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New Method for Predicting the Motion Responses of A Flexible Joint Multi-Body Floating System to Irregular Waves 被引量:13
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作者 陈徐均 崔维成 +1 位作者 沈庆 孙芦忠 《China Ocean Engineering》 SCIE EI 2001年第4期491-498,共8页
A new hybrid method of frequency domain and time domain is developed in this paper to predict the motion responses of a flexibly joint multi-body floating system to irregular waves. The main idea of the method is that... A new hybrid method of frequency domain and time domain is developed in this paper to predict the motion responses of a flexibly joint multi-body floating system to irregular waves. The main idea of the method is that the three-dimensional frequency method is used to obtain the hydrodynamic coefficients and the response equations are solved in time domain step by step. All the forces can be obtained at the same time. The motions and nonlinear mooring forces of a box type six-body floating system are predicted. A comparison of the theoretical method-based Solutions with experimental results has shown good agreement. 展开更多
关键词 flexible joint multi-body floating system nonlinear mooring forces
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Migration Networks Pattern of China’s Floating Population from the Perspective of Complex Network
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作者 LIU Wangbao CHEN Ranran 《Chinese Geographical Science》 SCIE CSCD 2024年第2期327-341,共15页
Since China’s reform and opening-up,the growing disparity between urban and rural areas and regions has led to massive migration.With China’s Rural Revitalization Strategy and the industrial transfer from the easter... Since China’s reform and opening-up,the growing disparity between urban and rural areas and regions has led to massive migration.With China’s Rural Revitalization Strategy and the industrial transfer from the eastern coastal areas to the inland,the migration direction and pattern of the floating population have undergone certain changes.Using the 2017 China Migrants Dynamic Survey(CMDS),excluding Hong Kong,Macao,and Taiwan regions of China,organized by China’s National Health Commission,the relationship matrix of the floating population is constructed according to the inflow place of the interviewees and their outflow place(the location of the registered residence)in the questionnaire survey.We then apply the complex network model to analyze the migration direction and network pattern of China’s floating population from the city scale.The migration network shows an obvious hierarchical agglomeration.The first-,second-,third-and fourth-tier distribution cities are municipalities directly under the central government,provincial capital cities,major cities in the central and western regions and ordinary cities in all provinces,respectively.The migration trend is from the central and western regions to the eastern coastal areas.The migration network has‘small world’characteristics,forming nine communities.It shows that most node cities in the same community are closely linked and geographically close,indicating that the migration network of floating population is still affected by geographical proximity.Narrowing the urban-rural and regional differences will promote the rational distribution this population.It is necessary to strengthen the reform of the registered residence system,so that the floating population can enjoy urban public services comparable to other populations,and allow migrants to live and work in peace. 展开更多
关键词 complex network floating population migration network spatial pattern community structure
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Scattering of Water Waves by Dual Symmetric Inclined Floating Porous Barriers Using the DBEM
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作者 WANG Li-xian DENG Yan-wen +1 位作者 YE Yang-sha DENG Zheng-zhi 《China Ocean Engineering》 SCIE EI CSCD 2024年第1期156-168,共13页
The scattering of normally incident water waves by two surface-piercing inclined perforated barriers in water with a uniform finite depth is investigated within the framework of linear water wave theory.Considering th... The scattering of normally incident water waves by two surface-piercing inclined perforated barriers in water with a uniform finite depth is investigated within the framework of linear water wave theory.Considering that thin barriers are zero-thickness,a novel numerical method involving the the coupling of the dual boundary element method(DBEM)with damping layers is applied.In order to effectively damp out the reflected waves,two damping layers,instead of pseudoboundaries are implemented near the two side boundaries of the computational domain.Thus,the modified linearized free surface boundary conditions are formulated and used for solving both the ordinary boundary integral equation as well as the hypersingular boundary integral equation for degenerate boundaries.The newly developed numerical method is validated against analytical methods using the matched eigenfunction expansion method for the special case of two vertical barriers or the inclined angle to the vertical being zero.The influence of the length of the two damping layers has been discussed.Moreover,these findings are also validated against previous results for several cases.After validation,the numerical results for the reflection coefficient,transmission coefficient and dissipation coefficient are obtained by varying the inclination angle and porosity-effect parameter.The effects of both the inclination angle and the porosity on the amplitudes of wave forces acting on both the front and rear barriers are also investigated.It is found that the effect of the inclination angle mainly shifts the location of the extremal values of the reflection and the transmission coefficients.Additionally,a moderate value of the porosity-parameter is quite effective at dissipating wave energy and mitigating the wave loads on dual barriers. 展开更多
