Effects of fluid therapy combined with a preoperative glucose load regimen on postoperative recovery in patients with rectal cancer

BACKGROUND Patients with rectal cancer undergoing radical resection often have poor post-operative recovery due to preoperative fasting and water deprivation and the removal of diseased tissue,and have a high risk of complications.Therefore,it is of great significance to apply appropriate rehydration regimens to patients un-dergoing radical resection of rectal cancer during the perioperative period to improve the postoperative outcomes of patients.AIM To analyze the effects of goal-directed fluid therapy(GDFT)with a preoperative glucose load regimen on postoperative recovery and complications in patients undergoing radical resection for rectal cancer.METHODS Patients with rectal cancer who underwent radical resection(n=184)between January 2021 and December 2023 at our hospital were randomly divided into either a control group or an observation group(n=92 in each group).Both groups received a preoperative glucose load regimen,and routine fluid replacement and GDFT were additionally implements in the control and observation groups,res-pectively.The operative conditions,blood levels of lactic acid and inflammatory markers,postoperative recovery,cognitive status,hemodynamic indicators,brain oxygen metabolism,and complication rates were compared between the groups.RESULTS The colloidal fluid dosage,total infusion,and urine volume,as well as time to first exhaust,time to food intake,and postoperative length of hospital stay,were lower in the observation group(P<0.05).No significant differences were observed between the two groups in terms of operation time,bleeding volume,crystalloid liquid consumption,time to tracheal extubation,complication rate,heart rate,or mean arterial pressure(P>0.05).Compared with the control group,in the ob-servation group the lactic acid level was lower immediately after the surgery(P<0.05);the Mini-Mental State Examination score was higher on postoperative day 3(P<0.05);the pulse pressure variability(PPV)was lower at 30 min after pneumoperitoneum(P<0.05),though the differences in the PPV of the two groups was not significant at the remaining time points(P>0.05);tumor necrosis factor-αand interleukin-6 levels were lower on postoperative day 3(P<0.05);and the left and right regional cerebral oxygen saturation was higher immediately after the surgery and 30 min after pneumoperitoneum(P<0.05).CONCLUSION GDFT combined with the preoperative glucose load regimen is a safe and effective treatment strategy for im-proving postoperative recovery and risk of complications in patients with rectal cancer undergoing radical re-section.

DYNAMIC BUCKLING OF STATICALLY PRELOADED RING-STIFFENED CYLINDRICAL SHELLS UNDER AXIAL FLUID-SOLID IMPACT LOADING

The Initial Imperfection Amplified Criterion is applied toinvestigate the geometric nonlinear dynamic buckling of staticallypreloaded ring-stiffened cylindrical shells under axial fluid-solidimpact. Tak- ing account of the effects of large deformation andinitial geometric imperfection, the governing equations are obtainedby the Galerkin method and solved by the Runge-Kutta method. Theeffects of static preloading (uniform external radial pressure) onthe buckling features and the load-carrying ability of ring-stiffenedcy- lindrical shells against axial impact are discussed.

Numerical Investigation of Green Water Loading on Flexible Structures Using Three-Step CFD-BEM-FEM Approach

In this paper, the effect of green water impact on a flexible structure is studied based on three-step computational fluid dynamics(CFD)–boundary element method(BEM)–finite element method(FEM) approach. The impact due to shipping of water on the deck of the vessel is computed using commercial CFD software and used as an external force in coupled BEM-FEM solver. Other hydrodynamic forces such as radiation, diffraction, and Froude-Krylov forces acting on the structure are evaluated using 3 D time domain panel method. To capture the structural responses such as bending moment and shear force, 1 D finite element method is developed. Moreover, a direct integration scheme based on the Newmark–Beta method is employed to get the structural velocity,displacement, etc., at each time step. To check the effect of the green water impact on the structure, a rectangular barge without forward speed is taken for the analysis. The influence is studied in terms of bending moment, shear force, etc. Results show that the effect of green water impact on the bow region can be severe in extreme seas and lead to various structural damages. Similarly,it is also verified that vessel motion affects green water loading significantly and therefore one must consider its effect while designing a vessel.

