional beam forming algorithm by calculating and fusing the beam forming results at multi-frequency band and multi-azimuth interval,showing an excellent way to extract the line spectrum when the interference and the target are not in the same azimuth interval simultaneously.Statistical efficiency of the estimated azimuth variance and corresponding power of the line spectrum band depends on the line spectra ratio(LSR)of the line spectrum.The change laws of the output signal to noise ratio(SNR)with the LSR,the input SNR,the integration time and the filtering bandwidth of different algorithms bring the selection principle of the critical LSR.As the basis,the detection gain of wideband energy integration and the narrowband line spectrum algorithm are theoretically analyzed.The simulation detection gain demonstrates a good match with the theoretical model.The application conditions of all methods are verified by the receiver operating characteristic(ROC)curve and experimental data from Qiandao Lake.In fact,combining the two methods for target detection reduces the missed detection rate.The proposed post-processing method in2-dimension with the Kalman filter in the time dimension and the background equalization algorithm in the azimuth dimension makes use of the strong correlation between adjacent frames,could further remove background fluctuation and improve the display effect.
文摘This paper proposed improvements to the low bit rate parametric audio coder with sinusoid model as its kernel. Firstly, we propose a new method to effectively order and select the perceptually most important sinusoids. The sinusoid which contributes most to the reduction of overall NMR is chosen. Combined with our improved parametric psychoacoustic model and advanced peak riddling techniques, the number of sinusoids required can be greatly reduced and the coding efficiency can be greatly enhanced. A lightweight version is also given to reduce the amount of computation with only little sacrifice of performance. Secondly, we propose two enhancement techniques for sinusoid synthesis: bandwidth enhancement and line enhancement. With little overhead, the effective bandwidth can be extended one more octave; the timbre tends to sound much brighter, thicker and more beautiful.
基金This work was supported by Taif university Researchers Supporting Project Number(TURSP-2020/114),Taif University,Taif,Saudi Arabia.
文摘Low contrast of Magnetic Resonance(MR)images limits the visibility of subtle structures and adversely affects the outcome of both subjective and automated diagnosis.State-of-the-art contrast boosting techniques intolerably alter inherent features of MR images.Drastic changes in brightness features,induced by post-processing are not appreciated in medical imaging as the grey level values have certain diagnostic meanings.To overcome these issues this paper proposes an algorithm that enhance the contrast of MR images while preserving the underlying features as well.This method termed as Power-law and Logarithmic Modification-based Histogram Equalization(PLMHE)partitions the histogram of the image into two sub histograms after a power-law transformation and a log compression.After a modification intended for improving the dispersion of the sub-histograms and subsequent normalization,cumulative histograms are computed.Enhanced grey level values are computed from the resultant cumulative histograms.The performance of the PLMHE algorithm is comparedwith traditional histogram equalization based algorithms and it has been observed from the results that PLMHE can boost the image contrast without causing dynamic range compression,a significant change in mean brightness,and contrast-overshoot.
文摘In the analysis of high-rise building, traditional displacement-based plane elements are often used to get the in-plane internal forces of the shear walls by stress integration. Limited by the singular problem produced by wall holes and the loss of precision induced by using differential method to derive strains, the displacement-based elements cannot always present accuracy enough for design. In this paper, the hybrid post-processing procedure based on the Hellinger-Reissner variational principle is used for improving the stress precision of two quadrilateral plane elements. In order to find the best stress field, three different forms are assumed for the displacement-based plane elements and with drilling DOF. Numerical results show that by using the proposed method, the accuracy of stress solutions of these two displacement-based plane elements can be improved.
文摘The purpose of this research was to investigate the manner of deaths in Marion County, throughout the years of 2018 to 2021 to see if there were any correlative increases in homicide, suicide, natural, accidental, or drug overdose related deaths. We surveyed the incidence of all deaths that occurred from 2018 through 2021 which came through the Marion County Coroner’s Office, Indiana. The data was then divided into two halves. According to the data, the leading manner of death in the first half and second half was accidental. This study revealed a total of 8732 cases: 3817 of them were observed to be accidental, 3092 natural, 956 homicide, 689 suicide, and 178 were undetermined. There were initially 318 drug overdose related deaths in 2018 and they increased to 2163 by 2021. In 2018, the number of deaths due to fentanyl related overdoses increased from 195 to 799 in 2021. This research will contribute to the forensic science field by providing information about the manner of death and fentanyl trends in Marion County over the last four years.
