Effect of Cadmium on the Developmental Instability of Anabas testudineus through Evaluation of Fluctuating Asymmetry of Eye Diameter

Biomonitoring using fish has been a popular method of assessing the toxic effects of cadmium concentrations of cadmium in water bodies and has led to bioaccumulation in fish contributing to various morphological alterations. Among the known effects of these alterations is developmental instability via fluctuating asymmetry (FA). The utilization of FA data is a simple yet effective method to evaluate the toxic effects of cadmium on the stability of development. This study used climbing perch (Anabas testudieneus) to assess the FA in the diameter of the eye because of low-level cadmium exposure. The left and right sides of the traits were measured once every four weeks for 16 weeks. The average measurements from both sides of the traits were used to calculate the FA value. Results found that the highest mean FA for the diameter of the eye was obtained in the highest treatment group, 0.015 mg/L. The results also indicate that increasing concentrations of cadmium exposure had a statistically significant effect on the FA of eye diameter. There was also a statistically significant interaction between the duration of exposure and treatment groups in FA of the diameter of the eye. The results from the study indicate that prolonged exposure to sub-lethal concentrations of cadmium can cause significant effects on the normal development of eyes in Anabas testudineus. This study can add to the body of research regarding fluctuating asymmetry as a tool to study developmental toxicants and assess other bilateral organs.

Random vortex induced vibration response of suspended flexible cable to fluctuating wind

A popular dynamical model for the vortex induced vibration(VIV)of a suspended flexible cable consists of two coupled equations.The first equation is a partial differential equation governing the cable vibration.The second equation is a wake oscillator that models the lift coefficient acting on the cable.The incoming wind acting on the cable is usually assumed as the uniform wind with a constant velocity,which makes the VIV model be a deterministic one.In the real world,however,the wind velocity is randomly fluctuant and makes the VIV of a suspended flexible cable be treated as a random vibration.In the present paper,the deterministic VIV model of a suspended flexible cable is modified to a random one by introducing the fluctuating wind.Using the normal mode approach,the random VIV system is transformed into an infinite-dimensional modal vibration system.Depending on whether a modal frequency is close to the aeolian frequency or not,the corresponding modal vibration is characterized as a resonant vibration or a non-resonant vibration.By applying the stochastic averaging method of quasi Hamiltonian systems,the response of modal vibrations in the case of resonance or non-resonance can be analytically predicted.Then,the random VIV response of the whole cable can be approximately calculated by superimposing the response of the most influential modal vibrations.Some numerical simulation results confirm the obtained analytical results.It is found that the intensity of the resonant modal vibration is much higher than that of the non-resonant modal vibration.Thus,the analytical results of the resonant modal vibration can be used as a rough estimation for the whole response of a cable.

Congenital stapes suprastructure fixation presenting with fluctuating auditory symptoms:A case report

BACKGROUND Stapes ankylosis is a rare cause of conductive hearing loss,and stapes suprastructure fixation is extremely rare with fewer than 30 reported cases.Patients usually visit the clinic with non-progressive conductive hearing loss that typically began in the early years of life.CASE SUMMARY Herein,we report a case of a 37-year-old female with an isolated stapedial suprastructure fixation.The patient presented with unusual fluctuating auditory symptoms of tinnitus,ear fullness and mixed hearing loss.Pre-operative temporal bone computed tomography findings and operative findings revealed an isolated stapedial suprastructure fixation with monopod stapes caused by elongated pyramidal eminence.The hearing threshold recovered completely,and fluctuating auditory symptoms disappeared after the surgery.CONCLUSION This is the first report of stapedial suprastructure fixation with fluctuating auditory symptoms.Successful results are expected with surgical treatment.

Optimization of Gas Production from Hydrate-Bearing Sediments with Fluctuation Characteristics

