Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

Recently, the phase compensation technique has allowed the ultrasound to propagate through the skull and focus into the brain. However, the temperature evolution during treatment is hard to control to achieve effective treatment and avoid over-high temperature. Proposed in this paper is a method to modulate the temperature distribution in the focal region. It superimposes two signals which focus on two preset different targets with a certain distance. Then the temperature distribution is modulated by changing triggering time delay and amplitudes of the two signals. The simulation model is established based on an 82-element transducer and computed tomography （CT） data of a volunteer＇s head. A finite- difference time-domain （FDTD） method is used to calculate the temperature distributions. The results show that when the distances between the two targets respectively are 7.5-12.5 mm on the acoustic axis and 2.0-3.0 mm in the direction perpendicular to the acoustic axis, a focal region with a uniform temperature distribution （64-65 ℃） can be created. Moreover, the volume of the focal region formed by one irradiation can be adjusted （26.8-266.7 mm3） along with the uniform temperature distribution. This method may ensure the safety and efficacy of HIFU brain tumor therapy.

Estimation of the stress levels in the focal region before and after the 2001 M=8.1 Western Kunlun Mountain Pass earth-quake

A method estimating the stress level in the focal region of an earthquake is proposed here. Taking the 2001 M=8.1 Western Kunlun Mountain Pass earthquake as an example, we estimate its stress level in the focal region before and after it by this method. The results show that the stress level in the focal region just prior to the initiation of this event is approximately 6.3-8 MPa, and about 5-6.7 MPa remained in the focal region after its occurrence. The stress in the focal region decreased by roughly twenty percent after this event.

Focal region field of a two dimensional Gregorian system coated with isotropic Chiral medium

Focal region field of a two dimensional Gregorian system coated with chiral medium is analyzed at high frequency. Maslov's method is used because the Geometrical Optics approximation fails at focal points. Maslov’s method combines the simplicity of ray theory and the generality of Fourier transform. Fields patterns are calculated numerically and the results are plotted. The effects of thickness of chiral layer, chirality parameter of the chiral medium and permittivity of the medium are analyzed. The problem of simple dielectric layer is discussed as a special case of this problem.

Applying artificial neural networks to achieve quantitative division of potential focal regions

There are put forward in this paper the principle of using artificial neural networks to determine the featureswhich reflect seismotectonics and seismicity of the potential focal regions and the method to divide quantitativelythe potential focal regions. The calculation of the actual data of North China area shows that it may fully reveal the relations between the potential focal regions and their controling characteristics by the method, of which the principle is concise and convenient to apply, the calculated results reasonable, the division in a meticulous way and the achievement practicable.

Regional stress field in Yunnan revealed by the focal mechanisms of moderate and small earthquakes

We determined focal mechanism solutions of 627 earthquakes of magnitude M ≥ 3.0 in Yunnan from January 2008 to May 2018 by using broadband waveforms recorded by 287 permanent and temporary regional stations. The results clearly revealed predominantly strike-slip faulting characteristics for earthquakes in Yunnan, with focal depths concentrated in the top 10 km of the crust. The earthquake mechanisms obtained were combined with the global centroid moment tensor solutions of 80 additional earthquakes from 1976 to 2016 to invert for the regional variations of stress field orientation by using a damped regional-scale stress inversion scheme.Results of the stress field inversion confirmed that the Yunnan region is under a strike–slip stress regime, with both maximum and minimum stress axes being nearly horizontal. The maximum compressional axes are primarily oriented in a northwest-southeast direction, and they experience a clockwise rotation from north to south, whereas the maximum extensional axes are oriented largely northeast-southwest. The maximum compressional axes are in line with the global positioning system–inferred horizontal velocity field and the southeastward escape of the Sichuan–Yunnan Rhombic Block, whereas the maximum extensional axes are consistent with anisotropy derived from SKS splitting. Against the strike–slip background, normal faulting stress regimes can be seen in the Tengchong volcanic area as well as in other areas with complex crisscrossing fault zones.

Present Tectonic Stress Field in the Capital Region of China Inverted from Focal Mechanisms of Small and Strong Earthquakes

A dense seismic network was installed in the capital region of China in recent years,which makes it possible to resolve the focal mechanisms of small earthquakes. We gathered large earthquake focal mechanisms from the last fifty years and moderate or small earthquake focal mechanisms from between 2002 and 2004,and calculated the present tectonic stress field of the capital region by the grid search method, which weighs different sized earthquakes and can improve the accuracy of the stress field inversion. The analysis of inversion results of different sub-regions shows that the azinuth of the maximum principal compressive stress axis is NE43°- 86° in the Beijing-Zhangjiakou-Datong area,NE38°-86° in the Tangshan area,and NE79°- 81° in the Xingtai area. Inversion results of this paper are similar to previous results,which proves the correctness of the approach. As revealed by the results,the stress field of the capital region is characterized by overall consistency and sub-regional differences. This study provides reference for earthquake mechanism explanation and geodynamics research.