A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone

The transport of fluid, nutrients, and signaling molecules in the bone lacunar-canalicular system （LCS） is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching （FRAP） approach to quantify load-induced fluid and solute transport in the LCS in situ, but the measurements were limited to cortical regions 30-50 μm underneath the periosteum due to the constrains of laser penetration. With this work, we aimed to expand our understanding of load-induced fluid and solute transport in both trabecular and cortical bone using a multiscaled image-based finite element analysis （FEA） approach. An intact murine tibia was first re-constructed from microCT images into a three-dimensional （3D） linear elastic FEA model, and the matrix deformations at various locations were calculated under axial loading. A segment of the above 3D model was then imported to the biphasic poroelasticity analysis platform （FEBio） to predict load-induced fluid pressure fields, and interstitial solute/fluid flows through LCS in both cortical and trabecular regions. Further, secondary flow effects such as the shear stress and/or drag force acting on osteocytes, the presumed mechano-sensors in bone, were derived using the previously developed ultrastructural model of Brinkman flow in the canaliculi. The material properties assumed in the FEA models were validated against previously obtained strain and FRAP transport data measured on the cortical cortex. Our results demonstrated the feasibility of this computational approach in estimating the fluid flux in the LCS and the cellular stimulation forces （shear and drag forces） for osteocytes in any cortical and trabecular bone locations, allowing further studies of how the activation of osteocytes correlates with in vivo functional bone formation. The study provides a promising platform to reveal potential cellular mechanisms underlying the anabolic power of exercises and physical activities in treating patients with skeletal deficiencies.

LOADING CAPACITY ANALYSIS OF THE MISALIGNED CONICAL-CYLINDRICAL BEARING WITH NON NEWTONIAN LUBRICANTS

A novel numerical method to lubricate a conventional finite diameterconical-cylindrical bearing with a non-Newtonian lubricant, while adhering to the power-law model,is presented. The elastic deformation of bearing and varied viscosity of lubrication due to thepressure distribution of film thickness are also considered. Simulation results indicate that thenormal load carrying capacity is more pronounced for higher values of flow behavior index n, highereccentricity ratios and larger misalignment factors. It is found that the viscosity-pressure to theeffect of lubricant viscosity is significant.

Elastodynamic analysis at an interface of viscous fluid/thermoelastic micropolar honeycomb medium due to inclined load

In this paper, the effect of angle inclination at the interface of a viscous fluid and thermoelastic micropolar honeycomb solid due to inclined load is investigated. The inclined load is assumed to be a linear combination of normal load and tangential load. Laplace transform with respect to time variable and Fourier transform with respect to space variable are applied to solve the problem. Expressions of stresses, temperature distribution, and pressures in the transformed domain are obtained by introducing potential functions. The numerical inversion technique is used to obtain the solution in the physical domain. The frequency domain expressions for steady state are also obtained with appropriate change of variables. Graphic representations due to the response of different sources and changes of angle inclination are shown. Some particular cases are also discussed.

Stability Analysis of Cylindrical Tanks under Static and Earthquake Loading

Large thin walled cylindrical above ground tanks have become more susceptible to failure by buckling during earthquakes. In this study, three different geometries of tanks with H/D （height to diameter） ratios of 2.0, 0.56, 1.0, and D/t （depth to thickness） ratios of 960.0, 1,706.67 and 640.0 respectively were analyzed for stability when subjected to the E1 Centro earthquake at the base. The Budiansky and Roth procedure was used to find the buckling loads when the tanks were empty and when they were filled with liquid up to 90% of their depth. Also, nonlinear time history analysis using ANSYS finite element computer program was performed. Analysis results show that the dynamic buckling occurs for empty tanks at very high PGA （peak ground accelerations） which are unrealistic even for major earthquakes. Furthermore, when the tanks filled with water up to 90% of its height, analysis results show that when the H/D ratio reduced by two times （i.e., from 2 to 1）, the PGA for the buckling increased by six times （increase from 0.25g to 1 .Sg）. Hence, H/D ratio plays an important role in the earthquake stability design of over ground steel tanks.

