Let D be a 2-（v, k, 4） symmetric design and G be a flag-transitive point-primitive automorphism group of D with X ≥G ≤Aut（X） where X ≌ PSL2（q）.Then D is a 2-（15,8,4） symmetric design with X = PSL2（9） and ...Let D be a 2-（v, k, 4） symmetric design and G be a flag-transitive point-primitive automorphism group of D with X ≥G ≤Aut（X） where X ≌ PSL2（q）.Then D is a 2-（15,8,4） symmetric design with X = PSL2（9） and Xx = PGL2（3） where x is a point of D.展开更多
The automorphism group of a flag-transitive 6–(v, k, 2) design is a 3-homogeneous permutation group. Therefore, using the classification theorem of 3–homogeneous permutation groups, the classification of flag-transi...The automorphism group of a flag-transitive 6–(v, k, 2) design is a 3-homogeneous permutation group. Therefore, using the classification theorem of 3–homogeneous permutation groups, the classification of flag-transitive 6-(v, k,2) designs can be discussed. In this paper, by analyzing the combination quantity relation of 6–(v, k, 2) design and the characteristics of 3-homogeneous permutation groups, it is proved that: there are no 6–(v, k, 2) designs D admitting a flag transitive group G ≤ Aut (D) of automorphisms.展开更多
Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary fibrosis.However,whether circRNA is involved in the process remains unclear.The present study aimed to investigate the ...Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary fibrosis.However,whether circRNA is involved in the process remains unclear.The present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying mechanisms.We found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial cells.The isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the cytoplasm.RNA immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to miR-497-5p.Furthermore,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial cells.Collectively,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial cells.Once validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.展开更多
This article is a contribution to the study of the automorphism groups of designs. Let be a non-trivial design where for some positive integer , and is block-transitive. If the socle of G is iso...This article is a contribution to the study of the automorphism groups of designs. Let be a non-trivial design where for some positive integer , and is block-transitive. If the socle of G is isomorphic to the simple groups of lie type, then G is not flag-transitive.展开更多
Transition on a flared cone with zero angle of at- tack was studied in our newly established Mach 6 quiet wind tunnel （M6QT） via wall pressure measurement and flow visualization. High-frequency pressure transducers ...Transition on a flared cone with zero angle of at- tack was studied in our newly established Mach 6 quiet wind tunnel （M6QT） via wall pressure measurement and flow visualization. High-frequency pressure transducers were used to measure the second-mode waves＇ amplitudes and frequencies. Using pulsed schlieren diagnostic and Rayleigh scattering technique, we got a clear evolution of the second-mode disturbances. The second-mode waves exist for a long distance, which means that the second-mode waves grow linearly in a large region. Strong Mach waves are radiated from the edge of the boundary layer. With further development, the second-mode waves reach their maximum magnitude and harmonics of the second-mode instability appear. Then the disturbances grow nonlinearly. The second modes become weak and merge with each other. Finally, the nonlinear interaction of disturbance leads to a relatively quiet zone, which further breaks down, resulting in the transition of the bound- ary layer. Our results show that transition is determined by the second mode. The quiet zone before the final breakdown is observed in flow visualization for the first time. Eventual transition requires the presence of a quiet zone generated by nonlinear interactions.展开更多
We investigate a kind of noise-induced transition to noisy chaos in dynamical systems. Due to similar phenomenological structures of stable hyperbolic attractors excited by various physical realizations from a given s...We investigate a kind of noise-induced transition to noisy chaos in dynamical systems. Due to similar phenomenological structures of stable hyperbolic attractors excited by various physical realizations from a given stationary random process, a specific Poincar6 map is established for stochastically perturbed quasi-Hamiltonian system. Based on this kind of map, various point sets in the Poincar6＇s cross-section and dynamical transitions can be analyzed. Results from the customary Duffing oscillator show that, the point sets in the Poincare＇s global cross-section will be highly compressed in one direction, and extend slowly along the deterministic period-doubling bifurcation trail in another direction when the strength of the harmonic excitation is fixed while the strength of the stochastic excitation is slowly increased. This kind of transition is called the noise-induced point-overspreading route to noisy chaos.展开更多
