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keep one's fingers crossed
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作者 张其云 《英语知识》 2000年第1期34-34,共1页
keep one s fingers crossed 的字面意思是将手指交叉起来,通常是用中指压住食指,也有人习惯于食指压住中指。这个短语的比喻意义是 to hope that nothing will happento upset one s plans,即“希望一切如愿”“但愿别出差错”。如:He ... keep one s fingers crossed 的字面意思是将手指交叉起来,通常是用中指压住食指,也有人习惯于食指压住中指。这个短语的比喻意义是 to hope that nothing will happento upset one s plans,即“希望一切如愿”“但愿别出差错”。如:He is keeping his fingers crossed that itwon t rain on Sunday when he wants to playfootball.他想星期天去踢球。 展开更多
关键词 基督教徒 keep one’s fingers crossed
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Individualized music for dementia:Evolution and application of evidence-based protocol 被引量:3
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作者 Linda A Gerdner 《World Journal of Psychiatry》 SCIE 2012年第2期26-32,共7页
The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded versio... The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded version of the protocol was written for professional health care providers with a consumer version tailored for family caregivers. The underlying mid-range theory is presented along with a seminal study that was followed by further research in the United States, Canada, Great Britain, France, Sweden, Norway, Japan and Taiwan. Key studies are summarized. Given its efficacy when implemented by research staff, studies have advanced to testing the intervention under real-life conditions when implemented and evaluated by trained nursing assistants in long-term care facilities and visiting family members. In addition, one study evaluated the implementation of music by family members in the home setting. Initial research focused on agitation as the dependent variable with subsequent research indicating a more holistic response such as positive affect, expressed satisfaction, and meaningful interaction with others. The article advances by describing on-line programs designed to train health care professionals in the assessment, implementation and evaluation of individualized music. In addition, Gerdner has written a story for apicture book intended for children and their families(in press). The story models principles of individualized music to elicit positive memories, reduce anxiety and agitation, and promote communication. The article concludes with implications for future research. 展开更多
关键词 individualized MUsIC DEMENTIA Alzheimer’s disease AGITATION EVIDENCE-BAsED PROTOCOL
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Timing of individualized surgical intervention in Crohn’s disease 被引量:1
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作者 Kai Xia Ren-Yuan Gao +2 位作者 Xiao-Cai Wu Lu Yin Chun-Qiu Chen 《World Journal of Gastrointestinal Surgery》 SCIE 2022年第12期1320-1328,共9页
Crohn’s disease(CD)is a chronic inflammatory disorder of the gastrointestinal tract with an increasing incidence worldwide.Comprehensive therapy for CD focuses on symptom control and healing the intestinal mucosa to ... Crohn’s disease(CD)is a chronic inflammatory disorder of the gastrointestinal tract with an increasing incidence worldwide.Comprehensive therapy for CD focuses on symptom control and healing the intestinal mucosa to improve the quality of life and prevent complications.Surgical intervention plays a vital role in comprehensive therapy.However,deciding the optimal timing for surgical intervention has long been a focus of controversy.This review provides insights into the timing of surgery for CD and guides clinicians in daily treatment. 展开更多
关键词 Crohn’s disease surgical intervention Timing of surgery individuALIZATION THERAPY
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Identification of Microplankton in South China Sea with Image-Matching Individual PCR
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作者 LI Si YANG Guanpin +1 位作者 ZHU Baohua PAN Kehou 《Journal of Ocean University of China》 SCIE CAS CSCD 2019年第1期219-226,共8页
In this study, marine microplankton were identified by combining standard light microscopy with Sanger 18S rRNA gene sequencing. The image-matching individual PCR technique was applied to identify the image collectabl... In this study, marine microplankton were identified by combining standard light microscopy with Sanger 18S rRNA gene sequencing. The image-matching individual PCR technique was applied to identify the image collectable unicellular microplankton to genera. Instead of pure strain culture and morphological identification, microplankton individual cells were isolated and fixed with glutaraldehyde, frozen and stored for months. Finally, they were imaged under a microscope and molecularly identified via phylogenetic analysis of their 18S ribosomal RNA gene(18S rDNA). Microplankton cells were collected at 30 locations in South China Sea, and were assigned to 21 known and 4 unidentified genera(2 uncultured fungi and 2 uncultured stramenopiles) with phylogenetic analysis in parallel to the morphological identification. 展开更多
关键词 image-matching individuAL PCR MICROPLANKTON 18s ribosomal RNA gene morphological IDENTIFICATION molecular IDENTIFICATION south China sea
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Understanding the individual with Alzheimer’s disease: Can socioemotional selectivity theory guide us?