关键词 dual boundary element method inclined perforated floating breakwater reflection coefficient transmission coefficient damping layer
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Comparisons of Wave Force Model Effects on the Structural Responses and Fatigue Loads of a Semi-Submersible Floating Wind Turbine
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作者 HAN Yanqing LE Conghuan +1 位作者 ZHANG Puyang XU Shengnan 《Journal of Ocean University of China》 CAS CSCD 2024年第1期69-79,共11页
The selection of wave force models will significantly impact the structural responses of floating wind turbines.In this study,comparisons of wave force model effects on the structural responses and fatigue loads of a ... The selection of wave force models will significantly impact the structural responses of floating wind turbines.In this study,comparisons of wave force model effects on the structural responses and fatigue loads of a semi-submersible floating wind turbine(SFWT)were conducted.Simulations were performed by employing the Morison equation(ME)with linear or second-order wave kinematics and potential flow theory(PFT)with first-or second-order wave forces.A comparison of regular waves,irregular waves,and coupled wind/waves analyses with the experimental data showed that many of the simulation results and experimental data are relatively consistent.However,notable discrepancies are found in the response amplitude operators for platform heave,tower base bending moment,and tension in mooring lines.PFT models give more satisfactory results of heave but more significant discrepan-cies in tower base bending moment than the ME models.In irregular wave analyses,low-frequency resonances were captured by PFT models with second-order difference-frequency terms,and high-frequency resonances were captured by the ME models or PFT models with second-order sum-frequency terms.These force models capture the response frequencies but do not reasonably predict the response amplitudes.The coupled wind/waves analyses showed more satisfactory results than the wave-only analyses.However,an important detail to note is that this satisfactory result is based on the overprediction of wind-induced responses. 展开更多
关键词 floating wind turbine wave force model potential flow theory Morison equation second-order wave forces
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Dynamic Analysis of a 10 MW Floating Offshore Wind Turbine Considering the Tower and Platform Flexibility
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作者 GAO Shan ZHANG Lixian +3 位作者 SHI Wei WANG Wenhua WANG Bin LI Xin 《Journal of Ocean University of China》 CAS CSCD 2024年第2期358-370,共13页
Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered ... Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic responses.The dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed herein.The simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is conducted.The effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are investigated.The results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind turbine.Considering the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid model.Moreover,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and platform.Thus,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined. 展开更多
关键词 floating offshore wind turbine TripleSpar semisubmersible platform rigidity and flexibility platform coupled simulation
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Simulation of wave scattering over a floating platform in the ocean with a coupled CFD-IBM model
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作者 Pengxuan Luo Jingxin Zhang +1 位作者 Yongyong Cao Shaohong Song 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2024年第3期157-161,共5页
A numerical study of linear wave scattering over a floating platform has been simulated by an efficient numericalmodel in this letter.The non-hydrostatic model is used to simulate the free surface and the uneven botto... A numerical study of linear wave scattering over a floating platform has been simulated by an efficient numericalmodel in this letter.The non-hydrostatic model is used to simulate the free surface and the uneven bottom.For thesolid body modelling,the immersed boundary method(IBM)is implemented by introducing a virtual boundaryforce into the momentum equations to emulate the boundary conditions.This implementation enhances theability of the model to simulate interactions between waves and floating structures.A numerical case involvingwave interactions with a floating platform is studied to validate the numerical model.By simulating the wavepropagation,the numerical model captures the variation of the wave scattering very well,which verifies theperformance of the numerical model and the robust strategy of the IBM. 展开更多
