复查记录表在肾移植病人医院-家庭过渡期 中的应用效果

目的:探讨复查记录表在肾移植病人医院-家庭过渡期中的应用效果。方法:选取2021年4月1日-9月30日在医院接受肾移植手术并在医院门诊进行随访的病人为对照组,2021年10月1日-2022年3月31日行肾移植手术并在门诊随访的病人为试验组,从2021年10月起将自行设计的复查记录表应用于肾移植病人医院-家庭过渡期管理中,比较实施前后两组服药偏差发生率、门诊随访率、自我效能、自我管理能力的差异。结果:复查记录表应用于肾移植病人医院-家庭过渡期管理,能降低病人服药偏差发生率,提高病人门诊随访率、自我效能、自我管理能力(P<0.05)。结论:复查记录表应用于医院-家庭过渡期管理能有效指导肾移植病人精准用药、按时随访,帮助病人养成良好的自我健康管理习惯,对预防并发症的发生和保持移植肾的长期存活具有积极的促进作用,为肾移植病人随访的规范化建设提供了实践依据。

Variations of Frost-free Period and Its Impact on Grain Yields in Henan Province during 1961-2013

The aim of this study was to investigate the responses of frost dates to global warming and its influences on grain yields. In this study, based on the frost date series defined by daily minimum ground temperature, the spatial and temporal characteristics of first frost date （FFD）, last frost date （LFD） and frost-free period （FFP） were analyzed. The impact of extending FFP on major crop yields was also studied. The results were as follows： FFD showed a significantly delaying trend of 2.2 d/10 y, and LFD presented an advancing trend of 2.4 d/10 y. FFP extended at a rate of 4.5 d/10 y due to the later FFD and earlier LFD. The most obvious trend of FFD was in westem Henan, while the most significant trend of LFD and FFP oc- curred in south central parts of the study area. However, in eestem region, the trends of FFD, LFD and FFP were not so obvious. Major crop yield showed a sig- nificant correlation with frost-free period for Henan during 1961-2013. The yields of grain, rice, wheat, and maize increased by 79.5, 90.0, 79.5 and 70.5 kg/hm2 with FFP extending by one day.

Periodic oscillation and fine structure of wedge-induced oblique detonation waves

An oblique detonation wave for a Mach 7 inlet flow over a long enough wedge of 30 turning angle is simulated numerically using Euler equation and one-step rection model.The fifth-order WENO scheme is adopted to capture the shock wave.The numerical results show that with the compression of the wedge wall the detonation wave front structure is divided into three sections：the ZND model-like strcuture,single-sided triple point structure and dual-headed triple point strucuture.The first structure is the smooth straight,and the second has the characteristic of the triple points propagating dowanstream only with the same velocity,while the dual-headed triple point structure is very complicated.The detonation waves facing upstream and downstream propagate with different velocities,in which the periodic collisions of the triple points cause the oscillation of the detonation wave front.This oscillation process has temporal and spatial periodicity.In addition,the triple point trace are recorded to obtain different cell structures in three sections.

Periodic Packing Mode for Trickle-Bed Reactors: Experiments and Modeling

A periodic packing mode of trickle-bed reactor (TBR) for the gas limited reaction was proposed. Hy-drogenation of 2-ethylanthraquinone over Pd/Al2O3 in a laboratory-scale TBR was taken as a test reaction for determining whether the periodic packing mode is advantageous. The effects of operating conditions and packing type on TBR performance were experimentally examined to demonstrate the cause-effect relationships. A mathe-matic model of TBR considering axial dispersion and fractional wetting was developed to quantitatively illuminate the reason of performance enhancement.