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作者 Ruth E. Mark 《Advances in Alzheimer's Disease》 2012年第3期77-86,共10页
Individuals often get lost behind the diagnosis of Alzheimer’s disease (AD) while widespread differences between these patients are morecommon than similarities. Socioemotional Selectivity Theory (SST) suggests that ... Individuals often get lost behind the diagnosis of Alzheimer’s disease (AD) while widespread differences between these patients are morecommon than similarities. Socioemotional Selectivity Theory (SST) suggests that as we age our goals change from future-oriented (acquiringnew information) to present-oriented (enhancing the emotional, especially positive, meaning of encounters). The goal of the current article is to examine whether the principles of SST might also apply for people with AD. Some aspects of SST are found especially in the early stages of AD when awareness is often intact and cognitive impairment is relatively limited. This review has clinical significance for the treatment of AD because it focuses on what is important to the individual rather than treating patients as a homogenous group. It also highlights the importance of social networks and emphasizes the role of the proxy in AD care. Lastly, it suggests that if those with AD (like the healthy elderly) have a positivity bias then positive emotional stimuli/wording/instructions could usefully be employed in their daily treatment. I suggest that SST may be a useful starting point when attempting to address what matters to individuals with AD and conclude by providing a few suggestions for future studies. 展开更多
关键词 Alzheimer’s Disease socioemotional sELECTIVITY Theory individuAL Differences Awareness POsITIVITY Bias sOCIALIZATION
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A Review on Ethnomedicinal, Pharmacological, Phytochemical and Pharmaceutical Profile of Lady’s Finger (<i>Abelmoschus esculentus</i>L.) Plant
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作者 Nargis Sultana Chowdhury Sifat Jamaly +2 位作者 Farhana Farjana Nadira Begum Elina Akher Zenat 《Pharmacology & Pharmacy》 2019年第2期94-108,共15页
Abelmoschus is a genus of about fifteen species belongs to the family Malvaceae. The herb, popularly known as Lady’s Finger or Okra (in English) is a nutritional source used for both medicinal and culinary purposes. ... Abelmoschus is a genus of about fifteen species belongs to the family Malvaceae. The herb, popularly known as Lady’s Finger or Okra (in English) is a nutritional source used for both medicinal and culinary purposes. The plant is widely distributed from Africa to Asia, Southern Europe, and America. This comprehensive account provides a botanical description of the plant, its phytochemical constituents and pharmacological activities focusing anti-diabetic, anti-oxidant, anti-adhesive, gastro-protective, hepatoprotective, and immunomodulating actions. Most