Computational Fluid Dynamics Approach for Predicting Pipeline Response to Various Blast Scenarios: A Numerical Modeling Study

Recent industrial explosions globally have intensified the focus in mechanical engineering on designing infras-tructure systems and networks capable of withstanding blast loading.Initially centered on high-profile facilities such as embassies and petrochemical plants,this concern now extends to a wider array of infrastructures and facilities.Engineers and scholars increasingly prioritize structural safety against explosions,particularly to prevent disproportionate collapse and damage to nearby structures.Urbanization has further amplified the reliance on oil and gas pipelines,making them vital for urban life and prime targets for terrorist activities.Consequently,there is a growing imperative for computational engineering solutions to tackle blast loading on pipelines and mitigate associated risks to avert disasters.In this study,an empty pipe model was successfully validated under contact blast conditions using Abaqus software,a powerful tool in mechanical engineering for simulating blast effects on buried pipelines.Employing a Eulerian-Lagrangian computational fluid dynamics approach,the investigation extended to above-surface and below-surface blasts at standoff distances of 25 and 50 mm.Material descriptions in the numerical model relied on Abaqus’default mechanical models.Comparative analysis revealed varying pipe performance,with deformation decreasing as explosion-to-pipe distance increased.The explosion’s location relative to the pipe surface notably influenced deformation levels,a key finding highlighted in the study.Moreover,quantitative findings indicated varying ratios of plastic dissipation energy(PDE)for different blast scenarios compared to the contact blast(P0).Specifically,P1(25 mm subsurface blast)and P2(50 mm subsurface blast)showed approximately 24.07%and 14.77%of P0’s PDE,respectively,while P3(25 mm above-surface blast)and P4(50 mm above-surface blast)exhibited lower PDE values,accounting for about 18.08%and 9.67%of P0’s PDE,respectively.Utilising energy-absorbing materials such as thin coatings of ultra-high-strength concrete,metallic foams,carbon fiber-reinforced polymer wraps,and others on the pipeline to effectively mitigate blast damage is recommended.This research contributes to the advancement of mechanical engineering by providing insights and solutions crucial for enhancing the resilience and safety of underground pipelines in the face of blast events.

Modelling dynamic pantograph loads with combined numerical analysis

Appropriate interaction between pantograph and catenary is imperative for smooth operation of electric trains.Changing heights of overhead lines to accommodate level crossings,overbridges,and tunnels pose significant challenges in maintaining consistent current collection performance as the pantograph aerodynamic profile,and thus aerodynamic load changes significantly with operational height.This research aims to analyse the global flow characteristics and aerodynamic forces acting on individual components of an HSX pantograph operating in different configurations and orientations,such that the results can be combined with multibody simulations to obtain accurate dynamic insight into contact forces.Specifically,computational fluid dynamics simulations are used to investigate the pantograph component loads in a representative setting,such as that of the recessed cavity on a Class 800 train.From an aerodynamic perspective,this study indicates that the total drag force acting on non-fixed components of the pantograph is larger for the knuckle-leading orientation rather than the knuckle-trailing,although the difference between the two is found to reduce with increasing pantograph extension.Combining the aerodynamic loads acting on individual components with multibody tools allows for realistic dynamic insight into the pantograph behaviour.The results obtained show how considering aerodynamic forces enhance the realism of the models,leading to behaviour of the pantograph-catenary contact forces closely matching that seen in experimental tests.

THEORETICAL PREDICTION OF SOUND RADIATION FROM A HEAVY FLUID-LOADED CYLINDRICAL COATED SHELL

A theoretical model is developed to predict the sound radiation ability of a cylindrical thin elastic shell of finite length, covered with a damp layer and terminated with infinite cylindrical rigid baffles. This shell is immersed in a heavy fluid extending up to infinity, and excited by a constant point load continuously traveling along the circumferential direction. A frequency-domain representation of the rotating load and three equations of the vibroacoustic coupling problem are given. The equations are solved by means of modal analysis method and asymptotic expansion method. Also, a mathematical expression of modal amplitude of shell radial displacement is obtained. The sound radiation ability of this kind of shell is evaluated and the corresponding numerical results are given.