Determinations of directions of the mean stress field in Sichuan-Yunnan region from a number of focal mechanism solutions

Based on the spatial orientation and slip direction of the fault plane solutions, we present the expression of corresponding mechanical axis tensor in geographic coordinate system, and then put forward a method for calculating average mechanical axis tensor and its eigenvalues, which involves solving the corresponding eigenequation. The method for deducing mean stress field from T, B, and P axes parameters of a number of focal mechanism solutions has been verified by inverting data of mean stress fields in Fuyun region and in Tangshan region with fitting method of slip direction, and both results are consistent. To study regional average stress field, we need to choose a population of focal mechanism solutions of earthquakes in the massifs where there are significant tectonic structures. According to the focal mechanism solutions of 256 moderate-strong earthquakes occurred in 13 seismic zones of Sichuan-Yunnan region, the quantitative analysis results of stress tensor in each seismic zone have been given. The algorithm of such method is simple and convenient, which makes the method for analyzing tectonic stress field with large amount of focal mechanism solution data become quantified.

盖州青石岭震群断层面参数的确定及构造应力场特征研究

根据之前学者的双差定位结果,使用Fit_Fault软件包计算盖州青石岭震群发震断层面走向为114.30°,倾角74.67°。收集2001年至2011年辽宁地区的震源机制解资料,采用全局网格搜索算法,反演该地区的构造应力场,其主压应力轴为NEE向,主张应力轴为NNW向,整体呈现拉张的应力状态。并据此确定出青石岭震群发震断层的滑动角是35.49°,为左旋走滑性质。模拟在辽宁地区构造应力体系下各种产状的断层面上可产生的相对剪应力和相对正应力分布情况,发现该震群发震断层面上的相对剪应力和相对正应力分别为0.513和0.576。分析认为盖州青石岭震群是一处地质薄弱带,背景构造应力场在其最近一期的活动中未起主导作用。

TFAP2A对肾小球硬化相关基因ADCK4转录调控机制的研究

目的探索细胞中TFAP2A对局灶节段性肾小球硬化(FSGS)相关基因含aarF结构域的激酶4(ADCK4)的转录调控机制及TFAP2A与ADCK4是否存在特定的结合区域。方法生物信息学分析肾小球硬化基因火山图,ADCK4及TFAP2A表达水平的关系。JASPAR数据库预测ADCK4基因转录起始位点-464 bp/+206 bp区域包含TFAP2A转录因子结合位点;TFAP2A siRNA浓度分别为5、10、15µmol/L,TFAP2A过表达质粒质量浓度分别为50、100、300µg/L,通过双萤光素酶报告基因实验验证TFAP2A对ADCK4基因启动子水平的调控作用。TFAP2A siRNA及TFAP2A过表达质粒转染细胞,实时荧光定量PCR检测TFAP2A、ADCK4 mRNA表达,蛋白免疫印迹实验检测TFAP2A、ADCK4蛋白表达。染色质免疫沉淀试验验证TFAP2A与ADCK4启动子的特定区域结合。结果生物信息学分析显示FSGS肾组织中RNA-Seq RNA表达上调的基因273个,表达下调的基因219个;ADCK4与TFAP2A表达水平呈正相关(P<0.01)。双萤光素酶报告基因实验证明TFAP2A siRNA浓度为10、15µmol/L的ADCK4启动子相对萤光素酶活性增强,TFAP2A过表达质粒质量浓度为100、300µg/L的ADCK4启动子萤光素酶活性降低(P<0.05)。与对照组相比,实验组ADCK4 mRNA和蛋白表达水平升高;过表达实验中,与对照组比较,实验组ADCK4 mRNA和蛋白表达水平降低(P<0.05)。染色质免疫沉淀试验发现TFAP2A能与ADCK4启动子的特定区域结合。结论转录因子TFAP2A负向调控ADCK4基因表达,增加了调控足细胞重要基因的转录因子成员。

Variation of stress field in the source region around a strong shock：an example

An earthquake with magnitude 6.6 occurred on November 16,1983 in the Kaoiki,Hawii.The hierarchical clustering analyses were made by stages for the focal mechanism solutions of 74 earthquakes with M≥3.0 in this area from 1977 to 1985,it was found that each type of focal mechanism is roughly with invariable percentage,and that the strike-slip events including the mainshock,which did not appear in other stages,occurred in the stage around M=6.6 mainshock.The dominant types in the other stages were depressed in the period around the mainshock. This is a believable precursor phenomena.orientation of the principal axes of stress field was inversed by fitting slip vector based on the focal mechanisms in the different periods.The results show that the stress field around the main shock with M=6.6 was more stable,its maximum and minimum principal axes is nearly horizontal in EW and NS direction respectively,the middle one is nearly vertical.The middle principal axis of stress field in the other periods appeared to be horizontal and the corresponding seismic rupture horizontally slip with a small dip.The significant difference between the stress field of source region in the period around the strong shock and that in the other periods shows that the seismogeny and occurrence of the strong shock were controlled by the variation of stress field.The characteristic environment factors of Kaoiki region and its effects were discussed.