of the pharmacological effects can be explained by the constituents like tannins, terpenoids, flavonoids and glycosides present in all plant parts. However, future efforts should concentrate more on in vitro and in vivo studies and also on clinical trials in order to confirm traditional wisdom in the light of a rational phytotherapy. The present review is an overview of phytochemistry and ethnopharmacological studies that support many of the traditional?ethnomedicinal uses of the plant. 展开更多
关键词 Lady’s finger Abelmoschus esculentus MEDICINAL Plants PHYTOCHEMICALs PHARMACOLOGICAL Activities
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Research of Social Problems under Global Vision, Local Consciousness and People's Standard --Take analysis of the design intention of individual account as example
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作者 Wang Min Min Zhu Yi 《International English Education Research》 2015年第5期78-80,共3页
In the study of social problems, it is important to realize the organic combination of global view, local people standard,, which plays an important role in handing and understanding specific social problems undoubted... In the study of social problems, it is important to realize the organic combination of global view, local people standard,, which plays an important role in handing and understanding specific social problems undoubtedly. This article takes our country's public pension personal account as example ,analyzing how to realize the combination of all three in the whole research process of the individual account. 展开更多
关键词 global view native consciousness people's standard individual account
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Analysis on the Individual Discrepancy in English Teaching
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作者 罗兰 《海外英语》 2011年第15期88-90,共3页
Recently, a great tide of English teaching reform swept across China, advocating the innovation of educational concept and teaching mode. However, the phenomenon of rigid uniformity in teaching process is still common... Recently, a great tide of English teaching reform swept across China, advocating the innovation of educational concept and teaching mode. However, the phenomenon of rigid uniformity in teaching process is still commonly seen, neglecting the individual discrepancy of students. The individual discrepancy is manifested by both the congenital heredity and the acquired disposition. Supported by the Chinese traditional theory of teaching students in accordance with their aptitude and Vygotsky's "the zone of proximal development" theory, this paper illustrates the importance of paying attention to the individual discrepancy from the perspective of students' growing background and personality. In addition, standing on the point of view of relevant authority and English teacher, the author tries to put forward some countermeasures. 展开更多
