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DEM simulations of die filling during pharmaceutical tabletting 被引量:6
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作者 Chuan-Yu Wu 《Particuology》 SCIE EI CAS CSCD 2008年第6期412-418,共7页
The flow behaviour of powders from a stationary shoe into a moving die, which mimics the die filling process in a rotary tablet press, was analysed using a discrete element method (DEM), in which 2D irregular shaped... The flow behaviour of powders from a stationary shoe into a moving die, which mimics the die filling process in a rotary tablet press, was analysed using a discrete element method (DEM), in which 2D irregular shaped particles were considered. The influence of the particle shape, size and size distribution, the number of particles used in the simulation, the initial height of powder bed in the shoe, and the filling speed on the average mass flow rate and the critical filling speed (the highest speed at which the die can be completely filled) were explored. It has been found that a maximum flow rate is obtained at the critical filling speed for all systems investigated and poly-disperse systems have higher mass flow rates and higher critical filling speeds than mono-disperse systems. In addition, the powder with particles which can tessellate generally has a lower filling rate and a lower critical titling speed. 展开更多
关键词 DEM Die filling TABLETTING Powder compaction Mass flow rate Critical filling speed
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