LHP1 mediates recruitment of the PRC2 histone methyltransferase complex to chromatin and thereby facilitates maintenance of H3K27me3 on FLC, a key flowering repressor gene. Here, we report that the PWWP domain protei...LHP1 mediates recruitment of the PRC2 histone methyltransferase complex to chromatin and thereby facilitates maintenance of H3K27me3 on FLC, a key flowering repressor gene. Here, we report that the PWWP domain proteins （PDPs） interact with FVE and MSI5 to suppress FLC expression and thereby promote flowering. We demonstrated that FVE, MSI5, and PDP3 were co-purified with LHP1. The H3K27me3 level on FLC was decreased in the pdp mutants as welt as in the fve/ msi5 double mutant. This study suggests that PDPs function together with FVE and MSI5 to regulate the function of the PRC2 complex on FLC.展开更多
The shoot apical meristem（SAM） continuously produces lateral organs in plants.Based on the identity of the lateral organs,the life cycle of a plant can be divided into two phases： vegetative and reproductive.The SA...The shoot apical meristem（SAM） continuously produces lateral organs in plants.Based on the identity of the lateral organs,the life cycle of a plant can be divided into two phases： vegetative and reproductive.The SAM produces leaves during the vegetative phase,whereas it gives rise to flowers in the reproductive phase（reviewed in Poethig,2003）.The floral transition,namely the switch from vegetative to reproductive growth,展开更多
基金supported by the National Key Research and Development Program of China (2016YFA0500801)the 973 Program (2011CB812600) from the Chinese Ministry of Science and Technology (to X.J.H.)the National Natural Science Foundation of China (31370317 and 31571584 to B.W.)
文摘LHP1 mediates recruitment of the PRC2 histone methyltransferase complex to chromatin and thereby facilitates maintenance of H3K27me3 on FLC, a key flowering repressor gene. Here, we report that the PWWP domain proteins （PDPs） interact with FVE and MSI5 to suppress FLC expression and thereby promote flowering. We demonstrated that FVE, MSI5, and PDP3 were co-purified with LHP1. The H3K27me3 level on FLC was decreased in the pdp mutants as welt as in the fve/ msi5 double mutant. This study suggests that PDPs function together with FVE and MSI5 to regulate the function of the PRC2 complex on FLC.
基金supported by the grant from the National Natural Science Foundation of China(Nos.31222029 and 91217306)State Key Basic Research Program of China(No. 2013CB 127000)+2 种基金Shanghai Pujiang Program(No.12PJ 1409900)Recruitment Program of Global Expects(China)the initiation grant from NKLPMG(SIPPE,SIBS)
文摘The shoot apical meristem（SAM） continuously produces lateral organs in plants.Based on the identity of the lateral organs,the life cycle of a plant can be divided into two phases： vegetative and reproductive.The SAM produces leaves during the vegetative phase,whereas it gives rise to flowers in the reproductive phase（reviewed in Poethig,2003）.The floral transition,namely the switch from vegetative to reproductive growth,
