Influence of Electric Field Direction on Enhanced Transdermal Delivery of Caffeine by Electroporation

Aim To study the influence of electric field direction on the in vitro enhanced transdermal delivery of caffeine by eleetroporation. Methods Using side-by-side compartment diffusion cells method and Ag-Ag/AgCl electrodes, the transport of caffeine through human cadaver skin by electroporation （exponentially decaying pulse, pulse voltage = 350 V, pulse frequency = 4 pulses· min^-1, capacity = 22 μF, pulse length = 7 ms, 25 pulses） with different electric field directions was carried out and compared with passive diffusion and iontophoresis （0.25 mA·cm^ - 2, lasted for 4 h）. Results （i） The cumulative quantity and flux of caffeine through human skin were increased significantly by eleetroporation or iontophoresis. （ii） The transport of caffeine by positive iontophoresis （ with electric field from donor to receptor compartment） was significantly greater than that by negative iontophoresis （with electric field from receptor to donor compartment）. （iii） The transport of caffeine by positive eleetroporation （with electric field from donor to receptor compartment） was similar to that by negative eleetroporation （with electric field from receptor to donor compartment）. （iv） The enhancing effect of positive iontophoresis on the transdermal delivery of caffeine was significantly greater than that of electroporation （positive or negative）. Conclusion Electric field direction significantly influences the enhancing effect of iontophoresis on the transdermal delivery of caffeine, but does not influence the enhancing effect of eleetroporation.

Universal converse flexoelectricity in dielectric materials via varying electric field direction

Flexoelectricity is a symmetry independent electromechanical cou-pling phenomenon that outperforms piezoelectricity at micro and nanoscales due to its size-dependent behavior arising from gradi-ent terms in its constitutive relations.However,due to this gradient term flexoelectricity,to exhibit itself,requires specially designed geometry or material composition of the dielectric material.First of its kind,the present study put forward a novel strategy of achieving electric field gradient and thereby converse flexoelectri-city,independent of geometry and material composition of the material.The spatial variation of the electric field is established inside the dielectric material,Ba_(0.67)Sr_(0.33)TiO_(3)(BST),by manipulating electrical boundary conditions.Three unique patterns of electrode placement are suggested to achieve this spatial variation.This varying direction of electric field gives rise to electric field gradient,the prerequisite of converse flexoelectricity.A multi-physics cou-pling based theoretical framework is established to solve the flexo-electric actuation by employing isogeometric analysis(IGA).Electromechanically coupled equations of flexoelectricity are solved to obtain the electric field distribution and the resulting displace-ments thereby.The maximum displacements of 0.2 nm and 2.36 nm are obtained with patterns I and II,respectively,while pattern III can yield up to 85 nm of maximum displacement.

Three-dimensional transformation of magnetization direction and magnetic field component at low latitudes based on vertical relationship

The transformation of the magnetization direction and the magnetic fi eld component is one of the important methods in magnetic data processing and transformation,which can be conducted in both wavenumber and spatial domains.The transformation method in the wavenumber domain has simpler processing expression and higher processing effi ciency than in the spatial domain;however,they are unstable at low latitude.In this paper,the conclusion that the sum is 0 of two vertical magnetic fi eld components(magnetization inclinations are also perpendicular)in 2D is used for the 3D transformation of the magnetization direction and the magnetic field component.In addition,the transformation method at low latitudes based on vertical relationship(VMT)is proposed,which is an iterative algorithm that converts the transformation of the magnetization direction and the magnetic field component at the low latitude into the high latitude.This method restrains the instability of transformation of constant and variable magnetization direction and magnetic fi eld components in low latitudes.The accuracy,stability,and practicality are verifi ed from synthetic models and real data.