Pure W and W-Cu-W trilayer coatings were deposited on an Fe substrate by d.c. magnetron sputtering. The α-β phase evolution, intragranular stress evolution in sputter-deposited W layer were investigated by x-ray dif...Pure W and W-Cu-W trilayer coatings were deposited on an Fe substrate by d.c. magnetron sputtering. The α-β phase evolution, intragranular stress evolution in sputter-deposited W layer were investigated by x-ray diffraction. They are directly related to the film microstructure, density and adhesion. Therefore, control of the film stress and phase component transition is essential for its applications. The phase component transition from β-W to α-W and intragranular stress evolution from tensile to compressive strongly depend on the deposition parameters and can be induced by lowering Ar pressure and rising target power. The compressively stressed films with α-W phase have a dense microstructure and high adhesion to Fe substrate.展开更多
The present work investigates the effect of europium substitution on the （Bi, Pb）-2212 system in the concentration range 0.5 ≤ x ≤1.0. Phase analysis and lattice parameter calculations on the powder diffraction da...The present work investigates the effect of europium substitution on the （Bi, Pb）-2212 system in the concentration range 0.5 ≤ x ≤1.0. Phase analysis and lattice parameter calculations on the powder diffraction data and the elemental analysis of EDX show that the Eu atoms are successfully substituted into the （Bi, Pb）-2212 system. Resistivity measurements （64-300 K） reveal that the system exhibits superconductivity at x ≤ 0.5 and semiconductivity at x 〉 0.5. With the complete suppression of superconductivity which is known to be a quasi-two dimensional phenomenon in these materials, a metal to insulator transition takes place at x = 0.6 and the predominant conduction mechanism is found to be variable range hopping between localized states, resulting in macroscopic semiconducting behaviour. The results of electrical and structural properties of the doped （Bi, Pb）-2212 compounds suggest that the decrease of charge carrier concentration and the induced structural disorder are the more effective and dominant mechanisms in the origin of the metal to insulator transition and suppression of superconductivity due to Eu substitution at its Sr site.展开更多
BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer physiology.However,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC...BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer physiology.However,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of GC.METHODS Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and cells.The ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,respectively.Cell proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow cytometry.Expression of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western blot.Targets of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter system.Serpin family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical staining.The correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot analysis.The association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and miR-145-5p.The mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude mice.RESULTS GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this miRNA.Overexpression of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 expression.Kaplan-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 expression.Nude mouse tumorigenesis experiments confirmed that miR-145-5p targets SERPINE1 to regulate extracellular signal-regulated kinase-1/2(ERK1/2).CONCLUSION This study found that miR-145-5p inhibits tumor progression and is expressed in lower amounts in patients with GC.MiR-145-5p was found to affect GC cell proliferation,migration,and invasion by negatively regulating SERPINE1 levels and controlling the ERK1/2 pathway.展开更多
Based on analysis of newly collected 3D seismic and drilled well data,the geological structure and fault system of Baodao sag have been systematically examined to figure out characteristics of the transition fault ter...Based on analysis of newly collected 3D seismic and drilled well data,the geological structure and fault system of Baodao sag have been systematically examined to figure out characteristics of the transition fault terrace belt and its control on the formation of natural gas reservoirs.The research results show that the Baodao sag has the northern fault terrace belt,central depression belt and southern slope belt developed,among them,the northern fault terrace belt consists of multiple transition fault terrace belts such as Baodao B,A and C from west to east which control the source rocks,traps,reservoirs,oil and gas migration and hydrocarbon enrichment in the Baodao sag.The activity of the main fault of the transition belt in the sedimentary period of Yacheng Formation in the Early Oligocene controlled the hydrocarbon generation kitchen and hydrocarbon generation potential.From west to east,getting closer to the provenance,the transition belt increased in activity strength,thickness of source rock and scale of delta,and had multiple hydrocarbon generation depressions developed.The main fault had local compression under the background of tension and torsion,giving rise to composite traps under the background of large nose structure,and the Baodao A and Baodao C traps to the east are