Herein,we report a geometrically well-defined prism assembled by two floxuridine(F)integrated RNA strands as a precise nanomedicine for chemodrug delivery.Owing to the similarity between chemotherapeutic F and uridine...Herein,we report a geometrically well-defined prism assembled by two floxuridine(F)integrated RNA strands as a precise nanomedicine for chemodrug delivery.Owing to the similarity between chemotherapeutic F and uridine(U),all uridines in the component RNA strands are replaced by F during their in vitro transcription syntheses.By specifically designing their sequences,F-containing S-shape tiles with the single-stranded loops are constructed and then further assemble into the RNA prism through T-junction interactions and sticky-end cohesions.The present study demonstrates that the F-integrated RNA prism can serve as an efficient platform for chemodrug delivery and anticancer treatment.We believe that the study would help the future development of RNA-based nanomedicine in various applications.展开更多
基金Supported by the National Key Research and Development Program of China(Nos.2018YFC1106100,2018YFC1106102)the National Natural Science Foundation of China(Nos.21661162001,21673139,51690151,51473093,51973112)+1 种基金the Special Program for Collaborative Innovation in Shanghai University of Medicine&Health Sciences,China(No.SPCI-17-15-001)the Program of Shanghai Medical Professionals Across Subject Funds,China(No.YG2016MS74).
文摘Herein,we report a geometrically well-defined prism assembled by two floxuridine(F)integrated RNA strands as a precise nanomedicine for chemodrug delivery.Owing to the similarity between chemotherapeutic F and uridine(U),all uridines in the component RNA strands are replaced by F during their in vitro transcription syntheses.By specifically designing their sequences,F-containing S-shape tiles with the single-stranded loops are constructed and then further assemble into the RNA prism through T-junction interactions and sticky-end cohesions.The present study demonstrates that the F-integrated RNA prism can serve as an efficient platform for chemodrug delivery and anticancer treatment.We believe that the study would help the future development of RNA-based nanomedicine in various applications.
