Myopia induced by flickering light in guinea pigs: a detailed assessment on susceptibility of different frequencies

AIM: To investigate the effectiveness and feasibility of inducing myopia in guinea pigs by flickering light (FL) stimulation with different frequencies. METHODS: Seventy 2 -week-old guinea pigs were randomly assigned to six groups: five FL groups and a control group (n =12 for each). Animals in the five FL groups were raised under 500lx illumination with a duty diurnal cycle of 50% at a flash rate of 5, 1, 0.5, 0.25 and 0.1Hz respectively. Those in the control group were reared under steady 250lx illumination. Refraction, axial length, and radius of curvature were measured before and at 2, 4, 6, 8, 10 and 12 weeks after treatment. At week 12, the eyeballs were taken out and three ocular dimensions and dry weight of sclera were measured. RESULTS: A myopic shift and axial eye length increase developed in the five FL groups. Stimulation at 0.5Hz caused greater changes in myopic shift, axial elongation, eyeball dimension, and dry weight of sclera than stimulation at other frequencies. Compared with controls, eyes in 0.5Hz group were approximately -5.5 ±1.5D more myopic with increase in horizontal, vertical, axial dimensions by 0.89 ±0.3mm, 0.69 ±0.2mm, 1.12 ±0.2mm respectively and with increase in dry weight of sclera by 0.44mg. CONCLUSION: Chronic exposure to periodic illumination at temporal frequency is attended by development of excessive ocular enlargement and myopic refractive error. Emmetropization could bedisrupted differently by frequency alteration.

多频谐和与噪声作用下Flickering振子的安全盆侵蚀与混沌

研究了催化反应Flickering振子在多频率确定性谐和外力和有界随机噪声联合作用下,系统安全盆的侵蚀和混沌现象.将Melnikov方法推广到包含有限多个频率外力和随机噪声联合作用的情形,推导出了系统的随机Melnikov过程,根据Melnikov过程在均方意义上出现简单零点的条件给出了系统出现混沌的临界值,然后用数值模拟方法计算了系统的安全盆分岔点.结果表明,由于随机扰动的影响,系统的安全盆分岔点发生了偏移,并且使得混沌容易发生.同时证明,激励频率数目的增加扩大了参数空间上的混沌区域,也使得安全盆分岔提前发生,系统变得不安全.

Cell Registration and Flickering Detection for the Complexity Analysis of Red Blood Cell Dynamics with GSM Exposure

Red blood cells(RBC)' flickering present the dynamic properties of the cytomembrane. Its complexity could be used for aging analysis or the evaluation for the storage quality. The flickering activity is a kind of reversible perpendicular motion of the specified pixel. Therefore, the complexity analysis depends on the reliable detection of temporal variation for the gray-scale values from each pixel of the cells. In this paper, we improved our previous work on the screening of the horizontal drifted cells with a surface based on cell registration method and the effect of GSM exposure to the dynamic properties of the RBCs in terms of multi-scale sample entropy was presented in the paper.

高分辨率TFT-LCD光电自动校正系统设计

针对当前MIPI接口的高分辨率TFT-LCD(液晶显示屏)光电校正基本是手动校正,或者部分自动校正现状,搭建了适合目前高分辨率液晶显示的ARM+FPGA+双SSD2828光电自动校正系统,实现了GAMMA2.2、Flicker最佳Vcom自动校正算法的优化,改善了影响高分辨率TFT-LCD显示品质的亮度、暗度、对比度、色度、闪烁等光电参数,提升了显示品质。实验结果表明该系统可支持2 K×4 K高分辨率TFT-LCD,刷新率最高可达144 Hz。整体校正时间稳定在30 s,满足厂线快速生产的需要,且校正系统成本低、系统升级方便,在显示技术行业具有较强的应用价值。

Design of Digital Linear Power Supply with Low Current Ripple

A linear power supply is a circuit architecture directly driven by AC. Multiple high-voltage LEDs (light-emitting diodes) are connected in series to withstand the input voltage. The LEDs are divided into multiple segments through a segment switching mechanism to adapt to the pulsating DC changes after bridge rectification. Due to imperfect switching between control signals, there may be signal overlap or misalignment, which reduces circuit performance and component lifespan. Firstly, signal overlap occurs when the next segment opens before the previous segment is about to close. This state causes overlapping intervals where two segments of current combine, resulting in a high combined current that can lead to significant power losses and generate heat, potentially reducing the lifespan of the components. Secondly, signal misalignment occurs when the next segment prepares to open after the previous segment has completely closed. In this state, there is a time gap with no current flow, resulting in reduced output power and exacerbating LED flickering. Both of these undesirable phenomena introduce ripple into the LED output current. In this paper, a digitalized design is proposed to precisely compensate for the timing between alternating signals, significantly reducing output current ripple. This approach helps enhance power supply performance, extend component lifespan, and reduce LED index flicker.