As an important source of low-carbon,clean fossil energy,natural gas hydrate plays an important role in improving the global energy consumption structure.Developing the hydrate industry in the South China Sea is important to achieving‘carbon peak and carbon neutrality’goals as soon as possible.Deep-water areas subjected to the action of long-term stress and tectonic movement have developed complex and volatile terrains,and as such,the morphologies of hydrate-bearing sediments(HBSs)fluctuate correspondingly.The key to numerically simulating HBS morphologies is the establishment of the conceptual model,which represents the objective and real description of the actual geological body.However,current numerical simulation models have characterized HBSs into horizontal strata without considering the fluctuation characteristics.Simply representing the HBS as a horizontal element reduces simulation accuracy.Therefore,the commonly used horizontal HBS model and a model considering the HBS’s fluctuation characteristics with the data of the SH2 site in the Shenhu Sea area were first constructed in this paper.Then,their production behaviors were compared,and the huge impact of the fluctuation characteristics on HBS production was determined.On this basis,the key parameters affecting the depressurization production of the fluctuating HBSs were studied and optimized.The research results show that the fluctuation characteristics have an obvious influence on the hydrate production of HBSs by affecting their temperatures and pressure distributions,as well as the transmission of the pressure drop and methane gas discharge.Furthermore,the results show that the gas productivity of fluctuating HBSs was about 5%less than that of horizontal HBSs.By optimizing the depressurization amplitude,well length,and layout location of vertical wells,the productivity of fluctuating HBSs increased by about 56.6%.

Research on Anti-Fluctuation Control of Winding Tension System Based on Feedforward Compensation

In the fiber winding process,strong disturbance,uncertainty,strong coupling,and fiber friction complicate the winding constant tension control.In order to effectively reduce the influence of these problems on the tension output,this paper proposed a tension fluctuation rejection strategy based on feedforward compensation.In addition to the bias harmonic curve of the unknown state,the tension fluctuation also contains the influence of bounded noise.A tension fluctuation observer(TFO)is designed to cancel the uncertain periodic signal,in which the frequency generator is used to estimate the critical parameter information.Then,the fluctuation signal is reconstructed by a third-order auxiliary filter.The estimated signal feedforward compensates for the actual tension fluctuation.Furthermore,a time-varying parameters fractional-order PID controller(TPFOPID)is realized to attenuate the bounded noise in the fluctuation.Finally,TPFOPID is enhanced by TFO and applied to control a tension control system considering multi-source disturbances.The stability of the method is analyzed by using the Lyapunov theorem.Finally,numerical simulations verify that the proposed scheme improves the tracking ability and robustness of the system in response to tension fluctuations.

Influence of blood glucose fluctuations on chemotherapy efficacy and safety in type 2 diabetes mellitus patients complicated with lung carcinoma

BACKGROUND Patients with type 2 diabetes mellitus(T2DM)have large fluctuations in blood glucose(BG),abnormal metabolic function and low immunity to varying degrees,which increases the risk of malignant tumor diseases and affects the efficacy of tumor chemotherapy.Controlling hyperglycemia may have important therapeutic implications for cancer patients.AIM To clarify the influence of BG fluctuations on chemotherapy efficacy and safety in T2DM patients complicated with lung carcinoma(LC).METHODS The clinical data of 60 T2DM+LC patients who presented to the First Affiliated Hospital of Ningbo University between January 2019 and January 2021 were retrospectively analyzed.All patients underwent chemotherapy and were grouped as a control group(CG;normal BG fluctuation with a mean fluctuation<3.9 mmol/L)and an observation group(OG;high BG fluctuation with a mean fluctuation≥3.9 mmol/L)based on their BG fluctuations,with 30 cases each.BGrelated indices,tumor markers,serum inflammatory cytokines and adverse reactions were comparatively analyzed.Pearson correlation analysis was performed to analyze the correlation between BG fluctuations and tumor markers.RESULTS The fasting blood glucose and 2-hour postprandial blood glucose levels in the OG were notably elevated compared with those in the CG,together with markedly higher mean amplitude of glycemic excursions(MAGE),mean of daily differences,largest amplitude of glycemic excursions and standard deviation of blood glucose(P<0.05).In addition,the OG exhibited evidently higher levels of carbohydrate antigen 19-9,carbohydrate antigen 125,carcinoembryonic antigen,neuron-specific enolase,cytokeratin 19,tumor necrosis factor-α,interleukin-6,and highsensitivity C-reactive protein than the CG(P<0.05).Pearson analysis revealed a positive association of MAGE with serum tumor markers.The incidence of adverse reactions was significantly higher in the OG than in the CG(P<0.05).CONCLUSION The greater the BG fluctuation in LC patients after chemotherapy,the more unfavorable the therapeutic effect of chemotherapy;the higher the level of tumor markers and inflammatory cytokines,the more adverse reactions the patient experiences.

