Composition and Structure of Fibrous Hydroxyapatite Growth on an Injectale Bone Tissue Engineering Scaffolds Material

Fibrous hydroxyapatite （ HA ） wns grown upwards from the crosslinked unsaturated polyphosphoester（ UPPE ） which was used us an injectable bone tissue engineering scaffolds. Composition of fibrous HA was determined by FT- IR, XRD and EDX, which suggested that the fibrous HA was calcium deficient carbonated apatitie with low crystallinity. SEM micrographs indicated that the fibrous HA had a hollow tubing structure and tube wall wus a flakelike assembly. The fibre with poor mechanical property arm with a growth rate about 0. 5 mm/min reached several centimeters in length after 2 hours. The growth was at the tip of the fibre suggested that the procedure of forming fibrous HA was as follows ： Co^2＋ ions were firstly incorporated into the crosslinked UPPE by dipping in Ca^2＋ solution, then supplied through micropores of the material reacted with PO4^3- ions to form α small tuhe , the osmotic pressure or capillary force lead the Ca^2＋ continuously gushed oat into the PO4^3- solution, thus fibrous HA was obtained.

Solitary fibrous tumor:A case report of this multifaceted tumor

BACKGROUND Solitary fibrous tumor(SFT)is a remarkably uncommon mesenchymal tumor.STAT6 level and a combination of clinical,pathological,and molecular features are required to arrive at a proper diagnosis.CASE SUMMARY In this report,we present an intriguing case involving a 43-year-old woman who initially exhibited symptoms of a bleeding retroperitoneal tumor,initially resembling a gastrointestinal stromal tumor,but later confirmed as an SFT.However,a year later,what was initially believed to be a recurrence of her SFT was instead identified as a desmoid tumor.CONCLUSION Distinguishing SFT from other tumors was pivotal.Correcting misdiagnoses of tumor type initially and of recurrence later was necessary for appropriate treatment of the correct desmoid type.

Primary malignant fibrous histiocytoma of the abdominal cavity:CT findings and pathological correlation

AIM:To study computed tomography(CT)features of abdominal malignant fibrous histiocytoma(MFH)in various rare locations.METHODS:We retroprospectively identified cases of MFH involving the abdominal cavity.Particular attention was paid to details regarding imaging features and histological types.RESULTS:The study population consisted of seven men and one woman,with a mean age of 52.5 years.Seven patients had some physical symptoms,while one was incidentally detected.The sites of origin were liver(n=3),greater omentum(n=1),superior mesentery(n=1),ileum(n=1),right psoas muscle(n=1)and right kidney(n=1).With the exception of the ileum lesion,all were of huge size.The contour of the lesions was more or less clear.Foci of necrosis were present in six lesions(n=6).On plain CT scan,all lesions were hypo to iso dense.The lesion in the greater omentum was cystic.One lesion(n=1)showed significant enhancement and the cystic lesion showed mild peripheral enhancement.An abundance of blood vessels surrounding the mass was seen in two lesions(n=2)and both were of the inflammatory variety.Pathological examination revealed storiform-pleomorphic variety(n=4),inflammatory variety(n=3)and myxoid variety(n=1).Two of the patients with inflammatory MFH had a clinical presentation of fever and one was afebrile,however,blood investigations in all three showed leukocytosis.CONCLUSION:Primary MFHs of the abdominal viscera and gastrointestinal tract are generally huge soft tissue masses containing areas of low attenuation and mild to moderate contrast enhancement.

Fiber-Reinforced Silk Microneedle Patches for Improved Tissue Adhesion in Treating Diabetic Wound Infections

Microneedles(MNs)with unique three-dimensional stereochemical structures are suitable candidates for tissue fixation and drug delivery.However,existing hydrogel MNs exhibit poor mechanical properties after swelling and require complex preparation procedures,impeding their practical application.Hence,we engineered chitosan fiber-reinforced silk fibroin MN patches containing epigallocatechin gallate(SCEMN).A formic acid-calcium chloride system was introduced to fabricate hydrogel MNs with excellent inherent adhesion,and the incorporation of chitosan fiber as a reinforcing material enhanced mechanical strength and viscosity,thereby increasing the physical interlocking with tissue and the ability to maintain shape.The SCEMN with a lower insertion force firmly adhered to porcine skin,with a maximum detachment force of 11.98 N/cm2.Additionally,SCEMN has excellent antioxidant and antibacterial properties,facilitates macrophage polarization from M1 to M2,and demonstrates superior performance in vivo for diabetic wound repair compared with the commercial product Tegaderm^(TM).This study represents the first trial of fiber-reinforced hydrogel MNs for robust tissue adhesion.Our findings underscore the significance of this innovative approach for advancing MN technology to enhance tissue adhesion and accel-erate wound healing.

A Constitutive Model for Softening Behaviors of Skin Tissue

Skin tissue is a kind of complex biological material abundant with fibers.A new constitutive model,relating macroscopic responses with microstructural fiber configuration alteration,is developed to investigate the stress softening behaviors of skin tissue observed during cyclic loading-unloading tests.Two influential factors are introduced to describe the impact of fiber configuration change and stretch-induced damage.The present model achieves good agreement between predicted stress distribution of human skin and corresponding ex vivo experimental data obtained from the literature,affirming its capability to effectively capture the characteristic softening behaviors of human skin under cyclic loading conditions.

Fibrous Structure of Connective Tissue of Normal Human Lamina Cribrosa.

Fibrous components and structural morphology of the connective tissue of the lamina cribrosa obtained from 35 normal human autopsy eyes were examined by histochemical staining, transmission electron microscopic and computer-

Clinical pathological analysis and immunohistochemical study of ten solitary fibrous tumors

OBJECTIVE: To study the clinical and pathological characteristics of solitary fibrous tumor (SFT). METHODS: Clinical pathological analysis and immunohistochemical studies were performed on ten patients with SFT. RESULTS: The SFTs located variously and showed different histological features. All cases showed positive staining for CD(34), VM (vimentin) and Bcl-2, but negative staining for Desmin, S-100, CK (cytokeratin) and EMA (epithelial membrane antigen). CONCLUSIONS: SFT is described as a 'patternless' growth pattern. According to clinical pathological features and immunohistochemistry, it is different from other soft tissue tumors. Long-term clinical follow-up is necessary for this kind of tumor.