larger than Baodao B trap.Multiple fault terraces controlled the material source input from the uplift area to form large delta sand bodies,and the synthetic transition belt of the west and middle sections and the gentle slope of the east section of the F12 fault in the Baodao A transition belt controlled the input of two major material sources,giving rise to a number of delta lobes in the west and east branches.The large structural ridge formed under the control of the main fault close to the hydrocarbon generation center allows efficient migration and accumulation of oil and gas.The combination mode and active time of the main faults matched well with the natural gas charging period,resulting in the hydrocarbon gas enrichment.Baodao A transition belt is adjacent to Baodao 27,25 and 21 lows,where large braided river delta deposits supplied by Shenhu uplift provenance develop,and it is characterized by large structural ridges allowing high efficient hydrocarbon accumulation,parallel combination of main faults and early cessation of faulting activity,so it is a favorable area for hydrocarbon gas accumulation.Thick high-quality gas reservoirs have been revealed through drilling,leading to the discovery of the first large-scale gas field in Baodo 21-1 of Baodao sag.This discovery also confirms that the north transition zone of Songnan-Baodao sag has good reservoir forming conditions,and the transition fault terrace belt has great exploration potential eastward.展开更多
Objective: To investigate the correlation of SphK1, FAK, Musashi 1 and CA199 expression with angiogenesis and epithelial-mesenchymal transition in surgically removed colon cancer lesions. Methods: A total of 60 patien...Objective: To investigate the correlation of SphK1, FAK, Musashi 1 and CA199 expression with angiogenesis and epithelial-mesenchymal transition in surgically removed colon cancer lesions. Methods: A total of 60 patients with colon cancer who underwent radical operation in our hospital between August 2015 and August 2017 were selected, intraoperative colon cancer tissue samples were collected as colon cancer group, and normal tissue specimens adjacent to carcinoma were collected as adjacent tissue group. Fluorescence quantitative PCR was adopted to determine the expression levels of SphK1, FAK, Musashi 1, CA199 as well as the genes related to angiogenesis and epithelial-mesenchymal transition in colon tissues with different properties. Results: SphK1, FAK, Musashi 1 and CA199 mRNA expression in colon cancer group were higher than those in adjacent tissue group;angiogenesis-related genes ANGPTL4, Apelin-13, DLL1, VEGF and HIF-α mRNA expression were higher than those in adjacent tissue group whereas TSP-1 mRNA expression was lower than that in adjacent tissue group;epithelial-mesenchymal transition-related gene E-cadherin mRNA expression was lower than that in adjacent tissue group whereas Vimentin, N-cadherin, Twist and Snail mRNA expression were higher than those in adjacent tissue group. Correlation analysis showed that the SphK1, FAK, Musashi 1 and CA199 expression in colon cancer tissues were directly correlated with the angiogenesis genes and epithelial-mesenchymal transition genes. Conclusion: SphK1, FAK, Musashi 1 and CA199 genes are abnormally expressed in colon cancer tissues and their expression levels are directly correlated with tumor angiogenesis and epithelial-mesenchymal transition process.展开更多
基金Supported by the National Natural Science Foundation of China(11071081)
文摘Let D be a 2-（v, k, 4） symmetric design and G be a flag-transitive point-primitive automorphism group of D with X ≥G ≤Aut（X） where X ≌ PSL2（q）.Then D is a 2-（15,8,4） symmetric design with X = PSL2（9） and Xx = PGL2（3） where x is a point of D.
文摘The automorphism group of a flag-transitive 6–(v, k, 2) design is a 3-homogeneous permutation group. Therefore, using the classification theorem of 3–homogeneous permutation groups, the classification of flag-transitive 6-(v, k,2) designs can be discussed. In this paper, by analyzing the combination quantity relation of 6–(v, k, 2) design and the characteristics of 3-homogeneous permutation groups, it is proved that: there are no 6–(v, k, 2) designs D admitting a flag transitive group G ≤ Aut (D) of automorphisms.
基金funded by the National Natural Science Foundation of China(Grant No.82073518).
文摘Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary fibrosis.However,whether circRNA is involved in the process remains unclear.The present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying mechanisms.We found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial cells.The isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the cytoplasm.RNA immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to miR-497-5p.Furthermore,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial cells.Collectively,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial cells.Once validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.
文摘This article is a contribution to the study of the automorphism groups of designs. Let be a non-trivial design where for some positive integer , and is block-transitive. If the socle of G is isomorphic to the simple groups of lie type, then G is not flag-transitive.