A model for the response of wave directions in slowly turning wind fields

On the basis of the wave energy balance equation, the response model of mean directions of locally wind-generated waves in slowly turning wind fields has been derived. The results show that in a homogeneous field, the time scale of the response is not only related to the rate of wave growth, but also to the directional energy distribution and the angle between the wind direction and the mean wave direction. Furthermore, the law of change in the mean wave direction has been derived. The numerical computations show that the response of wave directions to slowly turning wind directions can be treated as the superposition of the responses of wave directions to a series of sudden small-angle changes of wind directions and the turning rate of the mean wave direction depends on the turning rate and the total turning angles of the wind direction. The response of wave directions is in agreement with the response for a sudden change of wind directions if the change in wind directions is very fast. Based on the normalized rates of wave growth under local winds presented by Wen et al. (1989), a quantitative estimate of the time scale of the response shows that the relationships between the dimensionless time scale and both the dimensionless total wave energy and the dimensionless peak frequency agree fairly well with the observations in comparison with other models.

Detection of the movement direction by the cells with directional receptive fields in the primary visual cortex of the cat

The study was performed on neurons with direction selective (DS) receptive fields (RFs) in the primary visual cortex of the cat. Preferred directions (PDs) of these cells to a single light spot and a system of two identical light spots moving across the RF with a given angle between them were compared. Directional interactions appeared when the angles between the directions of the two moving spots were 30o or 60o. PD for 56% of the cells coincided with bisectors of these angles. These cells responded to a combination of the two moving stimuli as if only one stimulus moved in the RF in an intermediate direction. This direction coincided with PD of the DS neuron to a single spot. Also, the investigation revealed that DS neurons responded to stimuli moving at such angles as 180o (to preferred and opposite directions simultaneously). In the further experiment we investigated responses of the DS cells in the primary visual cortex of RF. The angle between the directions of the two moving spots was 60o. These cells responded to a combination of the two moving stimuli as if only one stimulus moved in RF in an intermediate direction. The more relative luminance of one of spots in pair was, the closer the intermediate direction approached to the direction of this spot).

Effects of direct current electric field on corrosion behaviour of copper, Cl- ion migration behaviour and dendrites growth under thin electrolyte layer

Effect of direct current electric field （DCEF） on corrosion behaviour of copper printed circuit board （PCB-Cu）, Cl-ion migration behaviour, dendrites growth under thin electrolyte layer was investigated using potentiodynamic polarization and scanning electron microscopy （SEM） with energy dispersive spectrometer （EDS）. Results indicate that DCEF decreases the corrosion of PCB-Cu;Cl-ions directionally migrate from the negative pole to the positive pole, and enrich on the surface of the positive pole, which causes serious localized corrosion; dendrites grow on the surface of the negative pole, and the rate and scale of dendrite growth become faster and greater with the increase of external voltage and exposure time, respectively.

Grain refinement of pure aluminum by direct current pulsed magnetic field and inoculation

The combined effects of direct current pulsed magnetic field （DC-PMF） and inoculation on pure aluminum were investigated, the grain refinement behavior of DC-PMF and inoculation was discussed. The experimental results indicate that the solidification micro structure of pure aluminum can be greatly refined under DC-PMF. Refinement of pure aluminum is attributed to electromagnetic undercooling and forced convection caused by DC-PMF. With single DC-PMF, the grain size in the equiaxed zone is uneven. However, under DC-PMF, by adding 0.05% （mass fraction） Al5Ti-B, the grain size of the sample is smaller, and the size distribution is more uniform than that of single DC-PMF. Furthermore, under the combination of DC-PMF and inoculation, with the increase of output current, the grain size is further reduced. When the output current increases to 100 A, the average grain size can decrease to 113 μn.

