From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl, the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring, allows us to synthesize the studied comp...From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl, the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in <i>para</i> position has the lowest activity in both cases. Therefore the <i>para</i> position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.展开更多
文摘From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl, the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in <i>para</i> position has the lowest activity in both cases. Therefore the <i>para</i> position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.