Non-Local Theory of Bose-Einstein Condensate and Stopping of Light

The problem of an adequate description of the transport processes in Bose-Einstein condensates (CBE), including space-temporal evolution of CBE in a gravitational field is considered. The full nonlocal system for the CBE evolution is delivered including particular case and analytical solutions. We show (analytically) that a black hole can evolve in the Bose-Einstein condensate (CBE) regime. At the same time, there are modes in which black hole flickering occurs. Quantization of the black holes flickering is discovered. The corresponding nonlocal hydrodynamic equations indicated for fermions gas.

光照对ADS模式TFT-LCD Flicker漂移的影响

在挠曲电效应的基础上,研究了光照对ADS模式TFT-LCD Flicker漂移的影响。首先研究了正常点灯下Flicker漂移情况,然后测试了不加背光和降低背光亮度下的Flicker漂移,最后研究了光照panel一段时间后Flicker漂移情况。实验结果表明,光照使Cell盒内产生了离子,驱动信号电压存在时液晶发生极化,产生的"力"吸附离子,从而形成了直流偏压,产生了Flicker漂移。降低光照强度Flicker漂移程度减弱。利用该结果在一定程度上对显示器整体设计和品质的改善有重要指导意义。

Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis

BACKGROUND:Minimal hepatic encephalopathy (MHE) impairs quality of life and predicts overt hepatic encephalopathy (HE) in cirrhotic patients.Diagnosis of MHE requires cumbersome tests.Lactulose is effective in the treatment of MHE.This study aimed to evaluate the use of critical flicker frequency (CFF) for the diagnosis of MHE in cirrhotic patients after treatment.METHODS:One hundred and ten patients were evaluated by psychometry (number connection tests A,B or figure connection tests A,B),P300 auditory event related potential (P300ERP),venous ammonia,and CFF for MHE.MHE was diagnosed by abnormal psychometry (>2SD age matched controls) and P300ERP.MHE patients were treated with lactulose for one month.Response was defined by normalization (<2SD of matched controls) of both psychometry and P300ERP.RESULTS:Of the 110 patients [Child Turcott Pugh score A:B:C 39:42:29,(age 41.6±11.6 years,M:F 82:28)],75 (68%) had abnormal results of psychometric tests,and 74 (67%) had prolonged P300ERP.Fifteen (20%) patients with abnormal results of psychometric tests had normal P300ERP.Thus sixty (54.5%) patients were diagnosed as having MHE.After treatment for one month,34 (57%) recovered while 26 (43%) continued to have abnormal resents of psychometric or P300ERP tests.CFF was <39 Hz in 72 (65.4%) patients before treatment and in 20 (33.3%) after treatment.CFF sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy for the assessment of recovery of MHE were 65%,91%,85%,77% and 80%,respectively.CONCLUSION:CFF is a simple,relatively reliable,and accurate test without any dependence on age or literacy in the diagnosis and assessment of recovery of patients with MHE.

The motion analysis of fire video images based on moment features and flicker frequency

In this paper, motion analysis methods based on the moment features and flicker frequency features for early fire flame from ordinary CCD video camera were proposed, and in order to describe the changing of flame and disturbance of non-flame phenomena further more, the average changing pixel number of the first-order moments of consecutive flames has been defined in the moment analysis as well. The first-order moments of all kinds of flames used in our experiments present irregularly flickering, and their average changing pixel numbers of first-order moments are greater than fire-like disturbances. For the analysis of flicker frequency of flame, which is extracted and calculated in spatial domain, and therefore it is computational simple and fast. The method of extracting flicker frequency from video images is not affected by the catalogues of combustion material and distance. In experiments, we adopted two kinds of flames, i. e. , fixed flame and movable flame. Many comparing and disturbing experiments were done and verified that the methods can be used as criteria for early fire detection.