关键词 individuAL DIsCREPANCY teaching students in accordance with their APTITUDE the zone of PROXIMAL development (ZPD) teacher’s role
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The Birth of Modern Poetry:Tradition and Individual Talent——An Understanding of T. S. Eliot's Critical Essay‘Tradition and Individual Talent'in comparison with Nietzsche's Spirits of Tragedy
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作者 熊若琳 《海外英语》 2019年第2期210-213,共4页
As one of the most significant critical essays of T.S.Eliot,Tradition and Individual Talent has defined writing as a process during which the primitive oneness has seized the individual writer of figurative descriptio... As one of the most significant critical essays of T.S.Eliot,Tradition and Individual Talent has defined writing as a process during which the primitive oneness has seized the individual writer of figurative descriptions to help represent itself.This theory has latter been practiced in Eliot’s Wasteland,and shows its similarity with The Birth of Tragedy,written by Friedrick Nietzsche,the German philosopher.Eliot’s‘tradition’has been concluded by Nietzsche as‘Dionysian Spirit’,which represents oneness transcending good and evil,past and present,while‘individual talent’has resembled‘Apollonian Spirit’in the urge for original figuration as an apparatus.The paper aims to explain and compare the definitions of‘tradition’and‘individual talent’of Eliot’s work with that of‘Dionysian spirit’and‘Apollonian Spirit’in Nietzsche’s illustrations,so as to provide a deeper understanding of these two works by unveiling the individual and social sameness and difference of Eliot and Nietzsche. 展开更多
关键词 T.s.Eliot Friedrick NIETZsCHE TRADITION TRADITION and individuAL TALENT TRAGEDY Dionysian spirit Modernity
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Teacher's in-Class Feedback Based on Individual Learner Differences in EFL Writing Classroom
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作者 王荣荣 《海外英语》 2019年第3期253-256,260,共5页
Studies on feedback in second language(L2) writing have mainly focused on feedback per se, with little attention paid tothe individual learner differences. This study investigates how teacher’s in-class feedback base... Studies on feedback in second language(L2) writing have mainly focused on feedback per se, with little attention paid tothe individual learner differences. This study investigates how teacher’s in-class feedback based on individual learner differencesaffects EFL students’correction of writings and students’attitude towards teacher’s in-class feedback based on their individualdifference, as well as the factors that influence teachers’feedback among three EFL students and an in-service English teacher byemploying interviews, classroom observations. The findings indicate that students pay more attention to their errors in their writingsand students hold a positive attitude towards teacher’s in-class feedback based on their individual differences, students’aptitudeand personality mostly affect teacher’s in-class feedback. 展开更多