The Study on the Strong Ground Motion Attenuation Relationship in the Pishan Area,Xinjiang Uygur Autonomous Region

Small earthquake data from the Pishan MS6.5 aftershocks is collected by the Xinjiang Regional Digital Seismic Observation Network.Five parameters of the focal region are obtained by micro genetic inversion:stress dropΔσof 75.95 bars,quality factor parameters Q0of 186.33 andηof 0.26,geometric attenuation parameters R1of 72.18km and R2of 139.70km.We calculate the Fourier spectrum and combine it with the random phase spectrum to get the ground motion time history,and build the strong motion acceleration attenuation relationship.The strong ground motion acceleration attenuation of the Pishan area is thus obtained.Because of the insufficiency of strong ground motion records,we added the records from the Wuqia MS6.9 earthquake on October 5,2008,the Akto MS6.2 earthquake on October 6,2008,and the Lop MS6.0 earthquake on March 9,2012 to the data.The comparison of the calculation results and the empirical attenuation relationships with strong ground motion records reveal that the strong motion data of Pishan and Lop earthquakes is higher than the empirical attenuation relationships.The Wuqia MS6.9 earthquake strong motion data is consistent with Yu Yanxiangs(2013)short axis result,and lower than the present result.

A study on the focal parameters of Shidian M=5.9 earthquake sequences in 2001

On the basis of about 300 earthquake wave forms observed in the Shidian MS=5.9 sequences on April 12, 2001 recorded in Kunming Digital Seismic Network, the spectra of shear wave have been used to estimate the focal parameters of these earthquake sequences. The results show that within the magnitude range of 1.5~5.3, the seis-mic moments are 1010~1016 N?m, the corner frequencies are 0.2~0.8 Hz, radii of the focal rupture are 200~2 500 m and the stress drops are 0.1×105~20×105Pa. Through the statistical analyses of variation of corner frequency fc and stress drop ?σ with time, it is discovered that the average corner frequency of the foreshock sequences is obviously lower than that of the aftershock sequences. Contrarily, the average stress drops ?σ of the foreshock sequences are clearly higher than that of the aftershocks. It is considered that these variation characteristics of av-erage corner frequency and stress drops before and after the main shock have index significance to the precursory information before a strong earthquake. The higher stress drops for the foreshock sequences show that the higher shear stresses have been stored in the area of main shock. After the main shock, most of the stresses have been released, so the aftershock sequences show a rupture process of lower stresses.

The Focal Depth Analysis of the Inner Mongolia-Ningxia Border Area Earthquakes

We selected the 103 M_L≥2. 5 earthquake waveform data from the Inner Mongolia-Ningxia border during 2009-2015,which was recorded by the Inner Mongolia Digital Seismic Networks and used the simplex method, Hyposat method, double difference location method,and deterministic method (PTD) for the determination of focal depth,and compared the results. The CAP moment tensor inversion method is used to determine the focal depths of the Alxa Left Banner M5. 8 and M4. 2 earthquakes. The final results of the focal depth by the deterministic method (PTD) and the double difference location method fit well with the tectonic characteristics of the Inner Mongolia-Ningxia border area,but those of the simplex method and the Hyposat method do not. The average depth of the Inner Mongolia-Ningxia border seismic tectonic zone is 13. 32 ± 8 km.

Study on the Recent Tectonic Stress Field in the Yunnan Region

In this paper, using focal mechanism solutions of moderate-strong earthquakes in Yunnan and its adjacent areas, and based on the statistical analysis of the parameters of focal mechanism solutions, we discussed in detail the earthquake fault types and the characteristics of the modern tectonic stress field in the Yunnan region. The results show that most moderate-strong earthquakes occurring in the Yunnan region are of the strike-slip type, amounting to 80% of the total. Normal faulting and normal with strike-slip and reverse and reverse with strike-slip earthquakes is almost equivalent in proportion, about 8% each. The tectonic stress field of the Yunnan region is near-horizontal, and the dips of earthquake fault planes are large. There are three main dynamic sources acting on the Yunnan region: one is the NE, NNE and NNW-directed acting force from Myanmar, Laos and Vietnam; the second is the SE-SSE directed force from the Sichuan and Sichuan-Yunnan rhombus block and the third is the NW-NNW directed force from the South China block. These three acting forces have controlled the faulting behavior of the main faults and the characteristics of strong earthquake activity of Yunnan and its adjacent regions.