Relationship between glutathione and malonaldehyde levels in erythrocytes and the deformation index of erythrocyte in patients at various periods following acute cerebral infarction

BACKGROUND： Glutathione, as an in vivo free radical scavenger, plays an important role in the anti-oxidation defense mechanism in patients with acute cerebral infarction. OBJECTIVE： To observe the relationship between the levels of glutathione （GSH） and malonaldehyde （MDA）, the metabolite of lipid peroxidation, in erythrocyte and deformation index of erythrocyte in patients at various periods following acute cerebral infarction. DESIGN： Controlled observation.SETTING： Qilu Hospital of Shandong University and Institute of Cerebrovascular Disease of Qingdao Medical College. PARTICIPANTS： We chose 98 inpatients with acute cerebral infarction from Department of Neurology, Qilu Hospital of Shandong University from January to December 2000 , serving as cerebral infarction group, including 50 male and 48 female, with mean age of （62±7）years. There were 23 cases found on the 1^st day after onset; 25 cases on the 3^rd day after onset; 25 cases on the 7^th day after onset; 25 cases on the 14th days after onset, and they were all confirmed by craniocerebral CT or MRI. Another 30 homeochronous inpatients with neurosis, cervical syndrome, lumbar intervertebral disc herniation and motor neuron disease were chosen as control group, including 20 male and 10 female, with mean age of （52±8）years . There was no significant difference in age and gender distribution between two groups （P 〉 0.05）. Patients in the two groups were informed of detected index.METHODS：①Ulnar venous blood was chosen from the patients who were fasted on the 1^st, 3^rd,7^th and 14^th days after onset. Deformation index of erythrocyte was measured with BL88-CKX laser diffraction erythrocyte deformeter and photographing was performed. GSH level in erythrocyte was measured with DTNB assay introduced by Beu-tler. MDA level in erythrocyte was measured with modified thiobarbituric acid colorimetric method.②At each sample collecting , according to the criteria accepted by the Fourth National Conference of Cerebrovascular Disease, intergrant of neurologic impairment 〈 15 points was regarded as mild （n=46）, 15 to 30 points as moderate （n=40）and, 〉 30 points as severe （n=12）. ③ t test was used to compare data between two groups , and linear correlation analysis was used in relationship analysis among indexes. MAIN OUTCOME MEASURES ：① Comparison of erythrocyte GSH and MDA levels and deformation index of erythrocyte at various periods between patients with acute cerebral infarction and controls. ②Correlation of erythrocyte GSH level with erythrocyte MDA level and with deformation index of erythrocyte in patients with cerebral infarction . ③ Relationship between erythrocyte GSH level and severity of disease in patients with acute cerebral infarction. RESULTS： Totally 98 patients with acute cerebral infarction and 30 controls all entered the stage of result analysis. ① Erythrocyte GSH level and deformation index of erythrocyte were lower on the 1^st, 3^rd, 7^th and 14^th days after onset in cerebral infarction group than in control group （P 〈 0.05-0.01）, and erythrocyte MDA level was significantly higher in cerebral infarction group than in control group （P 〈 0.05-0.01）. The three indexes changed most significantly on day 3 after onset in patients, and began to recover or decrease on day 7 after onset and inclined to be normal on day 14 after onset. ② Erythrocyte GSH level was significantly negatively correlated with erythrocyte MDA level in patients with acute cerebral infarction on the 1^st, 3^rd, 7^th and 14^th days after onset （r=-0.534, -0.713, -0.645, -0.656, respectively, P 〈 0.05-0.01 ） ,and significantly positively correlated with erythrocyte deformation index （t-=0.502, 0.560, 0.455, 0.504, respectively, P 〈 0.05）. ③Erythrocyte GSH level was significantly lower in moderate or severe patients with acute cerebral infarction than in mild patients[（0.215±0.088）,（0.192±0.102）, （0.281±0.090） g/L, P〈 0.05]. CONCLUSION：①Erythrocyte GSH and MDA levels and deformation index of erythrocyte change significantly on the 3^rd day following acute cerebral infarction. Index detection results gradually tended to be normal on from the 7^th day to 14^th days day after onset. ② Change of erythrocyte GSH level can reflect the severity of disease of patients with acute cerebral infarction.③Decrease of erythrocyte GSH level in patients with acute cerebral infarction is one of reasons that result in the decrease of deformation ability of erythrocyte.