关键词 teacher’s in-class feedback individuAL LEARNER DIFFERENCEs students’aptitude students’personality EFL writing
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The Effects of Learner’s Individual Differences on the Written Corrective Feedback
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作者 付璐 《海外英语》 2020年第9期263-265,共3页
From the perspective of individual learner differences,this paper aims to show the readers an outline of the influence of individual learner differences on written corrective feedback.Based on 200 eighth and ninth gra... From the perspective of individual learner differences,this paper aims to show the readers an outline of the influence of individual learner differences on written corrective feedback.Based on 200 eighth and ninth grade junior high school students’thinking patterns and tests,60 students were selected as subjects in this study.Based on the comparative analysis and error analysis in second language acquisition as the main theoretical basis,this study analyzed the common types of errors in the use of nonpredicate verbs in junior high school students and their causes.There are three main questions in this study:how about the error frequency of the five forms(present participle,past participle,infinitive,gerund and independent nominative structure)in the nonpredicate verb learning of junior high school students?What kind of mistakes do junior high school students make in the process of learning non-predicate verbs?According to the conclusion of the investigation and research,the author puts forward some suggestions from the aspects of teachers and students in the last part of the article. 展开更多
关键词 learner’s individual differences written corrective feedback second language acquisition cognitive factors mode of thinking
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Clinical study of correction of finger flexion deformity in Dupuytren's disease
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作者 沈尊理 《外科研究与新技术》 2011年第4期270-270,共1页
Objective To explore surgical technique and its result in correcting finger contracture in Dupuytren’s disease. Methods Seventeen cases of Dupuytren’s disease with 58 years mean age were studied in this group ( 15 m... Objective To explore surgical technique and its result in correcting finger contracture in Dupuytren’s disease. Methods Seventeen cases of Dupuytren’s disease with 58 years mean age were studied in this group ( 15 males and 2 females) . Among them,8 sides were with flexion eontracture of little finger,8 sides with flexion contracture of little and ring fingers,1 side with 展开更多
关键词 Clinical study of correction of finger flexion deformity in Dupuytren’s disease
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北京沙尘暴的干盐湖盐渍土源——单颗粒物分析和XPS表面结构分析 被引量:18
