Pharmacokinetics of flunixin meglumine （FM） was investigated in 14 healthy pigs following single intravenous （i.v.） and intramuscular （i.m.） administration of the drug at the dosage of 2.2 and 1.1 mg kg-1. Blood...Pharmacokinetics of flunixin meglumine （FM） was investigated in 14 healthy pigs following single intravenous （i.v.） and intramuscular （i.m.） administration of the drug at the dosage of 2.2 and 1.1 mg kg-1. Blood samples were collected at different intervals after administration, and concentrations of FM were determined by HPLC method with a limit of detection of 0.1μg mL-1. The FM concentration-time data were fitted to a two-compartment open model after single i.v. dosing in pigs. The main pharmacokinetic parameters were as follows： tl/2a, 0.49 ± 0.03 and 0.58±0.07 h; tl/2β, 6.28±0.13 and 7.37 ±0.59 h; V/F, 0.01 ±0.001 and 0.01 ±0.002 L kg-1; CL, 0.01 ± 0.002 and 0.01 ± 0.002 L h-l; AUC, 237.73 ± 52.46 and 147.71 ± 36.76μg h-1 mL-1. The drug concentration-time data were fitted to a two-compartment model with first-order absorption after single i.m. administration in pigs. The main pharmacokinetic parameters were as follows： t1/2α, 0.90± 0.07 and 0.86±0.10 h; t1/2β, 8.79±0.85 and 9.60±0.10 h; V/F, 0.02±0.004 and 0.02±0.003 L kg-1; CL, 0.01±0.002 and 0.01 ±0.003 L h-l; AUC, 174.63 ± 45.84 and 112.42 ± 31.19 pg h-1 mL 1. The results of the present study showed that FM was rapidly absorbed, extensively distributed, and slowly eliminated in pigs. The drug was completely absorbed after single i.m. administration and a good bioavailability in pigs.展开更多
The study was conducted to evaluate the safety of Flunixin meglumine injection on target animal dogs, and to provide a scientific basis for the dose selec- tion of clinical application. A total of 24 healthy Springer ...The study was conducted to evaluate the safety of Flunixin meglumine injection on target animal dogs, and to provide a scientific basis for the dose selec- tion of clinical application. A total of 24 healthy Springer Spaniels were randomly divided into four groups. Intramuscular injection of Flunixin meglumine was carried out to test group dogs with the doses of 2 rag/kg, 6 rag/kg, 10 mg/kg for 5 days, respectively. The injected doses were one times, three times and five times as the recommended clinical dose. Intramuscular injection of water was carried out to control group dogs for 5 days. Clinical symptom was observed after the injection, and the blood was collected at different times （before, during and after the injection） to conduct blood routine examination and blood biochemical indexes measurement. Post-mortem examination and histopathological examination were carried out after the test. The results indicated that test dogs showed normal spirit, with no death and no other adverse reactions. Part values of blood routine examination indexes and blood biochemical indexes in test groups showed significant differences between pre-administration and post-administration, but basically fluctuated within the reference range. Autopsy results showed no obvious pathological changes. Histological examination showed the viscera and tissues （liver, heart, spleen, lung, kidney） in high dose group and control group showed no abnormality and pathological changes. The results indicated that Flunixin meglumine injection with the dose of 2 - 10 rag/kg had a minimal effect on physiological and biochemical indexes of dog blood.展开更多
文摘Pharmacokinetics of flunixin meglumine （FM） was investigated in 14 healthy pigs following single intravenous （i.v.） and intramuscular （i.m.） administration of the drug at the dosage of 2.2 and 1.1 mg kg-1. Blood samples were collected at different intervals after administration, and concentrations of FM were determined by HPLC method with a limit of detection of 0.1μg mL-1. The FM concentration-time data were fitted to a two-compartment open model after single i.v. dosing in pigs. The main pharmacokinetic parameters were as follows： tl/2a, 0.49 ± 0.03 and 0.58±0.07 h; tl/2β, 6.28±0.13 and 7.37 ±0.59 h; V/F, 0.01 ±0.001 and 0.01 ±0.002 L kg-1; CL, 0.01 ± 0.002 and 0.01 ± 0.002 L h-l; AUC, 237.73 ± 52.46 and 147.71 ± 36.76μg h-1 mL-1. The drug concentration-time data were fitted to a two-compartment model with first-order absorption after single i.m. administration in pigs. The main pharmacokinetic parameters were as follows： t1/2α, 0.90± 0.07 and 0.86±0.10 h; t1/2β, 8.79±0.85 and 9.60±0.10 h; V/F, 0.02±0.004 and 0.02±0.003 L kg-1; CL, 0.01±0.002 and 0.01 ±0.003 L h-l; AUC, 174.63 ± 45.84 and 112.42 ± 31.19 pg h-1 mL 1. The results of the present study showed that FM was rapidly absorbed, extensively distributed, and slowly eliminated in pigs. The drug was completely absorbed after single i.m. administration and a good bioavailability in pigs.
文摘The study was conducted to evaluate the safety of Flunixin meglumine injection on target animal dogs, and to provide a scientific basis for the dose selec- tion of clinical application. A total of 24 healthy Springer Spaniels were randomly divided into four groups. Intramuscular injection of Flunixin meglumine was carried out to test group dogs with the doses of 2 rag/kg, 6 rag/kg, 10 mg/kg for 5 days, respectively. The injected doses were one times, three times and five times as the recommended clinical dose. Intramuscular injection of water was carried out to control group dogs for 5 days. Clinical symptom was observed after the injection, and the blood was collected at different times （before, during and after the injection） to conduct blood routine examination and blood biochemical indexes measurement. Post-mortem examination and histopathological examination were carried out after the test. The results indicated that test dogs showed normal spirit, with no death and no other adverse reactions. Part values of blood routine examination indexes and blood biochemical indexes in test groups showed significant differences between pre-administration and post-administration, but basically fluctuated within the reference range. Autopsy results showed no obvious pathological changes. Histological examination showed the viscera and tissues （liver, heart, spleen, lung, kidney） in high dose group and control group showed no abnormality and pathological changes. The results indicated that Flunixin meglumine injection with the dose of 2 - 10 rag/kg had a minimal effect on physiological and biochemical indexes of dog blood.
