IRAK4-IN-1对SD大鼠炎症软骨细胞炎症和衰老表型的影响

目的研究IRAK4-IN-1对炎症软骨细胞的炎症、分解代谢、衰老表型的影响及其作用机制。方法利用免疫荧光染色和甲苯胺蓝染色法鉴定SD大鼠的乳鼠原代软骨细胞,使用CCK8法筛选IRAK4-IN-1的安全浓度范围,本实验设置空白对照组(Control)、IL-1β刺激组、IL-1β+IRAK4-IN-1(1、5、10μM)组,通过蛋白免疫印迹法检测炎症因子、基质降解酶、衰老标志物及P65/NF-ĸB通路蛋白的表达。结果IRAK4-IN-1显著抑制IL-1β刺激下炎症因子iNOS、COX2,基质降解酶MMP13、ADAMTS5以及衰老标志物P16蛋白的表达,此外P65/NF-ĸB通路的激活也受到显著抑制。结论IRAK4-IN-1在炎症软骨细胞中具有抗炎、抑制分解代谢和衰老的作用,其可能是通过抑制P65/NF-ĸB通路发挥炎症调控作用。

一种布尔公式的代数逻辑约化新方法

布尔可满足问题是最早被证明的NP完全问题之一,1-in-3-SAT问题是一个NP完全的布尔可满足子类问题。1-in-3-SAT的计算复杂度取决于对应公式的变量以及子句的个数。将1-in-3公式归约为一个变量数或者子句数更少的1-in-3公式,是提高1-in-3-SAT问题求解效率的一个关键。基于一个新的范式形式——XCNF,针对1-in-3-SAT问题提出一种新的代数逻辑约化方法,用于在多项式时间内约减一个1-in-3公式的变量数和子句数。所提算法的主要思想为:首先将1-in-3公式转化为XCNF公式,然后尝试找出XCNF公式中的X-纯文字,并利用X-纯文字法则对1-in-3公式中相应的布尔变量赋值,最后得到一个约减公式,该约减公式与原公式的1-in-3可满足性等价。

VIA 4—in—1补丁包——自己打“包”

最近购机,我用的是KT133主板,硬盘为IBM Deskstar 75GXP DTLA-307030.不过在运行3DMark2000时明显地丢帧,打上VIA的4-in-1补丁,再次运行,平均上升了15帧.但又出现一个新问题--我的硬盘长时间地进行连续读写操作,如删除大量的文件后,仍会不停读写.此时用侦测软件一看,CPU占用率竟在百分之九十以上,在控制面板中打开或关闭DMA选项也没有用,又到驱动之家DOWN了一个新的驱动,装了一下,情况照旧.

驱动月报

ATi冶天催化剂驱动4.11版For Win200/XP,VIA威盛Hyperion 4-IN-1驱动4．55版,nVIDIA ForceWare驱动70．90 Beta版,S3 DellaChrome系列显示芯片驱动06．1410．1761-15．11．06．

Observation of a 3-in-1 Russian-doll-like Complex in Solution

Supramolecular chemistry is based on non-covalent interactions that enable molecular recognition.By weak interactions,a large number of structures,such as rotaxane[1-2]and catenane[3-4],as well as more complex structures[5-6]have been assembled.

Effect of time resolution of rainfall measurements on the erosivity factor in the USLE in China

Rainfall erosivity,one of the factors in the Universal Soil Loss Equation.quantifies the effect of rainfall and runoffon soil erosion.High-resolution data are required to compute rainfall erosivity,but are not widely available in many parts of the world.As the temporal resolution of rainfall measurement decreases,computed rainfall erosivity decreases.The objective of the paper is to derive a series of conversion factors as a function of the time interval to compute rainfall erosivity so that the R factor computed using data at different time intervals could be converted to that computed using 1-min data.Rainfall data at 1-min intervals from 62 stations over China were collected to first compute the~ue'R factor values.Underestimation of the R factor was systematically evaluated using data aggregated at 5,6.10,15,20,30,and 60-min to develop conversion factors for the R factor and the 1-in-10-year storm EI30 values.Compared with true values,the relative error in R factor using data at fixed intervals of≤10min was<10%for at least 44 out of 62 stations.Errors increased rapidly when the time interval of the rainfall data exceeded 15 min.Relative errors were>10%using 15-min data for 66.1%of stations and>20%using 30-min data for 61.3%of stations.The conversion factors for the R factor,ranging from 1.051 to 1.871 for 5 to 60-min data,are higher than those for the 1-in-10-years storm EI30,ranging from 1.034 to 1.489 for the 62stations.

12月优化先锋

nVlDIA系列显卡，SiS矽统SiS961 962 963南桥芯片组，VIA威盛4-IN-1，ALi扬智芯片组Integrated DriVer综台驱动工具包，罗技全系列鼠标，Acer宏基310P、320P、610P、620P、620U、620PT扫描仪，优化程序——内存维护管理软件RegRun,优化程序——显卡工具PowerStrip。