关键词 Non-hydrostatic model Immersed boundary method Wave structure interaction floating platform
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Research on Cultural Consumption and Urban Integration of Floating Population
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作者 Zhang Rui Dai Xiaowen 《Contemporary Social Sciences》 2024年第2期16-33,共18页
This paper examined the relationship between cultural consumption and the floating population’s integration into host cities based on data from China’s Seventh National Population Census and the 2018 China Migrants ... This paper examined the relationship between cultural consumption and the floating population’s integration into host cities based on data from China’s Seventh National Population Census and the 2018 China Migrants Dynamic Survey(CMDS).The findings indicate that improving the floating population’s consumption level and quality,especially the quality of development-oriented cultural consumption,can significantly improve the level of their integration.Moreover,development-oriented cultural consumption has a positive effect on the floating population’s integration and social participation,while entertainment-oriented cultural consumption facilitates their integration mainly by improving their sense of well-being.These findings could guide policymakers in developing targeted cultural consumption policies,implementing specific regional industry adjustments,and expanding domestic consumption demand. 展开更多
关键词 cultural consumption floating population urban integration social participation sense of well-being
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Preparation and Properties of Spray Polyurea Elastomer for Aquaculture Foam Floating Balls
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作者 Guifang HUANG Guanyuan WEI +3 位作者 Shengjun WEI Lan DING Wenhong CAI Bolin PAN 《Agricultural Biotechnology》 2024年第2期38-42,共5页
[Objectives] This study was conducted to develop a polyurea elastomer which can be sprayed on the surface of expanded polystyrene (EPS) floating balls, so as to improve the surface strength and service life of the flo... [Objectives] This study was conducted to develop a polyurea elastomer which can be sprayed on the surface of expanded polystyrene (EPS) floating balls, so as to improve the surface strength and service life of the floating balls. [Methods] The effects of the types and amounts of isocyanate, chain extenders and polyether polyols on the gelation rate, adhesion and wear resistance of polyurea elastomer were investigated, and it was finally determined the preparation process of polyurea elastomer using liquid isophorone diisocyanate (IPDI) and amino-terminated polyether (D2000) as the main raw materials, dimethylthiotoluene diamine (E300) as the chain extender and silica as the wear resistance modifier through two-step solution polymerization of prepolymerization and chain extension. [Results] The physical properties and chemical resistance tests of spray polyurea elastomer showed that it had good physical properties and acid and alkali resistance, and could meet the requirements of spraying and protection of EPS floating ball surface in marine environment. [Conclusions] Polyurea elastomer coating can improve the aging resistance, wear resistance and acid and alkali resistance of EPS floating balls, and prevent them from being fragile and floating randomly to form marine floating garbage which results in "white pollution". 展开更多
关键词 EPS floating ball Spray polyurea elastomer Gelation rate Wear resistant ADHESION Chemical resistance
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Experiment Study of Dynamics Response for Wind Turbine System of Floating Foundation 被引量:3
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作者 唐友刚 宋凯 王宾 《China Ocean Engineering》 SCIE EI CSCD 2015年第6期835-846,共12页
The floating foundation is designed to support a 1.5 MW wind turbine in 30 m water depth. With consideration of the viscous damping of foundation and heave plates, the amplitude-frequency response characteristics of t... The floating foundation is designed to support a 1.5 MW wind turbine in 30 m water depth. With consideration of the viscous damping of foundation and heave plates, the amplitude-frequency response characteristics of the foundation are studied. By taking into account the elastic effect of blades and tower, the classic quasi-steady blade-element/momentum(BEM) theory is used to calculate the aerodynamic elastic loads. A coupled dynamic model of the turbine-foundationmooring lines is established to calculate the motion response of floating foundation under Kaimal wind spectrum and regular wave by using the FAST codes. The model experiment is carried out to test damping characteristics and natural motion behaviors of the wind turbine system. The dynamics response is tested by considering only waves and the joint action of wind and waves. It is shown that the wind turbine system can avoid resonances under the action of wind and waves. In addition, the heave motion of the floating foundation is induced by waves and the surge motion is induced by wind. The action of wind and waves is of significance for pitch. 展开更多
关键词 offshore wind turbine semi-submersible floating foundation coupled dynamic model model experiment
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LOW TEMPERATURE ALUMINUM FLOATING ELECTROLYSIS IN HEAVY ELECTROLYTE Na_3AlF_6-AlF_3-BaC1_2-NaCl BATH SYSTEM 被引量:4