Solution of general dynamic equation for nanoparticles in turbulent flow considering fluctuating coagulation

A new averaged general dynamic equation （GDE） for nanoparticles in the turbulent flow is derived by considering the combined effect of convection, Brownian diffusion, turbulent diffusion, turbulent coagulation, and fluctuating coagulation. The equation is solved with the Taylor-series expansion moment method in a turbulent pipe flow. The experiments are performed. The numerical results of particle size distribu- tion correlate well with the experimental data. The results show that, for a turbulent nanoparticulate flow, a fluctuating coagulation term should be included in the averaged particle GDE. The larger the Schmidt number is and the lower the Reynolds number is, the smaller the value of ratio of particle diameter at the outlet to that at the inlet is. At the outlet, the particle number concentration increases from the near-wall region to the near-center region. The larger the Schmidt number is and the higher the Reynolds num- ber is, the larger the difference in particle number concentration between the near-wall region and near-center region is. Particle polydispersity increases from the near-center region to the near-wall region. The particles with a smaller Schmidt number and the flow with a higher Reynolds number show a higher polydispersity. The degree of particle polydispersity is higher considering fluctuating coagulation than that without considering fluctuating coagulation.

Change trend analysis of ammonia nitrogen in Nenjiang River main stream under fluctuating precipitation

将2004-2010年嫩江流域沿途13个气象站的降水量作为径流的主要考察因子，以嫩江最下游的自沙滩水环境监测站获得的氨氮监测数据为流域总体氨氮污染水平表征，分析了降水波动对嫩江流域氨氮污染变化的影响。结果表明，嫩江流域在年度内的氨氮质量浓度以枯水期最高，平均为（0．99±0．48）mg／L，在丰水期最低，平均为（O．58±0．08）mg／L。从年际总体变化趋势来看，2004-2010年嫩江流域氨氮浓度总体呈增加趋势。降水量的年内分布格局对嫩江流域氨氮浓度的影响在不同时期略有差别。在平水期，降水量变化对氨氮浓度的影响不显著；但在枯水期、丰水期，降水量的波动对氨氮浓度有较显著（Sig．〈O．05）的影响。从年尺度上看，随降水量增加，嫩江流域中氨氮浓度总体呈下降趋势。

Fluctuating resources,disturbance and plant strategies:diverse mechanisms underlying plant invasions

This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. （2000）. I measured relative functional responses of both invasive and native plants to changed resource availability due to nutrient enrichment and rainfall, and to increased disturbance. Data are presented from studies in two contrasting ecosystems. First is a series of glasshouse and field experiments on the invader Hieracium lepidulum and associated invasive and native species in subalpine temperate New Zealand. Second is a field study of invasive and native plant responses to altered disturbance regimes and rainfall from tropical savannas of north eastern Australia. Invaders responded differently from native species to changes in resource availability in both subalpine and tropical studies. However, invaders differed among themselves showing that different species exploit different functional niches to invade their respective habitats. These findings contribute to the contention that the fluctuating resource hypothesis does not provide a universal explanation for plant invasions. The diverse functional responses to increased resource availability among invaders in this and previous studies suggest that the cause of invasion depends on unique combinations of habitat and functional attributes of invaders and native assemblages. Such findings imply that universal predictions of what will happen under climate change scenarios across the globe will be difficult to make.

Control of mean and fluctuating forces on a circular cylinder at high Reynolds numbers

A narrow strip is used to control mean and fluctuating forces on a circular cylinder at Reynolds numbers from 2.0 ×10^4 to 1.0 ×^ 10^5. The axes of the strip and cylinder are parallel. The control parameters are strip width ratio and strip position characterized by angle of attack and distance from the cylinder. Wind tunnel tests show that the vortex shedding from both sides of the cylinder can be suppressed, and mean drag and fluctuating lift on the cylinder can be reduced if the strip is installed in an effective zone downstream of the cylinder. A phenomenon of mono-side vortex shedding is found. The strip-induced local changes of velocity profiles in the near wake of the cylinder are measured, and the relation between base suction and peak value in the power spectrum of fluctuating lift is studied. The control mechanism is then discussed from different points of view.