Research into the Regional Characteristics of the Tectonic Stress Field in Jiashi, Xinjiang and Its Surrounding Areas

Jiashi and its surrounding areas are composed of many structural zones. Using the focal mechanism solutions of 59 moderately strong earthquakes in Jiashi and its surrounding areas, and combining these with the calculation results of system cluster and stress field inversion, we analyzed the evolvement characteristics of the stress field for different times and different regions. The results were as follows: The earthquakes in Jiashi are mainly strike-slip. However, those of the Kalpin block are mainly reverse events, showing an obvious thrusting. The regional characteristics are different from other areas. The direction of the regional principal stress field is near NS. However, under different tectonic backgrounds, the directions of the stress fields are different. The direction of the principal compress stress is near NS in the Kashi-Wuqia area. But before and after the 3 earthquakes with M7.0, dynamic evolution from NW to NS and then to NE with time process was observed. The Kalpin block has been dominated by a consistent stress field in the NW direction for a long time. However, the direction of the stress field of the Jiashi region is NE. Since 1996, the direction of the regional stress field has changed obviously. The direction of the P axis was deflected towards the NE, and the plunge angle increased. The result shows clearly the regional characteristics and variation of the distribution pattern of the stress field in different tectonic environments.

Features of the M7.9 Earthquake in the Russia-Mongolia-China Boundary Region

At 19:33 p.m on September 27, 2003, an earthquake with M7.9 occurred in the Russia-Mongolia-China boundary Region. It was strongly felt in the Altay region of Xinjiang. The losses caused by the earthquake was 76 million yuan (RMB). Some information about the earthquake was outlined, including basic parameters, focal mechanism, evaluation of earthquake disaster losses and so on. The satellite remote sensing information worked initial analysis for deformation of ground and failure phenomenon.

1932年昌马7.6级地震震源区及其邻近地区尾波衰减特征研究

Q c值是描述地震波在地下衰减变化的重要物理参数之一,其大小能够反映该地区地震活动的强弱和地下介质非均匀性程度。基于Aki的单次散射模型,选用2008—2020年间昌马地震震源区及其周边区域5个固定数字化地震台站接收到的震中距小于100 km、M>2.0的1252次地震记录,计算分析该区域的尾波衰减特征。研究结果表明:(1)窗长为20 s、30 s和40 s的Q c值与频率f的衰减关系分别为Q c=(71.76±8)f^((1.10±0.04))、Q c=(103.83±17)f^((1.04±0.06))和Q c=(120.77±22)f^((1.00±0.06));(2)通过克里金插值绘制的Q c值空间分布图表明昌马地震震源区及其周边区域的Q c值分布与地质构造、地震活动性存在较明显的相关性;(3)研究区域的Q 0值较低,η值较高,与该区域构造活动性较强的特征相符。

基于震源机制解分析邢台地震的发震构造

活动断层几何形状的确定为评估一个地区的地震危险性提供重要的理论依据,邢台老震区内构造背景复杂,前人对邢台地震的发震构造展开大量研究,取得丰富成果。通过震源机制节面聚类得到邢台地震发震断层的走向、倾角及其标准差,综合前人研究结果求取发震断层面的平均解;结合区域地壳应力张量,估计该断层的滑动方向及其误差,分析该区域的地震活动危险性。结果表明:邢台地震发震断层的走向为32.45°,倾角为79.44°,滑动角-153.96°,标准差为4.55°。该断层为走向NNE、倾向NWW的高倾角走滑型断层,而非正断性质的新河断裂。区域地壳应力场在断层面上产生的相对剪应力为0.83,相对正应力为0.59。该断层不是最大剪应力的断层面形状,但剪应力强度仍较大,表明该断层在地震能量积累和释放过程中仍起到必不可少的作用。

聚焦换能器焦域声场扫描路径规划及测量

聚焦换能器的焦域声压扫描是其声学特性计量的重要步骤,而传统的扫描路径测量效率较低,提出基于聚焦声场分布特征的扫描路径规划方法。首先给出了实验方案和原理,分析了聚焦换能器声场的焦域声场特性,然后对聚焦换能器进行有限元仿真分析,获得焦域声场的声压分布,根据声场同心圆分布特性,以焦点处为0 dB声压级,获得不同声压级对应区域作为水听器扫描特征区域。最后,搭建了实验系统,实验结果表明,-6 dB的焦域长度和宽度等参数均与理论值、传统机械测量机构的测量值一致,保证了测量精度并且有效提高了测量效率。