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作者 H.M. Lu and K.M. Fang Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China Z.X. Qiu Department of Nonferrous Metallurgy, Northeastern University, Shenyang 110006, China 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2000年第4期949-954,共6页
Multiple regression equations of liquidus temperature, electrical conductivity and bath density of the Na_3AlF_6-AlF_3-BaC1_2-NaCl system were obtained from experiments by using orthogonal regression method. The exper... Multiple regression equations of liquidus temperature, electrical conductivity and bath density of the Na_3AlF_6-AlF_3-BaC1_2-NaCl system were obtained from experiments by using orthogonal regression method. The experiments were carried out in 100A cell with low melting point electrolyte, the influences of cathodic current density, electrolytic temperature, density differences of bath and liquid aluminum on current efficiency (CE) were studied; when the electrolyte cryolite ratio was 2.5, w(BaC1_2) and w(NaCl) were 48% and 10%, respectively, CE reached 90% and specific energy consumption was 10.97k Wb/kg/kg. Because of the fact that aluminum metal obtained floated on the surface of molten electrolyte, this electrolysis method was then defined as low temperature aluminum floating electrolysis. The results showed that the new low temperature aluminum electrolysis process in the Na_3AlF_6-AlF_3-BaC1_2-NaCl bath system was practical and promising. 展开更多
关键词 low temperature aluminum floating electrolysis Na_3AlF_6- AlF_3BaC1_2-NaCl bath system current efficiency physico-chemical property
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Effects of incident wind/wave directions on dynamic response of a SPAR-type floating offshore wind turbine system 被引量:2
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作者 Guoqin Lyu Huiqin Zhang Jiachun Li 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2019年第5期954-963,共10页
As a promising renewable energy,offshore wind energy currently is gaining more attention,by which the economic and efficient operation of floating wind turbine systems is a potential research direction.This study is p... As a promising renewable energy,offshore wind energy currently is gaining more attention,by which the economic and efficient operation of floating wind turbine systems is a potential research direction.This study is primarily devoted to the analysis of dynamic response of the NREL-5 MW reference wind turbine supported by an OC3-Hywind SPAR-type platform using a recompiled code which combines FAST with WAMIT.To verify the reliability of the recompiled code,the free decay motions of a floating wind turbine system in still water are examined with satisfactory results.After that,thirteen scenarios with different angles between wind and wave from 0°to 90°are investigated.The dynamic responses of the turbine system in various degrees of freedom(DOFs)for different incident wind/wave directions are presented in both time and frequency domains via the fast Fourier transform. 展开更多
关键词 OFFSHORE floating WIND TURBINE Dynamic responses SPAR-type WIND TURBINE Distributions of WIND and wave DIRECTIONS
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Impact Analysis of Air Gap Motion with Respect to Parameters of Mooring System for Floating Platform 被引量:3
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作者 SHEN Zhong-xiang HUO Fa-li +1 位作者 NIE Yan LIU Yin-dong 《China Ocean Engineering》 SCIE EI CSCD 2017年第2期141-150,共10页
In this paper, the impact analysis of air gap concerning the parameters of mooring system for the semi-submersible platform is conducted. It is challenging to simulate the wave, current and wind loads of a platform ba... In this paper, the impact analysis of air gap concerning the parameters of mooring system for the semi-submersible platform is conducted. It is challenging to simulate the wave, current and wind loads of a platform based on a model test simultaneously. Furthermore, the dynamic equivalence between the truncated and full-depth mooring system is still a tuff work. However, the wind and current loads can be tested accurately in wind tunnel model. Furthermore, the wave can be simulated accurately in wave tank test. The full-scale mooring system and the all environment loads can be simulated accurately by using the numerical model based on the model tests simultaneously. In this paper, the air gap response of a floating platform is calculated based on the results of tunnel test and wave tank. Meanwhile, full-scale mooring system, the wind, wave and current load can be considered simultaneously. In addition, a numerical model of the platform is tuned and validated by ANSYS AQWA according to the model test results. With the support of the tuned numerical model, seventeen simulation cases about the presented platform are considered to study the wave, wind, and current loads simultaneously. Then, the impact analysis studies of air gap motion regarding the length, elasticity, and type of the mooring line are performed in the time domain under the beam wave, head wave, and oblique wave conditions. 展开更多
关键词 mooring system air gap floating platform
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Aero-Hydrodynamic Coupled Dynamic Characteristics of Semi-Submersible Floating Offshore Wind Turbines Under Inflow Turbulence 被引量:2