文摘Transition on a flared cone with zero angle of at- tack was studied in our newly established Mach 6 quiet wind tunnel （M6QT） via wall pressure measurement and flow visualization. High-frequency pressure transducers were used to measure the second-mode waves＇ amplitudes and frequencies. Using pulsed schlieren diagnostic and Rayleigh scattering technique, we got a clear evolution of the second-mode disturbances. The second-mode waves exist for a long distance, which means that the second-mode waves grow linearly in a large region. Strong Mach waves are radiated from the edge of the boundary layer. With further development, the second-mode waves reach their maximum magnitude and harmonics of the second-mode instability appear. Then the disturbances grow nonlinearly. The second modes become weak and merge with each other. Finally, the nonlinear interaction of disturbance leads to a relatively quiet zone, which further breaks down, resulting in the transition of the bound- ary layer. Our results show that transition is determined by the second mode. The quiet zone before the final breakdown is observed in flow visualization for the first time. Eventual transition requires the presence of a quiet zone generated by nonlinear interactions.
基金supported by the National Natural Science Foundation of China (11172260 and 11072213)the Fundamental Research Fund for the Central University of China (2011QNA4001)
文摘We investigate a kind of noise-induced transition to noisy chaos in dynamical systems. Due to similar phenomenological structures of stable hyperbolic attractors excited by various physical realizations from a given stationary random process, a specific Poincar6 map is established for stochastically perturbed quasi-Hamiltonian system. Based on this kind of map, various point sets in the Poincar6＇s cross-section and dynamical transitions can be analyzed. Results from the customary Duffing oscillator show that, the point sets in the Poincare＇s global cross-section will be highly compressed in one direction, and extend slowly along the deterministic period-doubling bifurcation trail in another direction when the strength of the harmonic excitation is fixed while the strength of the stochastic excitation is slowly increased. This kind of transition is called the noise-induced point-overspreading route to noisy chaos.
文摘Pure W and W-Cu-W trilayer coatings were deposited on an Fe substrate by d.c. magnetron sputtering. The α-β phase evolution, intragranular stress evolution in sputter-deposited W layer were investigated by x-ray diffraction. They are directly related to the film microstructure, density and adhesion. Therefore, control of the film stress and phase component transition is essential for its applications. The phase component transition from β-W to α-W and intragranular stress evolution from tensile to compressive strongly depend on the deposition parameters and can be induced by lowering Ar pressure and rising target power. The compressively stressed films with α-W phase have a dense microstructure and high adhesion to Fe substrate.
基金supported by Kerala State Council for Science,Technology and Environment,Council of Scientific and Industrial Researchthe University Grants Commission of India
文摘The present work investigates the effect of europium substitution on the （Bi, Pb）-2212 system in the concentration range 0.5 ≤ x ≤1.0. Phase analysis and lattice parameter calculations on the powder diffraction data and the elemental analysis of EDX show that the Eu atoms are successfully substituted into the （Bi, Pb）-2212 system. Resistivity measurements （64-300 K） reveal that the system exhibits superconductivity at x ≤ 0.5 and semiconductivity at x 〉 0.5. With the complete suppression of superconductivity which is known to be a quasi-two dimensional phenomenon in these materials, a metal to insulator transition takes place at x = 0.6 and the predominant conduction mechanism is found to be variable range hopping between localized states, resulting in macroscopic semiconducting behaviour. The results of electrical and structural properties of the doped （Bi, Pb）-2212 compounds suggest that the decrease of charge carrier concentration and the induced structural disorder are the more effective and dominant mechanisms in the origin of the metal to insulator transition and suppression of superconductivity due to Eu substitution at its Sr site.
文摘BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer physiology.However,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of GC.METHODS Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and cells.The ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,respectively.Cell proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow cytometry.Expression of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western blot.Targets of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter system.Serpin family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical staining.The correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot analysis.The association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and miR-145-5p.The mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude mice.RESULTS GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this miRNA.Overexpression of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 expression.Kaplan-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 expression.Nude mouse tumorigenesis experiments confirmed that miR-145-5p targets SERPINE1 to regulate extracellular signal-regulated kinase-1/2(ERK1/2).CONCLUSION This study found that miR-145-5p inhibits tumor progression and is expressed in lower amounts in patients with GC.MiR-145-5p was found to affect GC cell proliferation,migration,and invasion by negatively regulating SERPINE1 levels and controlling the ERK1/2 pathway.