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作者 张兴赢 庄国顺 袁蕙 《中国环境科学》 EI CAS CSCD 北大核心 2004年第5期533-537,共5页
2002年3月20日北京特大沙尘暴565个单颗粒物分析结果表明,S和Cl是唯一呈现显著正相关的一对元素.同时含有S和Cl的单颗粒物检出率高达82.5%,其中S和Cl的含量还高于所有颗粒物平均值.同时含有S、Cl和Na的颗粒物检出率为62.0%,其中Na的含... 2002年3月20日北京特大沙尘暴565个单颗粒物分析结果表明,S和Cl是唯一呈现显著正相关的一对元素.同时含有S和Cl的单颗粒物检出率高达82.5%,其中S和Cl的含量还高于所有颗粒物平均值.同时含有S、Cl和Na的颗粒物检出率为62.0%,其中Na的含量更比所有颗粒物平均值高出1.4倍.PMF因子分析显示NaCl和Na2SO4是北京沙尘暴S和Cl显著相关的那些单颗粒物的主要成分.沙尘暴样品中SO42-和Cl-浓度呈高度线性相关.X射线光电子谱对气溶胶表面结构分析显示,Na和S在沙尘暴颗粒物表面的百分含量比北京非沙尘暴和内蒙古地区气溶胶样品高.这些同时含有S、Cl和Na,且S和Cl显著正相关,Na相对富集的颗粒物多数来自于沙尘暴途中所经过的其表层土成分富含氯化物和硫酸盐的干盐湖盐渍土地区.证明了北京沙尘暴不仅来自于其源头沙漠,沙尘暴所经过的包括干盐湖盐渍土的大范围干旱、半干旱地区的表层土也是其主要来源. 展开更多
关键词 沙尘暴 单颗粒物分析 XPs表面结构分析 氯-硫相关 干盐湖盐渍土
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基于B/S模式的医学影像学网络化教学平台的设计 被引量:2
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作者 辛立强 李劲华 +2 位作者 贾小珠 孟庆兰 刘丰春 《青岛大学学报(工程技术版)》 CAS 2012年第4期22-24,共3页
为实现医学影像归档与通信系统在医学影像学教学上的应用,本文采用B/S模式及模块化结构设计方法,构建了一个医学影像学网络化教学平台,在.net平台下,运用C#编程及SQL Server数据库管理等计算机技术,使服务器端与客户端的交互式连接,完... 为实现医学影像归档与通信系统在医学影像学教学上的应用,本文采用B/S模式及模块化结构设计方法,构建了一个医学影像学网络化教学平台,在.net平台下,运用C#编程及SQL Server数据库管理等计算机技术,使服务器端与客户端的交互式连接,完成了在线浏览学习、自我检测、素材管理和公共讨论等功能。该设计为医学影像学教学提供了一种互动、自主、不受时空限制的全新教学模式,改善了教学效果,提高了教学质量。 展开更多
关键词 B s模式 个性化 交互 网络教学平台 医学影像学
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30例献血者ELISA检测HBsAg高S/CO值阴性标本在血液核酸混检与单检中的结果分析 被引量:8
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作者 陈少彬 陈庆恺 +2 位作者 何子毅 余霖 王庆 《中国输血杂志》 CAS 2021年第5期528-531,共4页
目的比较某核酸检测系统混检和单检2种模式对ELISA法HBsAg检测S/CO值在0.25~0.90的献血者血液标本的结果,为重新评估此类标本的核酸检测安全性和优化检测流程提供参考。方法收集本站2020年2~10月献血者血液标本进行2遍ELISA法HBsAg检测... 目的比较某核酸检测系统混检和单检2种模式对ELISA法HBsAg检测S/CO值在0.25~0.90的献血者血液标本的结果,为重新评估此类标本的核酸检测安全性和优化检测流程提供参考。方法收集本站2020年2~10月献血者血液标本进行2遍ELISA法HBsAg检测均为无反应性且任1种试剂S/CO值在0.25~0.90(定义为"高S/CO值阴性")的标本共30例,分别进行核酸6人份混检和单检;对其中混检阴性而单检阳性的11例标本再次进行多次重复的核酸混检,记录和分析各检测结果。结果30例标本在2种ELISA试剂的S/CO值中位数分别为:0.565和0.320,差异有统计学意义(P<0.01);进行首次核酸混检阳性率为13.33%(4/30),核酸单检的阳性率为76.67%(23/30),2种模式的阳性率差异有统计学意义(P<0.05);11例核酸混检阴性而单检阳性的标本再次进行多次重复混检,有1例重复10次混检均为阴性结果,有10(90.91%)例标本能重现至少1次阳性结果,重复阳性率范围是5.88%(1/17)~70.00%(7/10);核酸检测的Ct值在首次混检时范围是34.4~38.5(中位数36.76),在单检的Ct值范围29.6~42.8(中位数36.50),而在多次重复混检的Ct值范围36.1~56.0(中位数37.75),重复混检Ct值与首次混检Ct值的差异无统计学意义(P>0.05),而与单检Ct值的差异有统计学意义(P<0.01)。结论酶免检测HBsAg高阴性值标本进行核酸混检的阳性检出率低,而单检的阳性检出率高,多次重复核酸混检能重现出一定比例阳性检出率;因此,以核酸混检模式为主的血站应重新评估HBsAg高阴性值标本的核酸检测安全性,在没有其他更高灵敏度的检测方法作为辅助诊断时,建议此类标本直接采用核酸单检模式,以提高血液安全性。 展开更多
关键词 HBsAG s/CO值阴性标本 核酸检测 混检 单检 献血者
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基于B/S多层结构的个性化网络教学系统设计 被引量:6
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作者 兰丽娜 文福安 王建坤 《吉林大学学报(信息科学版)》 CAS 2007年第3期308-313,共6页
针对现有网络教学系统支持个性化学习的不足,提出了5个方面的个性化策略,并给出了一种个性化的网络教学系统设计。该设计采用基于B/S(Browser/Server)的多层体系结构,其中服务层分为应用服务层和公共服务层。公共服务层的引入提高了系... 针对现有网络教学系统支持个性化学习的不足,提出了5个方面的个性化策略,并给出了一种个性化的网络教学系统设计。该设计采用基于B/S(Browser/Server)的多层体系结构,其中服务层分为应用服务层和公共服务层。公共服务层的引入提高了系统的可重用性和可扩展性;系统提供个性化信息过滤,具有明显的智能性个性化特点。软件实现采用Struts+Spring+Hibernate技术架构。系统已在近20所中小学校示范应用,效果良好。 展开更多