Diffraction of Water Waves by A Vertically Floating Cylinder in A Two-Layer Fluid

In this paper, the diffraction of water waves by a vertically floating cylinder in a two-layer fluid of a finite depth is studied. Analytical expressions for the hydrodynamic loads on the vertically floating cylinder are obtained by use of the method of eigenfunction expansions. The hydrodynamic loads on the vertically floating cylinder in a two-layer fluid inelude not only the surge, heave and pitch exciting forces due to the incident wave of the surface-wave mode, but also those due to the incident wave of the internal-wave mode. This is different from the case of a homogenous fluid. Some given examples show that, for a two-layer fluid system with a small density difference, the hydrodynamic loads for the surface-wave mode do not differ significantly from those due to surface waves in a single-layer fluid, but the hydrodynamic loads for the internal-wave mode are important over a wide range of frequencies. Moreover, also considered are the free surface and interface elevations generated by the diffraction wave due to the incident wave of the surface-wave and interhal-wave modes, and transfer of energy between modes.

Earth's deformation due to the dynamical perturbations of the fluid outer core

The elasto-gravitational deformation response of the Earths solid parts to the perturbations of the pressure and gravity on the core-mantle boundary (CMB) and the solid inner core boundary (ICB), due to the dynamical behaviors of the fluid outer core (FOC), is discussed. The internal load Love numbers, which are formulized in a general form in this study, are employed to describe the Earths deformation. The preliminary reference Earth model (PREM) is used as an example to calculate the internal load Love numbers on the Earths surface, CMB and ICB, respectively. The characteristics of the Earths deformation variation with the depth and the perturbation periods on the boundaries of the FOC are also investigated. The numerical results indicate that the internal load Love numbers decrease quickly with the increasing degree of the spherical harmonics of the displacement and depend strongly on the perturbation frequencies, especially on the high frequencies. The results, obtained in this work, can be used to construct the boundary conditions for the core dynamics of the long-period oscillations of the Earths fluid outer core.

Dynamic Response of Fluid-Single Leg Gravity Platform-Soil Interaction System

An approximate method is presented to investigate the earthquake response of the fluid-single leg (shortened for S. L.) gravity platform-soil interaction system. By assuming a suitable form of the velocity potential of the radiation waves and by using the motion equation and the boundary conditions, the unknown coefficients can be obtained. Thereafter the function of frequency for the interaction system may also be obtained. In this paper, the difference of the system dynamic response between rigid foundation is analyzed and the influences of the various foundation geometric dimension and the various water-depth on the hydrodynamic loading and dynamic response of the system is illustrated.

Size and temperature effects on band gaps in periodic fluid-filled micropipes

A new model is proposed for determining the band gaps of flexural wave propagation in periodic fluid-filled micropipes with circular and square thin-wall cross-sectional shapes, which incorporates temperature, microstructure, and surface energy effects. The band gaps depend on the thin-wall cross-sectional shape, the microstructure and surface elastic material constants, the pipe wall thickness, the unit cell length, the volume fraction, the fluid velocity in the pipe, the temperature change,and the thermal expansion coefficient. A systematic parametric study is conducted to quantitatively illustrate these factors. The numerical results show that the band gap frequencies of the current non-classical model with both circular and square thin-wall cross-sectional shapes are always higher than those of the classical model. In addition,the band gap size and frequency decrease with the increase of the unit cell length according to all the cases. Moreover, the large band gaps can be obtained by tailoring these factors.

Stochastic Response Analysis of Piled Offshore Platforms to Earthquake Load

In this paper, using the theory of stochastic analysis of the response to earthquake load, a stochastic analysis method of the response of piled platforms to earthquake load has been established. In the method, the strong ground motion is considered as three dimensional stationary white noise process and the pile-soil interaction and water-structure interaction are considered. The stochastic response of a typical platform to earthquake load has been computed with this method and the results compared with those obtained with the response spectrum analysis method. The comparison shows that the stochastic analysis method of the response of piled platforms to earthquake load is suitable for this kind of analysis.

Research on gas leakage through suction valves of reciprocating compressor under varying load conditions

A research concerning the coupling conditions of gas leakage through suction valves and capacity regulation is performed in an industrial reciprocating compressor.Both internal flow and thermodynamic characteristic are discussed in detail.The results show that the capacity of compressor can be regulated steplessly by controlling suction valve closure moment.And then the quantitative relationship between the capacity load and the closing angle of suction valve is revealed.The capacity load and valve leakage rate show obvious different features in P-V diagrams,which makes it easier to define appropriate features for detecting cracked or broken reciprocating compressor valves under varying load conditions.A set of curves of compression work and discharge gas mass are obtained and a method for rating thermal performance of a compressor is presented using these curves.