A New Critical Value Concerning the Genealogy of Long Period Families at L_4 in the Restricted Three-body Problem

We found another critical mass ratio value -↑μ between μ4 and μ5 concerning the genealogy of the long period family around the equilateral equilibrium point L4 in the restricted three-body problem. This value has not been pointed out before. We used numerical computations to show how the long period family evolves around this critical value. The case is similar to that of the critical values between μ2 and μ4, with slight difference in evolution details.

On the Period Variation of the W UMa-type Contact Binary V502 Ophiuchi

The variation in the orbital period of the W UMa type contact binary V502 Oph is analyzed. The orbital period exhibits a wavelike variation with a periodicity of 23.0 years and an amplitude of AP = 1.24 ×10^-5 days superimposed on secular decrease of dP/dt = 1.68× 10^-7 day per year. The long-term decrease may be accompanied by the contraction of the secondary at a rate of 83 m per year and a mass transfer rate from the primary to the secondary of 4.28×10^-8M· per year. The short-term oscillation may be explained by the presence of a third component. Orbital elements of the third body and its possible mass are presented.

Effects of Electrical Stimulation During Absolute Refractory Period on Contraction and Relaxation of Cardiomyocytes from Normal Guinea - pigs

Objectives To investi-gate the effect of electrical stimulation during absolute refractory period on contraction and relaxation of ventricular myocytes from normal guinea - pigs. Methods The guinea - pig ventricular myocytes were obtained by enzyme digesting, and the extent of its contraction and relaxation and Ca2+ transient were recorded through the motion edge detection system. Results (1) The contracting extent of guinea - pig ventricular myocytes increased 15.45±6.48% , and the peak velocity of shorting (contraction) and the peak veloci ty of relengthening (relaxation) increased 15.97 ± 8.37% and 21. 63±8. 06% respectively (n = 10); (2) The extent of ventricular myocytes fluorescence ra tio(360/380) (F360/F380) increased 22. 55±9. 08%, and the peak velocity of ventricular myocytes F360 /F380 increased 36. 75 ± 9. 77% and 23. 62±4. 47% during shorting and relengthening respectively (n = 6) . Conclusions Appropriate electrical stimulation may strengthen the contracting and relaxing function of normal guinea - pig ventricular myocytes.

随访护理在缓解期成年癫痫患者中的应用效果

目的探讨随访护理在缓解期成年癫痫患者中的应用效果。方法使用随机数表法将2022年1月至2023年6月在郑州大学第一附属医院就诊的68例缓解期成年癫痫患者分为对照组(34例)和观察组(34例)。在对对照组实施常规护理基础上给予观察组随访护理干预。比较两组干预前后的汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、志气缺失综合征量表(DS-MV)、中文改良版癫痫自我管理行为量表(ESME)、癫痫患者生活质量评定量表(QOLIE-31)评分。结果干预后,两组HAMA、HAMD、DS-MV评分均下降,ESME、QOLIE-31评分均上升,且观察组HAMA、HAMD、DS-MV评分较低,ESME、QOLIE-31评分较高(P<0.05)。结论随访护理可有效改善缓解期成人癫痫患者的焦虑、抑郁情绪和志气缺失水平,对提高患者自护能力和生活质量有积极作用。