Seabed scene simulation and its realization in extending Vega

Realistic simulation of underwater scene is always difficult because of the special and complex vision effects in underwater space. Seabed is an important part of underwater environment. This paper describes the methods for seabed scene simulation based on OpenGL. It includes construction of fluctuant terrain based on the random sinusoidal algorithm, simulation of seabed flicker effect by means of circular texture mapping and generation of turbidity effect by using fog techniques. For the application based on the leading high level 3D development environment - Vega, underwater scene simulation is still a difficulty since there is no module for it. Rased on the analysis of Vega software and the research on seabed scene simulation methods, a Vega extending module named 'Underwater Space' was created through developing module class and extending lynx interface. The module class was designed through developing DLL written in C + + . The Lynx was extended through developing keyword configure file, GUI configure file and lynx plug-in DLL. The problem that Vega can't simulate underwater space, is elementarily resolved. The results show that this module is efficient, easy using, and the seabed scene images are vivid.

Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy

AIM: To evaluate the association between serum concentrations of S100&#x003b2; in patients with cirrhosis and the presence of low grade hepatic encephalopathy (HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy (CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney&#x02019;s U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100&#x003b2; values were different among all groups, and differences remained significant between groups 1 and 2 (P &#x0003c; 0.001), and also between groups 2 and 3 (P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100&#x003b2; was higher than in patients without HE [0.18 (0.14-0.28) ng/mL vs 0.11 (0.06-0.14) ng/mL, P &#x0003c; 0.001]. There was a close correlation between serum concentrations of S100&#x003b2; and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE (r = -0.413, P = 0.019). ROC curve analysis yielded &#x0003e; 0.13 ng/mL as the best cutoff value of S100&#x003b2; for the diagnosis of HE (sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100&#x003b2; are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100&#x003b2; could help in the correct characterization of incipient stages of HE.

Which lamp will be optimum to eye? Incandescent,fluorescent or LED etc

Low frequency flicker,high frequency flicker,strong light,strong blue light,infrared,ultraviolet,electromagnetic radiation,ripple flicker and dimming flicker produced by different lamps have negative impact on vision,eyes and health. Negative impact on eyes resulting in myopia or cataract etc: the solution is to remove all the negative factors by applying upright lighting technology and that is optimum to vision,eyes and health.

TFT-LCD屏的Flicker和DC残留的研究及改善

由于平面电场的非对称设计和挠曲电效应的存在,导致正负帧作用下透过率不同,目视有很明显的闪烁。本文在396 mm(15.6 in)FHD(1 920×1 080)竖双畴结构的基础上,通过LCD expert软件模拟平面电场显示模式正负帧作用下电压-穿透率(Voltage-Transmittance,V-T)曲线,同时,实测了像素电极(pixel-ITO)不同线宽线距产品的残留DC(Direct Current)值/Flrcker数值等,得出较好的实验条件,对今后的像素设计有一定的指导意义。

An electrophoretic display driving waveform based on improvement of activation pattern

Electrophoretic display(EPD) technology has become one of the main supporting pillars of the electronic paper display industry.Despite its benefits,the EPD technology suffers from several disadvantages such as non-fixed threshold voltage value for gray scale display.In addition,the display has to repeatedly refresh between white and black states to eliminate ghost image when it needs to update a new image.The traditional driving waveform for the EPD includes four stages: erasing the original image,resetting to black state,clearing to white state,and writing a new image.A flicker can be found when transferring between two adjacent stages.A new driving waveform based on the improvement of activation pattern is proposed to weaken the ghost image and reduce the flicker.Experimental results show that the proposed driving waveform could weaken the ghost image effectively and reduce the number of flickers by 50%.Compared with the traditional driving waveform,the driving waveform of this work has a better performance.

A new dimmer for alternating-current directly driven light-emitting-diode lamp

A new dimmer using a mental-oxide-semiconductor field-effect transistor (MOSFET) for alternating-current (AC) directly driven light-emitting-diode (LED) lamp was presented. The control method of proposed dimmer is pulse width control (PWM) method. Compared with the conventional phase-controlled dimmer, the proposed PWM dimmer can produce sine wave and did not cause harmonics problem. Furthermore, the proposed control method did not amplify the light flicker due to the independence of input voltage. Therefore, the PWM dimmer can be used as the dimmer of the AC LED lamp instead of the conventional phase-controlled dimmer. The experimental result shows that the proposed PWM dimmer has good performances.