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作者 JIANG Hai-rui BAI Xing-lan Murilo A.VAZ 《China Ocean Engineering》 SCIE EI CSCD 2023年第4期660-672,共13页
In this study,the frequency characteristics of the turbulent wind and the effects of wind-wave coupling on the low-and high-frequency responses of semi-submersible floating offshore wind turbines(FOWT)are investigated... In this study,the frequency characteristics of the turbulent wind and the effects of wind-wave coupling on the low-and high-frequency responses of semi-submersible floating offshore wind turbines(FOWT)are investigated.Various wave load components,such as first-order wave loads,combined first-and second-order difference-frequency wave loads,combined first-and second-order sum-frequency wave loads,and first-and complete second-order wave loads are taken into consideration,while different turbulent environments are considered in aerodynamic loads.The com-parison is based on time histories and frequency spectra of platform motions and structural load responses and statistical values.The findings indicate that the second-order difference-frequency wave loads will significantly increase the natural frequency of low-frequency motion in the responses of the platform motion and structure load of the semi-submersible platform,which will cause structural fatigue damage.Under the action of turbulent wind,the influences of second-order wave loads on the platform motion and structural load response cannot be ignored,especially under extreme sea conditions.Therefore,in order to evaluate the dynamic responses of semi-submersible FOWT more accurately,the actual environment should be simulated more realistically. 展开更多
关键词 turbulence characteristics floating offshore wind turbines second-order hydrodynamic loads low-and high-frequency responses aero-hydrodynamic coupling
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One-step floating conversion of biomass into highly graphitized and continuous carbon nanotube yarns 被引量:1
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作者 Gongxun Zhai Qianqian Wang +5 位作者 Fuyao Liu Zexu Hu Chao Jia Dengxin Li Hengxue Xiang Meifang Zhu 《Green Energy & Environment》 SCIE EI CAS CSCD 2023年第6期1711-1718,共8页
The rapid growth of the demand for carbon nanotubes(CNTs) has greatly promoted their large-scale synthesis and development. However,the continuous production of CNT fibers by floating catalyst chemical vapor depositio... The rapid growth of the demand for carbon nanotubes(CNTs) has greatly promoted their large-scale synthesis and development. However,the continuous production of CNT fibers by floating catalyst chemical vapor deposition(FCCVD) requires a large amount of non-renewable carbon sources. Here, the continuous production of highly graphitized CNT yarns from biomass tannic acid(TA) is reported. The chelation of TA and catalyst promotes the rapid cracking of biomass into carbon source gas, and the pyrolysis cracking produces the reducing gas, which solves the problems of the continuous production of CNT yarns using biomass. Through simple twisting, the mechanical strength of CNT yarn can reach 886 ± 46 MPa, and the electrical conductivity and graphitization(IG/ID) can reach 2 × 10^(5)S m^(-1)and 6.3, respectively. This work presents a promising solution for the continuous preparation of CNT yarns based on green raw material. 展开更多
关键词 Carbon nanotube Tannic acid BIOMASS Pyrolysis floating catalyst chemical vapor deposition
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Coupled Time-Domain Investigation on a Vertical Axis Wind Turbine Supported on a Floating Platform 被引量:1
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作者 CUI Jianhui ZHAI Yongjian +2 位作者 GUO Ying DENG Wanru LIU Liqin 《Journal of Ocean University of China》 SCIE CAS CSCD 2023年第2期365-376,共12页
The dynamic responses of a floating vertical axis wind turbine(VAWT)are assessed on the basis of an aero-hydro-mooring coupled model.The aerodynamic loads on the rotor are acquired with double-multiple stream tube met... The dynamic responses of a floating vertical axis wind turbine(VAWT)are assessed on the basis of an aero-hydro-mooring coupled model.The aerodynamic loads on the rotor are acquired with double-multiple stream tube method.First-and second-order wave loads are calculated on the basis of 3D potential theory.The mooring loads are simulated by catenary theory.The coupled model is established,and a numerical code is programmed to investigate the dynamic response of the semi-submersible VAWT.A model test is then conducted,and the numerical code is validated considering the hydrodynamic performance of the floating buoy.The responses of the floating VAWT are studied through the numerical simulation under the sea states of wind and regular/irregular waves.The effects of the second-order wave force on the motions are also investigated.Results show that the slow-drift responses in surge and pitch motions are significantly excited by the second-order wave forces.Furthermore,the effect of foundation motion on aerodynamic loads is examined.The normal and tangential forces of the blades demonstrate a slight increase due to the coupling effect between the buoy motion and the aerodynamic loads. 展开更多
关键词 offshore wind power semi-submersible floating foundation vertical axis wind turbine numerical calculation model test