生物钟基因Period2对卵巢癌裸鼠移植瘤生长抑制作用的机制研究

目的:探讨生物钟基因Period2对卵巢癌裸鼠移植瘤生长抑制的作用机制。方法:采用卵巢癌SKVO3细胞株构建裸鼠卵巢癌移植瘤,利用基因转染技术外源性导入重组基因质粒Period2。采用Real-time PCR法和Western bolt法检测移植瘤中Period2表达,治疗期间测量移植瘤体积。治疗后2周处死裸鼠,称取瘤重,采用Real-time PCR和Western blot法检测肿瘤组织中Bcl-2和Bax基因的表达。结果:外源性导入Period2基因在裸鼠移植瘤肿瘤组织中成功稳定表达。与对照组比较,Period2基因过表达组的肿瘤生长速度减慢,肿瘤体积和重量降低,抑瘤率升高,凋亡基因Bax表达明显升高,凋亡抑制基因Bcl-2表达明显降低,差异均有统计学意义(P<0.05)。结论:Period2可能通过下调肿瘤凋亡抑制基因Bcl-2,促进凋亡基因Bax表达,促进肿瘤细胞凋亡,从而抑制卵巢癌的生长转移,发挥抑瘤作用。

MCP-1在脑动脉支架植入术围术期及随访期间的炎症研究

目的以脑血管支架植入患者为研究对象,通过ELISA方法探讨单核细胞趋化蛋白-1(MCP-1)在围术期及随访期间的表达,进一步了解MCP-1在支架植入术后的炎症免疫反应过程。方法筛选50例该中心给予脑血管支架植入的患者,另有30例同期住院未接受支架术治疗的同病患者为对照组。签署知情同意书后,分别在两组患者术前、术后7 d和术后6个月,用ELISA检测其相关炎性细胞因子MCP-1的表达水平。结果与对照组比较,支架治疗患者外周血中MCP-1水平在术前分布接近(P>0.05),在术后7 d和术后6个月明显升高(P<0.01)。支架治疗组患者术后6个月经影像学检查证实发生再狭窄患者16例(32%),其血清MCP-1水平分布在术前和术后7 d与支架术后无再狭窄患者接近(P>0.05),但术后6个月MCP-1水平显著高于后者(P<0.01)。结论血浆MCP-1的表达增高可能参与了脑血管支架植入后引发的局部和系统的急性炎症反应,且指标随访期间高表达是支架术后再狭窄的危险因素。

The biosynthesis of alarm pheromone in the wheat aphid Rhopalosiphum padi is regulated by hormones via fatty acid metabolism

Aphids are major insect pests in agriculture and forestry worldwide.Following attacks by natural enemies,many aphids release an alarm pheromone to protect their population.In most aphids,the main component of the aphid alarm pheromone(AAP)is the sesquiterpene hydrocarbon(E)-β-farnesene(EβF).However,the mechanisms behind its biosynthesis and regulation remain poorly understood.In this study,we used the bird cherry–oat aphid Rhopalosiphum padi,which is an important wheat aphid,to investigate the regulatory mechanisms of EβF biosynthesis.Our results showed that EβF biosynthesis occurs during the mature embryo period and the molting period of the 1st-and 2nd-instar nymphs.Triglycerides provide the prerequisite material for EβF production and release.Based on transcriptome sequencing,RNAi analysis,hormone treatments,and quantitative measurements,we found that the biosynthesis of EβF utilizes acetyl coenzyme A produced from fatty acid degradation,which can be suppressed by juvenile hormone but it is promoted by 20-hydroxyecdysone through the modulation of fatty acid metabolism.This is the first systemic study on the modulation of EβF production in aphids.The results of our study provide insights into the molecular regulatory mechanisms of AAP biosynthesis,as well as valuable information for designing potential aphid control strategies.

Novel implementation of homogenization method to predict effective properties of periodic materials

Representative volume element （RVE） method and asymptotic homogenization （AH） method are two widely used methods in predicting effective properties of pe- riodic materials. This paper develops a novel implementa- tion of the AH method, which has rigorous mathematical foundation of the AH method, and also simplicity as the RVE method. This implementation can be easily realized using commercial software as a black box, and can use all kinds of elements available in commercial software to model unit cells with rather complicated microstructures, so the model may remain a fairly small scale. Several examples were car- fled out to demonstrate the simplicity and effectiveness of the new implementation.