Studies on sedimentary events in Mariana Trough and characteristics of geomagnetic field change

The analysis on the magnetic fabric of profile of the sedimentary core taken in five stations in the small spreading ridge area in Mariana Trough shows that the effect of indicating its depositional fabric, sedimentary rhythm.sedimentary events, sedimentary interfaces and sediment composition as well as sedimentary dynamic environment by magnetic. Parameters is clearer than that by traditional method of analysis. The indication of sedimentary events can show its high resolution. The study on the Late Quaternary sedimentary events in this area shows that this area underwent four big events of sudden change in the Holocene epoch based on the sudden change of underflow direction and the position relationship between ash beds and erosion sediment layers. The sudden change of underflow direction is a believable evidence for judgement and study of sudden event within this area. The direction changes of its geomagnetic field show three morphotypes i. e. relatively stable type and non-stable type of oscillatory amplitude of magnetic inclination (Inc) which existed during the relatively stable period of amplitude of magnetic declination (Dnc). Anothertype is characterized by big amplitude of both inclination and declination.The space-time series of the three type mentioned above is a new way for forming a high-resolution stratigraphical timetable.

Control Efficiency and Crop Safety of 20% Cyhalofop-butyl WP on Grass Weeds in Direct Seeded Rice Fields

The purpose was to define the control efficiency and safety of 20% cy- halofop-butyl WP on grass weeds in direct seeded rice fields, in order to provide the basis for chemical weeding. This study measured Leptochloa chinensis（L.） Nees, Echinoch/oa crusgalli （L.） Beauv and other gramineous weed control efficiency with four concentrations of 20% cyhalofop-dutyl WP and 100 g/L cyhalofop-dutyl EC in direct seeded rice fields, and analyzed the yield-increasing effect and safety of rice. The results showed that 20% cyhalofop-butyl WP had a good control efficiency on grass weeds such as Leptochloa chinensis（L.） Nees, Echinoch/oa crusgalli（L.） Beauv and other grasses. The effective dosage of 90-150 g/hm2 was over 90.7% on Lep- foch/oa chinensis（L.） Nees and the comprehensive control effect of the grass weeds was above 86.7%, which was basically consistent with 100 g/L cyhalofop-dutyl EC. Furthermore, 20% cyhalofop-dutyl WP was high security for direct seeded rice fields. The yield of rice was increased by 10.18%-11.22% after spraying herbicide. There- fore, 20% of cyhalofop-dutyl WP can be used as a special herbicide for controlling Leptochloa chinensis（L.） Beauv in direct seeded rice fields, and has a good applica- tion prospect.

Single Bubble Behavior in Direct Current Electric Field

The investigation on bubble behavior in electric field helps to analyze the mechanism of electric enhancement of boiling heat transfer. Experiments were performed to investigate the bubble deformation in direct current （DC） electric field with bubbles attached to the orifice. The air bubbles were slowly generated in the transformer oil pool at different orifices, so that the effect of flow on bubble shape was eliminated. The results showed that the bubbles were elongated and the departure volume decreased when the electric field was intensified. The major and minor axes, aspect ratio and departure volume increased with increasing the orifice diameter. Both the electric field and orifice size have great influence on bubble behavior. The bubble deformation was also simulated to compare with the experimental results. The numerical and experimental data qualitatively agree with each other.

Horizontal-Longitudinal Spatial Correlation of Acoustic Field with Deep Receiver in the Direct Zone in Deep Water

The horizontal-longitudinal correlation of acoustic field for the receiver near the bottom is analyzed by using nu- merical modeling. An approximate analytical solution of horizontal-longitudinal correlation coefficient is derived based on the ray method. Combining the characteristic of Lloyd＇s mirror interference pattern, the variability of acoustic field and its effect on horizontal-longitudinal spatial correlation are discussed. The theoretical pre- diction agrees well with the numerical results. Experimental results confirm the validity of analytical solution. Finally, the applicability of the analytical solution is summarized. The conclusion is beneficial for the design of bottom-moored array and the estimation of integral time for moving source localization.