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Wave Extraction and Attenuation Performance of A Hybrid System of An Edinburgh Duck WEC and A Floating Breakwater
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作者 ZHOU Bin-zhen WANG Yu +3 位作者 ZHANG Heng-ming JIN Peng WANG Lei ZHOU Zhao-min 《China Ocean Engineering》 SCIE EI CSCD 2022年第2期167-178,共12页
Installing the Edinburgh Duck Wave Energy Converter(ED WEC)on a floating breakwater provides a potential solution to reduce costs and improve the reliability of the ED WEC.To investigate the interactions between the E... Installing the Edinburgh Duck Wave Energy Converter(ED WEC)on a floating breakwater provides a potential solution to reduce costs and improve the reliability of the ED WEC.To investigate the interactions between the ED WEC and the breakwater,a two-dimensional numerical model of a hybrid WEC-breakwater system is established based on Star-CCM+Computational Fluid Dynamics(CFD)software.The wave energy extraction performance,wave attenuation performance,and wave forces on the breakwater of the hybrid system are compared with those of the corresponding single device.The effects of the initial attack angle,the distance between the WEC and the breakwater,and the incident wave height on the pitch motion,energy conversion efficiency,transmission coefficient,and wave forces on the breakwater of the hybrid system are analyzed.The results indicate that combing the ED WEC with a breakwater can improve the energy extraction performance of the ED WEC and reduce the wave forces on the breakwater in shorter-period waves.The conversion efficiency of the hybrid system with the initial attack angle of 42°is the largest in shorter-period waves,but is reduced with the increase of initial attack angle in longer-period waves.The wave attenuation performance of the hybrid system is determined by the draft of the breakwater.The distance between the WEC and the breakwater has little effect on the hybrid system.Wave energy extraction of the ED WEC of the hybrid system decreases significantly with the increase of the incident wave height. 展开更多
关键词 Edinburgh Duck wave energy converter floating breakwater wave energy extraction wave attenuation wave nonlinearity
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In vitro and in vivo evaluation of gastroretentive floating drug delivery system of ofloxacin
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作者 Rajani Shaky Panna Thapa Ranendra N.Saha 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2013年第3期191-198,共8页
This study aimed to develop hydrophilicmatrix based controlled release gastroretentive drug delivery system of ofloxacin and conducting its in vitro and in vivo evaluations.Effervescent floating gastroretentive drug d... This study aimed to develop hydrophilicmatrix based controlled release gastroretentive drug delivery system of ofloxacin and conducting its in vitro and in vivo evaluations.Effervescent floating gastroretentive drug delivery system of ofloxacin was prepared utilizing Boxe Behnken statistical design with 3 factors,3 levels and 15 experimental trials.Formulation optimization was done by setting targets on selected responses.In vivo studies were carried out for the optimized formulation with 12 healthy human volunteers and obtained pharmacokinetic parameters were compared with themarketed once daily formulation,“Zanocin OD”.Optimized formulation showed satisfactory controlled in vitro drug release for more than 12 h with excellent buoyancy properties(floating lag time<1 min,floating duration>16 h).Optimized and marketed formulations were found to have similar in vitro release profile(f2¼79.22)and also were found to be bioequivalent.Serum ofloxacin concentration was well maintained above its reported minimum inhibitory concentrations for most of the pathogens for sufficiently longer duration.Cmax and AUC values of optimized formulation were found to be significantly higher than of marketed product despite their bioequivalence.Bettertherapeutic effect can be expected since ofloxacin exhibits concentration dependent killing.Hence,gastroretention can be a promising approach to enhance bioavailability of ofloxacin with narrow absorption window in upper GIT. 展开更多
关键词 OFLOXACIN Gastroretentive drug delivery system BoxeBehnken design BIOAVAILABILITY floating
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Hydrodynamic Performance of A Dual-Floater Integrated System Com-bining Hybrid WECs and Floating Breakwaters
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作者 FU Lei CHENG Yong 《China Ocean Engineering》 SCIE EI CSCD 2022年第6期969-979,共11页
The high investment and low return of wave energy converters(WECs)seriously hamper their large-scale commercial application.The integration of WECs and floating breakwaters is conducive to enhance the competitiveness ... The high investment and low return of wave energy converters(WECs)seriously hamper their large-scale commercial application.The integration of WECs and floating breakwaters is conducive to enhance the competitiveness of wave energy conversion.The objective of this paper is to investigate the hydrodynamic performance of a WEC-breakwater integrated system combining an upstream oscillating water column(OWC)and a downstream oscillating buoy(OB)via numerical simulations and physical experiments.A nonlinear numerical wave flume using Star-CCM+software is employed to obtain calculated results,where a tiny transverse