Tides and short-term variabilities in the Kuroshio west of Yonakuni-jima

Direct current measurements at the mooring station M southwest of Yonakuni-jima are carried out from May 18 to June 1, 1996. The Observed Kuroshio Current at 290 and 594 m depths of the mooring station M is quite steady ddring the pened of Observation. The rotary spectral estimates of the current data by the maximum entropy method show that there are prominent diurnal and semidiurnal spectral peaks. The semidiurnal tide is predominant at 290 m depth while there is the current fluctuation with the inertial period except for the tidal oscillation at 594 m depth. There are also peaks at the pened of 4-7 d. There is a significant coherence between two time series of currents at 290 and 594 m depths in the pened range of 3 - 5 d. The Japan Meteorological Agency (JMA) wind data during the same period as the oceanic measurement are used in comparison with the current meter data. Rotary spectral estimates for the wind data show significant peaks at the period of 3 - 5 d. It is concluded from the cross spectra between the wind and the current that the current fluctuation of 3 - 5 d period at 290 m depth response to the wind fluctuation of the same periods with time lags smaller than 1 d.

S-ROM假体联合转子下截骨治疗Crowe Ⅳ型髋关节发育不良

目的探讨采用S-ROM假体联合股骨转子下横形截骨行全髋关节置换术的方法,评价其对于治疗Crowe Ⅳ型成人髋关节发育不良疾病的疗效。方法收集11例(13髋)Crowe Ⅳ型髋关节发育不良患者,采用S-ROM假体联合股骨转子下横断截骨短缩法行全髋关节置换手术。采集双下肢长度差、髋关节活动度、改良Harris髋关节评分、简明健康调查表及髋关节X线片等相关临床资料进行对比分析。结果 11例患者均得到有效随访,中位随访时间60月(8~78月)。未发现感染、骨折、脱位等并发症。双下肢长度差术前为(25.2±7.6)mm,术后为(1.2±0.4)mm(t=10.481,P<0.01)。改良Harris评分由术前的(38.2±6.4)分提高到术后(82.1±8.6)分,差别有统计学意义(t=14.186,P<0.01)。影像学示假体固定优良,无临近骨质溶解表现。所有施行臼侧植骨及股骨截骨处均骨性愈合。结论 S-ROM假体联合股骨转子下横形截骨行全髋关节置换术,对于恢复Crowe Ⅳ型成人髋关节发育不良患者髋关节功能、解除髋关节疼痛疗效确切,并能有效改善患者的生活质量。

Periodic Orbits in Rotating Second Degree and Order Gravity Fields

Periodic orbits in an arbitrary 2nd degree and order uniformly rotating gravity field are studied. We investigate the four equilibrium points in this gravity field. We see that close relation exists between the stability of these equilibria and the existence and stability of their nearby periodic orbits. We check the periodic orbits with non-zero periods. In our searching procedure for these periodic orbits, we remove the two unity eigenvalues from the state transition matrix to find a robust, non-singular linear map to solve for the periodic orbits. The algorithm converges well, especially for stable periodic orbits. Using the searching procedure, which is relatively automatic, we find five basic families of periodic orbits in the rotating second degree and order gravity field for planar motion, and discuss their existence and stability at different central body rotation rates.

Formation conditions and exploration direction of large natural gas reservoirs in the oil-prone Bohai Bay Basin, East China