文摘Objective: Objective: To assess the effect and adverse effects of transdermal fentanyl for elderly patients with cancer pain in China. Methods: A total of 1664 elderly patients (aged 65-90 with mean age of 72.6) with cancer pain enrolled in the multicenter study from 136 institutes in China. Of them, 408 (28.8%) patients were 75 years old or older. All patients received transdermal fentanyl for the management of cancer pain. The patients were asked to record the attacks of pain, quality of life, and any side effects of the treatment. Results: Baseline mean of pain intensity was 7.34. On day 1, 3, 6, 9 15, and 30, the pain mean scores were decreased to 3.82, 2.80, 2.43, 2.11, 1.83, 1.64 (P=0.000). The effective rate was 97.18%. The mean doses of fentanyl was 31.34 g/h (25-150 g/h) initially, and 40.59 g/h and 47.50 g/h (25-200 g/h) at day 15 and day 30. At treatment day 15, the dose of fentanyl was ranger from 25 to 50 g/h in 91.8% of patients, 75 to 100 g/h in 7.5% patients, and 125 to 200 g/h only in 0.8% patients. The fine quality of life was in 25.4% patients before treatment, and was 71.15% and 73.04% at day 15 and day 30 respectively (P=0.0000). The common side effects were constipation (10.70%), nausea (11.96%), dizzy (6.85%), vomiting (3.85%), sedation (2.40%), Respiratory depression (0.12%). 86.2% patients preferred continue treated by transdermal fentanyl. Conclusions: Transdermal fentanyl for the elderly with cancer pain is effective, safe, convenient, and can improve the quality of life. Transdermal fentanyl can be recommended as a first-line drug for the treatment of elderly patients with moderate to severe cancer pain, and the initial doses is recommended as 25 g/h.
文摘Objective: To evaluate the effect of test dose fentanyl on predictingpostoperative analgesia and respiratory depression. Methods: Preoperatively the lowest pulseoximeter saturation (SpO_2) under room air breathing was measured after 2 μg/kg of fentanyl givenintravenously in 35 patients who were scheduled with continuous intravenous morphine analgesia (12μg·kg^(-1)·h^(-1)) postoperatively. Results: The test dose fentanyl resulted in respiratorydepression in 19 of 35 cases, while 8 (42.1%) of the 19 cases developed respiratory depressionpostoperatively. However in the rest 16 patients, no patient (0) developed respiratory depression (P< 0.01). The fentanyl-induced lowest SpO_2 significantly correlated with the lowest SpO_2postoperatively (P < 0.01). The analgesia effect in terms of verbal analogue scale was correlatedneither with the fentanyl-induced lowest SpO_2 nor with the lowest SpO_2 postoperatively (P > 0.05).Conclusion: The patient who was sensitive to fentanyl-induced respiratory depression would take ahigh risk to develop postoperative respiratory depression with intravenous morphine analgesia andthe patient with respiratory depression does not always go with satisfactory analgesia.
文摘目的:对比鞘内注射舒芬太尼与芬太尼对高龄股骨粗隆骨折近端股骨钉抗旋(PFNA)内固定术患者的镇痛效果及安全性对比。方法:选取2019年1月—2022年12月于常熟市第五人民医院接受股骨粗隆骨折PFNA内固定术的108例高龄患者作为研究对象,根据随机数表法将患者分为研究组54例与常规组54例。研究组采用鞘内注射舒芬太尼,常规组采用鞘内注射芬太尼。比较两组手术时间、镇痛时间、术后6 h、12 h视觉模拟评分法(VAS)评分及不良反应发生情况。结果:两组手术时间比较,差异无统计学意义(P>0.05);研究组镇痛时间长于常规组,差异有统计学意义(P<0.05)。研究组术后6 h、12 h VAS评分低于常规组,且两组术后12 h VAS评分低于术后6 h,差异有统计学意义(P<0.05)。研究组不良反应发生率低于常规组,差异有统计学意义(P<0.05)。结论:相比芬太尼,舒芬太尼在高龄股骨粗隆骨折PFNA内固定术患者中的镇痛作用显著,能缓解术后疼痛,还可降低不良反应发生率。
基金supported by the National Natural Science Foundation of China (Project No.42375192)the China Meteorological Administration Climate Change Special Program (CMA-CCSP+1 种基金Project No.QBZ202315)support by the Vector Stiftung through the Young Investigator Group"Artificial Intelligence for Probabilistic Weather Forecasting."
文摘Despite the maturity of ensemble numerical weather prediction(NWP),the resulting forecasts are still,more often than not,under-dispersed.As such,forecast calibration tools have become popular.Among those tools,quantile regression(QR)is highly competitive in terms of both flexibility and predictive performance.Nevertheless,a long-standing problem of QR is quantile crossing,which greatly limits the interpretability of QR-calibrated forecasts.On this point,this study proposes a non-crossing quantile regression neural network(NCQRNN),for calibrating ensemble NWP forecasts into a set of reliable quantile forecasts without crossing.The overarching design principle of NCQRNN is to add on top of the conventional QRNN structure another hidden layer,which imposes a non-decreasing mapping between the combined output from nodes of the last hidden layer to the nodes of the output layer,through a triangular weight matrix with positive entries.The empirical part of the work considers a solar irradiance case study,in which four years of ensemble irradiance forecasts at seven locations,issued by the European Centre for Medium-Range Weather Forecasts,are calibrated via NCQRNN,as well as via an eclectic mix of benchmarking models,ranging from the naïve climatology to the state-of-the-art deep-learning and other non-crossing models.Formal and stringent forecast verification suggests that the forecasts post-processed via NCQRNN attain the maximum sharpness subject to calibration,amongst all competitors.Furthermore,the proposed conception to resolve quantile crossing is remarkably simple yet general,and thus has broad applicability as it can be integrated with many shallow-and deep-learning-based neural networks.