With the aid of the Fluorescent lipophilic probe DPH (1, 6- diphenyl- 1, 3, 5- hexatriene ), the degree of microviscosity (η) and lipid fluidity (LFU) obtained from lung cancer lines and carcinogenesis cells induced ...With the aid of the Fluorescent lipophilic probe DPH (1, 6- diphenyl- 1, 3, 5- hexatriene ), the degree of microviscosity (η) and lipid fluidity (LFU) obtained from lung cancer lines and carcinogenesis cells induced by irradiation as well as the patients with lung cancer were quantitatively monitored by Fluorescence polarization. The results have shown a marked decreased in η and a significant increase in LFU in various tumor cells as compared to normal cells. Sometime, the degree of fluidity in carcinogenesis cells Induced by radiation and the patients with lung cancer have shown to be similar pattern. The possibility that these dynamic parameter may serve as a diagnostic tool for an early detection of lung cancer is discussed.展开更多
文摘With the aid of the Fluorescent lipophilic probe DPH (1, 6- diphenyl- 1, 3, 5- hexatriene ), the degree of microviscosity (η) and lipid fluidity (LFU) obtained from lung cancer lines and carcinogenesis cells induced by irradiation as well as the patients with lung cancer were quantitatively monitored by Fluorescence polarization. The results have shown a marked decreased in η and a significant increase in LFU in various tumor cells as compared to normal cells. Sometime, the degree of fluidity in carcinogenesis cells Induced by radiation and the patients with lung cancer have shown to be similar pattern. The possibility that these dynamic parameter may serve as a diagnostic tool for an early detection of lung cancer is discussed.