基金Supported by the CNOOC Science and Technology Project(KJZH-2021-0003-00,CNOOC-KJ 135 ZDXM 38 ZJ 03 ZJ).
文摘Based on analysis of newly collected 3D seismic and drilled well data,the geological structure and fault system of Baodao sag have been systematically examined to figure out characteristics of the transition fault terrace belt and its control on the formation of natural gas reservoirs.The research results show that the Baodao sag has the northern fault terrace belt,central depression belt and southern slope belt developed,among them,the northern fault terrace belt consists of multiple transition fault terrace belts such as Baodao B,A and C from west to east which control the source rocks,traps,reservoirs,oil and gas migration and hydrocarbon enrichment in the Baodao sag.The activity of the main fault of the transition belt in the sedimentary period of Yacheng Formation in the Early Oligocene controlled the hydrocarbon generation kitchen and hydrocarbon generation potential.From west to east,getting closer to the provenance,the transition belt increased in activity strength,thickness of source rock and scale of delta,and had multiple hydrocarbon generation depressions developed.The main fault had local compression under the background of tension and torsion,giving rise to composite traps under the background of large nose structure,and the Baodao A and Baodao C traps to the east are larger than Baodao B trap.Multiple fault terraces controlled the material source input from the uplift area to form large delta sand bodies,and the synthetic transition belt of the west and middle sections and the gentle slope of the east section of the F12 fault in the Baodao A transition belt controlled the input of two major material sources,giving rise to a number of delta lobes in the west and east branches.The large structural ridge formed under the control of the main fault close to the hydrocarbon generation center allows efficient migration and accumulation of oil and gas.The combination mode and active time of the main faults matched well with the natural gas charging period,resulting in the hydrocarbon gas enrichment.Baodao A transition belt is adjacent to Baodao 27,25 and 21 lows,where large braided river delta deposits supplied by Shenhu uplift provenance develop,and it is characterized by large structural ridges allowing high efficient hydrocarbon accumulation,parallel combination of main faults and early cessation of faulting activity,so it is a favorable area for hydrocarbon gas accumulation.Thick high-quality gas reservoirs have been revealed through drilling,leading to the discovery of the first large-scale gas field in Baodo 21-1 of Baodao sag.This discovery also confirms that the north transition zone of Songnan-Baodao sag has good reservoir forming conditions,and the transition fault terrace belt has great exploration potential eastward.
文摘Objective: To investigate the correlation of SphK1, FAK, Musashi 1 and CA199 expression with angiogenesis and epithelial-mesenchymal transition in surgically removed colon cancer lesions. Methods: A total of 60 patients with colon cancer who underwent radical operation in our hospital between August 2015 and August 2017 were selected, intraoperative colon cancer tissue samples were collected as colon cancer group, and normal tissue specimens adjacent to carcinoma were collected as adjacent tissue group. Fluorescence quantitative PCR was adopted to determine the expression levels of SphK1, FAK, Musashi 1, CA199 as well as the genes related to angiogenesis and epithelial-mesenchymal transition in colon tissues with different properties. Results: SphK1, FAK, Musashi 1 and CA199 mRNA expression in colon cancer group were higher than those in adjacent tissue group;angiogenesis-related genes ANGPTL4, Apelin-13, DLL1, VEGF and HIF-α mRNA expression were higher than those in adjacent tissue group whereas TSP-1 mRNA expression was lower than that in adjacent tissue group;epithelial-mesenchymal transition-related gene E-cadherin mRNA expression was lower than that in adjacent tissue group whereas Vimentin, N-cadherin, Twist and Snail mRNA expression were higher than those in adjacent tissue group. Correlation analysis showed that the SphK1, FAK, Musashi 1 and CA199 expression in colon cancer tissues were directly correlated with the angiogenesis genes and epithelial-mesenchymal transition genes. Conclusion: SphK1, FAK, Musashi 1 and CA199 genes are abnormally expressed in colon cancer tissues and their expression levels are directly correlated with tumor angiogenesis and epithelial-mesenchymal transition process.