A User-Friendly SSVEP-Based BCI Using Imperceptible Phase-Coded Flickers at 60Hz

A brain-computer interface(BCI)system based on steady-state visual evoked potentials(SSVEP)was developed by four-class phase-coded stimuli.SSVEPs elicited by flickers at 60Hz,which is higher than the critical fusion frequency(CFF),were compared with those at 15Hz and 30Hz.SSVEP components in electroencephalogram(EEG)were detected using task related component analysis(TRCA)method.Offline analysis with 17 subjects indicated that the highest information transfer rate(ITR)was 29.80±4.65bpm with 0.5s data length for 60Hz and the classification accuracy was 70.07±4.15%.The online BCI system reached an averaged classification accuracy of 87.75±3.50%at 60Hz with 4s,resulting in an ITR of 16.73±1.63bpm.In particular,the maximum ITR for a subject was 80bpm with 0.5s at 60Hz.Although the BCI performance of 60Hz was lower than that of 15Hz and 30Hz,the results of the behavioral test indicated that,with no perception of flicker,the BCI system with 60Hz was more comfortable to use than 15Hz and 30Hz.Correlation analysis revealed that SSVEP with higher signal-to-noise ratio(SNR)corresponded to better classification performance and the improvement in comfortableness was accompanied by a decrease in performance.This study demonstrates the feasibility and potential of a user-friendly SSVEP-based BCI using imperceptible flickers.

LED Flicker: A Drawback or an Opportunity?

In this paper we examine the flicker of commercial LED lamps and with the help of volunteers we explore the parameter space (frequency and duty cycle) in order to find pulsing operating conditions under which the light fluctuations are not visually perceived. The results show that LEDs under mains voltage manifest the most extreme cases of flicker and we also confirm that under pulsing mode the overall impression is of higher brightness which is an opportunity for energy savings. The results also show that the background color and luminance contrast is of high importance. Finally we propose an easy method for consumers to detect flickering of light sources under mains voltage.

A Novel Automatic Method for Removal of Flicker in Video

Intensity flicker is a common form of degradation in archived film. Most algorithms on this distortion are complicated and uncontrolled. This paper presented a discrete mathematical model of flicker, designed a block-based estimation method of the model＇s parameters according to their features of intensity variation in large area. With this estimation result it constructed a compensation model to repair the current frame. This restoration approach is full automatic and the repair process of current frame does not need the information of frames behind it. The algorithm was realized to establish a simple and adjustable repair system. The experimental results show that the proposed algorithm can remove most intensity flicker and preserve tho wanted effects.

One-Branch Zero-IF Wireless Receiver Topology with Multiphase Local Oscillator

This paper proposes a one-branch zero-IF receiver topology, which samples the I and Q signals of the modulated RF carrier with one signal path by means of a multiphase local oscillator. The suggested one-branch re- ceiver works without matching problem, and it is also capable of cancelling out the flicker noise and DC-offset when the local oscillator is configured to the four-phase mode. The one-branch receiver saves much area and power com- pared with the traditional two-branch ones. All of the advantages above make the one-branch receiver topology a promising architectural candidate for low-power and low-cost RF CMOS receiver designs. Keywords： RF CMOS; zero-IF; flicker noise; image rejection; low-power; IQ matching

FLICKER INDEX METHOD FOR EVALUATING FLICKER IN COLOR PDPs

Objective In order to red uc e the flicker in color plasma display panel (PDP), the highly peaked light outpu t at certain positions and the strong luminance difference among subfields, whic h cause flicker in PDP, is analyzed; and a flicker index method is developed to evaluate flicker in PDP based on the flicker theory and the electroencephalograp h response model for luminance. Methods This method considers f licker as a main result of the fundamental frequency component of luminance supe rimposed on the DC-component, the flicker index is defined as ratio between the positive square roots of the sum of the two square components. Results & Conclusion The calculation results of flicker index indicate that flicker can be obviously weakened via increase of subfield number, symmetrical s election and homogeneous interlaced distribution of major weight subfields . Fli cker can be further reduced by choosing the suitable subfield order according to gray scale region of image.