Non-Newtonian Effect of Temperature on Load Carrying Capacity of Thrust Bearings

The influeuce of temperature on rheological characteristics of lubricants is analyzed. The constitutive equation, which describes the non-Newtonian properties of lubricants caused by thermal effect, is founded and coupled with equations or continuity and momentum of fluid to calculate the load carrying capacity of thrust bearings. The results or numerical solution show that lubricants have ultimate shear strength as a result or nou-Newtonian effect of temperature, and the thermal effect plays an.important role in load carrying capacity of thrust bearings The mechanism of film failure in thrust bearings is investigated initially’ Theoretlcal bases for predicting the lubrication situatlon and improving the design of thrust bearings are provided in this paper.

CFD-Based Load Calculation Method for Monopile Support Configuration of Offshore Wind Turbine

An unsteady load calculation method for the support configuration of a monopile-supported offshore wind turbine is developed based on the Fluent software platform.Firstly,the water wave is generated by imposing the inlet boundary conditions according to the exact potential flow solution.Then the wave evolution is simulated by solving the unsteady incompressible Navier-Stokes(N-S)equations coupled with the volume of fluid method.For the small amplitude wave with reasonable wave parameters,the numerical wave result agrees well with that of the given wave model.Finally,a monopile support configuration is introduced and a CFD-based load calculation method is established to accurately calculate the unsteady load under the combined action of wave and wind.The computed unsteady wave load on a small-size monopile support located in the small amplitude wave flow coincides with that of the Morison formula.The load calculations are also performed on a large-size monopile support and a monopile-supported offshore wind turbine under the combined action of small amplitude wave and wind.

A simplified approach to modelling blasts in computational fluid dynamics (CFD)

This paper presents a time-efficient numerical approach to modelling high explosive(HE)blastwave propagation using Computational Fluid Dynamics(CFD).One of the main issues of using conventional CFD modelling in high explosive simulations is the ability to accurately define the initial blastwave properties that arise from the ignition and consequent explosion.Specialised codes often employ Jones-Wilkins-Lee(JWL)or similar equation of state(EOS)to simulate blasts.However,most available CFD codes are limited in terms of EOS modelling.They are restrictive to the Ideal Gas Law(IGL)for compressible flows,which is generally unsuitable for blast simulations.To this end,this paper presents a numerical approach to simulate blastwave propagation for any generic CFD code using the IGL EOS.A new method known as the Input Cavity Method(ICM)is defined where input conditions of the high explosives are given in the form of pressure,velocity and temperature time-history curves.These time history curves are input at a certain distance from the centre of the charge.It is shown that the ICM numerical method can accurately predict over-pressure and impulse time history at measured locations for the incident,reflective and complex multiple reflection scenarios with high numerical accuracy compared to experimental measurements.The ICM is compared to the Pressure Bubble Method(PBM),a common approach to replicating initial conditions for a high explosive in Finite Volume modelling.It is shown that the ICM outperforms the PBM on multiple fronts,such as peak values and overall overpressure curve shape.Finally,the paper also presents the importance of choosing an appropriate solver between the Pressure Based Solver(PBS)and Density-Based Solver(DBS)and provides the advantages and disadvantages of either choice.In general,it is shown that the PBS can resolve and capture the interactions of blastwaves to a higher degree of resolution than the DBS.This is achieved at a much higher computational cost,showing that the DBS is much preferred for quick turnarounds.

Vertical Crustal Displacements Due to Surface Fluid Changes

Using the model data for surface mass changes of the atmosphere, ocean, soil moisture and snow depth, the vertical crustal displacements of 25 ficual stations in China were calculated according to the loading theory. From the spectral analysis of the results, we can see that the periods of displacements are 12 months and the semi-periods are 6 months. The results also show that the maximum seasonal displacements can reach 20 mm and even larger. The covariance analyses and significance tests show that the coefficients of 96 percent of the stations are significant at the 0.1 significance level. The results show that one of the reasons of the vertical crustal displacements is the changing surface fluid loads.