gap is set between the flume wall and the block surface to simulate a similar two-dimensional(2D)model.The corresponding physical experiments are also carried out in a practical wave flume to verified the numerical results.The comparison of the isolated and hybrid system shows that the hybrid design leads to the decreased conversion efficiency of each WEC,but improves the transmission performance of the hybrid system.The wave resonance between two devices causes the abrupt reduction of OWC efficiency and a positive correlation exists with the OB efficiency.The total efficiency of the hybrid system is raised by an optimal opening ratio,a shallow OWC draft and a short spacing distance.Except for the OWC draft,other design parameters have weak effect on the wave attenuation of the hybrid system.This paper can help understand hydrodynamics of the hybrid WECs integrated with breakwaters and improve their performances. 展开更多
关键词 wave energy converters floating breakwater oscillating buoy oscillating water column numerical wave flume physical experiment
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A Method Based on Multi-Body Dynamic Analysis for A Floating Two-Stage Buffer Collision-Prevention System Under Ship Collision Loads
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作者 LU Kai CHEN Xu-jun +2 位作者 YUAN Hui HUANG Heng WU Guang-huai 《China Ocean Engineering》 SCIE EI CSCD 2021年第6期828-840,共13页
The collision of ships poses a great threat to the piers in navigable waters.The kinetic energy of the moving ship can be consumed not only with the structural deformation,but also with tensile force from the proposed... The collision of ships poses a great threat to the piers in navigable waters.The kinetic energy of the moving ship can be consumed not only with the structural deformation,but also with tensile force from the proposed Floating Two-stage Buffer Collision-Prevention System(FTBCPS).The actual anti-collision effect of the current designed FTBCPS can be evaluated by the dynamic simulation.The construction method of 3D model is introduced,and the system initial state is defined.The transformation matrix and the basic kinematics vector are given,and the system basic dynamics equation is then created.The mechanical analysis on each component is carried out,and the detailed process of numerical simulation is also given.The simulation results indicate that collision direction and collision position have a great influence on the system kinematic response.Bridge pier faces the greatest threat when a ship hits the floater on the front beam in a nearly vertical direction,or on the side beam in a larger course angle.The study shows that the current designed FTBCPS can make full use of the fracture tensile property of polyester ropes and keep the tensile force acted on pier within its bearable range at the same time.The collision direction has a significant effect on the dynamic response of the colliding bodies,but no failure appeared in the simulations,which indicates that the current designed FTBCPS can protect bridge piers of all cases for the 5000-t ship with a velocity smaller than 5 m/s in navigable waters. 展开更多
关键词 bridge engineering floating Two-stage Buffer Collision-Prevention system dynamics response compression force anti-collision tensile force anti-collision
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Investigation on Effects of Mooring Line Fractures and Connector Failures for A Hybrid Modular Floating Structure System
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作者 LIU Ya-qiong REN Nian-xin OU Jin-ping 《China Ocean Engineering》 SCIE EI CSCD 2022年第6期880-893,共14页
The present work reports a Hybrid Modular Floating Structure(HMFS)system with typical malfunction conditions.The effects of both fractured mooring lines and failed connectors on main hydrodynamic responses(mooring lin... The present work reports a Hybrid Modular Floating Structure(HMFS)system with typical malfunction conditions.The effects of both fractured mooring lines and failed connectors on main hydrodynamic responses(mooring line tensions,module motions,connector loads and wave power production)of the HMFS system under typical sea con-ditions are comparatively investigated.The results indicate that the mooring tension distribution,certain module motions(surge,sway and yaw)and connector loads(Mz)are significantly influenced by mooring line fractures.The adjacent mooring line of the fractured line on the upstream side suffers the largest tension among the remaining mooring lines,and the case with two fractured mooring lines in the same group on the upstream side is the most dangerous among all cases of two-line failures in view of mooring line tensions,module motions and connector loads.There-fore,one emergency strategy with appropriate relaxation of a proper mooring line has been proposed and proved effective to reduce the risk of more progressive mooring line fractures.In addition,connector failures substantially affect certain module motions(heave and pitch),certain connector loads(Fz and My)and wave power production.The present work can be helpful and instructive for studies on malfunction conditions of modular floating structure(MFS)systems. 展开更多
关键词 Hybrid Modular floating Structure(HMFS)system mooring line fractures connector failures hydrodynamic responses emergency strategy
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