The Bohai Bay Basin is a typical oil-prone basin, in which natural gas geological reserves have a small proportion. In this basin, the gas source rock is largely medium-deep lake mudstone with oil-prone type Ⅱ2-Ⅱ1 kerogens, and natural gas preservation conditions are poor due to active late tectonic movements. The formation conditions of large natural gas fields in the Bohai Bay Basin have been elusive. Based on the exploration results of Bohai Bay Basin and comparison with large gas fields in China and abroad, the formation conditions of conventional large-scale natural gas reservoirs in the Bohai Bay Basin were examined from accumulation dynamics, structure and sedimentation. The results show that the formation conditions of conventional large natural gas reservoirs in Bohai Bay Basin mainly include one core element and two key elements. The core factor is the strong sealing of Paleogene "quilt-like" overpressure mudstone. The two key factors include the rapid maturation and high-intensity gas generation of source rock in the late stage and large scale reservoir. On this basis, large-scale nature gas accumulation models in the Bohai Bay Basin have been worked out, including regional overpressure mudstone enriching model, local overpressure mudstone depleting model, sand-rich sedimentary subsag depleting model and late strongly-developed fault depleting model. It is found that Bozhong sag, northern Liaozhong sag and Banqiao sag have favorable conditions for the formation of large-scale natural gas reservoirs, and are worth exploring. The study results have important guidance for exploration of large scale natural gas reservoirs in the Bohai Bay Basin.

Analytical and Traveling Wave Solutions to the Fifth Order Standard Sawada-Kotera Equation via the Generalized exp(-Φ(ξ))-Expansion Method

In this article, we propose a generalized exp(-Φ(ξ))-expansion method and successfully implement it to find exact traveling wave solutions to the fifth order standard Sawada-Kotera (SK) equation. The exact traveling wave solutions are established in the form of trigonometric, hyperbolic, exponential and rational functions with some free parameters. It is shown that this method is standard, effective and easily applicable mathematical tool for solving nonlinear partial differential equations arises in the field of mathematical physics and engineering.

Clinical Experience with the Fifth-Generation of a Breast Implant with a Smooth, Fine Surface from a Korean Manufacturer in Asian Women

Background: In this study, we describe our clinical experience with the fifth-generation of a breast implant with a smooth, fine surface from a Korean manufacturer (BellaGel® SmoothFine;HansBiomed Co. Ltd., Seoul, Korea) in Asian women. Methods: We analyzed 223 women (mean age = 35.28 ± 9.45 years and mean follow-up period = 12.03 ± 2.48 months), comprising 118 bilateral cases and 109 unilateral ones, who received breast augmentation using the BellaGel® SmoothFine at our hospital between June 4, 2018 and February 28, 2019. For safety assessment, we analyzed frequencies of postoperative complications and overall survival of the BellaGel® SmoothFine. Results: Postoperatively, complications (12 cases, 5.38%) include asymmetry (3 cases, 1.35%), hematoma (2 cases, 0.90%), hypertrophic scars (2 cases, 0.90%), wound disruption (2 cases, 0.90%), rippling (1 case, 0.45%), capsular contracture (1 case, 0.45%), stretch deformities with skin excess (1 case, 0.45%). In addition, time-to-events were calculated as 10.94 ± 0.64 months (95% CI 9.69 - 12.19) and the survival rate reached 0.290 ± 0.168 (95% CI 0.094 - 0.901) at 12 months postoperatively. Conclusions: Here, we describe our clinical experience with the BellaGel® SmoothFine. Our results are of significance in that this is the first report about the fifth-generation of a breast implant with a smooth, fine surface from a Korean manufacturer for Asian women.

SOME PHENOMENA NEAR THE NUCLEUS OF THE COMET HALE-BOPP

An observational result from March 12 to April 15 for comet Hale-Bopp is given in this paper. During this period a fan-shaped erupted region with angular extent of about 100 degrees near the nucleus was seen continually. In addition, a shell structure with at most 5 layers often appeared. It is found that these layers were equal-spaced with a distance of about 2×10 4 km and were moving outward with a speed of about 35 m/s. It is suggested that this phenomenon was possibly a kind of wave created by charged attogram dust grains erupted from the nucleus, which collided with either the solar wind or material of the coma. The propagation period of the wave was about 6 days but the spin of the Comet Hale-Bopp could be very slow and the period was about 3 yr. This spin movement had the opposite direction as its orbital motion.