Reversal of radial glow distribution in helicon plasma induced by reversed magnetic field

In this work, the reversal of radial glow distribution induced by reversed magnetic field is reported. Based on the Boswell antenna which is symmetric and insensitive to the magnetic field direction, it seems such a phenomenon in theory appears impossible. However, according to the diagnostic of the helicon waves by magnetic probe, it is found that the direction of magnetic field significantly affects the propagation characteristic of helicon waves, i.e., the interchange of the helicon waves at the upper and the lower half of tube was caused by reversing the direction of magnetic field. It is suggested that the variation of helicon wave against the direction of magnetic field causes the reversed radial glow distribution. The appearance of the traveling wave does not only improve the discharge strength, but also determines the transition of the discharge mode.

Chemical Weeding in Dry Direct Seeding Fields of Single Cropping Middlelate Rice

Chemical weeding in dry direct seeding fields of single cropping middle-late rice was studied in Huida vegetable farm of Huizhou City in 2012. The main treatment was herbicide（ pretilachlor ＋ bensulfuron-methyl,Yangguo and butachlor）,and the sub-treatment was application method（ soil treatments,seedling treatment and integrated treatment）. The results showed that 80 g pretilachlor ＋ bensulfuron-methyl（ 36% pretilachlor ＋ 4% bensulfuron-methyl） diluted with 50 kg water could be sprayed or 200 g Yangguo（ 23. 9% butachlor ＋ 1. 1% bensulfuron-methyl） mixed with 15 kg sandy soil could be broadcasted per 667 m2 on the sowing day or the second day under moist condition of soil,which could effectively control weeds in dry direct seeding fields of single cropping middle-late rice.

基于Haar小波变换的重力场方向性适配区选取方法

水下重力场适配区的选取在重力匹配导航系统中起着至关重要的作用,传统适配区选取方法通常以重力场区域统计特性作为评价标准,而存在对方向适配性特征描述不准确的问题,在适配区中往往存在某一航向轨迹的匹配精度大幅下降的情况。针对此问题,提出一种基于Haar小波变换的方向性适配区选取方法,将小波变换后得到的高频信息图进行再组合,从而得到针对于任意指定航向的重力高频信息图。通过对某一海域的船载重力数据进行实验验证,基于所提方法可以根据当前航向选取出更具有针对性的适配区域,适配区内匹配率提升6.3%。所提出的方法不仅解决了现有适配区选取方法对方向适配性描述不准确的局限性,而且为潜航器选择以何种航向进入适配区起到了指导性作用。

海峡海域海洋环境噪声三维空间特性分析

研究了与其他海底海域有显著差异的海峡海域的环境噪声特性。假设海洋环境噪声源均匀分布于接收阵上方海面的圆形范围内,利用考虑声线水平折射的3D射线声传播理论,仿真计算了V字型海峡地形下环境噪声的高频与低频特性,分析了不同方位角内海洋环境噪声空间特性。研究发现,海峡海底会影响水平方向的声传播过程,使声能量在一定程度上会聚。当接收阵位于海峡海底正上方位置时,来自海面的噪声随着接收深度的增加向海峡中心位置会聚,并且在某些深度形成水平会聚区。对于由海面噪声源辐射到达声道轴深度的声能量,海峡的存在使声能量沿海峡传播时不会从海峡内部泄漏,而声能量跨越海峡传播时其损失也较小。

近距离煤层群隔层“探、治”瓦斯技术体系研究及应用

为解决贵州地区近距离复杂群层群采掘过程中邻近煤层瓦斯防治难题,提出了包括邻近煤层瓦斯参数探查技术、保护层开采上覆岩层“三带”范围考察技术和邻近煤层瓦斯抽采防治技术的隔层“探、治”瓦斯技术体系。该技术体系在安顺煤矿的应用结果表明:M9煤层工作面采空区冒落带和裂隙带高度分别约为3.8 m和15.7 m,能够有效增益上覆M8煤层瓦斯治理;临近煤层瓦斯抽采效果受到抽采孔空间位置、长度和工作面推进情况影响,高位钻场、高位巷、高位定向长钻孔和密集穿层高位钻孔抽采方式的抽采纯量分别能达到12、37.7、10.0、40.1 m^(3)/min,高位巷和密集穿层高位钻孔抽采效果更优。研究成果为贵州地区煤层群瓦斯高效治理提供了理论和工程实践基础。