关键词 网络教学系统 个性化 B/s多层结构 公共服务层 可重用性 信息过滤
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B/S模式的个性化交互式网络教学平台的结构与设计 被引量:39
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作者 龙银香 《计算机与现代化》 2005年第6期23-26,29,共5页
网络教学支持平台的建设是从事网络教学或网络辅助教学的基础设施,需要综合网络通信技术、网络多媒体技术、网络编程技术、网络数据库技术、虚拟现实和人工智能等技术。B/S结构的软件工作模式具有许多优点,非常适合于网络教学支持平台... 网络教学支持平台的建设是从事网络教学或网络辅助教学的基础设施,需要综合网络通信技术、网络多媒体技术、网络编程技术、网络数据库技术、虚拟现实和人工智能等技术。B/S结构的软件工作模式具有许多优点,非常适合于网络教学支持平台的开发。个性化和交互性是网络教学平台的核心和灵魂。本文提出了一个基于B/S模式的网络教学支持平台的五层体系结构,分析了其功能组成,并给出了一个笔者设计的用于网络辅助教学的网络教学支持平台,它包含网络教学支持平台所应具备的核心功能,在个性化和交互方式的设计上有一些独特的考虑。 展开更多
关键词 B/s模式 个性化 交互 网络教学平台 体系结构
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粉防己碱对胃癌耐药细胞ZNF139、MDR1及GST-π mRNA的影响 被引量:5
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作者 张旭 《东南大学学报(医学版)》 CAS 2018年第3期467-470,共4页
目的:探讨粉防己碱(TET)对胃癌耐药细胞锌指蛋白139(ZNF139)、多耐药基因1(MDR1)及谷胱甘肽S转移酶-π(GST-π)mRNA的影响。方法:选取胃癌细胞SGC7901以及胃癌耐阿霉素细胞SGC7901/ADR,采用逆转录-聚合酶链反应和蛋白质印迹法检测两种细... 目的:探讨粉防己碱(TET)对胃癌耐药细胞锌指蛋白139(ZNF139)、多耐药基因1(MDR1)及谷胱甘肽S转移酶-π(GST-π)mRNA的影响。方法:选取胃癌细胞SGC7901以及胃癌耐阿霉素细胞SGC7901/ADR,采用逆转录-聚合酶链反应和蛋白质印迹法检测两种细胞ZNF139、MDR1、GST-πmRNA及蛋白表达,同时检测2.0!g·ml-1TET处理前后SGC7901/ADR细胞ZNF139、MDR1、GST-πmRNA及蛋白表达。结果:SGC7901/ADR细胞ZNF139、MDR1、GST-πmRNA相对表达量明显高于SGC7901细胞(P<0.05);SGC7901/ADR细胞ZNF139、MDR1、GST-π蛋白相对表达量明显高于SGC7901细胞(P<0.05);TET处理后SGC7901/ADR细胞ZNF139、MDR1、GST-πmRNA及蛋白相对表达量均较处理前明显降低(P<0.05)。结论:TET能下调胃癌耐药细胞ZNF139、MDR1、GST-πmRNA和蛋白表达水平,从而在逆转胃癌多药耐药特性方面有重要作用。 展开更多
关键词 胃癌 粉防己碱 锌指蛋白139 多耐药基因1 谷胱甘肽s转移酶-Π 耐药
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基于图像质量加权的D-S证据理论多生物特征融合识别 被引量:4
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作者 肖宾杰 《计算机应用》 CSCD 北大核心 2012年第1期264-268,共5页
对人脸和指静脉在决策层的融合识别,给出一种新的组合图像质量评价方法,并采用一种改进的基于图像质量加权的D-S证据理论融合这两种生物特征。首先,组合图像质量评价法采用清晰度和对比度、相关系数的组合方法来评价生物特征图像质量;其... 对人脸和指静脉在决策层的融合识别,给出一种新的组合图像质量评价方法,并采用一种改进的基于图像质量加权的D-S证据理论融合这两种生物特征。首先,组合图像质量评价法采用清晰度和对比度、相关系数的组合方法来评价生物特征图像质量;其次,应用改进的基于图像质量的匹配值增强方法和D-S证据理论,减少了极大值图像质量指标的影响,使图像质量加权与实际情况更趋一致。实验结果表明,与没有考虑图像质量因素相比,考虑了图像质量信息的D-S证据理论融合方法提高了识别效果。 展开更多
关键词 人脸 指静脉 独立成分分析 主元分析 图像质量 D-s证据理论
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宫颈癌组织中Skp2和有丝分裂前期检查点蛋白的表达
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作者 王敏杰 邓克红 +3 位作者 李元昆 鲁笑钦 侯瑞杰 崔金全 《郑州大学学报(医学版)》 CAS 北大核心 2012年第1期69-72,共4页
目的:探讨宫颈癌组织中S期激酶相关蛋白2(Skp2)及有丝分裂前期检查点(Chfr)蛋白的表达及其与宫颈癌临床病理特征的关系。方法:采用免疫组织化学SP法检测60例宫颈癌组织、30例宫颈上皮内瘤变(CIN)组织及30例正常宫颈组织中Skp2和Chfr蛋... 目的:探讨宫颈癌组织中S期激酶相关蛋白2(Skp2)及有丝分裂前期检查点(Chfr)蛋白的表达及其与宫颈癌临床病理特征的关系。方法:采用免疫组织化学SP法检测60例宫颈癌组织、30例宫颈上皮内瘤变(CIN)组织及30例正常宫颈组织中Skp2和Chfr蛋白的表达。结果:宫颈癌、CIN和正常宫颈组织中Skp2的阳性表达率分别为63.3%、30.0%和6.7%,而Chfr的阳性表达率分别为48.3%、73.3%和90.0%,组间差异均有统计学意义(χ2=28.525和16.484,P<0.001)。Skp2和Chfr蛋白的表达与宫颈癌的分化程度(χ2=14.713和20.356,P<0.001)及淋巴结转移(χ2=6.854和8.477,P=0.009和0.004)有关,而与肿瘤大小、临床分期无关。宫颈癌组织中Skp2与Chfr蛋白的表达呈负关联(rP=0.501,P<0.001)。结论:Skp2和Chfr蛋白的表达与宫颈癌的发生发展有密切的关系。 展开更多
关键词 宫颈癌 s期激酶相关蛋白2 有丝分裂前期检查点
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