Effects of Reneging, Server Breakdowns and Vacation on a Batch Arrival Single Server Queueing System with Three Fluctuating Modes of Service

This article examines the effects of reneging, server breakdown and server vacation on the various states of the batch arrivals queueing system with single server providing service to customers in three fluctuating modes. In this queueing system, any batch arrival joins the queue if the server is busy or on vacation or under repair. However, if the server is free, one customer from the arriving batch joins the service immediately while others join the queue. In case of server breakdown, the customer whose service is interrupted returns back to the head of the queue. As soon as the server has is repaired, the server attends to the customer in mode 1. For this queueing system, customers that are impatient due to breakdown and server vacation may renege (leave the queue without getting service). Due to fluctuating modes of service delivery, the system may provide service with complete or reduced efficiency. Consequently, we construct the mathematical model and derive the probability generating functions of the steady state probabilities of several states of the system including the steady state queue size distribution. Further, we discuss some particular cases of the proposed queueing model. We present numerical examples in order to demonstrate the effects of server vacation and reneging on the various states of the system. The study revealed that an increase in reneging and a decrease in server vacation results in a decrease in server utilization and an increase in server’s idle time provided rates of server breakdown and repair completion are constant. In addition, the probability of server vacation, the probability of system is under repair and the probabilities that the server provides service in three fluctuating modes decreases due to an increase in reneging and a decrease in vacation completion rates.

Simulation of unsteady aerodynamic loads on high-speed trains in fluctuating crosswinds

To study the unsteady aerodynamic loads of high-speed trains in fluctuating crosswinds, the fluctuating winds of a moving point shifting with high-speed trains are calculated in this paper based on Cooper theory and harmonic superposition method. The computational fluid dynamics method is used to obtain the aerodynamic load coefficients at different mean yaw angles, and the aero- dynamic admittance function is introduced to calculate unsteady aerodynamic loads of high-speed trains in fluctuating winds. Using this method, the standard deviation and maximum value of the aerodynamic force （moment） are simulated. The results show that when the train speed is fixed, the varying mean wind speeds have large impact on the fluctuating value of the wind speeds and aerodynamic loads; in contrast, when the wind speed is fixed, the varying train speeds have little impact on the fluctuating value of the wind speeds or aerodynamic loads. The ratio of standard deviation to 0.SpKU2, or maximum value to 0.5pKU2, can be expressed as the function of mean yaw angle. The peak factors of the side force and roll moment are the same （ - 3.28）, the peak factor of the lift force is - 3.33, and the peak factors of the yaw moment and pitch moment are also the same （- 3.77）.

Annual and Diurnal Variabilities in the Critical Frequency (foF2) during Geomagnetic Fluctuating Activity over Solar Cycles 21 and 22 at Ouagadougou

Geomagnetic activity is characterized by four solar wind conditions. Each condition has specific impact on ionosphere. This paper review on fluctuating activity effects on ionosphere F2 layer through its critical frequency foF2 variations. Under fluctuating wind conditions, we have investigated on annual, diurnal and seasonal variations of foF2 during solar cycles 21 and 22 phases covered by Ouagadougou ionosonde station data (Lat: 12.5&#176N;Long: 358.5&#176E;dip: 1.43&#176). Our investigations show that foF2 annual’ variability is in phase with solar cycle. The diurnal variation is “noon bite out” most of the time except for the solar maximum where we have a morning peak testifying to the fact that the vertical drift E × B is disturbed. The seasonal variations show that the fluctuating activity has no particular effect on certain characteristics of the equatorial ionosphere such as electrojet and vertical drift E × B. However, the increase of the electric field pre-reversal phenomenon in autumn is a characteristic effect observed during the fluctuating activity.

Distribution of non-spherical nanoparticles in turbulent flow of ventilation chamber considering fluctuating particle number density

The Reynolds-averaged general dynamic equation(RAGDE)for the nanoparticle size distribution function is derived,including the contribution to particle coagulation resulting from the fluctuating concentration.The equation together with that of a turbulent gas flow is solved numerically in the turbulent flow of a ventilation chamber with a jet on the wall based on the proposed model relating the fluctuating coagulation to the gradient of mean concentration.Some results are compared with the experimental data.The results show that the proposed model relating the fluctuating coagulation to the gradient of mean concentration is reasonable,and it is necessary to consider the contribution to coagulation resulting from the fluctuating concentration in such a flow.The changes of the particle number concentration M_(0) and the geometric mean diameter dg are more obvious in the core area of the jet,but less obvious in other areas.With the increase in the initial particle number concentration m00,the values of M_(0) and the standard deviation of the particle sizeσdecrease,but the value of d_(g) increases.The decrease in the initial particle diameter leads to the reduction of M_(0) andσand the increase in d_(g).With the increase in the Reynolds number,particles have few chances of collision,and hence the coagulation rate is reduced,leading to the increase in M_(0) andσand the decrease in d_(g).