基于逐层扩张卷积的3D牙颌实例分割

在计算机辅助的正畸手术规划和牙齿识别中,准确地从3D牙颌模型中分割出每颗牙齿至关重要。无需候选区域的分割方法虽然高效且易用,但存在诸多限制:在局部特征聚合时,现有方法依赖欧氏距离寻找特征空间内最近的多个网格单元,只能实现较小的感受野,这可能导致对牙齿网格的错误预测;此外,现有方法未充分考虑3D牙颌模型的方向性和同一牙齿实例的网格单元间的潜在信息。针对上述问题,提出一种名为“逐层扩张卷积”的卷积方法,它能在有效提取特征的同时,不增加任何计算成本;同时,提出方向特征对齐模块和潜在信息挖掘模块,以进一步优化牙颌分割结果。在真实采集的3D牙颌内口扫描数据集上的实验结果表明,所提方法在总体准确率(OA)和平均交并比(mIoU)方面分别达到了98.46%和94.47%,相较于TSGCNet(Two-Stream Graph Convolutional Network),分别提升了3.27个百分点和10.45个百分点。

横向静磁场对Cu-10%Ag合金定向凝固组织的影响

在有无横向静磁场条件下进行了Cu-10%Ag(质量分数)合金定向凝固实验,研究了横向磁场对Cu-10%Ag合金的宏观组织和微观组织及硬度的影响。发现无磁场条件下,合金晶粒较长,尺寸粗大,初生Cu枝晶臂直径和间距较粗大,取向较好,共晶组织粗大;1T横向磁场条件下,晶粒细化、增多,枝晶臂直径和间距较小,取向消失,共晶组织细化,硬度提高。通过对比有无横向磁场条件下初生Cu枝晶以及共晶组织变化,讨论了横向磁场对初生Cu枝晶及共晶组织的影响机理。

一维线阵离轴高斯光束的远场发散角和方向性

根据广义惠更斯-菲涅尔原理,采用积分变换,推导出一维线阵离轴高斯光束通过自由空间传输的远场发散角解析式,以研究其远场发散角的特性和方向性.研究表明:一维线阵离轴高斯光束的远场发散角随子光束数目增加和子光束相对间距减小而减小;当子光束数目和相对间距增大到一定值后,远场发散角变化缓慢;在一定条件下,一维线阵离轴高斯光束与单束高斯光束具有相同的方向性.

Positive direction of polarization-induced electric field improves formic acid electrooxidation on Pd

Adjusting the adsorption energy of adsorbates on catalyst can directly regulate the catalytic performance and reaction pathways of heterogeneous catalysis.Herein,we report a novel strategy,introducing polarization-induced electric field(PIEF)with different directions,to manipulate the adsorption energy of intermediates and reaction pathway of formic acid electrooxidation on Pd.Tourmaline nanoparticles are applied as the PIEF provider,of which the direction is successfully controlled via aligning the dipoles in tourmaline in a strong external electric field.Experimental and theoretical results systematically reveal that positive PIEF leads to an electron-deficient state of Pd,reduced adsorption energy of COad,enhanced adsorption energy of*HCOOH and*OH,and promoted formate pathway of formic acid electrooxidation.Pd/TNP+/FTO,with the aid of positive PIEF,shows three-fold enhancement in the formic acid electrooxidation(4.74 mA·cm^(−2))with high durability and anti-poisoning ability compared with pristine Pd.This study leads a new route to design formic acid electrocatalysts and provides an understanding on how to control the adsorption energy of adsorbates on electrocatalysts by an internal electric field.