Effect of Fluctuating Temperatures on Forest SoilNitrogen Mineralization

Nitrogen mineralization in forest soil was studied in laboratory by incubating undisturbed soil cores enclosed within PVC columns at different temperatures to compare the effect of fluctuating temperature with that of constant temperature, and to find out whether soil nitrification shows linearity over time. The results showed that there was no significant difference between soil nitrification at fluctuating temperature and that at constant temperature, and suggested that it must be careful to make the conclusion that soil nitrification has linearity over time.

AN EXPERIMENTAL STUDY OF FLUCTUATING LIFT ON A SQUARE-SECTION CYLINDER OSCILLATING TRANSVERSELY IN A UNIFORM STREAM

Experiments on a square section cylinder fixed and forced to oscillate transversely in a uni- form stream were conducted in a water tank.The Reynolds numberof the experiments is in the range of 3·10~3 tO 10~4,the amplitude to side length ratio A/D is up to 0.7 and the range of reduced velocity is 4.5<Vr<12.This study aims at investigating the lock-in phenomenon,the fluctuating lift and the phase shift between fluctuating lift and displacement of the oscillating cylinder.The problems on the aeroelastic insta. bility relating to present experimental results have been discussed.The flow visualization clearly shows that there are drastic changes of vortex-shedding from cylinder at the resonance point and the upper end of the lock-in range.The results of the flow visualization give better understanding of the physical mechanism of the phase shift.

Spatial relation between fluctuating wall pressure and near-wall streamwise vortices in wall bounded turbulent flow

A new view of the spatial relation between fluctuating wall pressure and near-wall streamwise vortices （NWSV） is proposed for wall bounded turbulent flow by use of the direct numerical simulation （DNS） database. The results show that the wall region with low pressure forms just below the strong NWSV, which is mostly associated with the overhead NWSV. The wall region with high pressure forms downstream of the NWSV, which has a good correspondence with the downwash of the fluids induced by the upstream NWSV. The results provide a significant basis for the detection of NWSV.

Natural ventilation performance of single room building with fluctuating wind speed and thermal mass

Natural ventilation is driven by either buoyancy forces or wind pressure forces or their combinations that inherit stochastic variation into ventilation rates.Since the ventilation rate is a nonlinear function of multiple variable factors including wind speed,wind direction,internal heat source and building structural thermal mass,the conventional methods for quantifying ventilation rate simply using dominant wind direction and average wind speed may not accurately describe the characteristic performance of natural ventilation.From a new point of view,the natural ventilation performance of a single room building under fluctuating wind speed condition using the Monte-Carlo simulation approach was investigated by incorporating building fa-ade thermal mass effect.Given a same hourly turbulence intensity distribution,the wind speeds with 1 min frequency fluctuations were generated using a stochastic model,the modified GARCH model.Comparisons of natural ventilation profiles,effective ventilation rates,and air conditioning electricity use for a three-month period show statistically significant differences(for 80% confidence interval) between the new calculations and the traditional methods based on hourly average wind speed.

Fluctuating hydrodynamic methods for fluid-structure interactions in confined channel geometries

We develop computational teractions subject to thermal fluctuations geometry. The methods take into account methods for the study of fluid-structure in- when confined within channels with slit-like the hydrodynamic coupling and diffusivity of microstructures when influenced by their proximity to no-slip walls. We develop stochas- tic numerical methods subject to no-slip boundary conditions using a staggered finite volume discretization. We introduce techniques for discretizing stochastic systems in a manner that ensures results consistent with statistical mechanics. We show how an exact fluctuation-dissipation condition can be used for this purpose to discretize the stochastic driving fields and combined with an exact projection method to enforce incompressibil- ity. We demonstrate our computational methods by investigating how the proximity of ellipsoidal colloids to the channel wall affects their active hydrodynamic responses and passive diffusivity. We also study for a large number of interacting particles collective drift-diffusion dynamics and associated correlation h/actions. We expect the introduced stochastic computational methods to be broadly applicable to applications in which con- finement effects play an important role in the dynamics of microstructures subject to hydrodynamic coupling and thermal fluctuations.